paclitaxel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, taxane derivatives 2044 33069-62-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • paclitaxel
  • (-)-Paclitaxel
  • abraxane
  • capxol
  • cyclopax
  • ebetaxel
  • genaxol
  • mitotax
  • padexol
  • plaxicel
  • taxol
  • Taxol A
  • Tocosol Paclitaxel
  • nabpaclitaxel
  • ABI-007
  • nab-paclitaxel
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
  • Molecular weight: 853.92
  • Formula: C47H51NO14
  • CLOGP: 3.88
  • LIPINSKI: 2
  • HAC: 15
  • HDO: 4
  • TPSA: 221.29
  • ALOGS: -5.19
  • ROTB: 14
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.54 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 6.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 11 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.361 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 9.977 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 24.604 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 17.179 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 4.450 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 11.600 % High 1
herg hERG pIC50 4.705 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 4.581 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 23.067 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 8.750 % High 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.603 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 11.066 High 1
mh-clint Mouse hepatocyte intrinsic clearance 36.475 High 1
mppb Mouse plasma protein binding (% unbound) 3.300 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 86.497 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 9.360 % High 1
rat-kpuu-brain Rat brain Kpuu 0.007 % High 1
rh-clint Rat hepatocyte intrinsic clearance 15.101 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 31.870 % High 1
rppb Rat plasma protein binding (% unbound) 5.680 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 5.309 uM High 1

Approvals:

DateAgencyCompanyOrphan
May 10, 2019 EMA TEVA BV
Sept. 20, 2019 PMDA Taiho Pharmaceutical Co., Ltd.
Dec. 29, 1992 FDA HQ SPCLT PHARMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Malignant neoplasm progression 3658.41 12.41 2561 209619 104309 90311958
Neutropenia 3338.44 12.41 3320 208860 221584 90194683
Neuropathy peripheral 3090.53 12.41 2560 209620 134410 90281857
Disease progression 2603.38 12.41 2462 209718 154153 90262114
Myelosuppression 2596.09 12.41 1597 210583 51994 90364273
Febrile neutropenia 1693.96 12.41 1968 210212 156381 90259886
Anaemia 1598.58 12.41 2916 209264 349886 90066381
Flushing 1568.52 12.41 1443 210737 87048 90329219
Metastases to liver 1493.30 12.41 897 211283 27910 90388357
Erythema 1446.92 12.41 2200 209980 227046 90189221
Metastases to bone 1368.34 12.41 812 211368 24693 90391574
Neutrophil count decreased 1121.18 12.41 1090 211090 70442 90345825
Metastases to lung 971.42 12.41 552 211628 15439 90400828
Joint swelling 942.64 12.41 60 212120 503240 89913027
Neoplasm progression 915.95 12.41 790 211390 43696 90372571
Polyneuropathy 904.41 12.41 564 211616 18777 90397490
Dyspnoea 874.78 12.41 4220 207960 876735 89539532
Palmar-plantar erythrodysaesthesia syndrome 825.41 12.41 614 211566 27409 90388858
Acute myeloid leukaemia 821.95 12.41 544 211636 20096 90396171
Thrombocytopenia 815.67 12.41 1622 210558 207103 90209164
Pneumonitis 760.20 12.41 709 211471 43461 90372806
Leukopenia 740.74 12.41 1040 211140 99670 90316597
Systemic lupus erythematosus 739.34 12.41 24 212156 361872 90054395
Pemphigus 726.75 12.41 7 212173 326857 90089410
Synovitis 719.93 12.41 10 212170 329742 90086525
Metastases to central nervous system 717.11 12.41 470 211710 17072 90399195
Arthropathy 712.10 12.41 35 212145 366207 90050060
Chest discomfort 705.07 12.41 1206 210974 137159 90279108
Rheumatoid arthritis 697.59 12.41 37 212143 362577 90053690
Glossodynia 697.16 12.41 11 212169 321768 90094499
Peripheral sensory neuropathy 687.92 12.41 365 211815 8885 90407382
Therapy partial responder 651.45 12.41 484 211696 21559 90394708
Anaphylactic shock 647.78 12.41 560 211620 31057 90385210
Neurotoxicity 642.60 12.41 475 211705 20992 90395275
Ejection fraction decreased 635.32 12.41 512 211668 25741 90390526
Contraindicated product administered 620.98 12.41 31 212149 320108 90096159
Haematotoxicity 599.85 12.41 371 211809 12164 90404103
Swelling 592.10 12.41 129 212051 418929 89997338
Abdominal discomfort 584.09 12.41 195 211985 477133 89939134
Mucosal inflammation 568.50 12.41 688 211492 56937 90359330
Myelodysplastic syndrome 547.25 12.41 427 211753 20476 90395791
Therapeutic product effect decreased 537.88 12.41 27 212153 277544 90138723
Metastases to lymph nodes 521.70 12.41 331 211849 11358 90404909
Wound 517.29 12.41 54 212126 302926 90113341
Psoriatic arthropathy 516.70 12.41 3 212177 228332 90187935
Helicobacter infection 508.20 12.41 4 212176 226846 90189421
Weight increased 507.23 12.41 173 212007 417754 89998513
Sinusitis 506.62 12.41 95 212085 342993 90073274
Breast cancer metastatic 505.75 12.41 358 211822 14774 90401493
Ascites 502.22 12.41 589 211591 47151 90369116
Pain 490.72 12.41 999 211181 995342 89420925
Product dose omission issue 480.34 12.41 59 212121 291628 90124639
Duodenal ulcer perforation 473.22 12.41 9 212171 221279 90194988
Interstitial lung disease 472.00 12.41 727 211453 75678 90340589
Musculoskeletal stiffness 459.99 12.41 72 212108 296460 90119807
Pericarditis 458.95 12.41 49 212131 270102 90146165
Skin toxicity 452.49 12.41 249 211931 6530 90409737
Peripheral swelling 450.20 12.41 202 211978 412904 90003363
Death 449.84 12.41 2186 209994 454365 89961902
Epistaxis 447.97 12.41 753 211427 84372 90331895
Fibromyalgia 446.82 12.41 7 212173 206262 90210005
Irritable bowel syndrome 445.37 12.41 8 212172 207440 90208827
Second primary malignancy 424.01 12.41 278 211902 10100 90406167
Headache 420.21 12.41 870 211310 861876 89554391
Mobility decreased 417.03 12.41 49 212131 250685 90165582
Blood cholesterol increased 413.49 12.41 17 212163 207995 90208272
Nasopharyngitis 408.91 12.41 222 211958 406882 90009385
Fall 405.13 12.41 321 211859 481489 89934778
Condition aggravated 396.98 12.41 487 211693 595058 89821209
Muscle injury 396.20 12.41 3 212177 176651 90239616
Drug ineffective 395.14 12.41 1787 210393 1382511 89033756
Immune-mediated hepatic disorder 390.74 12.41 150 212030 1642 90414625
Immune-mediated adrenal insuficiency 380.58 12.41 129 212051 953 90415314
Folliculitis 380.13 12.41 25 212155 204328 90211939
Bone marrow failure 376.84 12.41 420 211760 31801 90384466
Cystoid macular oedema 374.52 12.41 152 212028 1948 90414319
Pseudocirrhosis 373.60 12.41 123 212057 821 90415446
Injury 373.51 12.41 22 212158 197327 90218940
Immune-mediated hypothyroidism 370.71 12.41 139 212041 1419 90414848
Hepatic function abnormal 365.63 12.41 495 211685 45793 90370474
Proteinuria 361.05 12.41 353 211827 22938 90393329
Feeling hot 360.87 12.41 652 211528 77356 90338911
Treatment failure 359.67 12.41 131 212049 303797 90112470
Hepatic enzyme increased 356 12.41 201 211979 360535 90055732
Cardiotoxicity 349.83 12.41 256 211924 11133 90405134
Back pain 345.17 12.41 1564 210616 315611 90100656
Metastases to peritoneum 340.51 12.41 175 212005 3980 90412287
Drug intolerance 338.98 12.41 329 211851 447262 89969005
Platelet count decreased 333.83 12.41 884 211296 136085 90280182
Asthma 330.85 12.41 80 212100 242080 90174187
Type 2 diabetes mellitus 325.15 12.41 45 212135 203199 90213068
Oxygen saturation decreased 323.47 12.41 752 211428 106731 90309536
Pleural effusion 323.41 12.41 771 211409 111220 90305047
Contusion 322.36 12.41 94 212086 251122 90165145
Migraine 322.09 12.41 35 212145 190357 90225910
Bronchospasm 319.38 12.41 313 211867 20396 90395871
Maternal exposure during pregnancy 319.06 12.41 227 211953 359836 90056431
Immune-mediated enterocolitis 318.24 12.41 175 212005 4582 90411685
Completed suicide 318.11 12.41 4 212176 145054 90271213
White blood cell count decreased 317.48 12.41 986 211194 166123 90250144
Blister 313.59 12.41 103 212077 254895 90161372
Pancytopenia 312.39 12.41 795 211385 119468 90296799
Lower respiratory tract infection 306.92 12.41 102 212078 250557 90165710
Onycholysis 306.11 12.41 134 212046 2096 90414171
Diarrhoea 301.61 12.41 3439 208741 935751 89480516
Arthralgia 298.93 12.41 887 211293 777635 89638632
Discomfort 294.21 12.41 137 212043 274198 90142069
Nausea 291.41 12.41 3914 208266 1106402 89309865
Hypoxia 288.74 12.41 568 211612 71831 90344436
Osteoarthritis 287.02 12.41 55 212125 195675 90220592
Ovarian cancer recurrent 283.26 12.41 115 212065 1475 90414792
Hypothyroidism 282.14 12.41 472 211708 52655 90363612
Confusional state 281.90 12.41 293 211887 385912 90030355
Joint range of motion decreased 280.34 12.41 8 212172 135635 90280632
Product use issue 278.10 12.41 219 211961 329700 90086567
Depression 277.63 12.41 181 211999 300420 90115847
Immune-mediated hepatitis 276.51 12.41 136 212044 2808 90413459
Wheezing 270.99 12.41 109 212071 237971 90178296
Hypertransaminasaemia 270.21 12.41 253 211927 15572 90400695
Gastrointestinal perforation 264.28 12.41 150 212030 4182 90412085
Hepatic cytolysis 258.53 12.41 340 211840 30576 90385691
Breast cancer recurrent 256.01 12.41 160 212020 5343 90410924
Cardiac dysfunction 253.58 12.41 137 212043 3460 90412807
Psoriasis 252.87 12.41 26 212154 147728 90268539
Sleep disorder 250.55 12.41 76 212104 197954 90218313
Pyrexia 247.57 12.41 2496 209684 657989 89758278
Bursitis 245.10 12.41 16 212164 131638 90284629
C-reactive protein abnormal 244.80 12.41 13 212167 127416 90288851
Bone pain 237.19 12.41 478 211702 61505 90354762
Memory impairment 236.68 12.41 83 212097 197161 90219106
Asthenia 230.05 12.41 2078 210102 531673 89884594
Anaphylactic reaction 229.75 12.41 581 211599 86943 90329324
Impaired healing 225.91 12.41 134 212046 234065 90182202
Pulmonary embolism 224.85 12.41 746 211434 130074 90286193
Injection site pain 222.76 12.41 65 212115 173634 90242633
Metastasis 220.96 12.41 152 212028 5985 90410282
Exposure during pregnancy 219.48 12.41 144 212036 238266 90178001
Metastases to meninges 213.61 12.41 124 212056 3611 90412656
PIK3CA-activated mutation 210.79 12.41 86 212094 1118 90415149
Gait inability 206.71 12.41 45 212135 146411 90269856
Road traffic accident 206.67 12.41 11 212169 107615 90308652
Facet joint syndrome 206.32 12.41 5 212175 98384 90317883
Disease recurrence 205.91 12.41 339 211841 37314 90378953
Loss of personal independence in daily activities 204.34 12.41 36 212144 136069 90280198
Embolism 198.34 12.41 170 212010 9311 90406956
Overdose 196.83 12.41 62 212118 157647 90258620
Arthritis 194.64 12.41 74 212106 167241 90249026
Sense of oppression 194.04 12.41 79 212101 1021 90415246
Prescribed overdose 193.86 12.41 8 212172 97617 90318650
Hepatic failure 192.58 12.41 339 211841 39389 90376878
Immune-mediated dermatitis 192.57 12.41 75 212105 856 90415411
Radiotherapy 192.25 12.41 75 212105 860 90415407
Throat tightness 191.11 12.41 287 211893 29197 90387070
Tachycardia 190.65 12.41 803 211377 156870 90259397
Myocarditis 189.65 12.41 196 211984 13610 90402657
Hypokalaemia 188.52 12.41 705 211475 130411 90285856
Obesity 184.64 12.41 17 212163 105490 90310777
Cardiac failure 184.23 12.41 620 211560 108876 90307391
Insomnia 184.00 12.41 311 211869 333163 90083104
Urticaria 183.51 12.41 280 211900 312454 90103813
Night sweats 182.87 12.41 39 212141 128727 90287540
Large intestine perforation 180.85 12.41 163 212017 9549 90406718
Adrenal insufficiency 178.11 12.41 280 211900 29641 90386626
Cyanosis 176.84 12.41 223 211957 19232 90397035
Immune-mediated myocarditis 176.64 12.41 78 212102 1247 90415020
Colitis 175.99 12.41 457 211723 69485 90346782
Metastases to skin 174.98 12.41 90 212090 2050 90414217
Breast cancer stage III 174.41 12.41 5 212175 84442 90331825
Red blood cell sedimentation rate increased 173.94 12.41 4 212176 82591 90333676
Neutropenic sepsis 171.48 12.41 212 211968 17918 90398349
Hyperthyroidism 171.41 12.41 213 211967 18097 90398170
Drug hypersensitivity 171.22 12.41 537 211643 463072 89953195
Osteonecrosis of jaw 170.89 12.41 319 211861 38784 90377483
Sciatica 170.49 12.41 19 212161 101363 90314904
Left ventricular dysfunction 169.42 12.41 190 211990 14479 90401788
Gastrointestinal toxicity 166.73 12.41 154 212026 9313 90406954
Injection site reaction 166.17 12.41 13 212167 92067 90324200
Drug abuse 166.06 12.41 6 212174 82341 90333926
Thyroiditis 164.80 12.41 104 212076 3533 90412734
Hypercholesterolaemia 164.49 12.41 21 212159 100871 90315396
Immune-mediated lung disease 162.25 12.41 82 212098 1798 90414469
Cholangitis 158.90 12.41 133 212047 7049 90409218
Metastases to pleura 158.62 12.41 83 212097 1961 90414306
Pneumocystis jirovecii pneumonia 158.40 12.41 223 211957 21393 90394874
Abdominal pain 158.35 12.41 1517 210663 394204 90022063
Muscle spasms 158.11 12.41 215 211965 251668 90164599
Lymphangiosis carcinomatosa 156.32 12.41 77 212103 1595 90414672
Inflammation 156.19 12.41 114 212066 178478 90237789
Dehydration 155.67 12.41 880 211300 193567 90222700
Ill-defined disorder 154.08 12.41 124 212056 184767 90231500
Urogenital fistula 152.16 12.41 53 212127 429 90415838
Influenza 150.05 12.41 69 212111 139195 90277072
Intestinal perforation 148.82 12.41 173 212007 13708 90402559
Hospitalisation 148.40 12.41 57 212123 128043 90288224
Suicide attempt 147 12.41 7 212173 75392 90340875
Stress cardiomyopathy 145.79 12.41 168 212012 13187 90403080
Type I hypersensitivity 145.10 12.41 101 212079 4054 90412213
Hypophysitis 145.01 12.41 84 212096 2436 90413831
Rash maculo-papular 144.04 12.41 305 211875 40628 90375639
Injection site erythema 143.67 12.41 28 212152 98474 90317793
Dysaesthesia 143.30 12.41 110 212070 5145 90411122
Vomiting 142.90 12.41 2614 209566 785679 89630588
Cardiomyopathy 141.51 12.41 204 211976 20002 90396265
Autoimmune disorder 140.86 12.41 10 212170 76734 90339533
Immune-mediated hypophysitis 140.05 12.41 51 212129 476 90415791
Hydronephrosis 138.74 12.41 158 212022 12244 90404023
Lichenoid keratosis 136.68 12.41 81 212099 2453 90413814
Nail toxicity 135.96 12.41 47 212133 371 90415896
Ileus 135.29 12.41 180 212000 16366 90399901
Adrenocorticotropic hormone deficiency 134.94 12.41 55 212125 713 90415554
Amnesia 134.76 12.41 43 212137 108462 90307805
Ear infection 134.37 12.41 7 212173 69768 90346499
Peripheral venous disease 133.17 12.41 19 212161 83902 90332365
Intentional product misuse 129.57 12.41 26 212154 89578 90326689
Tumour marker increased 129.44 12.41 108 212072 5699 90410568
Thrombotic microangiopathy 128.32 12.41 171 212009 15572 90400695
Anaphylactoid reaction 127.29 12.41 96 212084 4372 90411895
Wound infection 127.20 12.41 45 212135 106357 90309910
Radiation pneumonitis 126.07 12.41 69 212111 1789 90414478
Gait disturbance 125.11 12.41 264 211916 260232 90156035
Somnolence 123.74 12.41 186 211994 208898 90207369
Biliary tract infection 123.31 12.41 53 212127 791 90415476
Nail discolouration 123.14 12.41 83 212097 3159 90413108
Metastatic neoplasm 123.06 12.41 97 212083 4718 90411549
Peripheral motor neuropathy 122.20 12.41 69 212111 1904 90414363
Gastrooesophageal reflux disease 121.42 12.41 126 212054 166211 90250056
Macular oedema 119.28 12.41 96 212084 4813 90411454
Toxic skin eruption 118.96 12.41 165 212015 15609 90400658
Hypopituitarism 118.67 12.41 65 212115 1688 90414579
Computerised tomogram thorax abnormal 118.59 12.41 69 212111 2018 90414249
Injection site swelling 118.47 12.41 5 212175 59834 90356433
Hepatotoxicity 116.82 12.41 301 211879 45541 90370726
Pain in extremity 116.78 12.41 600 211580 449929 89966338
Prescribed underdose 116.69 12.41 18 212162 75001 90341266
Anxiety 116.24 12.41 356 211824 309416 90106851
Illness 116.02 12.41 25 212155 81944 90334323
Osteoporosis 115.09 12.41 41 212139 96490 90319777
Hot flush 114.68 12.41 353 211827 59135 90357132
Lower limb fracture 114.24 12.41 29 212151 84984 90331283
Hypotension 113.05 12.41 1212 210968 324185 90092082
Fluid retention 112.84 12.41 33 212147 88058 90328209
Posterior reversible encephalopathy syndrome 112.65 12.41 194 211986 22145 90394122
Hepatitis B reactivation 112.36 12.41 85 212095 3889 90412378
Live birth 112.23 12.41 24 212156 79083 90337184
Sepsis 111.99 12.41 763 211417 179051 90237216
Tumour necrosis 111.53 12.41 52 212128 949 90415318
Metastases to spine 110.14 12.41 82 212098 3661 90412606
Immune-mediated hyperthyroidism 109.74 12.41 39 212141 337 90415930
Decreased appetite 109.13 12.41 1354 210826 375186 90041081
Pneumothorax 108.08 12.41 175 212005 18992 90397275
Medication error 107.90 12.41 32 212148 84620 90331647
Alanine aminotransferase increased 107.83 12.41 555 211625 117783 90298484
Laryngospasm 107.09 12.41 77 212103 3256 90413011
Bone erosion 106.43 12.41 4 212176 53017 90363250
Pregnancy 105.92 12.41 11 212169 62036 90354231
Injection site pruritus 104.94 12.41 5 212175 53829 90362438
Joint stiffness 104.14 12.41 27 212153 78015 90338252
Neoplasm recurrence 104.05 12.41 75 212105 3184 90413083
Hepatic atrophy 103.91 12.41 35 212145 253 90416014
Febrile bone marrow aplasia 103.78 12.41 121 212059 9617 90406650
Exostosis 103.36 12.41 5 212175 53129 90363138
Foot deformity 103.33 12.41 10 212170 59641 90356626
Liver injury 102.61 12.41 150 212030 170417 90245850
Intentional product use issue 101.48 12.41 223 211957 216669 90199598
Infection 101.44 12.41 469 211711 361625 90054642
Adverse drug reaction 101.35 12.41 75 212105 116626 90299641
Product quality issue 101.08 12.41 30 212150 79295 90336972
Neutropenic colitis 100.62 12.41 81 212099 4062 90412205
Enterocolitis 99.75 12.41 123 212057 10367 90405900
Small intestinal obstruction 98.79 12.41 178 212002 21056 90395211
Granulocyte count decreased 98.49 12.41 65 212115 2387 90413880
Immune-mediated endocrinopathy 98.28 12.41 28 212152 105 90416162
Suicidal ideation 97.70 12.41 26 212154 73829 90342438
Dizziness 97.45 12.41 896 211284 588388 89827879
Musculoskeletal pain 96.88 12.41 157 212023 171094 90245173
Suffocation feeling 95.63 12.41 55 212125 1573 90414694
Erythema multiforme 95.21 12.41 130 212050 12116 90404151
Infusion related hypersensitivity reaction 94.85 12.41 41 212139 621 90415646
Immune-mediated thyroiditis 94.83 12.41 38 212142 470 90415797
Immune-mediated pancreatitis 94.60 12.41 35 212145 343 90415924
Hyperaemia 94.09 12.41 65 212115 2577 90413690
Dysgeusia 94.07 12.41 304 211876 52256 90364011
Device related infection 94.05 12.41 195 211985 25591 90390676
Feeling abnormal 93.97 12.41 154 212026 167081 90249186
Dry mouth 93.94 12.41 180 212000 183879 90232388
Off label use 93.81 12.41 3302 208878 1098950 89317317
Glucocorticoid deficiency 93.63 12.41 39 212141 536 90415731
Therapeutic product effect incomplete 92.65 12.41 197 211983 193699 90222568
Disseminated intravascular coagulation 91.97 12.41 174 212006 21364 90394903
Joint dislocation 90.75 12.41 3 212177 44579 90371688
Pulmonary fibrosis 89.65 12.41 72 212108 107431 90308836
Malignant pleural effusion 89.61 12.41 66 212114 2898 90413369
Small intestinal perforation 89.51 12.41 56 212124 1873 90414394
Metastases to the mediastinum 88.63 12.41 39 212141 618 90415649
Bronchitis 88.58 12.41 138 212042 152789 90263478
Alveolitis 88.49 12.41 66 212114 2955 90413312
Transaminases increased 88.44 12.41 238 211942 36954 90379313
Acute promyelocytic leukaemia 88.05 12.41 46 212134 1083 90415184
Hypomagnesaemia 87.93 12.41 231 211949 35357 90380910
Tumour haemorrhage 87.75 12.41 57 212123 2037 90414230
Pericardial effusion 86.88 12.41 235 211945 36598 90379669
Loss of consciousness 86.66 12.41 594 211586 139644 90276623
Recurrent cancer 86.40 12.41 60 212120 2399 90413868
Constipation 85.84 12.41 1019 211161 279376 90136891
Dyspepsia 85.27 12.41 213 211967 197947 90218320
Recall phenomenon 85.08 12.41 41 212139 808 90415459
Cholangitis sclerosing 84.69 12.41 57 212123 2164 90414103
Troponin increased 84.24 12.41 128 212052 13153 90403114
Hypertensive crisis 83.91 12.41 150 212030 17634 90398633
Immune-mediated renal disorder 83.66 12.41 28 212152 198 90416069
Lymphoedema 83.65 12.41 130 212050 13623 90402644
Lymphopenia 82.24 12.41 172 212008 22709 90393558
Cytopenia 82.11 12.41 147 212033 17302 90398965
Disability 82.03 12.41 3 212177 40742 90375525
Hip arthroplasty 81.70 12.41 38 212142 76170 90340097
Tumour lysis syndrome 81.63 12.41 115 212065 11037 90405230
Pulmonary toxicity 81.59 12.41 117 212063 11414 90404853
General physical health deterioration 81.56 12.41 1225 210955 353890 90062377
Congestive cardiomyopathy 81.09 12.41 93 212087 7261 90409006
Aspartate aminotransferase increased 81.08 12.41 464 211716 102473 90313794
Carbohydrate antigen 15-3 increased 80.12 12.41 53 212127 1954 90414313
Performance status decreased 80.02 12.41 72 212108 4208 90412059
Lupus-like syndrome 80.02 12.41 10 212170 48836 90367431
Secondary cerebellar degeneration 79.92 12.41 21 212159 53 90416214
Subileus 79.62 12.41 67 212113 3577 90412690
Paronychia 79.57 12.41 96 212084 7910 90408357
Drug interaction 79.23 12.41 355 211825 276098 90140169
Atelectasis 79.16 12.41 176 212004 24233 90392034
Hyperpyrexia 79.13 12.41 75 212105 4686 90411581
Bronchostenosis 79.01 12.41 34 212146 509 90415758
Hepatic lesion 78.75 12.41 81 212099 5592 90410675
Ovarian cancer metastatic 77.79 12.41 42 212138 1059 90415208
Incorrect dose administered 77.70 12.41 44 212136 78886 90337381
Septic shock 77.55 12.41 396 211784 83764 90332503
Delirium 77.33 12.41 78 212102 104281 90311986
Computerised tomogram thorax 76.81 12.41 33 212147 492 90415775
Paraesthesia 76.73 12.41 910 211270 249416 90166851
Device related thrombosis 75.73 12.41 52 212128 2041 90414226
Immune-mediated adverse reaction 75.53 12.41 38 212142 825 90415442
Hypertension 75.32 12.41 1496 210684 456036 89960231
Back injury 75.27 12.41 10 212170 46612 90369655
Capillary leak syndrome 73.44 12.41 57 212123 2710 90413557
Incorrect route of product administration 72.55 12.41 15 212165 50611 90365656
Chills 71.70 12.41 542 211638 131439 90284828
Abortion spontaneous 71.56 12.41 19 212161 54037 90362230
Drug resistance 70.55 12.41 193 211987 30256 90386011
Blood pressure fluctuation 70.19 12.41 18 212162 52395 90363872
Walking aid user 70.18 12.41 3 212177 35503 90380764
Aortitis 69.81 12.41 42 212138 1308 90414959
Muscle spasticity 69.76 12.41 3 212177 35319 90380948
Eastern Cooperative Oncology Group performance status worsened 69.75 12.41 48 212132 1891 90414376
Bile duct stenosis 69.54 12.41 46 212134 1696 90414571
Respiratory distress 69.46 12.41 225 211955 38721 90377546
Metastases to kidney 69.16 12.41 25 212155 228 90416039
Adverse event 68.91 12.41 105 212075 117313 90298954
Lymphadenopathy mediastinal 68.73 12.41 58 212122 3109 90413158
Mastectomy 68.60 12.41 49 212131 2050 90414217
Neuromuscular toxicity 68.52 12.41 26 212154 275 90415992
Peritonitis 68.36 12.41 146 212034 19559 90396708
Palmar erythema 68.02 12.41 47 212133 1864 90414403
Cervix carcinoma recurrent 67.84 12.41 23 212157 170 90416097
Upper respiratory tract infection 67.66 12.41 123 212057 128195 90288072
Deep vein thrombosis 66.99 12.41 405 211775 91215 90325052
Immune-mediated arthritis 66.09 12.41 25 212155 262 90416005
Acute interstitial pneumonitis 65.68 12.41 34 212146 785 90415482
Urinary tract obstruction 65.57 12.41 49 212131 2200 90414067
Metastases to retroperitoneum 65.20 12.41 22 212158 160 90416107
Endocarditis noninfective 65.15 12.41 19 212161 79 90416188
Portal hypertension 65.03 12.41 67 212113 4634 90411633
COVID-19 64.74 12.41 192 211988 168651 90247616
Nasal congestion 64.52 12.41 60 212120 83354 90332913
Pulse absent 64.13 12.41 75 212105 5980 90410287
Ovarian cancer 63.78 12.41 79 212101 6688 90409579
Breast cancer 63.52 12.41 272 211908 53489 90362778
Superior vena cava syndrome 63.34 12.41 32 212148 701 90415566
Unresponsive to stimuli 63.32 12.41 215 211965 37906 90378361
Immune-mediated gastritis 63.17 12.41 22 212158 178 90416089
Intestinal obstruction 63.07 12.41 211 211969 36920 90379347
Neutrophil count abnormal 62.91 12.41 62 212118 4066 90412201
Hyperhidrosis 62.23 12.41 538 211642 135767 90280500
Nephritis 62.22 12.41 55 212125 3140 90413127
Bone lesion 62.05 12.41 76 212104 6361 90409906
Therapy interrupted 61.95 12.41 20 212160 50088 90366179
Scleroderma-like reaction 61.59 12.41 20 212160 127 90416140
Carcinoembryonic antigen increased 61.48 12.41 48 212132 2302 90413965
Subclavian vein thrombosis 61.47 12.41 46 212134 2070 90414197
Laryngitis 61.45 12.41 21 212159 50732 90365535
Cystitis haemorrhagic 61.27 12.41 70 212110 5443 90410824
Carbohydrate antigen 125 increased 61.17 12.41 55 212125 3211 90413056
Metastases to abdominal wall 61.16 12.41 21 212159 162 90416105
Pruritus 60.79 12.41 897 211283 540628 89875639
Oedema 60.54 12.41 252 211928 200043 90216224
Malignant ascites 60.22 12.41 34 212146 938 90415329
Frequent bowel movements 60.09 12.41 29 212151 56906 90359361
Metastases to chest wall 60.06 12.41 30 212150 641 90415626
Hypersensitivity pneumonitis 59.62 12.41 59 212121 3889 90412378
Neck pain 59.40 12.41 110 212070 113853 90302414
Serotonin syndrome 59.12 12.41 9 212171 37878 90378389
Blood bilirubin increased 58.53 12.41 229 211951 43241 90373026
Pneumonia 58.49 12.41 1097 211083 636962 89779305
Type 1 diabetes mellitus 58.45 12.41 64 212116 4748 90411519
Gastroenteritis radiation 58.23 12.41 28 212152 549 90415718
Joint injury 57.85 12.41 5 212175 32659 90383608
Hallucination 57.77 12.41 42 212138 65917 90350350
Periarticular thenar erythema with onycholysis 57.46 12.41 16 212164 54 90416213
Toxicity to various agents 56.90 12.41 417 211763 287429 90128838
Basal cell carcinoma 56.78 12.41 6 212174 33383 90382884
Plasma cell myeloma 56.67 12.41 13 212167 40815 90375452
Nephrolithiasis 56.57 12.41 22 212158 49063 90367204
Cachexia 56.50 12.41 75 212105 6803 90409464
Drug dependence 56.28 12.41 3 212177 29324 90386943
Cancer fatigue 55.85 12.41 20 212160 177 90416090
Metastases to pelvis 55.26 12.41 27 212153 549 90415718
Rectal perforation 54.44 12.41 26 212154 502 90415765
Lymphadenopathy 54.39 12.41 232 211948 45543 90370724
Procedural pain 54.23 12.41 7 212173 33353 90382914
Swollen tongue 53.96 12.41 20 212160 45936 90370331
Radiation skin injury 53.75 12.41 33 212147 1067 90415200
Guillain-Barre syndrome 53.70 12.41 60 212120 4552 90411715
Oesophagitis 53.28 12.41 122 212058 17127 90399140
Fulminant type 1 diabetes mellitus 52.48 12.41 30 212150 848 90415419
Hypoalbuminaemia 51.97 12.41 115 212065 15782 90400485
Cough 51.79 12.41 1179 211001 367783 90048484
Respiratory failure 51.77 12.41 463 211717 117955 90298312
Gastritis bacterial 51.64 12.41 18 212162 146 90416121
Chronic obstructive pulmonary disease 51.55 12.41 58 212122 73771 90342496
Venous thrombosis 51.16 12.41 64 212116 5473 90410794
Macular degeneration 50.92 12.41 13 212167 37957 90378310
Underdose 50.51 12.41 32 212148 53985 90362282
Dermatitis acneiform 50.23 12.41 68 212112 6286 90409981
Extravasation 49.85 12.41 47 212133 2917 90413350
Hyperthermia 49.83 12.41 88 212092 10247 90406020
Psychotic disorder 49.70 12.41 7 212173 31223 90385044
Cervix cancer metastatic 49.69 12.41 15 212165 72 90416195
Ulcer haemorrhage 49.56 12.41 3 212177 26318 90389949
Biliary sepsis 49.25 12.41 30 212150 956 90415311
No adverse event 49.02 12.41 52 212128 67930 90348337
Eye pain 48.95 12.41 21 212159 44147 90372120
Immunodeficiency 48.80 12.41 20 212160 43214 90373053
Axillary lymphadenectomy 48.57 12.41 16 212164 107 90416160
Stress 48.52 12.41 72 212108 81323 90334944
Hyponatraemia 48.45 12.41 502 211678 133036 90283231
Tumour associated fever 48.07 12.41 23 212157 446 90415821
Eczema asteatotic 48.00 12.41 21 212159 328 90415939
Immune-mediated nephritis 47.93 12.41 23 212157 449 90415818
Onychomycosis 47.86 12.41 14 212166 37362 90378905
Sinus disorder 47.75 12.41 11 212169 34436 90381831
Lung disorder 47.54 12.41 185 211995 149698 90266569
Multiple sclerosis 47.35 12.41 5 212175 27835 90388432
Wrong technique in product usage process 47.01 12.41 59 212121 71512 90344755
Acute myelomonocytic leukaemia 46.17 12.41 18 212162 206 90416061
Abdominal pain upper 46.15 12.41 527 211653 332147 90084120
Emphysematous cystitis 46.02 12.41 20 212160 307 90415960
Pseudocellulitis 45.99 12.41 16 212164 129 90416138
Hand dermatitis 45.83 12.41 24 212156 568 90415699
Radiation necrosis 45.68 12.41 25 212155 648 90415619
Enterocolitis infectious 45.48 12.41 38 212142 2009 90414258
Toxic erythema of chemotherapy 45.41 12.41 18 212162 216 90416051
Unevaluable event 45.39 12.41 37 212143 54811 90361456
Metastases to breast 45.30 12.41 21 212159 378 90415889
Acute respiratory distress syndrome 45.21 12.41 159 212021 28527 90387740
Immune-mediated encephalitis 45.11 12.41 23 212157 514 90415753
Toxic cardiomyopathy 45.05 12.41 20 212160 324 90415943
Dermatitis bullous 44.86 12.41 84 212096 10232 90406035
Injection site rash 44.79 12.41 3 212177 24170 90392097
BRCA1 gene mutation 44.78 12.41 13 212167 53 90416214
Sarcoid-like reaction 44.37 12.41 17 212163 185 90416082
Metastases to stomach 44.18 12.41 18 212162 233 90416034
Autoimmune nephritis 44.18 12.41 21 212159 401 90415866
Metastases to soft tissue 44.18 12.41 19 212161 284 90415983
Jugular vein thrombosis 44.14 12.41 48 212132 3533 90412734
Tumour pseudoprogression 44.07 12.41 25 212155 696 90415571
Cortisol decreased 44.02 12.41 35 212145 1724 90414543
Pulmonary sarcoidosis 44.02 12.41 31 212149 1268 90414999
Tumour pain 43.94 12.41 36 212144 1851 90414416
Treatment noncompliance 43.93 12.41 34 212146 51693 90364574
Gastric disorder 43.68 12.41 12 212168 33372 90382895
Oesophagobronchial fistula 43.21 12.41 12 212168 40 90416227
Administration site extravasation 43.19 12.41 30 212150 1200 90415067
Product prescribing error 43.05 12.41 9 212171 30136 90386131
Bone marrow infiltration 43.04 12.41 26 212154 816 90415451
Blood uric acid decreased 42.73 12.41 26 212154 827 90415440
Dyskinesia 42.72 12.41 16 212164 36518 90379749
Coma 42.56 12.41 65 212115 72567 90343700
Organising pneumonia 42.34 12.41 69 212111 7528 90408739
Food allergy 42.26 12.41 5 212175 25473 90390794
Dyspnoea at rest 42.09 12.41 54 212126 4737 90411530
Blood corticotrophin decreased 42.03 12.41 22 212158 520 90415747
Mastitis 42.02 12.41 43 212137 2950 90413317
Axonal and demyelinating polyneuropathy 41.87 12.41 10 212170 14 90416253
Pneumonitis chemical 41.81 12.41 19 212161 326 90415941
Sinus congestion 41.70 12.41 7 212173 27417 90388850
Duodenal perforation 41.44 12.41 28 212152 1070 90415197
Lymphocele 41.34 12.41 25 212155 786 90415481
Skin disorder 41.28 12.41 183 211997 36523 90379744
Periodontitis 41.27 12.41 48 212132 3805 90412462
Chronic sinusitis 41.20 12.41 4 212176 23798 90392469
Peritoneal disorder 41.15 12.41 23 212157 622 90415645
Gastrointestinal necrosis 41.11 12.41 44 212136 3181 90413086
Wound dehiscence 41.08 12.41 59 212121 5763 90410504
Febrile infection 41.06 12.41 36 212144 2033 90414234
Pleural neoplasm 40.74 12.41 20 212160 411 90415856
Therapy non-responder 40.68 12.41 173 212007 136531 90279736
Ear pain 40.64 12.41 45 212135 57657 90358610
Lactic acidosis 40.58 12.41 35 212145 50428 90365839
Acute monocytic leukaemia 40.36 12.41 15 212165 149 90416118
Onychalgia 40.18 12.41 28 212152 1126 90415141
Haemophagocytic lymphohistiocytosis 39.89 12.41 102 212078 15357 90400910
Polyneuropathy in malignant disease 39.84 12.41 13 212167 84 90416183
Vaginal fistula 39.83 12.41 22 212158 581 90415686
Autoimmune cholangitis 39.66 12.41 10 212170 20 90416247
Hormone receptor positive breast cancer 39.62 12.41 24 212156 757 90415510
Eye irritation 39.53 12.41 15 212165 33963 90382304
Tumour embolism 39.17 12.41 15 212165 163 90416104
Face oedema 39.15 12.41 132 212048 23186 90393081
Laboratory test abnormal 38.85 12.41 25 212155 41829 90374438
Hypocalcaemia 38.77 12.41 199 211981 42169 90374098
Choking sensation 38.74 12.41 47 212133 3895 90412372
Endometrial cancer recurrent 38.66 12.41 11 212169 41 90416226
Capillary permeability increased 38.41 12.41 10 212170 24 90416243
Accidental exposure to product 38.39 12.41 26 212154 42340 90373927
Hyperbilirubinaemia 38.10 12.41 94 212086 13842 90402425
Flatulence 38.00 12.41 25 212155 41342 90374925
Visual impairment 37.87 12.41 170 212010 132195 90284072
Tubulointerstitial nephritis 37.83 12.41 138 212042 25205 90391062
Morphoea 37.83 12.41 19 212161 411 90415856
Pseudomembranous colitis 37.82 12.41 46 212134 3822 90412445
Head injury 37.59 12.41 13 212167 31175 90385092
Cerebrovascular accident 37.58 12.41 155 212025 123378 90292889
Respiratory tract congestion 37.50 12.41 9 212171 27401 90388866
Pelvic abscess 37.26 12.41 34 212146 2024 90414243
C-reactive protein increased 37.17 12.41 260 211920 181129 90235138
Metastases to adrenals 37.05 12.41 25 212155 953 90415314
Activated PI3 kinase delta syndrome 36.98 12.41 12 212168 76 90416191
Nail dystrophy 36.84 12.41 28 212152 1290 90414977
Metastases to eye 36.83 12.41 15 212165 194 90416073
Autoimmune haemolytic anaemia 36.65 12.41 55 212125 5590 90410677
Metastases to bone marrow 36.59 12.41 21 212159 598 90415669
Diastolic dysfunction 36.08 12.41 63 212117 7270 90408997
Gastric pneumatosis 36.03 12.41 9 212171 17 90416250
Inappropriate antidiuretic hormone secretion 35.97 12.41 114 212066 19391 90396876
Skin haemorrhage 35.95 12.41 4 212176 21376 90394891
Gamma-glutamyltransferase increased 35.95 12.41 180 212000 37772 90378495
Intestinal metastasis 35.89 12.41 15 212165 208 90416059
Anastomotic leak 35.73 12.41 21 212159 626 90415641
Fistula 35.69 12.41 84 212096 12005 90404262
Primary cardiac lymphoma 35.69 12.41 9 212171 18 90416249
Hypervolaemia 35.62 12.41 16 212164 32741 90383526
Acute pulmonary oedema 35.58 12.41 73 212107 9507 90406760
Product administration error 35.52 12.41 9 212171 26414 90389853
Full blood count abnormal 35.16 12.41 21 212159 36576 90379691
Limb injury 34.88 12.41 15 212165 31493 90384774
Metastases to bladder 34.83 12.41 15 212165 225 90416042
Cancer pain 34.78 12.41 45 212135 3980 90412287
Hypermetabolism 34.67 12.41 16 212164 285 90415982
Tonsillar disorder 34.63 12.41 26 212154 1176 90415091
Adenocarcinoma 34.54 12.41 40 212140 3156 90413111
Drug level increased 34.46 12.41 11 212169 27751 90388516
Invasive ductal breast carcinoma 34.42 12.41 64 212116 7754 90408513
Anti-glomerular basement membrane disease 34.26 12.41 11 212169 67 90416200
Eosinophil percentage increased 33.90 12.41 24 212156 990 90415277
Acute megakaryocytic leukaemia 33.65 12.41 10 212170 45 90416222
Cholangitis infective 33.59 12.41 18 212162 447 90415820
Gastrointestinal disorder 33.51 12.41 412 211768 256275 90159992
Hydrothorax 33.50 12.41 24 212156 1009 90415258
Eye pruritus 33.46 12.41 13 212167 29014 90387253
Gastrointestinal fistula 33.46 12.41 19 212161 530 90415737
Blood pressure systolic increased 33.44 12.41 53 212127 58292 90357975
Hypoglycaemia 33.31 12.41 71 212109 69777 90346490
Duodenal obstruction 33.19 12.41 15 212165 254 90416013
Serous cystadenocarcinoma ovary 33.12 12.41 9 212171 27 90416240
Triple negative breast cancer 33.06 12.41 17 212163 387 90415880
Blood alkaline phosphatase increased 32.92 12.41 209 211971 47870 90368397
Liver function test increased 32.87 12.41 96 212084 84759 90331508
Impaired quality of life 32.87 12.41 7 212173 23137 90393130
Dermatomyositis 32.82 12.41 40 212140 3330 90412937
Hypothalamo-pituitary disorder 32.80 12.41 33 212147 2219 90414048
Blood pressure diastolic abnormal 32.73 12.41 4 212176 19877 90396390
Coronary artery disease 32.72 12.41 19 212161 33604 90382663
Kidney infection 32.65 12.41 10 212170 25906 90390361
Seroma 32.57 12.41 38 212142 3022 90413245
Hepatitis acute 32.53 12.41 76 212104 10811 90405456
Thrombophlebitis migrans 32.51 12.41 15 212165 267 90416000
Pustular psoriasis 32.43 12.41 3 212177 18553 90397714
Bronchial fistula 32.18 12.41 9 212171 31 90416236
Injection site haemorrhage 32.13 12.41 13 212167 28305 90387962
Embolism venous 32.11 12.41 41 212139 3579 90412688
Nervousness 32.08 12.41 20 212160 34036 90382231
Nightmare 32.04 12.41 6 212174 21719 90394548
Pulmonary tumour thrombotic microangiopathy 32.02 12.41 11 212169 85 90416182
Infected lymphocele 31.98 12.41 14 212166 219 90416048
Pelvic infection 31.94 12.41 16 212164 344 90415923
Device dislocation 31.78 12.41 17 212163 31465 90384802
Upper limb fracture 31.74 12.41 6 212174 21572 90394695
Blood pressure immeasurable 31.71 12.41 27 212153 1465 90414802
Acute kidney injury 31.69 12.41 978 211202 319409 90096858
Abdominal lymphadenopathy 31.59 12.41 23 212157 992 90415275
Gastroenteritis viral 31.22 12.41 16 212164 30339 90385928
Duodenal stenosis 31.04 12.41 19 212161 611 90415656
Lymphocyte count decreased 30.94 12.41 163 212017 34887 90381380
Bicytopenia 30.79 12.41 41 212139 3730 90412537
Retinal toxicity 30.77 12.41 26 212154 1396 90414871
HER2 positive breast cancer 30.64 12.41 17 212163 453 90415814
Cataract 30.59 12.41 78 212102 72014 90344253
Transfusion-associated dyspnoea 30.56 12.41 9 212171 39 90416228
Cerebral ischaemia 30.55 12.41 58 212122 7138 90409129
Herpes zoster 30.53 12.41 116 212064 94528 90321739
Immune-mediated cytopenia 30.36 12.41 11 212169 101 90416166
Hyperglycaemia 30.34 12.41 214 211966 50756 90365511
Sensory disturbance 30.20 12.41 92 212088 15321 90400946
Injection site warmth 30.16 12.41 3 212177 17512 90398755
Bronchopleural fistula 30.15 12.41 14 212166 253 90416014
Nasal septum perforation 30.05 12.41 20 212160 745 90415522
Mood swings 29.94 12.41 6 212174 20696 90395571
Metastases to heart 29.89 12.41 13 212167 200 90416067
Laryngeal oedema 29.89 12.41 56 212124 6825 90409442
Metastases to pancreas 29.88 12.41 15 212165 324 90415943
Peripheral sensorimotor neuropathy 29.84 12.41 30 212150 2015 90414252
Bone density decreased 29.80 12.41 3 212177 17342 90398925
Acute lymphocytic leukaemia 29.70 12.41 35 212145 2813 90413454
Agranulocytosis 29.69 12.41 161 212019 34841 90381426
Endocrine toxicity 29.68 12.41 9 212171 44 90416223
Cell death 29.33 12.41 36 212144 3019 90413248
Incorrect product administration duration 29.23 12.41 5 212175 19317 90396950
Acute erythroid leukaemia 29.21 12.41 12 212168 159 90416108
Aortic dissection 29.10 12.41 32 212148 2385 90413882
Metastases to abdominal cavity 29.04 12.41 18 212162 592 90415675
Duodenitis haemorrhagic 28.83 12.41 7 212173 11 90416256
Drug reaction with eosinophilia and systemic symptoms 28.34 12.41 35 212145 42723 90373544
BRAF gene mutation 28.29 12.41 9 212171 53 90416214
Cardiac cirrhosis 28.23 12.41 12 212168 174 90416093
Gallbladder disorder 28.10 12.41 6 212174 19797 90396470
Glaucoma 28.03 12.41 7 212173 20748 90395519
Hypertriglyceridaemia 28.00 12.41 59 212121 7830 90408437
Cerebral infarction 27.97 12.41 130 212050 26466 90389801
Dermatitis atopic 27.92 12.41 10 212170 23462 90392805
Skin laceration 27.87 12.41 13 212167 26022 90390245
Myalgia 27.86 12.41 570 211610 174555 90241712
Weight decreased 27.78 12.41 677 211503 379233 90037034
Retroperitoneal lymphadenopathy 27.78 12.41 19 212161 741 90415526
Maternal exposure timing unspecified 27.75 12.41 9 212171 22474 90393793
Hepatopulmonary syndrome 27.59 12.41 10 212170 92 90416175
Transformation to acute myeloid leukaemia 27.58 12.41 15 212165 384 90415883
Cholestasis 27.51 12.41 162 212018 36137 90380130
Immune-mediated neurological disorder 27.48 12.41 8 212172 33 90416234
Dermatitis 27.47 12.41 114 212066 22106 90394161
Radiation oesophagitis 27.46 12.41 16 212164 469 90415798
Blood magnesium decreased 27.38 12.41 90 212090 15603 90400664
Nephrotic syndrome 27.35 12.41 56 212124 7283 90408984
Eye disorder 27.34 12.41 15 212165 27375 90388892
Oxygen therapy 27.31 12.41 35 212145 3067 90413200
Peritoneal fibrosis 27.30 12.41 6 212174 4 90416263
Adverse reaction 27.24 12.41 18 212162 29694 90386573
Lividity 27.23 12.41 15 212165 394 90415873
Sudden death 27.14 12.41 71 212109 10838 90405429
Spinal pain 27.13 12.41 90 212090 15677 90400590
Porokeratosis 27.10 12.41 11 212169 141 90416126
Catheter site infection 27.07 12.41 48 212132 5606 90410661
Leukonychia 26.97 12.41 9 212171 63 90416204
Tachypnoea 26.87 12.41 110 212070 21199 90395068
Scintillating scotoma 26.82 12.41 11 212169 145 90416122
Dysuria 26.80 12.41 171 212009 39230 90377037
Haemolytic uraemic syndrome 26.79 12.41 33 212147 2778 90413489
Protein urine 26.64 12.41 19 212161 793 90415474
Gastric perforation 26.63 12.41 28 212152 1983 90414284
Osteolysis 26.57 12.41 37 212143 3513 90412754
Immune thrombocytopenia 26.54 12.41 80 212100 13246 90403021
Acne 26.50 12.41 17 212163 28490 90387777
Breast neoplasm 26.47 12.41 25 212155 1555 90414712
Electrolyte imbalance 26.41 12.41 118 212062 23627 90392640
Cholangitis acute 26.33 12.41 17 212163 601 90415666
Microvascular coronary artery disease 26.23 12.41 13 212167 273 90415994
Double hit lymphoma 26.21 12.41 6 212174 6 90416261
International normalised ratio increased 26.16 12.41 44 212136 47272 90368995
Accidental overdose 26.09 12.41 17 212163 28256 90388011
Vena cava thrombosis 26.02 12.41 31 212149 2521 90413746
Skin reaction 26.00 12.41 99 212081 18454 90397813
Joint effusion 25.95 12.41 7 212173 19703 90396564
Influenza like illness 25.87 12.41 99 212081 80512 90335755
Tumour hyperprogression 25.85 12.41 11 212169 160 90416107
Myocardial infarction 25.79 12.41 144 212036 105828 90310439
Oligoastrocytoma 25.76 12.41 7 212173 21 90416246
Rash pruritic 25.73 12.41 102 212078 82112 90334155
Immune-mediated myositis 25.66 12.41 30 212150 2391 90413876
Oropharyngeal pain 25.66 12.41 161 212019 115026 90301241
Ovarian failure 25.64 12.41 25 212155 1618 90414649
Gingival bleeding 25.58 12.41 85 212095 14818 90401449
Acute polyneuropathy 25.56 12.41 15 212165 446 90415821
Larynx irritation 25.54 12.41 11 212169 165 90416102
Lymphangitis 25.44 12.41 20 212160 969 90415298
Breast cellulitis 25.38 12.41 17 212163 640 90415627
Bladder perforation 25.36 12.41 11 212169 168 90416099
Eye swelling 25.36 12.41 19 212161 29367 90386900
Therapeutic response decreased 25.21 12.41 116 212064 89613 90326654
Nephropathy toxic 25.11 12.41 76 212104 12612 90403655
Malignant peritoneal neoplasm 25.06 12.41 18 212162 760 90415507
Bradycardia 25.00 12.41 106 212074 83741 90332526
Transient ischaemic attack 24.95 12.41 39 212141 43137 90373130
Drug eruption 24.91 12.41 155 212025 35252 90381015
Acquired gene mutation 24.87 12.41 22 212158 1257 90415010
Cardiac murmur 24.84 12.41 6 212174 18188 90398079
Xerophthalmia 24.76 12.41 17 212163 667 90415600
Intracranial tumour haemorrhage 24.70 12.41 12 212168 241 90416026
Thyroid dermatopathy 24.62 12.41 7 212173 26 90416241
Respiratory disorder 24.62 12.41 74 212106 64742 90351525
Pyogenic granuloma 24.58 12.41 13 212167 314 90415953
Schizophrenia 24.56 12.41 3 212177 14911 90401356
Papilloedema 24.48 12.41 41 212139 4574 90411693
Product substitution issue 24.47 12.41 6 212174 18002 90398265
Device issue 24.35 12.41 20 212160 29517 90386750
Breast conserving surgery 24.28 12.41 21 212159 1164 90415103
Tooth erosion 24.24 12.41 15 212165 492 90415775
Microangiopathic haemolytic anaemia 24.23 12.41 18 212162 801 90415466
Bacteraemia 24.19 12.41 110 212070 22190 90394077
Haemoglobin 24.19 12.41 11 212169 189 90416078
Shock 24.16 12.41 132 212048 28646 90387621
Panic attack 24.13 12.41 16 212164 26349 90389918
Vascular device infection 24.03 12.41 72 212108 11880 90404387
Haemolytic anaemia 24.03 12.41 71 212109 11626 90404641
Arterioenteric fistula 24.02 12.41 7 212173 29 90416238
Adrenal disorder 24.02 12.41 26 212154 1904 90414363
Breast disorder 24.01 12.41 31 212149 2736 90413531
Portal vein thrombosis 23.92 12.41 33 212147 3105 90413162
Irritability 23.83 12.41 29 212151 35633 90380634
Azotaemia 23.82 12.41 44 212136 5304 90410963
Drug tolerance decreased 23.81 12.41 24 212156 32106 90384161
Fixed bowel loop 23.79 12.41 6 212174 12 90416255
Hepatocellular injury 23.76 12.41 132 212048 28826 90387441
Wrist fracture 23.73 12.41 4 212176 15620 90400647
Sputum discoloured 23.73 12.41 9 212171 20382 90395885
Metastases to ovary 23.70 12.41 15 212165 512 90415755
Ototoxicity 23.64 12.41 26 212154 1938 90414329
Biliary obstruction 23.62 12.41 34 212146 3328 90412939
Cystitis noninfective 23.58 12.41 22 212158 1347 90414920
TP53 gene mutation 23.50 12.41 8 212172 60 90416207
Enteritis 23.49 12.41 65 212115 10256 90406011
Metastases to thorax 23.46 12.41 12 212168 270 90415997
Product storage error 23.44 12.41 9 212171 20232 90396035
Onychomadesis 23.43 12.41 45 212135 45953 90370314
Viral infection 23.37 12.41 38 212142 41376 90374891
Therapeutic response unexpected 23.31 12.41 11 212169 21869 90394398
Laryngeal discomfort 23.30 12.41 14 212166 435 90415832
Aorto-oesophageal fistula 23.29 12.41 7 212173 33 90416234
Encephalitis 23.27 12.41 68 212112 11066 90405201
Pelvic pain 23.24 12.41 84 212096 15273 90400994
Glomerular vascular disorder 23.16 12.41 8 212172 63 90416204
Ocular hyperaemia 23.10 12.41 27 212153 33771 90382496
Blast cells present 23.07 12.41 15 212165 537 90415730
Mental disorder 22.98 12.41 25 212155 32293 90383974
Acute motor-sensory axonal neuropathy 22.92 12.41 13 212167 362 90415905
Enterocutaneous fistula 22.80 12.41 23 212157 1551 90414716
Haemoglobin abnormal 22.80 12.41 51 212129 7049 90409218
Lung abscess 22.75 12.41 27 212153 2186 90414081
Colitis ulcerative 22.75 12.41 69 212111 60197 90356070
Affect lability 22.70 12.41 7 212173 18056 90398211
Abdominal infection 22.68 12.41 28 212152 2362 90413905
Immune-mediated cholestasis 22.64 12.41 7 212173 37 90416230
Sopor 22.49 12.41 15 212165 24629 90391638
Blood lactate dehydrogenase increased 22.48 12.41 120 212060 25812 90390455
Band sensation 22.46 12.41 20 212160 1153 90415114
Type IV hypersensitivity reaction 22.34 12.41 36 212144 3890 90412377
Embryonal rhabdomyosarcoma 22.33 12.41 6 212174 17 90416250
Laryngeal necrosis 22.33 12.41 6 212174 17 90416250
Vocal cord paralysis 22.31 12.41 28 212152 2402 90413865
Peritoneal neoplasm 22.22 12.41 8 212172 72 90416195
Orbital myositis 22.22 12.41 8 212172 72 90416195
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 22.22 12.41 8 212172 72 90416195
Neoplasm 22.20 12.41 58 212122 8845 90407422
Generalised oedema 22.19 12.41 96 212084 18957 90397310
Gout 22.17 12.41 6 212174 16853 90399414
Intentional dose omission 22.16 12.41 7 212173 17776 90398491
Herpes zoster oticus 22.09 12.41 14 212166 479 90415788
Non-small cell lung cancer 22.03 12.41 38 212142 4343 90411924
Hepatitis 22.01 12.41 258 211922 70481 90345786
Cranial nerve disorder 21.95 12.41 16 212164 691 90415576
Foot fracture 21.95 12.41 18 212162 26588 90389679
Surgery 21.93 12.41 45 212135 44842 90371425
Gene mutation 21.92 12.41 26 212154 2104 90414163
Retroperitoneal neoplasm metastatic 21.89 12.41 7 212173 42 90416225
Urosepsis 21.76 12.41 103 212077 21129 90395138
Impaired work ability 21.72 12.41 9 212171 19317 90396950
Agonal respiration 21.47 12.41 10 212170 182 90416085
Venous thrombosis limb 21.44 12.41 33 212147 3429 90412838
Hypoaesthesia 21.33 12.41 566 211614 313644 90102623
Panniculitis 21.31 12.41 4 212176 14454 90401813
Neutrophil count increased 21.30 12.41 96 212084 19294 90396973
Emotional distress 21.30 12.41 33 212147 36629 90379638
Angioedema 21.26 12.41 79 212101 64797 90351470
Immune-mediated cystitis 21.23 12.41 7 212173 47 90416220
Foetal death 21.20 12.41 11 212169 20712 90395555
Anaemia of malignant disease 21.18 12.41 15 212165 619 90415648
Vaginal perforation 21.17 12.41 6 212174 22 90416245
Hallucination, visual 21.15 12.41 14 212166 23078 90393189
Hypercalcaemia of malignancy 21.13 12.41 11 212169 257 90416010
Facial paralysis 21.04 12.41 82 212098 15452 90400815
Presyncope 21.00 12.41 137 212043 31668 90384599
Glossopharyngeal nerve paralysis 20.98 12.41 7 212173 49 90416218
Clonal haematopoiesis 20.96 12.41 6 212174 23 90416244
Muscular weakness 20.87 12.41 349 211831 206317 90209950
Aggression 20.84 12.41 19 212161 26649 90389618
Metabolic acidosis 20.83 12.41 64 212116 55612 90360655
Autoimmune thyroiditis 20.83 12.41 44 212136 5849 90410418
Poisoning 20.81 12.41 5 212175 15212 90401055
Ovarian stromal hyperplasia 20.76 12.41 6 212174 24 90416243
Spondylitis 20.73 12.41 4 212176 14174 90402093
Pulmonary vein stenosis 20.72 12.41 8 212172 89 90416178
Localised infection 20.68 12.41 29 212151 33533 90382734
Diverticulitis 20.67 12.41 47 212133 45140 90371127
Upper-airway cough syndrome 20.65 12.41 5 212175 15130 90401137
Cardiovascular disorder 20.59 12.41 74 212106 13418 90402849
Inappropriate schedule of product administration 20.57 12.41 238 211942 149695 90266572
Vessel puncture site bruise 20.56 12.41 13 212167 443 90415824
Pneumocystis jirovecii infection 20.54 12.41 24 212156 1912 90414355
Keratitis 20.47 12.41 35 212145 3971 90412296
Pancreatitis 20.38 12.41 89 212091 69737 90346530
Emotional disorder 20.37 12.41 5 212175 14992 90401275
Immune-mediated cholangitis 20.35 12.41 11 212169 278 90415989
Empyema 20.32 12.41 26 212154 2274 90413993
Metastases to spinal cord 20.28 12.41 11 212169 280 90415987
Intestinal ischaemia 20.27 12.41 56 212124 8827 90407440
Vesical fistula 20.26 12.41 9 212171 146 90416121
Bacterial parotitis 20.24 12.41 4 212176 0 90416267
Needle issue 20.23 12.41 4 212176 13930 90402337
Femur fracture 20.22 12.41 49 212131 46033 90370234
Secondary adrenocortical insufficiency 20.16 12.41 26 212154 2292 90413975
Pancreatic failure 20.16 12.41 21 212159 1471 90414796
Oesophageal varices haemorrhage 20.16 12.41 21 212159 1471 90414796
Hyperferritinaemia 20.14 12.41 12 212168 367 90415900
Scleroderma 20.14 12.41 45 212135 6216 90410051
Swelling face 20.09 12.41 110 212070 81242 90335025
Circulatory collapse 20.08 12.41 113 212067 24791 90391476
Splenic artery thrombosis 20.06 12.41 7 212173 57 90416210
Non-small cell lung cancer metastatic 19.88 12.41 16 212164 802 90415465
Pneumothorax spontaneous 19.88 12.41 17 212163 928 90415339
Myoclonus 19.87 12.41 10 212170 19158 90397109
Dementia 19.86 12.41 16 212164 23845 90392422
Cannabinoid hyperemesis syndrome 19.85 12.41 7 212173 59 90416208
Respiratory depth decreased 19.84 12.41 6 212174 29 90416238
Artificial menopause 19.84 12.41 6 212174 29 90416238
Retinal phototoxicity 19.83 12.41 5 212175 10 90416257
Fungal infection 19.82 12.41 44 212136 42617 90373650
Post procedural pneumonia 19.75 12.41 7 212173 60 90416207
Adenocarcinoma metastatic 19.71 12.41 10 212170 221 90416046
Myxoedema 19.67 12.41 9 212171 157 90416110
Cold sweat 19.62 12.41 75 212105 14006 90402261
Central nervous system lesion 19.62 12.41 66 212114 11580 90404687
Brachiocephalic vein thrombosis 19.61 12.41 8 212172 104 90416163
Lymphatic disorder 19.59 12.41 13 212167 482 90415785
Gelastic seizure 19.51 12.41 5 212175 11 90416256
Catheter site injury 19.43 12.41 11 212169 305 90415962
Mucosal dryness 19.35 12.41 30 212150 3137 90413130
Photophobia 19.34 12.41 13 212167 21256 90395011
Arterial occlusive disease 19.32 12.41 3 212177 12443 90403824
Extrapyramidal disorder 19.30 12.41 7 212173 16296 90399971
Female genital tract fistula 19.28 12.41 88 212092 17780 90398487
Aplasia 19.26 12.41 34 212146 3957 90412310
Laryngopharyngitis 19.25 12.41 7 212173 65 90416202
Haemoglobin decreased 19.21 12.41 506 211674 161450 90254817
Type 1 lepra reaction 19.21 12.41 5 212175 12 90416255
Systolic dysfunction 19.20 12.41 23 212157 1881 90414386
Metastases to gastrointestinal tract 19.14 12.41 8 212172 111 90416156
Oligohydramnios 19.08 12.41 48 212132 7153 90409114
Renal tubular disorder 19.07 12.41 30 212150 3177 90413090
Myeloid leukaemia 19.03 12.41 13 212167 506 90415761
Infectious pleural effusion 19.00 12.41 23 212157 1902 90414365
Blood creatinine decreased 18.94 12.41 45 212135 6470 90409797
Laryngeal cancer stage III 18.92 12.41 5 212175 13 90416254
Ileal perforation 18.83 12.41 13 212167 515 90415752
Blood glucose increased 18.79 12.41 138 212042 95108 90321159
Limb discomfort 18.73 12.41 38 212142 38022 90378245
Haematuria 18.69 12.41 143 212037 34794 90381473
Vaginal cuff dehiscence 18.66 12.41 5 212175 14 90416253
Acute hepatic failure 18.61 12.41 103 212077 22458 90393809
Syncope 18.59 12.41 424 211756 132239 90284028
Secretion discharge 18.52 12.41 7 212173 15889 90400378
Right ventricular failure 18.48 12.41 11 212169 19194 90397073
Hypersomnia 18.48 12.41 14 212166 21517 90394750
Biliary dilatation 18.44 12.41 27 212153 2684 90413583
Liver disorder 18.44 12.41 188 211992 121081 90295186
Electrocardiogram QT prolonged 18.43 12.41 97 212083 72359 90343908
Toxic neuropathy 18.39 12.41 13 212167 535 90415732
Leukocytosis 18.38 12.41 130 212050 30860 90385407
Myeloproliferative neoplasm 18.36 12.41 14 212166 648 90415619
Non-small cell lung cancer recurrent 18.34 12.41 8 212172 124 90416143
Cutaneous lupus erythematosus 18.31 12.41 29 212151 3089 90413178
Exposed bone in jaw 18.27 12.41 28 212152 2898 90413369
Chylothorax 18.27 12.41 12 212168 437 90415830
Epilepsy 18.26 12.41 115 212065 82091 90334176
Coordination abnormal 18.18 12.41 14 212166 21342 90394925
Breast tumour excision 18.16 12.41 5 212175 16 90416251
Intestinal prolapse 18.11 12.41 8 212172 128 90416139
Pain in jaw 18.07 12.41 55 212125 47930 90368337
Transaminases 17.96 12.41 7 212173 80 90416187
Female sexual dysfunction 17.96 12.41 7 212173 80 90416187
Movement disorder 17.95 12.41 25 212155 28994 90387273
Immunoglobulin G4 related disease 17.94 12.41 8 212172 131 90416136
Peritoneal lesion 17.93 12.41 5 212175 17 90416250
Dysentery 17.90 12.41 17 212163 1065 90415202
Omentectomy 17.86 12.41 6 212174 43 90416224
Cardiac failure acute 17.84 12.41 65 212115 11864 90404403
Cholelithiasis 17.82 12.41 63 212117 52443 90363824
Breast necrosis 17.82 12.41 9 212171 197 90416070
Infusion site swelling 17.80 12.41 3 212177 11717 90404550
Pharyngitis streptococcal 17.80 12.41 4 212176 12738 90403529
Autoimmune hypothyroidism 17.71 12.41 10 212170 276 90415991
Mood altered 17.68 12.41 9 212171 17135 90399132
Musculoskeletal disorder 17.62 12.41 15 212165 21754 90394513
Hiatus hernia 17.62 12.41 20 212160 25341 90390926
Carpal tunnel syndrome 17.59 12.41 18 212162 23910 90392357
Diarrhoea haemorrhagic 17.58 12.41 60 212120 10603 90405664
Device malfunction 17.54 12.41 14 212166 20963 90395304
Bone marrow disorder 17.52 12.41 28 212152 3004 90413263
Tumour cavitation 17.51 12.41 6 212174 46 90416221
Median nerve injury 17.50 12.41 5 212175 19 90416248
Lymphatic obstruction 17.50 12.41 5 212175 19 90416248
Maternal death affecting foetus 17.48 12.41 4 212176 4 90416263
Confluent and reticulate papillomatosis 17.48 12.41 4 212176 4 90416263
Breast sarcoma 17.48 12.41 4 212176 4 90416263
Ureteric stenosis 17.46 12.41 14 212166 698 90415569
Asphyxia 17.44 12.41 46 212134 7057 90409210
Visual acuity reduced 17.43 12.41 104 212076 23306 90392961
Liver scan abnormal 17.40 12.41 6 212174 47 90416220
Uterine atrophy 17.40 12.41 6 212174 47 90416220
Embolism arterial 17.39 12.41 17 212163 1104 90415163
Haemobilia 17.36 12.41 8 212172 142 90416125
Failure to thrive 17.23 12.41 51 212129 8360 90407907
Mediastinal disorder 17.17 12.41 12 212168 485 90415782
Extremity necrosis 17.10 12.41 22 212158 1935 90414332
Lung infiltration 17.04 12.41 76 212104 15206 90401061
Rhinitis allergic 17.03 12.41 9 212171 16776 90399491
Abdominal sepsis 17.02 12.41 19 212161 1440 90414827
Meningitis 16.97 12.41 51 212129 8430 90407837
Hepatic vein thrombosis 16.96 12.41 9 212171 219 90416048
Ureteric fistula 16.92 12.41 5 212175 22 90416245
Haematochezia 16.91 12.41 97 212083 70816 90345451
Cyanosis central 16.89 12.41 7 212173 95 90416172
Neutropenic infection 16.86 12.41 21 212159 1788 90414479
Biliary tract disorder 16.84 12.41 15 212165 865 90415402
Abnormal dreams 16.84 12.41 3 212177 11254 90405013
Infusion site reaction 16.83 12.41 12 212168 19027 90397240
Nail ridging 16.78 12.41 12 212168 503 90415764
Hyperproteinaemia 16.77 12.41 8 212172 154 90416113
Facial pain 16.76 12.41 5 212175 13177 90403090
Carbohydrate antigen 15-3 16.75 12.41 7 212173 97 90416170
Fear 16.74 12.41 9 212171 16613 90399654
Pelvic venous thrombosis 16.71 12.41 22 212158 1979 90414288
Abnormal behaviour 16.66 12.41 17 212163 22611 90393656
BRCA2 gene mutation 16.63 12.41 7 212173 99 90416168
Acute abdomen 16.62 12.41 20 212160 1643 90414624
Hepatic neoplasm 16.58 12.41 23 212157 2175 90414092
Status epilepticus 16.55 12.41 12 212168 18862 90397405
Eyelid oedema 16.54 12.41 62 212118 11472 90404795
Protein total decreased 16.48 12.41 45 212135 7044 90409223
Poor venous access 16.37 12.41 13 212167 19514 90396753
Corneal disorder 16.36 12.41 22 212158 2020 90414247
Metastases to muscle 16.32 12.41 8 212172 164 90416103
Delusion 16.29 12.41 6 212174 13834 90402433
Eosinophilia 16.27 12.41 26 212154 28507 90387760
Opsoclonus myoclonus 16.27 12.41 8 212172 165 90416102
Autoimmune colitis 16.23 12.41 14 212166 773 90415494
Blood pressure diastolic increased 16.22 12.41 5 212175 12901 90403366
Aortic dissection rupture 16.21 12.41 4 212176 7 90416260
Tumour ulceration 16.15 12.41 9 212171 242 90416025
Necrotising fasciitis 16.14 12.41 31 212149 3849 90412418
Nasal polyps 16.06 12.41 3 212177 10877 90405390
Aspartate aminotransferase abnormal 16.05 12.41 25 212155 2624 90413643
Full blood count decreased 16.05 12.41 28 212152 29661 90386606
Renal disorder 16.03 12.41 41 212139 37818 90378449
Language disorder 16.03 12.41 25 212155 2627 90413640
Neutrophil toxic granulation present 16.01 12.41 8 212172 171 90416096
Crying 15.96 12.41 22 212158 25623 90390644
Ulcerative gastritis 15.94 12.41 6 212174 62 90416205
Thrombotic thrombocytopenic purpura 15.92 12.41 32 212148 4106 90412161
Odynophagia 15.90 12.41 52 212128 8991 90407276
Electric shock sensation 15.89 12.41 19 212161 1551 90414716
Taste disorder 15.88 12.41 82 212098 61464 90354803
Liver abscess 15.87 12.41 29 212151 3467 90412800
HTLV-1 test positive 15.86 12.41 4 212176 8 90416259
Application site recall reaction 15.86 12.41 4 212176 8 90416259
EGFR gene mutation 15.84 12.41 10 212170 340 90415927
Hepatic cancer metastatic 15.84 12.41 11 212169 440 90415827
Balance disorder 15.81 12.41 148 212032 96932 90319335
Cholecystectomy 15.81 12.41 4 212176 11751 90404516
Immune-mediated neuropathy 15.79 12.41 7 212173 113 90416154
Acantholysis 15.78 12.41 5 212175 29 90416238
Tumour fistulisation 15.78 12.41 5 212175 29 90416238
Hepatitis fulminant 15.77 12.41 31 212149 3914 90412353
Thinking abnormal 15.76 12.41 4 212176 11728 90404539
Catheter site inflammation 15.76 12.41 15 212165 942 90415325
Blood glucose decreased 15.71 12.41 19 212161 23410 90392857
Xeroderma 15.68 12.41 10 212170 346 90415921
Mediastinitis 15.66 12.41 10 212170 347 90415920
Pathological fracture 15.62 12.41 54 212126 9606 90406661
Immediate post-injection reaction 15.55 12.41 11 212169 453 90415814
Poor quality sleep 15.55 12.41 21 212159 24672 90391595
Osteonecrosis 15.52 12.41 110 212070 26131 90390136
Productive cough 15.51 12.41 111 212069 76952 90339315
Endocarditis 15.41 12.41 44 212136 7069 90409198
Spinal stenosis 15.38 12.41 11 212169 17413 90398854
Tremor 15.35 12.41 259 211921 152914 90263353
Ankle fracture 15.34 12.41 15 212165 20355 90395912
Pleural disorder 15.31 12.41 13 212167 703 90415564
Obstructive airways disorder 15.30 12.41 23 212157 25846 90390421
Cytokine release syndrome 15.24 12.41 115 212065 27858 90388409
Cardiac pseudoaneurysm 15.23 12.41 5 212175 33 90416234
Breast inflammation 15.21 12.41 8 212172 191 90416076
Injection site induration 15.21 12.41 3 212177 10465 90405802
Small fibre neuropathy 15.18 12.41 13 212167 711 90415556
Granulocyte count 15.18 12.41 3 212177 0 90416267
Myiasis 15.18 12.41 3 212177 0 90416267
Ankyloglossia acquired 15.18 12.41 3 212177 0 90416267
Oesophageal stenosis 15.17 12.41 30 212150 3806 90412461
Anhedonia 15.16 12.41 4 212176 11427 90404840
Peripheral paralysis 15.15 12.41 7 212173 125 90416142
Hypophosphatasia 15.14 12.41 6 212174 72 90416195
Chemotherapy 15.13 12.41 20 212160 1807 90414460
Pancreatic carcinoma metastatic 15.12 12.41 23 212157 2365 90413902
Central venous catheterisation 15.11 12.41 25 212155 2761 90413506
Abdominal distension 15.07 12.41 215 211965 130386 90285881
Progressive multifocal leukoencephalopathy 15.02 12.41 9 212171 15646 90400621
Product dispensing error 14.99 12.41 5 212175 12268 90403999
Neuroendocrine breast tumour 14.98 12.41 5 212175 35 90416232
Hepatic cyst infection 14.95 12.41 7 212173 129 90416138
Polymicrogyria 14.92 12.41 6 212174 75 90416192
Post procedural fistula 14.85 12.41 10 212170 380 90415887
Left ventricular enlargement 14.85 12.41 6 212174 76 90416191
Blood potassium increased 14.81 12.41 16 212164 20733 90395534
Pulmonary arterial hypertension 14.80 12.41 24 212156 26163 90390104
Deformity 14.79 12.41 5 212175 12165 90404102
Thrombophlebitis 14.75 12.41 34 212146 4794 90411473
Mesenteric neoplasm 14.74 12.41 5 212175 37 90416230
Carbohydrate antigen 19-9 increased 14.66 12.41 9 212171 291 90415976
Venous oxygen saturation increased 14.63 12.41 5 212175 38 90416229
Acquired amegakaryocytic thrombocytopenia 14.63 12.41 5 212175 38 90416229
Speech disorder 14.62 12.41 56 212124 45529 90370738
Oesophageal squamous cell carcinoma 14.62 12.41 7 212173 136 90416131
Endometrial cancer metastatic 14.62 12.41 7 212173 136 90416131
Nasal disorder 14.56 12.41 27 212153 3265 90413002
Hormone receptor positive HER2 negative breast cancer 14.55 12.41 9 212171 295 90415972
Escherichia test positive 14.54 12.41 24 212156 2646 90413621
Labelled drug-drug interaction medication error 14.53 12.41 8 212172 14574 90401693
Anger 14.46 12.41 7 212173 13713 90402554
Tumour invasion 14.44 12.41 9 212171 299 90415968
Urge incontinence 14.44 12.41 16 212164 1203 90415064
Mediastinum neoplasm 14.44 12.41 6 212174 82 90416185
Carcinoid tumour pulmonary 14.43 12.41 11 212169 509 90415758
Blepharitis 14.42 12.41 30 212150 3946 90412321
Retinopathy 14.41 12.41 28 212152 3506 90412761
Urinary retention 14.40 12.41 43 212137 37701 90378566
Distal intestinal obstruction syndrome 14.37 12.41 11 212169 512 90415755
Pneumocystis test positive 14.30 12.41 5 212175 41 90416226
IIIrd nerve disorder 14.25 12.41 4 212176 14 90416253
Increased tendency to bruise 14.25 12.41 5 212175 11885 90404382
Colitis ischaemic 14.22 12.41 62 212118 12284 90403983
Torsade de pointes 14.18 12.41 9 212171 15173 90401094
Subacute cutaneous lupus erythematosus 14.14 12.41 28 212152 3554 90412713
Dysstasia 14.12 12.41 23 212157 25029 90391238
Systemic scleroderma 14.10 12.41 18 212162 1571 90414696
Aortic embolus 14.09 12.41 5 212175 43 90416224
Septic pulmonary embolism 14.08 12.41 7 212173 148 90416119
Paraneoplastic syndrome 14.08 12.41 12 212168 652 90415615
Tongue disorder 14.03 12.41 4 212176 10856 90405411
Vulvovaginal inflammation 14.03 12.41 15 212165 1083 90415184
Synovial cyst 13.99 12.41 5 212175 11747 90404520
Ovarian cyst 13.94 12.41 12 212168 17306 90398961
Cyst 13.92 12.41 11 212169 16550 90399717
Faecal vomiting 13.87 12.41 13 212167 801 90415466
Intervertebral disc degeneration 13.86 12.41 12 212168 17262 90399005
Bladder disorder 13.86 12.41 4 212176 10768 90405499
Nail infection 13.85 12.41 23 212157 2549 90413718
Hypergeusia 13.84 12.41 4 212176 16 90416251
Hepatic infection 13.83 12.41 12 212168 668 90415599
Carcinoembryonic antigen 13.81 12.41 6 212174 92 90416175
Troponin T increased 13.80 12.41 18 212162 1605 90414662
Clonal evolution 13.75 12.41 6 212174 93 90416174
Adenocarcinoma of the cervix 13.69 12.41 8 212172 236 90416031
Bone cancer metastatic 13.69 12.41 8 212172 236 90416031
Hysterectomy 13.67 12.41 5 212175 11579 90404688
Nail pigmentation 13.66 12.41 8 212172 237 90416030
Metastases to vagina 13.65 12.41 4 212176 17 90416250
Ventricular tachycardia 13.64 12.41 23 212157 24685 90391582
Normal newborn 13.60 12.41 21 212159 23341 90392926
Thymus enlargement 13.55 12.41 7 212173 161 90416106
Respiratory depression 13.53 12.41 10 212170 15565 90400702
Necrosis 13.46 12.41 40 212140 6570 90409697
Onychoclasis 13.42 12.41 43 212137 7356 90408911
Glomerulonephritis membranoproliferative 13.36 12.41 9 212171 342 90415925
Tumour rupture 13.36 12.41 8 212172 247 90416020
Nail avulsion 13.34 12.41 9 212171 343 90415924
General symptom 13.29 12.41 9 212171 14659 90401608
Pulmonary hilar enlargement 13.25 12.41 6 212174 102 90416165
Paratracheal lymphadenopathy 13.25 12.41 5 212175 52 90416215
Uterine adhesions 13.17 12.41 5 212175 53 90416214
Foetal malnutrition 13.15 12.41 6 212174 104 90416163
Hip fracture 13.12 12.41 37 212143 33040 90383227
Ovarian epithelial cancer metastatic 13.11 12.41 3 212177 3 90416264
Subclavian vein stenosis 13.11 12.41 3 212177 3 90416264
Breast prosthesis removal 13.11 12.41 3 212177 3 90416264
Cytoreductive surgery 13.11 12.41 3 212177 3 90416264
Urinary tract injury 13.11 12.41 3 212177 3 90416264
Cardiac arrest 13.07 12.41 330 211850 104605 90311662
Seasonal allergy 13.05 12.41 21 212159 22962 90393305
Periodontal disease 13.05 12.41 18 212162 1694 90414573
Vaginal disorder 13.01 12.41 12 212168 724 90415543
Middle insomnia 13.01 12.41 12 212168 16739 90399528
Cardio-respiratory arrest 13.00 12.41 214 211966 62926 90353341
Haemoglobinaemia 12.99 12.41 6 212174 107 90416160
Hereditary motor and sensory neuropathy 12.99 12.41 6 212174 107 90416160
Pulpitis dental 12.97 12.41 14 212166 1022 90415245
Cholangitis chronic 12.96 12.41 4 212176 21 90416246
Dandy-Walker syndrome 12.94 12.41 6 212174 108 90416159
Hallucination, auditory 12.94 12.41 11 212169 15964 90400303
Mesenteric vein thrombosis 12.93 12.41 15 212165 1186 90415081
Transaminases abnormal 12.92 12.41 12 212168 731 90415536
Hepatic cancer recurrent 12.91 12.41 7 212173 178 90416089
Injection site discolouration 12.87 12.41 3 212177 9317 90406950
Lymphorrhoea 12.84 12.41 5 212175 57 90416210
Therapy cessation 12.77 12.41 43 212137 36318 90379949
Sensorimotor disorder 12.75 12.41 12 212168 743 90415524
Escherichia infection 12.74 12.41 72 212108 15823 90400444
Sinus tachycardia 12.72 12.41 112 212068 28401 90387866
Ataxia 12.70 12.41 79 212101 17963 90398304
Blood urine present 12.70 12.41 13 212167 17265 90399002
Angiodermatitis 12.57 12.41 7 212173 188 90416079
KL-6 increased 12.56 12.41 6 212174 116 90416151
Axillary vein thrombosis 12.51 12.41 9 212171 381 90415886
Unwanted pregnancy 12.46 12.41 6 212174 118 90416149
Drug ineffective for unapproved indication 12.46 12.41 98 212082 66546 90349721
Ovarian cancer stage IV 12.44 12.41 8 212172 281 90415986
Pituitary tumour 12.42 12.41 13 212167 916 90415351

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Malignant neoplasm progression 969.55 14.99 1044 70298 107356 42442637
Neutropenia 790.01 14.99 1287 70055 198144 42351849
Myelosuppression 726.55 14.99 576 70766 39885 42510108
Interstitial lung disease 683.78 14.99 746 70596 77716 42472277
Febrile neutropenia 665.02 14.99 1146 70196 184557 42365436
Disease progression 652.58 14.99 988 70354 142668 42407325
Neuropathy peripheral 567.01 14.99 772 70570 101081 42448912
Neutrophil count decreased 397.78 14.99 510 70832 62905 42487088
Leukopenia 396.73 14.99 554 70788 74192 42475801
Alopecia 339.42 14.99 325 71017 28951 42521042
Thrombocytopenia 320.84 14.99 866 70476 189413 42360580
Pneumonitis 314.08 14.99 368 70974 41350 42508643
Anaemia 297.37 14.99 1086 70256 279192 42270801
Neoplasm progression 280.90 14.99 292 71050 28708 42521285
Therapy partial responder 235.31 14.99 224 71118 19797 42530196
Cholangitis 223.54 14.99 167 71175 10560 42539433
Pulmonary toxicity 219.91 14.99 152 71190 8503 42541490
Metastases to central nervous system 219.79 14.99 163 71179 10192 42539801
Product dose omission issue 216.30 14.99 10 71332 154355 42395638
Immune-mediated lung disease 213.46 14.99 108 71234 3365 42546628
Radiation pneumonitis 206.37 14.99 100 71242 2833 42547160
Immune-mediated enterocolitis 193.90 14.99 120 71222 5557 42544436
Neurotoxicity 175.20 14.99 207 71135 23444 42526549
Haematotoxicity 170.87 14.99 144 71198 10841 42539152
Mucosal inflammation 167.17 14.99 298 71044 49076 42500917
Immune-mediated hepatitis 158.12 14.99 91 71251 3683 42546310
Flushing 147.12 14.99 240 71102 36788 42513205
Completed suicide 142.85 14.99 4 71338 96461 42453532
Cystoid macular oedema 137.03 14.99 55 71287 978 42549015
Peripheral sensory neuropathy 128.39 14.99 111 71231 8651 42541342
Fall 126.16 14.99 124 71218 234396 42315597
Polyneuropathy 123.03 14.99 154 71188 18507 42531486
White blood cell count decreased 120.94 14.99 433 70909 109963 42440030
Immune-mediated hepatic disorder 119.91 14.99 66 71276 2448 42547545
Decreased appetite 119.02 14.99 637 70705 192500 42357493
Death 118.67 14.99 1256 70086 469929 42080064
Metastases to liver 117.78 14.99 141 71201 16185 42533808
Headache 117.14 14.99 137 71205 239232 42310761
Pyrexia 116.92 14.99 1087 70255 392955 42157038
Depression 115.47 14.99 23 71319 111340 42438653
Pneumothorax 107.94 14.99 163 71179 23380 42526613
Bone marrow failure 107.21 14.99 196 71146 32897 42517096
Infusion related reaction 106.37 14.99 281 71061 60525 42489468
Adrenal insufficiency 105.82 14.99 144 71198 18780 42531213
General physical health deterioration 105.08 14.99 516 70826 150730 42399263
Macular oedema 103.38 14.99 68 71274 3501 42546492
Anaphylactic shock 102.44 14.99 159 71183 23358 42526635
Pancytopenia 102.15 14.99 429 70913 117314 42432679
Haemoptysis 101.60 14.99 233 71109 45934 42504059
Anxiety 101.19 14.99 36 71306 118524 42431469
Drug interaction 99.23 14.99 185 71157 266814 42283179
Radiation oesophagitis 97.34 14.99 35 71307 453 42549540
Nasopharyngitis 96.76 14.99 13 71329 83983 42466010
Colitis 94.81 14.99 228 71114 46344 42503649
Biliary tract infection 93.00 14.99 39 71303 779 42549214
Somnolence 90.15 14.99 63 71279 141042 42408951
Platelet count decreased 86.58 14.99 459 70883 138122 42411871
Toxicity to various agents 84.01 14.99 160 71182 228976 42321017
Metastases to lung 82.95 14.99 99 71243 11325 42538668
Joint swelling 82.10 14.99 9 71333 68013 42481980
Insomnia 82.09 14.99 48 71294 118205 42431788
Delusion of grandeur 80.62 14.99 47 71295 1949 42548044
Off label use 79.00 14.99 1501 69841 636834 41913159
Metastases to bone 78.75 14.99 110 71232 14699 42535294
Injection site pain 76.99 14.99 5 71337 57793 42492200
Erythema 73.24 14.99 368 70974 108425 42441568
Liver abscess 72.89 14.99 63 71279 4907 42545086
Non-small cell lung cancer 70.83 14.99 62 71280 4912 42545081
Rhinalgia 70.74 14.99 42 71300 1802 42548191
Gastrointestinal perforation 70.15 14.99 59 71283 4427 42545566
Thrombotic microangiopathy 70.12 14.99 104 71238 14678 42535315
Erythema multiforme 70.05 14.99 85 71257 9892 42540101
Weight increased 69.23 14.99 48 71294 107935 42442058
Immune-mediated dermatitis 68.23 14.99 36 71306 1225 42548768
Adrenocorticotropic hormone deficiency 68.20 14.99 37 71305 1333 42548660
Suicidal ideation 67.78 14.99 3 71339 48158 42501835
Nausea 66.89 14.99 982 70360 395817 42154176
Pancreatic abscess 66.46 14.99 21 71321 177 42549816
Musculoskeletal stiffness 66.38 14.99 9 71333 57756 42492237
Tumour haemorrhage 65.63 14.99 52 71290 3586 42546407
Diarrhoea 65.42 14.99 1108 70234 459741 42090252
Lymphocyte count abnormal 64.15 14.99 42 71300 2145 42547848
Eastern Cooperative Oncology Group performance status worsened 63.51 14.99 35 71307 1301 42548692
Pancreatic carcinoma metastatic 63.09 14.99 48 71294 3118 42546875
Suicide attempt 61.36 14.99 4 71338 46096 42503897
Tremor 60.93 14.99 44 71298 96885 42453108
Immune-mediated myocarditis 60.21 14.99 40 71302 2094 42547899
Skin toxicity 59.91 14.99 64 71278 6485 42543508
Septic shock 59.52 14.99 307 71035 91365 42458628
Right ventricular ejection fraction decreased 59.47 14.99 15 71327 48 42549945
Enterocolitis 59.24 14.99 78 71264 9851 42540142
Cardiac failure congestive 59.04 14.99 35 71307 85567 42464426
Bradycardia 58.89 14.99 35 71307 85449 42464544
Bronchial fistula 58.72 14.99 20 71322 218 42549775
Pneumonia 58.42 14.99 1011 70331 421138 42128855
Plasma cell myeloma 58.16 14.99 6 71336 47572 42502421
Gastrointestinal toxicity 57.47 14.99 50 71292 3929 42546064
Sepsis 56.39 14.99 545 70797 198789 42351204
Electrocardiogram QT prolonged 56.22 14.99 7 71335 47938 42502055
Aggression 55.49 14.99 5 71337 44158 42505835
Cardiac disorder 55.33 14.99 8 71334 48924 42501069
Onycholysis 55.26 14.99 29 71313 976 42549017
Drug reaction with eosinophilia and systemic symptoms 54.99 14.99 4 71338 42071 42507922
Loss of personal independence in daily activities 54.39 14.99 9 71333 49807 42500186
Hypersensitivity 53.85 14.99 252 71090 72118 42477875
Prostate cancer 53.63 14.99 6 71336 44637 42505356
Dyspnoea 53.53 14.99 1038 70304 441583 42108410
Memory impairment 52.81 14.99 10 71332 50212 42499781
Overdose 52.74 14.99 59 71283 105205 42444788
Coronary artery disease 51.82 14.99 13 71329 53707 42496286
Asthma 51.32 14.99 20 71322 62294 42487699
Neutropenic sepsis 51.07 14.99 94 71248 15852 42534141
Stomatitis 50.49 14.99 192 71150 50137 42499856
Therapeutic product effect decreased 50.37 14.99 4 71338 39146 42510847
Hallucination 49.83 14.99 17 71325 57490 42492503
Hypoglycaemia 49.64 14.99 19 71323 59835 42490158
Anaphylactic reaction 49.61 14.99 171 71171 42572 42507421
Dehydration 49.00 14.99 405 70937 141362 42408631
Tumour pseudoprogression 48.52 14.99 27 71315 1023 42548970
Enterocolitis infectious 48.43 14.99 34 71308 1949 42548044
Hypothyroidism 47.90 14.99 140 71202 31944 42518049
Peripheral swelling 46.99 14.99 49 71293 90221 42459772
Dizziness 46.98 14.99 236 71106 249018 42300975
Nephrolithiasis 46.73 14.99 4 71338 36826 42513167
Metastases to meninges 46.45 14.99 33 71309 1928 42548065
Pancreatic enzyme abnormality 46.21 14.99 14 71328 101 42549892
Coma 46.11 14.99 16 71326 53538 42496455
Haemolytic uraemic syndrome 45.94 14.99 36 71306 2443 42547550
Pain 45.48 14.99 233 71109 244615 42305378
Arthralgia 45.46 14.99 183 71159 205055 42344938
Immune-mediated encephalitis 45.34 14.99 22 71320 625 42549368
Pancreatic carcinoma 45.25 14.99 67 71275 9439 42540554
Immune-mediated adrenal insuficiency 45.17 14.99 23 71319 726 42549267
Cholangitis sclerosing 45.04 14.99 32 71310 1870 42548123
Influenza 44.91 14.99 24 71318 62151 42487842
Dysphagia 44.76 14.99 240 71102 72479 42477514
Feeling abnormal 44.74 14.99 31 71311 69755 42480238
Myocarditis 44.34 14.99 98 71244 18840 42531153
Hypopituitarism 44.25 14.99 37 71305 2754 42547239
Condition aggravated 44.11 14.99 256 71086 260498 42289495
Stress 44.02 14.99 10 71332 44202 42505791
Abdominal discomfort 43.69 14.99 37 71305 75218 42474775
Oesophagitis 42.81 14.99 85 71257 15162 42534831
Drug ineffective 42.11 14.99 773 70569 629424 41920569
Blood glucose increased 41.86 14.99 37 71305 73662 42476331
Wrong technique in product usage process 41.74 14.99 10 71332 42625 42507368
Hepatic function abnormal 41.66 14.99 184 71158 51383 42498610
Angioedema 41.51 14.99 10 71332 42467 42507526
Fluid retention 41.33 14.99 3 71339 31616 42518377
Heart rate decreased 41.24 14.99 6 71336 36526 42513467
Bronchopleural fistula 41.15 14.99 21 71321 666 42549327
Pneumatosis intestinalis 40.95 14.99 45 71297 4707 42545286
Affective disorder 40.58 14.99 50 71292 5910 42544083
Pulmonary radiation injury 40.23 14.99 11 71331 52 42549941
Immune-mediated cholangitis 40.14 14.99 19 71323 510 42549483
Pleural effusion 39.32 14.99 288 71054 96878 42453115
Myocardial infarction 39.20 14.99 94 71248 123915 42426078
Oesophagobronchial fistula 38.67 14.99 14 71328 185 42549808
Scleroderma-like reaction 38.33 14.99 11 71331 64 42549929
Performance status decreased 37.76 14.99 43 71299 4677 42545316
Tumour necrosis 37.41 14.99 27 71315 1617 42548376
Tracheal fistula 37.35 14.99 13 71329 152 42549841
Acute promyelocytic leukaemia 36.98 14.99 20 71322 716 42549277
Pain in extremity 36.77 14.99 129 71213 150475 42399518
Alveolitis 36.55 14.99 28 71314 1837 42548156
Intentional product misuse 36.47 14.99 30 71312 61870 42488123
Metastasis 36.19 14.99 42 71300 4663 42545330
Rheumatoid arthritis 35.99 14.99 13 71329 42427 42507566
Irritability 35.84 14.99 3 71339 28125 42521868
Hospitalisation 35.78 14.99 43 71299 74287 42475706
Oligohydramnios 35.26 14.99 16 71326 389 42549604
Muscle spasms 35.18 14.99 56 71286 85988 42464005
Mobility decreased 35.12 14.99 8 71334 35298 42514695
Embolism 35.05 14.99 57 71285 8706 42541287
Transient ischaemic attack 34.88 14.99 7 71335 33732 42516261
Oxygen saturation decreased 34.84 14.99 206 71136 64481 42485512
Kounis syndrome 34.55 14.99 35 71307 3333 42546660
Sinusitis 34.53 14.99 18 71324 47274 42502719
Recall phenomenon 34.51 14.99 18 71324 598 42549395
Immune-mediated hypothyroidism 33.83 14.99 23 71319 1251 42548742
Rhabdomyolysis 33.61 14.99 49 71293 77970 42472023
Accidental overdose 33.54 14.99 4 71338 28326 42521667
Disturbance in attention 33.49 14.99 5 71337 29861 42520132
Intestinal perforation 33.44 14.99 63 71279 10811 42539182
Blood pressure increased 33.22 14.99 76 71266 101852 42448141
Abnormal behaviour 33.21 14.99 3 71339 26448 42523545
Confusional state 33.10 14.99 156 71186 167441 42382552
Metastases to skin 32.98 14.99 17 71325 551 42549442
Drug level increased 32.82 14.99 3 71339 26197 42523796
Urticaria 32.38 14.99 46 71296 73990 42476003
Agitation 32.25 14.99 36 71306 64278 42485715
Hypomagnesaemia 32.21 14.99 113 71229 28375 42521618
Metabolic acidosis 31.98 14.99 24 71318 51834 42498159
Lung abscess 31.83 14.99 33 71309 3230 42546763
Inappropriate schedule of product administration 31.66 14.99 71 71271 95831 42454162
Pulmonary hypoplasia 31.63 14.99 16 71326 498 42549495
Hypertransaminasaemia 31.59 14.99 56 71286 9171 42540822
Immune-mediated nephritis 31.53 14.99 18 71324 717 42549276
Contraindicated product administered 31.37 14.99 3 71339 25269 42524724
Disseminated intravascular coagulation 31.25 14.99 102 71240 24692 42525301
Teratoma benign 31.17 14.99 8 71334 28 42549965
Ototoxicity 31.15 14.99 28 71314 2297 42547696
Upper respiratory tract infection 30.86 14.99 16 71326 42157 42507836
Pancreatic carcinoma recurrent 30.78 14.99 10 71332 93 42549900
Palpitations 30.70 14.99 24 71318 50773 42499220
Lymphangiosis carcinomatosa 30.62 14.99 20 71322 1017 42548976
Fungating wound 30.58 14.99 9 71333 58 42549935
Bronchospasm 30.53 14.99 67 71275 12818 42537175
Stress cardiomyopathy 30.52 14.99 30 71312 2755 42547238
Lactic acidosis 30.50 14.99 19 71323 45242 42504751
Tracheo-oesophageal fistula 30.44 14.99 16 71326 540 42549453
Radiation skin injury 30.43 14.99 18 71324 767 42549226
Vomiting 30.15 14.99 665 70677 289058 42260935
Brain teratoma 30.09 14.99 7 71335 14 42549979
Pneumonia bacterial 29.97 14.99 75 71267 15617 42534376
Incorrect route of product administration 29.87 14.99 3 71339 24302 42525691
Tidal volume decreased 29.76 14.99 8 71334 35 42549958
Type 1 diabetes mellitus 29.53 14.99 41 71301 5446 42544547
Drug hypersensitivity 29.34 14.99 78 71264 99311 42450682
Full blood count abnormal 29.26 14.99 7 71335 29869 42520124
Coronary artery aneurysm 28.96 14.99 10 71332 114 42549879
Infectious pleural effusion 28.83 14.99 31 71311 3164 42546829
Nasal congestion 28.72 14.99 7 71335 29494 42520499
Sleep disorder 28.71 14.99 23 71319 48072 42501921
Gout 28.63 14.99 6 71336 28049 42521944
Immune-mediated pancreatitis 28.61 14.99 13 71329 317 42549676
Thrombosis 28.56 14.99 44 71298 68467 42481526
Psoriatic arthropathy 28.42 14.99 4 71338 24963 42525030
Swelling 28.32 14.99 30 71312 54855 42495138
Rhinorrhoea 28.24 14.99 9 71333 31785 42518208
Subdural haematoma 28.07 14.99 3 71339 23135 42526858
Treatment noncompliance 28.01 14.99 14 71328 37658 42512335
Pneumocystis jirovecii pneumonia 27.71 14.99 99 71243 25082 42524911
Tumour lysis syndrome 27.61 14.99 91 71251 22140 42527853
International normalised ratio increased 27.57 14.99 24 71318 48144 42501849
Sense of oppression 27.56 14.99 15 71327 544 42549449
Unmasking of previously unidentified disease 27.55 14.99 20 71322 1209 42548784
Feeling hot 27.29 14.99 94 71248 23388 42526605
Periarticular thenar erythema with onycholysis 26.97 14.99 5 71337 0 42549993
Hyperthyroidism 26.82 14.99 68 71274 14273 42535720
Hypophysitis 26.79 14.99 29 71313 2982 42547011
Non-small cell lung cancer metastatic 26.72 14.99 17 71325 826 42549167
Oesophagopleural fistula 26.61 14.99 8 71334 56 42549937
Cataract 26.59 14.99 9 71333 30595 42519398
Contusion 26.44 14.99 19 71323 41966 42508027
Immune-mediated hypophysitis 25.78 14.99 13 71329 402 42549591
Sleep apnoea syndrome 25.71 14.99 3 71339 21605 42528388
Fulminant type 1 diabetes mellitus 25.56 14.99 20 71322 1354 42548639
No adverse event 25.45 14.99 17 71325 39004 42510989
Nail disorder 25.38 14.99 25 71317 2302 42547691
Chronic kidney disease 25.31 14.99 25 71317 47216 42502777
Arthritis 25.26 14.99 20 71322 42045 42507948
Hiccups 25.19 14.99 60 71282 12111 42537882
Benign prostatic hyperplasia 24.86 14.99 3 71339 21049 42528944
Gastritis bacterial 24.69 14.99 12 71330 342 42549651
Lichen planus 24.65 14.99 19 71323 1258 42548735
Hypersensitivity pneumonitis 24.64 14.99 23 71319 1981 42548012
Balance disorder 24.63 14.99 26 71316 47619 42502374
Hypoxia 24.41 14.99 200 71142 69586 42480407
Autoimmune hepatitis 24.34 14.99 38 71304 5607 42544386
Metastases to peritoneum 24.30 14.99 25 71317 2424 42547569
Clinomania 24.21 14.99 7 71335 42 42549951
Discontinued product administered 24.08 14.99 6 71336 18 42549975
Visual impairment 24.05 14.99 22 71320 43091 42506902
Metastases to lymph nodes 23.97 14.99 39 71303 5959 42544034
Product prescribing error 23.90 14.99 7 71335 26105 42523888
Vision blurred 23.84 14.99 33 71309 53666 42496327
Dysarthria 23.81 14.99 19 71323 39788 42510205
Jaundice cholestatic 23.54 14.99 36 71306 5217 42544776
Autoimmune dermatitis 23.41 14.99 7 71335 48 42549945
Acquired gene mutation 23.11 14.99 20 71322 1560 42548433
Pleurocutaneous fistula 23.04 14.99 7 71335 51 42549942
Taeniasis 22.93 14.99 7 71335 52 42549941
Dyskinesia 22.88 14.99 7 71335 25383 42524610
Demyelinating polyneuropathy 22.64 14.99 20 71322 1604 42548389
Tumour cavitation 22.56 14.99 6 71336 25 42549968
Infusion related hypersensitivity reaction 22.43 14.99 10 71332 233 42549760
Haemorrhage 22.39 14.99 42 71300 60521 42489472
Illness 22.24 14.99 7 71335 24923 42525070
Respiratory failure 22.19 14.99 319 71023 127813 42422180
Foetal growth abnormality 22.18 14.99 6 71336 27 42549966
Neutropenic colitis 21.99 14.99 32 71310 4438 42545555
Diabetes mellitus 21.92 14.99 42 71300 60045 42489948
Secondary adrenocortical insufficiency 21.87 14.99 22 71320 2077 42547916
Thrombocytosis 21.79 14.99 33 71309 4742 42545251
Accidental exposure to product 21.57 14.99 4 71338 20389 42529604
Localised infection 21.54 14.99 4 71338 20369 42529624
Aortic injury 21.50 14.99 5 71337 10 42549983
Immune-mediated encephalopathy 21.46 14.99 7 71335 66 42549927
Retroperitoneal lymphadenopathy 21.32 14.99 16 71326 1018 42548975
Encephalitis autoimmune 21.30 14.99 18 71324 1359 42548634
Acute respiratory distress syndrome 21.04 14.99 103 71239 30005 42519988
Radiation associated pain 21.04 14.99 6 71336 34 42549959
SARS-CoV-2 test positive 20.77 14.99 44 71298 8216 42541777
Blister 20.76 14.99 10 71332 27480 42522513
Schizophrenia 20.76 14.99 51 71291 10499 42539494
Product administration error 20.73 14.99 3 71339 18340 42531653
Acquired tracheo-oesophageal fistula 20.70 14.99 8 71334 128 42549865
Hepatic infection 20.68 14.99 14 71328 756 42549237
Product use in unapproved indication 20.63 14.99 428 70914 184028 42365965
Amnesia 20.50 14.99 11 71331 28426 42521567
Dry mouth 20.35 14.99 22 71320 39857 42510136
Herpes zoster 20.34 14.99 21 71321 38856 42511137
Oesophagomediastinal fistula 20.32 14.99 5 71337 14 42549979
Thyroiditis 20.20 14.99 26 71316 3210 42546783
Blood creatine phosphokinase increased 20.19 14.99 31 71311 48307 42501686
Nail dystrophy 19.91 14.99 11 71331 411 42549582
Large intestine infection 19.88 14.99 21 71321 2100 42547893
Cytomegalovirus infection 19.85 14.99 15 71327 32291 42517702
Osteoarthritis 19.81 14.99 8 71334 24397 42525596
Surgery 19.64 14.99 3 71339 17613 42532380
Gait disturbance 19.46 14.99 91 71251 97909 42452084
Pulmonary artery occlusion 19.34 14.99 4 71338 3 42549990
Lung disorder 19.34 14.99 142 71200 47781 42502212
Eosinophilia 19.30 14.99 16 71326 32883 42517110
Hyperlipidaemia 19.27 14.99 6 71336 21510 42528483
Lichenoid keratosis 19.03 14.99 28 71314 3922 42546071
Immune-mediated renal disorder 18.74 14.99 11 71331 462 42549531
Metastases to kidney 18.72 14.99 10 71332 349 42549644
Cytokine storm 18.61 14.99 14 71328 894 42549099
Second primary malignancy 18.53 14.99 46 71296 9529 42540464
Skin discolouration 18.40 14.99 6 71336 20884 42529109
Drug eruption 18.37 14.99 82 71260 22993 42527000
Dry skin 18.33 14.99 33 71309 48305 42501688
Immune-mediated gastritis 18.17 14.99 7 71335 111 42549882
Portal venous gas 17.99 14.99 11 71331 498 42549495
Hypophagia 17.97 14.99 91 71251 26865 42523128
Swelling face 17.97 14.99 12 71330 27542 42522451
Mitral valve incompetence 17.95 14.99 3 71339 16486 42533507
Lymphocyte count decreased 17.93 14.99 93 71249 27716 42522277
Haematochezia 17.90 14.99 45 71297 58391 42491602
Product quality issue 17.89 14.99 4 71338 17878 42532115
Empyema 17.83 14.99 28 71314 4152 42545841
Overflow diarrhoea 17.82 14.99 6 71336 63 42549930
Autoimmune cholangitis 17.74 14.99 5 71337 27 42549966
Pulmonary embolism 17.71 14.99 290 71052 119322 42430671
Psoriasis 17.71 14.99 34 71308 48570 42501423
Organising pneumonia 17.65 14.99 39 71303 7493 42542500
Adverse drug reaction 17.64 14.99 22 71320 37412 42512581
Blood thyroid stimulating hormone abnormal 17.57 14.99 10 71332 396 42549597
PIK3CA-activated mutation 17.52 14.99 7 71335 123 42549870
Lung squamous cell carcinoma metastatic 17.49 14.99 6 71336 67 42549926
Lymphopenia 17.45 14.99 77 71265 21486 42528507
Laryngopharyngitis 17.44 14.99 5 71337 29 42549964
Injection site erythema 17.44 14.99 6 71336 20189 42529804
Pericarditis malignant 17.41 14.99 6 71336 68 42549925
Penile necrosis 17.33 14.99 6 71336 69 42549924
Cancer with a high tumour mutational burden 17.29 14.99 5 71337 30 42549963
Vascular pseudoaneurysm 17.26 14.99 22 71320 2690 42547303
Non-small cell lung cancer recurrent 17.25 14.99 6 71336 70 42549923
Pruritus 17.13 14.99 218 71124 188553 42361440
Adrenal disorder 17.12 14.99 15 71327 1190 42548803
Oropharyngeal pain 17.05 14.99 28 71314 42482 42507511
Hyperkalaemia 17.00 14.99 73 71269 80385 42469608
Dermatitis acneiform 16.94 14.99 39 71303 7700 42542293
Depressed mood 16.92 14.99 9 71333 23375 42526618
Cholecystitis 16.88 14.99 54 71288 12934 42537059
Myositis 16.83 14.99 59 71283 14807 42535186
Cachexia 16.83 14.99 40 71302 8064 42541929
Injection site reaction 16.80 14.99 3 71339 15718 42534275
Blastic plasmacytoid dendritic cell neoplasia 16.80 14.99 6 71336 76 42549917
Haemorrhoids 16.75 14.99 4 71338 17093 42532900
Bladder cancer 16.68 14.99 4 71338 17043 42532950
Asthenia 16.64 14.99 600 70742 280193 42269800
Labelled drug-drug interaction medication error 16.60 14.99 3 71339 15579 42534414
Status epilepticus 16.59 14.99 3 71339 15575 42534418
Fatigue 16.54 14.99 889 70453 434752 42115241
EGFR gene mutation 16.53 14.99 8 71334 226 42549767
Gastric perforation 16.48 14.99 23 71319 3070 42546923
Bronchitis 16.35 14.99 34 71308 47167 42502826
Appendicitis 16.34 14.99 7 71335 20606 42529387
Head injury 16.30 14.99 7 71335 20575 42529418
Palmar-plantar erythrodysaesthesia syndrome 16.28 14.99 73 71269 20509 42529484
Glomerulonephritis rapidly progressive 16.27 14.99 13 71329 907 42549086
Pneumoperitoneum 16.27 14.99 20 71322 2358 42547635
Medication error 16.14 14.99 19 71323 33135 42516858
Arteriosclerosis 16.14 14.99 5 71337 17984 42532009
Pulmonary cavitation 16.10 14.99 15 71327 1289 42548704
Immune-mediated cystitis 16.07 14.99 6 71336 87 42549906
Liver scan abnormal 16.05 14.99 4 71338 12 42549981
Neck pain 15.94 14.99 16 71326 29998 42519995
Peptic ulcer perforation 15.87 14.99 9 71333 354 42549639
Pulmonary fistula 15.82 14.99 6 71336 91 42549902
Scleroderma 15.60 14.99 17 71325 1761 42548232
Osteoporosis 15.60 14.99 3 71339 14903 42535090
Toxic epidermal necrolysis 15.58 14.99 87 71255 26663 42523330
Injury 15.55 14.99 9 71333 22307 42527686
Angiosarcoma metastatic 15.47 14.99 6 71336 97 42549896
Immune-mediated adverse reaction 15.46 14.99 13 71329 975 42549018
Rectal haemorrhage 15.35 14.99 38 71304 49568 42500425
Tumour hyperprogression 15.28 14.99 7 71335 174 42549819
Lethargy 15.24 14.99 35 71307 46855 42503138
Ileus 15.23 14.99 68 71274 19071 42530922
Hypersomnia 15.18 14.99 3 71339 14615 42535378
Ocular hyperaemia 15.13 14.99 4 71338 15959 42534034
Rash maculo-papular 15.06 14.99 111 71231 37392 42512601
Renal hypoplasia 15.04 14.99 6 71336 105 42549888

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 3795.42 12.47 2466 247350 91874 110247609
Neuropathy peripheral 3339.88 12.47 2957 246859 176320 110163163
Malignant neoplasm progression 3181.46 12.47 2844 246972 171723 110167760
Neutropenia 3164.19 12.47 4054 245762 370566 109968917
Disease progression 2344.66 12.47 2820 246996 241214 110098269
Febrile neutropenia 1745.74 12.47 2801 247015 313966 110025517
Flushing 1633.78 12.47 1566 248250 103170 110236313
Anaemia 1496.17 12.47 3600 246216 543486 109795997
Erythema 1363.58 12.47 2396 247420 289051 110050432
Neutrophil count decreased 1318.81 12.47 1493 248323 119448 110220035
Metastases to liver 1116.78 12.47 797 249019 34589 110304894
Interstitial lung disease 1015.54 12.47 1406 248410 137928 110201555
Metastases to bone 990.93 12.47 707 249109 30665 110308818
Neoplasm progression 919.30 12.47 919 248897 63676 110275807
Thrombocytopenia 908.04 12.47 2255 247561 346630 109992853
Leukopenia 898.92 12.47 1374 248442 147417 110192066
Polyneuropathy 835.01 12.47 643 249173 31369 110308114
Pneumonitis 807.15 12.47 929 248887 75602 110263881
Dyspnoea 804.18 12.47 4743 245073 1102129 109237354
Joint swelling 793.46 12.47 53 249763 442792 109896691
Therapy partial responder 791.27 12.47 662 249154 36399 110303084
Metastases to lung 763.65 12.47 535 249281 22528 110316955
Metastases to central nervous system 692.60 12.47 502 249314 22315 110317168
Anaphylactic shock 663.75 12.47 695 249121 50851 110288632
Peripheral sensory neuropathy 606.65 12.47 410 249406 16270 110323213
Haematotoxicity 601.88 12.47 447 249369 20635 110318848
Palmar-plantar erythrodysaesthesia syndrome 589.73 12.47 587 249229 40438 110299045
Synovitis 568.65 12.47 10 249806 274082 110065401
Chest discomfort 564.97 12.47 1227 248589 172621 110166862
Acute myeloid leukaemia 560.23 12.47 552 249264 37558 110301925
Product dose omission issue 528.24 12.47 56 249760 321726 110017757
Mucosal inflammation 521.00 12.47 845 248971 95296 110244187
Completed suicide 519.64 12.47 5 249811 242376 110097107
Fall 516.63 12.47 367 249449 603115 109736368
Rheumatoid arthritis 516.10 12.47 43 249773 299570 110039913
Arthropathy 510.12 12.47 36 249780 287486 110051997
Neurotoxicity 507.84 12.47 549 249267 41658 110297825
Cystoid macular oedema 493.71 12.47 199 249617 2601 110336882
Glossodynia 473.95 12.47 5 249811 221999 110117484
Immune-mediated enterocolitis 470.57 12.47 291 249525 9894 110329589
Systemic lupus erythematosus 468.66 12.47 26 249790 254312 110085171
Weight increased 463.48 12.47 184 249632 419460 109920023
Immune-mediated hepatic disorder 450.58 12.47 214 249602 4236 110335247
Therapeutic product effect decreased 450.09 12.47 25 249791 244291 110095192
Contraindicated product administered 443.54 12.47 30 249786 248237 110091246
White blood cell count decreased 439.40 12.47 1326 248490 228064 110111419
Headache 438.82 12.47 830 248986 881547 109457936
Pemphigus 436.35 12.47 10 249806 214560 110124923
Swelling 436.10 12.47 126 249690 350915 109988568
Musculoskeletal stiffness 429.13 12.47 61 249755 279761 110059722
Psoriatic arthropathy 408.80 12.47 7 249809 196754 110142729
Nasopharyngitis 402.10 12.47 194 249622 394167 109945316
Skin toxicity 396.26 12.47 276 249540 11507 110327976
Abdominal discomfort 395.15 12.47 198 249618 393660 109945823
Helicobacter infection 393.43 12.47 3 249813 181874 110157609
Immune-mediated adrenal insuficiency 389.71 12.47 148 249668 1632 110337851
Peripheral swelling 389.28 12.47 214 249602 403820 109935663
Immune-mediated hepatitis 389.10 12.47 222 249594 6489 110332994
Metastases to lymph nodes 385.53 12.47 299 249517 14733 110324750
Sinusitis 384.44 12.47 98 249718 296590 110042893
Pain 381.88 12.47 1012 248804 953943 109385540
Platelet count decreased 375.45 12.47 1260 248556 229183 110110300
Breast cancer metastatic 371.57 12.47 260 249556 10921 110328562
Duodenal ulcer perforation 370.51 12.47 6 249810 177694 110161789
Feeling hot 369.35 12.47 705 249111 90401 110249082
Mobility decreased 365.80 12.47 51 249765 237371 110102112
Blood cholesterol increased 363.16 12.47 12 249804 184773 110154710
Nausea 362.76 12.47 4320 245496 1231370 109108113
Immune-mediated hypothyroidism 362.43 12.47 161 249655 2714 110336769
Drug abuse 361.76 12.47 8 249808 177403 110162080
Condition aggravated 361.74 12.47 695 249121 734141 109605342
Bone marrow failure 358.61 12.47 541 249275 57307 110282176
Pseudocirrhosis 356.32 12.47 117 249699 806 110338677
Fibromyalgia 355.38 12.47 6 249810 170903 110168580
Ejection fraction decreased 355.27 12.47 450 249366 40430 110299053
Myelodysplastic syndrome 348.78 12.47 427 249389 37057 110302426
Hypothyroidism 347.32 12.47 605 249211 72294 110267189
Wound 345.98 12.47 57 249759 234380 110105103
Onycholysis 344.06 12.47 154 249662 2645 110336838
Depression 343.99 12.47 143 249673 317192 110022291
Pyrexia 339.20 12.47 3304 246512 894961 109444522
Bronchospasm 337.21 12.47 378 249438 29861 110309622
Cholangitis 332.60 12.47 284 249532 16051 110323432
Irritable bowel syndrome 332.53 12.47 8 249808 164207 110175276
Pancytopenia 329.88 12.47 1133 248683 208480 110131003
Diarrhoea 328.56 12.47 3971 245845 1135534 109203949
Immune-mediated lung disease 327.95 12.47 183 249633 5120 110334363
Asthma 319.79 12.47 85 249731 250206 110089277
Pericarditis 317.32 12.47 56 249760 219058 110120425
Second primary malignancy 311.76 12.47 286 249530 17782 110321701
Oxygen saturation decreased 308.52 12.47 916 248900 156066 110183417
Injury 300.90 12.47 27 249789 177238 110162245
Migraine 297.24 12.47 24 249792 171628 110167855
Muscle injury 296.77 12.47 4 249812 140803 110198680
Confusional state 292.34 12.47 378 249438 468302 109871181
Back pain 291 12.47 1626 248190 369370 109970113
Arthralgia 290.69 12.47 854 248962 778778 109560705
Intentional overdose 282.68 12.47 3 249813 132498 110206985
Adrenal insufficiency 282.24 12.47 410 249406 41980 110297503
Hepatic function abnormal 281.63 12.47 623 249193 88672 110250811
Epistaxis 277.63 12.47 783 249033 129589 110209894
Radiation pneumonitis 276.34 12.47 155 249661 4381 110335102
Folliculitis 275.45 12.47 29 249787 167624 110171859
Metastases to peritoneum 273.76 12.47 166 249650 5444 110334039
Contusion 273.19 12.47 93 249723 233268 110106215
Blister 265.50 12.47 91 249725 227285 110112198
Drug intolerance 257.47 12.47 324 249492 406188 109933295
Osteoarthritis 257.29 12.47 50 249766 182573 110156910
Anaphylactic reaction 255.74 12.47 699 249117 113601 110225882
Gastrointestinal perforation 253.89 12.47 176 249640 7280 110332203
Proteinuria 250.50 12.47 376 249440 39642 110299841
Pulmonary toxicity 249.61 12.47 251 249565 17495 110321988
Cardiotoxicity 248.96 12.47 245 249571 16636 110322847
Type 2 diabetes mellitus 248.68 12.47 49 249767 177183 110162300
Joint range of motion decreased 246.40 12.47 6 249810 121826 110217657
Hypertransaminasaemia 244.82 12.47 288 249528 23967 110315516
Overdose 242.78 12.47 112 249704 233682 110105801
C-reactive protein abnormal 239.64 12.47 13 249803 129682 110209801
Ascites 238.75 12.47 598 249218 92210 110247273
Immune-mediated dermatitis 237.60 12.47 112 249704 2178 110337305
Hepatic enzyme increased 235.98 12.47 226 249590 320666 110018817
Lower respiratory tract infection 235.11 12.47 128 249688 242978 110096505
Wheezing 234.56 12.47 143 249673 255087 110084396
Bursitis 234.03 12.47 15 249801 129903 110209580
Insomnia 232.94 12.47 283 249533 360307 109979176
Drug ineffective 229.47 12.47 2265 247551 1518275 108821208
Colitis 229.15 12.47 626 249190 101697 110237786
Treatment failure 228.55 12.47 175 249641 277059 110062424
Memory impairment 224.48 12.47 82 249734 196862 110142621
Injection site pain 224.26 12.47 62 249754 177860 110161623
Hypoxia 219.53 12.47 718 249098 128797 110210686
Pleural effusion 217.33 12.47 886 248930 176823 110162660
Metastases to meninges 215.53 12.47 138 249678 4990 110334493
Sleep disorder 214.39 12.47 90 249726 198554 110140929
Loss of personal independence in daily activities 209.37 12.47 42 249774 149978 110189505
Obesity 207.45 12.47 12 249804 113339 110226144
Immune-mediated myocarditis 206.25 12.47 117 249699 3381 110336102
Lip dry 206.04 12.47 4 249812 100079 110239404
Toxicity to various agents 204.91 12.47 492 249324 480063 109859420
Hepatic cytolysis 204.83 12.47 411 249405 54642 110284841
Drug interaction 204.77 12.47 523 249293 499660 109839823
Facet joint syndrome 202.96 12.47 3 249813 96825 110242658
Myocarditis 200.51 12.47 291 249525 29764 110309719
Sense of oppression 200.42 12.47 90 249726 1558 110337925
Biliary tract infection 199.68 12.47 91 249725 1633 110337850
Somnolence 197.90 12.47 228 249588 297221 110042262
Road traffic accident 197.69 12.47 11 249805 107387 110232096
Throat tightness 197.38 12.47 306 249510 33183 110306300
Maternal exposure during pregnancy 195.08 12.47 173 249643 254710 110084773
Asthenia 195.07 12.47 2395 247421 686604 109652879
Macular oedema 195.01 12.47 146 249670 6820 110332663
Suicide attempt 192.15 12.47 10 249806 103384 110236099
Neutropenic sepsis 191.17 12.47 288 249528 30458 110309025
Cardiac dysfunction 186.74 12.47 136 249680 6087 110333396
Decreased appetite 185.16 12.47 1763 248053 474083 109865400
Impaired healing 183.83 12.47 108 249708 196609 110142874
Arthritis 182.34 12.47 75 249741 167511 110171972
Hyperthyroidism 181.81 12.47 274 249542 28987 110310496
Gastrointestinal toxicity 181.78 12.47 171 249645 10977 110328506
Discomfort 181.48 12.47 132 249684 214575 110124908
Night sweats 177.85 12.47 42 249774 133941 110205542
Metastases to skin 177.65 12.47 92 249724 2207 110337276
Radiotherapy 176.95 12.47 80 249736 1408 110338075
Thrombotic microangiopathy 176.93 12.47 270 249546 28879 110310604
Pneumothorax 174.79 12.47 298 249518 34987 110304496
Influenza 170.94 12.47 84 249732 169017 110170466
Adrenocorticotropic hormone deficiency 170.58 12.47 88 249728 2094 110337389
Anxiety 169.73 12.47 326 249490 344752 109994731
Stress cardiomyopathy 168.42 12.47 193 249623 15613 110323870
Cyanosis 167.30 12.47 266 249550 29475 110310008
Urticaria 166.82 12.47 290 249526 318567 110020916
Lymphangiosis carcinomatosa 165.45 12.47 90 249726 2392 110337091
Breast cancer recurrent 165.37 12.47 105 249711 3741 110335742
Exposure during pregnancy 165.00 12.47 86 249730 167338 110172145
Breast cancer stage III 163.52 12.47 3 249813 79114 110260369
Red blood cell sedimentation rate increased 161.71 12.47 3 249813 78299 110261184
Psoriasis 161.71 12.47 57 249759 139936 110199547
Intentional product misuse 160.72 12.47 50 249766 132854 110206629
Embolism 158.75 12.47 190 249626 16099 110323384
Hypophysitis 157.20 12.47 116 249700 5299 110334184
Gait inability 156.72 12.47 56 249760 136320 110203163
Thyroiditis 156.18 12.47 125 249691 6448 110333035
Injection site reaction 155.44 12.47 12 249804 89058 110250425
Ovarian cancer recurrent 155.24 12.47 58 249758 609 110338874
Metastasis 154.72 12.47 137 249679 8130 110331353
Muscle spasms 151.95 12.47 246 249570 277911 110061572
Nail toxicity 148.03 12.47 50 249766 380 110339103
Vomiting 147.20 12.47 2879 246937 907796 109431687
Immune-mediated hypophysitis 146.77 12.47 62 249754 919 110338564
Bone pain 146.31 12.47 399 249417 64734 110274749
Erythema multiforme 146.20 12.47 208 249608 20889 110318594
General physical health deterioration 144.28 12.47 1532 248284 423763 109915720
Inflammation 143.27 12.47 135 249681 193103 110146380
Sciatica 141.89 12.47 20 249796 92379 110247104
Hypercholesterolaemia 141.06 12.47 19 249797 90818 110248665
Dizziness 140.85 12.47 961 248855 697232 109642251
Pulmonary embolism 138.50 12.47 894 248922 213580 110125903
Drug hypersensitivity 138.48 12.47 542 249274 453548 109885935
Pain in extremity 138.21 12.47 598 249218 486520 109852963
Tachycardia 135.66 12.47 927 248889 225718 110113765
Hypopituitarism 134.14 12.47 97 249719 4293 110335190
Suicidal ideation 133.80 12.47 25 249791 93912 110245571
Product use issue 132.05 12.47 320 249496 311375 110028108
Dysaesthesia 129.20 12.47 114 249702 6733 110332750
Blood pressure fluctuation 128.02 12.47 11 249805 74813 110264670
Tumour haemorrhage 127.30 12.47 101 249715 5144 110334339
Type I hypersensitivity 125.78 12.47 109 249707 6284 110333199
Pneumocystis jirovecii pneumonia 125.60 12.47 290 249526 42445 110297038
Injection site swelling 125.10 12.47 3 249813 61787 110277696
Peripheral venous disease 125.05 12.47 20 249796 84097 110255386
Hypokalaemia 124.29 12.47 771 249045 181677 110157806
Injection site erythema 124.04 12.47 30 249786 94146 110245337
Urogenital fistula 123.28 12.47 44 249772 401 110339082
Fluid retention 122.35 12.47 31 249785 94276 110245207
Prescribed overdose 121.19 12.47 25 249791 87556 110251927
Intentional product use issue 121.15 12.47 235 249581 247671 110091812
Lichenoid keratosis 121.07 12.47 106 249710 6196 110333287
Intestinal perforation 120.12 12.47 189 249627 20755 110318728
Hospitalisation 118.58 12.47 89 249727 142404 110197079
Gastrooesophageal reflux disease 118.52 12.47 139 249677 179837 110159646
Gait disturbance 118.32 12.47 285 249531 277923 110061560
Medication error 118.14 12.47 45 249771 105321 110234162
Granulocyte count decreased 117.32 12.47 86 249730 3888 110335595
Recall phenomenon 116.97 12.47 59 249757 1337 110338146
Osteonecrosis of jaw 116.81 12.47 303 249513 47714 110291769
Dehydration 116.81 12.47 1052 248764 278459 110061024
Autoimmune disorder 116.62 12.47 8 249808 65475 110274008
Acute promyelocytic leukaemia 116.07 12.47 65 249751 1831 110337652
Immune-mediated pancreatitis 115.84 12.47 48 249768 676 110338807
Ill-defined disorder 114.61 12.47 111 249705 156742 110182741
Musculoskeletal pain 114.57 12.47 147 249669 182876 110156607
Ear infection 113.69 12.47 7 249809 62725 110276758
Amnesia 113.31 12.47 48 249768 105360 110234123
Alveolitis 113.18 12.47 88 249728 4351 110335132
Suffocation feeling 112.78 12.47 66 249750 2025 110337458
Hallucination 112.59 12.47 44 249772 101388 110238095
Abdominal pain 112.44 12.47 1704 248112 511285 109828198
Immune-mediated hyperthyroidism 111.99 12.47 45 249771 583 110338900
Rash maculo-papular 110.40 12.47 394 249422 73828 110265655
Infusion related hypersensitivity reaction 109.76 12.47 49 249767 836 110338647
Feeling abnormal 109.18 12.47 149 249667 180562 110158921
Cholangitis sclerosing 109.11 12.47 79 249737 3503 110335980
Hepatic failure 107.51 12.47 371 249445 68368 110271115
Metastases to pleura 105.72 12.47 63 249753 2000 110337483
Eastern Cooperative Oncology Group performance status worsened 105.61 12.47 72 249744 2897 110336586
Computerised tomogram thorax abnormal 104.73 12.47 70 249746 2725 110336758
Dry mouth 104.39 12.47 182 249634 199766 110139717
Illness 102.83 12.47 29 249787 82142 110257341
Anaphylactoid reaction 102.39 12.47 100 249716 6726 110332757
Large intestine perforation 102.29 12.47 155 249661 16474 110323009
Live birth 102.21 12.47 17 249799 69467 110270016
Infusion related reaction 102.03 12.47 1312 248504 379850 109959633
Injection site pruritus 101.86 12.47 3 249813 51255 110288228
Tumour necrosis 101.00 12.47 65 249751 2371 110337112
Performance status decreased 100.77 12.47 102 249714 7164 110332319
Disseminated intravascular coagulation 99.89 12.47 260 249556 41026 110298457
Drug dependence 99.13 12.47 3 249813 50017 110289466
Enterocolitis 99.12 12.47 164 249652 18785 110320698
Metastases to spine 98.91 12.47 88 249728 5255 110334228
Adverse drug reaction 98.52 12.47 58 249758 105501 110233982
Serotonin syndrome 97.73 12.47 10 249806 59143 110280340
Coma 97.58 12.47 74 249742 117795 110221688
Nail discolouration 96.91 12.47 74 249742 3561 110335922
Radiation oesophagitis 96.70 12.47 45 249771 849 110338634
Hypoglycaemia 95.98 12.47 73 249743 116031 110223452
Sepsis 95.43 12.47 1145 248671 326201 110013282
Bradycardia 95.19 12.47 127 249689 155390 110184093
Tumour marker increased 94.98 12.47 84 249732 4976 110334507
Oesophagitis 94.65 12.47 204 249612 28511 110310972
Nasal congestion 94.59 12.47 52 249764 98230 110241253
Ileus 94.15 12.47 212 249604 30517 110308966
Stress 94 12.47 61 249755 105287 110234196
Product quality issue 93.59 12.47 29 249787 77270 110262213
Lower limb fracture 93.54 12.47 27 249789 75321 110264162
Osteoporosis 93.18 12.47 40 249776 87112 110252371
Septic shock 92.85 12.47 642 249174 156886 110182597
Scleroderma-like reaction 92.46 12.47 30 249786 198 110339285
Neutropenic colitis 91.93 12.47 102 249714 7963 110331520
Metastatic neoplasm 91.78 12.47 88 249728 5785 110333698
Wound infection 91.46 12.47 52 249764 96413 110243070
Nephrolithiasis 91.40 12.47 19 249797 66193 110273290
Peripheral motor neuropathy 91.37 12.47 75 249741 4011 110335472
Cardiomyopathy 90.39 12.47 220 249596 33305 110306178
Exostosis 90.20 12.47 3 249813 45953 110293530
Hyperaemia 90.17 12.47 72 249744 3701 110335782
Hepatotoxicity 89.59 12.47 331 249485 63069 110276414
Incorrect route of product administration 89.22 12.47 18 249798 64043 110275440
PIK3CA-activated mutation 89.07 12.47 39 249777 634 110338849
Immune-mediated thyroiditis 87.98 12.47 45 249771 1051 110338432
Hypomagnesaemia 87.68 12.47 318 249498 60052 110279431
Joint stiffness 87.43 12.47 22 249794 67221 110272262
Hot flush 86.08 12.47 336 249480 65700 110273783
Frequent bowel movements 86.05 12.47 27 249789 71363 110268120
Pregnancy 86.03 12.47 8 249808 51059 110288424
Lactic acidosis 85.21 12.47 52 249764 92759 110246724
Immune-mediated renal disorder 85.16 12.47 39 249777 708 110338775
Plasma cell myeloma 84.96 12.47 19 249797 62917 110276566
Tumour pseudoprogression 84.51 12.47 50 249766 1566 110337917
Hyperpyrexia 83.40 12.47 97 249719 7972 110331511
Drug reaction with eosinophilia and systemic symptoms 82.61 12.47 41 249775 82054 110257429
Hypersensitivity pneumonitis 82.49 12.47 79 249737 5186 110334297
Lymphopenia 82.28 12.47 238 249578 39932 110299551
Toxic skin eruption 82.27 12.47 188 249628 27327 110312156
Myocardial infarction 82.26 12.47 196 249620 191887 110147596
Glucocorticoid deficiency 81.97 12.47 44 249772 1138 110338345
Bronchitis 81.00 12.47 144 249672 156888 110182595
Posterior reversible encephalopathy syndrome 80.64 12.47 212 249604 33649 110305834
Febrile bone marrow aplasia 80.62 12.47 143 249673 17322 110322161
Foot deformity 80.60 12.47 8 249808 48472 110291011
Periarticular thenar erythema with onycholysis 80.39 12.47 21 249795 54 110339429
Bronchial fistula 79.86 12.47 28 249788 241 110339242
Disease recurrence 79.82 12.47 310 249506 60474 110279009
Coronary artery disease 79.73 12.47 31 249785 71659 110267824
Electrocardiogram QT prolonged 79.71 12.47 77 249739 108883 110230600
Basal cell carcinoma 79.27 12.47 6 249810 45264 110294219
Type 1 diabetes mellitus 79.23 12.47 100 249716 8947 110330536
Immune-mediated encephalitis 78.90 12.47 43 249773 1147 110338336
Computerised tomogram thorax 77.88 12.47 33 249783 493 110338990
Capillary leak syndrome 77.57 12.47 74 249742 4834 110334649
Immune-mediated gastritis 77.24 12.47 29 249787 309 110339174
Metastases to kidney 76.75 12.47 34 249782 569 110338914
Lymphoedema 76.47 12.47 128 249688 14801 110324682
Bone erosion 76.19 12.47 8 249808 46363 110293120
Swollen tongue 76.10 12.47 21 249795 60341 110279142
Device related infection 76.04 12.47 229 249587 39290 110300193
Neck pain 75.91 12.47 100 249716 123030 110216453
Paraesthesia 75.71 12.47 956 248860 275565 110063918
Left ventricular dysfunction 75.26 12.47 165 249651 23328 110316155
Sleep apnoea syndrome 74.87 12.47 4 249812 40443 110299040
Tumour lysis syndrome 74.54 12.47 194 249622 30607 110308876
Product prescribing error 74.53 12.47 13 249803 51318 110288165
Hypertensive crisis 74.51 12.47 168 249648 24204 110315279
Hepatic atrophy 74.47 12.47 31 249785 442 110339041
Congestive cardiomyopathy 74.29 12.47 123 249693 14096 110325387
Radiation skin injury 73.79 12.47 46 249770 1586 110337897
Upper respiratory tract infection 73.70 12.47 114 249702 131214 110208269
Back injury 73.38 12.47 10 249806 47389 110292094
Accidental overdose 73.38 12.47 14 249802 51820 110287663
Liver abscess 73.34 12.47 89 249727 7650 110331833
Immune-mediated nephritis 72.08 12.47 41 249775 1191 110338292
Mastectomy 71.90 12.47 44 249772 1467 110338016
Ovarian cancer metastatic 70.91 12.47 35 249781 756 110338727
Metastases to the mediastinum 70.83 12.47 35 249781 758 110338725
Paronychia 70.60 12.47 105 249711 10976 110328507
Off label use 70.53 12.47 4098 245718 1496087 108843396
Hydronephrosis 69.47 12.47 148 249668 20517 110318966
Drug level increased 69.47 12.47 12 249804 47707 110291776
Secondary cerebellar degeneration 69.17 12.47 19 249797 63 110339420
Transaminases increased 68.86 12.47 305 249511 63085 110276398
Prostate cancer 68.82 12.47 4 249812 37637 110301846
Aggression 68.55 12.47 24 249792 59186 110280297
Treatment noncompliance 68.26 12.47 40 249776 72950 110266533
Joint injury 68.09 12.47 6 249810 39988 110299495
Oesophagobronchial fistula 68.09 12.47 25 249791 249 110339234
Pericardial effusion 68.08 12.47 283 249533 56934 110282549
Atelectasis 68.08 12.47 210 249606 36502 110302981
Hypersensitivity 67.97 12.47 1286 248530 402712 109936771
Full blood count abnormal 67.91 12.47 21 249795 56031 110283452
Small intestinal perforation 67.31 12.47 65 249751 4311 110335172
COVID-19 66.30 12.47 306 249510 244754 110094729
Wrong technique in product usage process 65.93 12.47 60 249756 87288 110252195
Nightmare 65.70 12.47 6 249810 38857 110300626
Gastritis bacterial 65.44 12.47 30 249786 546 110338937
Bronchostenosis 65.28 12.47 35 249781 903 110338580
Malignant pleural effusion 65.24 12.47 62 249754 4031 110335452
Fulminant type 1 diabetes mellitus 64.97 12.47 49 249767 2314 110337169
Joint dislocation 64.50 12.47 3 249813 34187 110305296
Nail dystrophy 64.23 12.47 38 249778 1190 110338293
Neuroleptic malignant syndrome 64.22 12.47 3 249813 34056 110305427
Cardiac failure 64.02 12.47 677 249139 186949 110152534
Metabolic acidosis 63.56 12.47 79 249737 99665 110239818
Acute interstitial pneumonitis 63.48 12.47 40 249776 1406 110338077
Neoplasm recurrence 62.81 12.47 68 249748 5164 110334319
International normalised ratio increased 62.69 12.47 62 249754 86710 110252773
Subileus 62.59 12.47 75 249741 6362 110333121
Dysgeusia 62.38 12.47 318 249498 69667 110269816
Non-small cell lung cancer 62.14 12.47 83 249733 7852 110331631
Eye pain 62.10 12.47 18 249798 50081 110289402
Rectal perforation 61.99 12.47 35 249781 1002 110338481
Haemoptysis 61.37 12.47 321 249495 71033 110268450
Dyskinesia 61.04 12.47 20 249796 51426 110288057
Rhabdomyolysis 60.66 12.47 112 249704 120289 110219194
Delusion of grandeur 60.23 12.47 46 249770 2214 110337269
Haemolytic uraemic syndrome 60.22 12.47 65 249751 4920 110334563
Carbohydrate antigen 15-3 increased 60.07 12.47 40 249776 1547 110337936
Lupus-like syndrome 59.95 12.47 10 249806 40782 110298701
Transient ischaemic attack 59.92 12.47 35 249781 63947 110275536
Angioedema 59.70 12.47 81 249735 98419 110241064
Oedema 59.31 12.47 258 249558 209718 110129765
Delirium 59.22 12.47 136 249680 134889 110204594
Prescribed underdose 59.15 12.47 37 249779 65137 110274346
Pancreatic carcinoma metastatic 58.75 12.47 59 249757 4105 110335378
Recurrent cancer 58.69 12.47 54 249762 3369 110336114
Lymphadenopathy mediastinal 58.49 12.47 67 249749 5417 110334066
Bronchopleural fistula 58.47 12.47 32 249784 861 110338622
Immune-mediated arthritis 58.03 12.47 29 249787 644 110338839
Neuromuscular toxicity 57.68 12.47 25 249791 396 110339087
Immune-mediated adverse reaction 57.58 12.47 40 249776 1660 110337823
Nephritis 57.32 12.47 70 249746 6056 110333427
Malignant ascites 56.93 12.47 37 249779 1373 110338110
Pulse absent 56.75 12.47 96 249720 11196 110328287
Laryngospasm 56.62 12.47 61 249755 4607 110334876
No adverse event 56.59 12.47 50 249766 73789 110265694
Enterocolitis infectious 56.48 12.47 53 249763 3391 110336092
Cardiac failure congestive 56.34 12.47 165 249651 150835 110188648
Immune-mediated cholangitis 56.01 12.47 31 249785 853 110338630
Gout 55.94 12.47 8 249808 36558 110302925
Loss of consciousness 55.56 12.47 683 249133 195623 110143860
Hyperhidrosis 55.34 12.47 657 249159 186641 110152842
Alopecia 54.93 12.47 1142 248674 363611 109975872
Palmar erythema 54.56 12.47 44 249772 2294 110337189
Death 54.31 12.47 2009 247807 696860 109642623
Head injury 54.16 12.47 15 249801 43002 110296481
Procedural pain 53.90 12.47 8 249808 35557 110303926
Autoimmune cholangitis 53.88 12.47 15 249801 53 110339430
Aortitis 53.68 12.47 41 249775 1974 110337509
Incorrect dose administered 53.47 12.47 95 249721 103546 110235937
Accidental exposure to product 53.38 12.47 23 249793 49985 110289498
Acute myelomonocytic leukaemia 53.26 12.47 24 249792 419 110339064
Right ventricular ejection fraction decreased 53.23 12.47 15 249801 56 110339427
Lymphocyte count abnormal 53.14 12.47 44 249772 2382 110337101
Blood pressure systolic increased 52.60 12.47 66 249750 82925 110256558
Device related thrombosis 52.45 12.47 51 249765 3411 110336072
Pancreatic abscess 52.40 12.47 19 249797 182 110339301
Chills 52.19 12.47 659 249157 189921 110149562
Unevaluable event 51.88 12.47 35 249781 59192 110280291
Respiratory tract congestion 51.54 12.47 5 249811 30852 110308631
Endocarditis noninfective 51.45 12.47 21 249795 284 110339199
Extravasation 51.35 12.47 59 249757 4786 110334697
Hypertension 51.34 12.47 1512 248304 508572 109830911
Respiratory distress 51.30 12.47 298 249518 68576 110270907
Onychomycosis 51.27 12.47 12 249804 38519 110300964
Carcinoembryonic antigen increased 51.26 12.47 46 249770 2778 110336705
Guillain-Barre syndrome 50.92 12.47 89 249727 10655 110328828
Constipation 50.58 12.47 1110 248706 356676 109982807
Choking sensation 50.38 12.47 56 249760 4380 110335103
Disability 50.21 12.47 5 249811 30218 110309265
Therapy non-responder 49.65 12.47 185 249631 157122 110182361
Cachexia 49.45 12.47 98 249718 12907 110326576
Carbohydrate antigen 125 increased 49.25 12.47 43 249773 2504 110336979
Hypotension 49.03 12.47 1539 248277 522310 109817173
Superior vena cava syndrome 48.84 12.47 33 249783 1308 110338175
Product administration error 48.72 12.47 12 249804 37205 110302278
Infection 48.70 12.47 553 249263 361647 109977836
Sinus congestion 48.18 12.47 6 249810 30453 110309030
Sinus disorder 48.15 12.47 8 249808 32720 110306763
Oligohydramnios 48.11 12.47 52 249764 3942 110335541
Biliary sepsis 48.00 12.47 37 249779 1806 110337677
Poisoning 47.87 12.47 5 249811 29100 110310383
Therapeutic product effect incomplete 47.53 12.47 303 249513 223502 110115981
Cervix cancer metastatic 47.35 12.47 13 249803 43 110339440
Therapy interrupted 47.02 12.47 27 249789 49795 110289688
Lung abscess 46.46 12.47 57 249759 4955 110334528
Bone lesion 46.37 12.47 68 249748 7019 110332464
Multiple sclerosis 46.17 12.47 3 249813 25695 110313788
Lymphocyte count decreased 46.15 12.47 253 249563 56990 110282493
Cardiac disorder 45.95 12.47 63 249753 76217 110263266
Limb injury 45.78 12.47 14 249802 37622 110301861
Cytopenia 45.74 12.47 161 249655 29955 110309528
Tumour associated fever 45.74 12.47 30 249786 1131 110338352
Febrile infection 45.19 12.47 53 249763 4395 110335088
Peritonitis 45.03 12.47 169 249647 32438 110307045
Impaired quality of life 44.92 12.47 7 249809 30010 110309473
Chronic sinusitis 44.85 12.47 3 249813 25081 110314402
Inappropriate schedule of product administration 44.63 12.47 273 249543 203364 110136119
Injection site haemorrhage 44.52 12.47 10 249806 33018 110306465
Retroperitoneal lymphadenopathy 44.49 12.47 32 249784 1404 110338079
Laryngitis 44.48 12.47 20 249796 42391 110297092
Non-small cell lung cancer metastatic 43.90 12.47 31 249785 1321 110338162
Transplant rejection 43.75 12.47 3 249813 24564 110314919
Hepatic lesion 43.74 12.47 73 249743 8420 110331063
Blood pressure diastolic abnormal 43.60 12.47 4 249812 25811 110313672
Irritability 43.58 12.47 27 249789 47782 110291701
Metastases to adrenals 43.54 12.47 33 249783 1570 110337913
Bile duct stenosis 43.54 12.47 41 249775 2635 110336848
Administration site extravasation 43.48 12.47 34 249782 1695 110337788
Subclavian vein thrombosis 43.44 12.47 42 249774 2790 110336693
Haematochezia 43.26 12.47 126 249690 115398 110224085
Gastric disorder 43.19 12.47 11 249805 33346 110306137
Drug withdrawal syndrome 43.07 12.47 16 249800 38038 110301445
Acute respiratory distress syndrome 42.80 12.47 235 249581 52963 110286520
Intestinal obstruction 42.74 12.47 235 249581 52992 110286491
Hip arthroplasty 42.52 12.47 38 249778 55775 110283708
Chronic obstructive pulmonary disease 42.39 12.47 117 249699 109041 110230442
Weight decreased 42.37 12.47 773 249043 467284 109872199
Tremor 42.32 12.47 275 249541 201957 110137526
Eosinophilia 42.30 12.47 41 249775 57895 110281588
Gastroenteritis radiation 42.26 12.47 25 249791 783 110338700
Organising pneumonia 42.23 12.47 97 249719 14146 110325337
Skin laceration 42.07 12.47 12 249804 33741 110305742
Subdural haematoma 41.81 12.47 15 249801 36439 110303044
Tumour pain 41.78 12.47 42 249774 2925 110336558
Cataract 41.78 12.47 72 249744 79413 110260070
Blood glucose increased 41.69 12.47 156 249660 132340 110207143
Abnormal behaviour 41.59 12.47 18 249798 39021 110300462
Flatulence 41.57 12.47 34 249782 52115 110287368
Alanine aminotransferase increased 41.53 12.47 614 249202 183159 110156324
Hypothalamo-pituitary disorder 41.39 12.47 41 249775 2805 110336678
Drug eruption 41.16 12.47 234 249582 53425 110286058
Infectious pleural effusion 41.16 12.47 53 249763 4838 110334645
Adrenal disorder 40.99 12.47 38 249778 2394 110337089
Metastases to stomach 40.92 12.47 18 249798 296 110339187
Breast cancer 40.77 12.47 184 249632 38358 110301125
Thrombophlebitis migrans 40.61 12.47 24 249792 750 110338733
Visual impairment 40.55 12.47 161 249655 134267 110205216
Eye pruritus 40.21 12.47 12 249804 32763 110306720
Drug resistance 40.10 12.47 241 249575 56133 110283350
Cancer pain 40.07 12.47 62 249754 6710 110332773
Axillary lymphadenectomy 40.04 12.47 13 249803 86 110339397
Emotional distress 39.96 12.47 26 249790 44821 110294662
Metastases to eye 39.65 12.47 18 249798 320 110339163
Oropharyngeal pain 39.56 12.47 164 249652 135112 110204371
Walking aid user 39.51 12.47 5 249811 25070 110314413
Mastitis 39.35 12.47 38 249778 2520 110336963
Skin haemorrhage 39.00 12.47 5 249811 24822 110314661
Myoclonus 38.85 12.47 13 249803 32985 110306498
Acquired gene mutation 38.81 12.47 39 249777 2715 110336768
Product dose omission in error 38.77 12.47 4 249812 23508 110315975
Hand dermatitis 38.66 12.47 23 249793 728 110338755
Cardiac murmur 38.59 12.47 5 249811 24623 110314860
Herpes zoster 38.58 12.47 121 249695 108258 110231225
Metastases to retroperitoneum 38.55 12.47 19 249797 409 110339074
Muscular weakness 38.43 12.47 367 249449 248101 110091382
Tumour hyperprogression 38.28 12.47 18 249798 348 110339135
Dermatitis acneiform 38.24 12.47 87 249729 12608 110326875
Unresponsive to stimuli 38.17 12.47 261 249555 63529 110275954
Respiratory failure 38.09 12.47 691 249125 214641 110124842
Bone marrow infiltration 38.08 12.47 24 249792 844 110338639
Small intestinal obstruction 38.06 12.47 159 249657 32054 110307429
Abortion spontaneous 37.83 12.47 15 249801 34267 110305216
Impaired work ability 37.68 12.47 7 249809 26412 110313071
Ovarian cancer 37.56 12.47 48 249768 4348 110335135
Onychomadesis 37.36 12.47 29 249787 45634 110293849
Mood swings 37.31 12.47 4 249812 22808 110316675
Hypervolaemia 37.29 12.47 34 249782 49426 110290057
Autoimmune nephritis 37.21 12.47 23 249793 781 110338702
Deep vein thrombosis 37.14 12.47 481 249335 139406 110200077
Adverse event 36.98 12.47 124 249692 108685 110230798
Localised infection 36.96 12.47 26 249790 43022 110296461
Duodenal perforation 36.81 12.47 38 249778 2732 110336751
Pulmonary sarcoidosis 36.46 12.47 31 249785 1741 110337742
Portal hypertension 36.42 12.47 68 249748 8569 110330914
Eye irritation 36.32 12.47 15 249801 33437 110306046
Ear pain 36.23 12.47 40 249776 53186 110286297
Kounis syndrome 36.12 12.47 55 249761 5870 110333613
Blood corticotrophin decreased 36.03 12.47 23 249793 827 110338656
Upper limb fracture 35.92 12.47 3 249813 20885 110318598
Dysphagia 35.81 12.47 516 249300 153084 110186399
Urinary tract obstruction 35.81 12.47 51 249765 5126 110334357
Pruritus 35.77 12.47 1020 248796 580540 109758943
Dermatitis 35.75 12.47 141 249675 27696 110311787
Cerebrovascular accident 35.70 12.47 251 249565 181033 110158450
Metastases to chest wall 35.57 12.47 21 249795 655 110338828
Ovarian failure 35.50 12.47 24 249792 952 110338531
Skin disorder 35.49 12.47 191 249625 42722 110296761
Labelled drug-drug interaction medication error 35.46 12.47 11 249805 29291 110310192
Gastric pneumatosis 35.35 12.47 10 249806 38 110339445
Fungating wound 35.22 12.47 11 249805 63 110339420
Viral infection 35.01 12.47 41 249775 53098 110286385
Heart rate decreased 34.97 12.47 85 249731 82671 110256812
Acne 34.86 12.47 16 249800 33504 110305979
Eye disorder 34.71 12.47 11 249805 28895 110310588
Neutrophil count abnormal 34.68 12.47 50 249766 5082 110334401
Pancreatic enzyme abnormality 34.59 12.47 14 249802 185 110339298
Immune-mediated cystitis 34.50 12.47 13 249803 140 110339343
Primary cardiac lymphoma 34.49 12.47 9 249807 23 110339460
Empyema 34.37 12.47 52 249764 5518 110333965
Pseudomembranous colitis 34.35 12.47 56 249760 6335 110333148
Pyogenic granuloma 34.29 12.47 19 249797 524 110338959
Sopor 34.21 12.47 20 249796 36526 110302957
Eczema asteatotic 34.20 12.47 22 249794 802 110338681
Pulmonary radiation injury 34.11 12.47 11 249805 71 110339412
BRCA1 gene mutation 34.11 12.47 11 249805 71 110339412
Cough 34.10 12.47 1320 248496 460321 109879162
Eye swelling 34.02 12.47 16 249800 33032 110306451
Cancer fatigue 33.95 12.47 17 249799 379 110339104
Mental disorder 33.87 12.47 23 249793 38768 110300715
Non-small cell lung cancer recurrent 33.86 12.47 14 249802 196 110339287
Tumour cavitation 33.85 12.47 11 249805 73 110339410
Pulmonary tumour thrombotic microangiopathy 33.78 12.47 13 249803 149 110339334
Hepatic infection 33.66 12.47 26 249790 1273 110338210
Duodenal obstruction 33.62 12.47 18 249798 463 110339020
Emphysematous cystitis 33.62 12.47 20 249796 633 110338850
Immune-mediated neurological disorder 33.60 12.47 11 249805 75 110339408
Blood pressure immeasurable 33.57 12.47 34 249782 2389 110337094
Laryngopharyngitis 33.56 12.47 12 249804 110 110339373
Rhinorrhoea 33.54 12.47 119 249697 102547 110236936
Metastases to pelvis 33.52 12.47 22 249794 830 110338653
Oxygen therapy 33.38 12.47 44 249772 4109 110335374
Abdominal pain upper 33.34 12.47 571 249245 348540 109990943
Scleroderma 33.32 12.47 55 249761 6286 110333197
Anti-glomerular basement membrane disease 33.32 12.47 13 249803 155 110339328
Toxic erythema of chemotherapy 33.32 12.47 17 249799 395 110339088
Obstructive airways disorder 33.30 12.47 33 249783 46116 110293367
Aspartate aminotransferase increased 33.30 12.47 527 249289 159409 110180074
Product substitution issue 33.13 12.47 6 249810 23055 110316428
Hypersomnia 33.13 12.47 11 249805 28050 110311433
Agitation 33.09 12.47 137 249679 112914 110226569
Colitis ulcerative 33.06 12.47 79 249737 77284 110262199
Coronary artery aneurysm 32.95 12.47 13 249803 160 110339323
Status epilepticus 32.94 12.47 15 249801 31556 110307927
Metastases to abdominal cavity 32.92 12.47 22 249794 856 110338627
Swelling face 32.91 12.47 103 249713 92218 110247265
Acute megakaryocytic leukaemia 32.82 12.47 10 249806 52 110339431
Anastomotic leak 32.74 12.47 26 249790 1326 110338157
Hypoalbuminaemia 32.67 12.47 141 249675 28833 110310650
Hallucination, visual 32.60 12.47 25 249791 39580 110299903
Metastases to heart 32.56 12.47 17 249799 415 110339068
Autoimmune hepatitis 32.55 12.47 90 249726 14714 110324769
Blood uric acid decreased 32.54 12.47 27 249789 1466 110338017
Azotaemia 32.49 12.47 71 249745 10014 110329469
Peritoneal neoplasm 32.46 12.47 12 249804 122 110339361
Tracheal fistula 32.46 12.47 14 249802 219 110339264
Bicytopenia 32.26 12.47 56 249760 6668 110332815
Cervix carcinoma recurrent 32.21 12.47 10 249806 56 110339427
Axonal and demyelinating polyneuropathy 32.21 12.47 10 249806 56 110339427
Rhinalgia 32.16 12.47 42 249774 3887 110335596
Ulcer haemorrhage 32.15 12.47 6 249810 22565 110316918
Haemophagocytic lymphohistiocytosis 32.14 12.47 149 249667 31410 110308073
Underdose 32.11 12.47 59 249757 63495 110275988
Pneumatosis intestinalis 32.10 12.47 64 249752 8465 110331018
Kidney infection 32.09 12.47 9 249807 25590 110313893
Retinal toxicity 32.06 12.47 28 249788 1631 110337852
Ototoxicity 32.03 12.47 43 249773 4088 110335395
Demyelinating polyneuropathy 31.97 12.47 32 249784 2217 110337266
Vaginal fistula 31.74 12.47 16 249800 362 110339121
Infected lymphocele 31.57 12.47 14 249802 235 110339248
Immune thrombocytopenia 31.40 12.47 117 249699 22377 110317106
Dermatomyositis 31.35 12.47 44 249772 4362 110335121
Capillary permeability increased 31.35 12.47 10 249806 62 110339421
Fear 31.31 12.47 7 249809 23186 110316297
Immune-mediated cytopenia 31.17 12.47 15 249801 306 110339177
Liver scan abnormal 31.08 12.47 10 249806 64 110339419
Venous thrombosis 31.03 12.47 63 249753 8442 110331041
Abdominal distension 30.89 12.47 250 249566 174853 110164630
Gastroenteritis viral 30.81 12.47 16 249800 31210 110308273
Device issue 30.80 12.47 20 249796 34515 110304968
Cytomegalovirus infection 30.79 12.47 47 249769 54397 110285086
C-reactive protein increased 30.75 12.47 329 249487 217590 110121893
Nervousness 30.67 12.47 23 249793 36828 110302655
Tonsillar disorder 30.54 12.47 26 249790 1463 110338020
Pleural neoplasm 30.37 12.47 16 249800 398 110339085
Biliary obstruction 30.28 12.47 49 249767 5509 110333974
Pulmonary fibrosis 30.28 12.47 123 249693 101919 110237564
Metastases to bladder 30.22 12.47 15 249801 328 110339155
Incorrect product administration duration 30.18 12.47 5 249811 20493 110318990
Hyperthermia 29.99 12.47 111 249705 21161 110318322
End stage renal disease 29.97 12.47 6 249810 21467 110318016
Movement disorder 29.94 12.47 23 249793 36381 110303102
Tumour embolism 29.76 12.47 14 249802 271 110339212
Paranoia 29.71 12.47 7 249809 22367 110317116
Sputum discoloured 29.59 12.47 13 249803 27932 110311551
Morphoea 29.42 12.47 18 249798 600 110338883
Metastases to soft tissue 29.35 12.47 19 249797 700 110338783
Pseudocellulitis 29.28 12.47 16 249800 429 110339054
Influenza like illness 29.20 12.47 102 249714 88310 110251173
Cortisol decreased 29.16 12.47 34 249782 2802 110336681
Food allergy 29.07 12.47 5 249811 19943 110319540
Metastases to breast 28.96 12.47 15 249801 360 110339123
Invasive ductal breast carcinoma 28.87 12.47 53 249763 6593 110332890
Device dislocation 28.77 12.47 18 249798 31686 110307797
Intestinal metastasis 28.75 12.47 17 249799 532 110338951
Radiation necrosis 28.70 12.47 20 249796 834 110338649
Gene mutation 28.61 12.47 37 249779 3392 110336091
Injection site warmth 28.60 12.47 3 249813 17402 110322081
Dysarthria 28.49 12.47 96 249720 84025 110255458
Dermatitis atopic 28.47 12.47 11 249805 25530 110313953
Balance disorder 28.37 12.47 151 249665 116409 110223074
Disturbance in attention 28.36 12.47 61 249755 61934 110277549
Panic attack 28.30 12.47 15 249801 28925 110310558
Anaemia of malignant disease 28.16 12.47 21 249795 975 110338508
Hyponatraemia 28.16 12.47 667 249149 216986 110122497
Adverse reaction 27.98 12.47 16 249800 29578 110309905
Immune-mediated endocrinopathy 27.91 12.47 11 249805 135 110339348
Enteritis 27.89 12.47 101 249715 19055 110320428
Benign prostatic hyperplasia 27.87 12.47 4 249812 18230 110321253
Mood altered 27.77 12.47 7 249809 21368 110318115
Blood urine present 27.77 12.47 10 249806 24235 110315248
Toxic cardiomyopathy 27.75 12.47 19 249797 770 110338713
Gastrointestinal necrosis 27.65 12.47 52 249764 6588 110332895
Pneumonitis chemical 27.65 12.47 18 249798 670 110338813
Jugular vein thrombosis 27.61 12.47 46 249770 5299 110334184
Vocal cord paralysis 27.56 12.47 34 249782 2972 110336511
Pelvic infection 27.56 12.47 15 249801 399 110339084
Drug use disorder 27.54 12.47 4 249812 18070 110321413
Cholestasis 27.50 12.47 244 249572 64274 110275209
Limb discomfort 27.48 12.47 31 249785 40823 110298660
Dyspepsia 27.47 12.47 287 249529 190678 110148805
Pancreatic carcinoma recurrent 27.41 12.47 12 249804 195 110339288
Dementia 27.36 12.47 19 249797 31654 110307829
Blood potassium increased 27.35 12.47 21 249795 33228 110306255
Laryngeal oedema 27.12 12.47 65 249751 9742 110329741
Needle issue 27.06 12.47 4 249812 17836 110321647
Liver injury 26.87 12.47 214 249602 150199 110189284
Joint effusion 26.86 12.47 7 249809 20898 110318585
Secondary adrenocortical insufficiency 26.80 12.47 41 249775 4393 110335090
Hypermetabolism 26.76 12.47 17 249799 606 110338877
Pathogen resistance 26.72 12.47 4 249812 17668 110321815
Band sensation 26.68 12.47 21 249795 1057 110338426
Hyperlipidaemia 26.60 12.47 25 249791 35823 110303660
Laryngeal necrosis 26.52 12.47 8 249808 40 110339443
Lymphadenopathy 26.48 12.47 240 249576 63595 110275888
Immune-mediated myositis 26.45 12.47 49 249767 6137 110333346
Affect lability 26.45 12.47 5 249811 18632 110320851
Product dispensing error 26.39 12.47 3 249813 16342 110323141
Diabetes mellitus 26.32 12.47 125 249691 99256 110240227
Pain in jaw 26.31 12.47 47 249769 51130 110288353
Glaucoma 26.28 12.47 9 249807 22508 110316975
Ocular hyperaemia 26.22 12.47 30 249786 39256 110300227
Chromaturia 26.19 12.47 17 249799 29343 110310140
Malignant peritoneal neoplasm 26.17 12.47 18 249798 735 110338748
Liver function test increased 26.10 12.47 107 249709 88441 110251042
Dyspnoea at rest 26.03 12.47 58 249758 8288 110331195
Agranulocytosis 26.03 12.47 233 249583 61527 110277956
Transfusion-associated dyspnoea 25.72 12.47 9 249807 77 110339406
EGFR gene mutation 25.61 12.47 16 249800 554 110338929
Wound dehiscence 25.59 12.47 56 249760 7906 110331577
Venous thrombosis limb 25.46 12.47 44 249772 5221 110334262
Speech disorder 25.42 12.47 64 249752 61505 110277978
Cholelithiasis 25.36 12.47 67 249749 63355 110276128
Foot fracture 25.34 12.47 13 249803 25533 110313950
Oligoastrocytoma 25.30 12.47 7 249809 24 110339459
Eosinophil percentage increased 25.28 12.47 24 249792 1558 110337925
Intentional dose omission 25.28 12.47 7 249809 20073 110319410
Adenocarcinoma metastatic 25.27 12.47 14 249802 386 110339097
Gallbladder disorder 25.26 12.47 8 249808 21021 110318462
Dermatitis bullous 25.16 12.47 92 249724 17437 110322046
Agonal respiration 25.13 12.47 13 249803 311 110339172
Autoimmune thyroiditis 25.09 12.47 49 249767 6385 110333098
Sinus bradycardia 25.06 12.47 18 249798 29465 110310018
Oesophagopleural fistula 25.03 12.47 8 249808 50 110339433
Inappropriate antidiuretic hormone secretion 24.90 12.47 146 249670 33705 110305778
Gastric perforation 24.90 12.47 42 249774 4887 110334596
Aplasia 24.88 12.47 55 249761 7818 110331665
Product storage error 24.82 12.47 9 249807 21719 110317764
Ventricular tachycardia 24.76 12.47 47 249769 49962 110289521
Myositis 24.73 12.47 137 249679 30979 110308504
Encephalitis 24.66 12.47 96 249720 18743 110320740
Autoimmune hypothyroidism 24.62 12.47 15 249801 496 110338987
Ulcer 24.59 12.47 37 249779 43079 110296404
Xerophthalmia 24.57 12.47 19 249797 932 110338551
Anhedonia 24.50 12.47 3 249813 15425 110324058
Cholangitis infective 24.41 12.47 18 249798 821 110338662
Dystonia 24.33 12.47 14 249802 25791 110313692
Catheter site infection 24.29 12.47 55 249761 7945 110331538
Photophobia 24.27 12.47 14 249802 25757 110313726
Larynx irritation 24.16 12.47 11 249805 197 110339286
Tooth erosion 24.15 12.47 14 249802 422 110339061
Fungal infection 24.07 12.47 49 249767 50757 110288726
Fixed bowel loop 24.01 12.47 6 249810 12 110339471
Autoimmune haemolytic anaemia 23.99 12.47 65 249751 10502 110328981
Leukonychia 23.88 12.47 9 249807 97 110339386
Carbohydrate antigen 15-3 23.88 12.47 9 249807 97 110339386
Duodenitis haemorrhagic 23.87 12.47 10 249806 145 110339338
Secretion discharge 23.79 12.47 8 249808 20236 110319247
Blood thyroid stimulating hormone abnormal 23.74 12.47 20 249796 1109 110338374
Thyroid dermatopathy 23.72 12.47 7 249809 32 110339451
Adenocarcinoma 23.68 12.47 38 249778 4242 110335241
Haemobilia 23.62 12.47 16 249800 637 110338846
Acute myocardial infarction 23.61 12.47 103 249713 83674 110255809
Cardiac cirrhosis 23.55 12.47 12 249804 278 110339205
Vena cava thrombosis 23.55 12.47 34 249782 3460 110336023
Arterioenteric fistula 23.54 12.47 7 249809 33 110339450
Blood bilirubin increased 23.54 12.47 269 249547 75703 110263780
Acute polyneuropathy 23.53 12.47 17 249799 751 110338732
Bone density decreased 23.43 12.47 4 249812 16038 110323445
Dysstasia 23.33 12.47 24 249792 32962 110306521
Cognitive disorder 23.22 12.47 110 249706 87401 110252082
Skin reaction 23.16 12.47 102 249714 21042 110318441
Scintillating scotoma 23.15 12.47 11 249805 218 110339265
Respiratory disorder 23.14 12.47 83 249733 71299 110268184
Uterine atrophy 23.09 12.47 6 249810 15 110339468
Upper-airway cough syndrome 23.05 12.47 4 249812 15853 110323630
Pancreatic carcinoma 23.01 12.47 80 249736 14792 110324691
Troponin increased 22.95 12.47 130 249686 29636 110309847
Hypophagia 22.93 12.47 200 249616 52426 110287057
Blood pressure diastolic increased 22.86 12.47 7 249809 18800 110320683
Hypoproteinaemia 22.85 12.47 45 249771 5900 110333583
Glomerular vascular disorder 22.79 12.47 11 249805 226 110339257
Cystitis haemorrhagic 22.78 12.47 70 249746 12139 110327344
Cytomegalovirus viraemia 22.73 12.47 6 249810 17758 110321725
Brachydactyly 22.73 12.47 7 249809 38 110339445
Lichen planus 22.72 12.47 33 249783 3377 110336106
Neutrophil count increased 22.68 12.47 145 249671 34507 110304976
Drug dose omission by device 22.62 12.47 3 249813 14513 110324970
Breast disorder 22.56 12.47 27 249789 2287 110337196
Oesophagomediastinal fistula 22.55 12.47 6 249810 17 110339466
Tumour ulceration 22.51 12.47 12 249804 306 110339177
Immunodeficiency 22.47 12.47 33 249783 38805 110300678
Wrist fracture 22.42 12.47 3 249813 14414 110325069
Adenocarcinoma of the cervix 22.35 12.47 11 249805 236 110339247
Metastases to gastrointestinal tract 22.22 12.47 10 249806 174 110339309
Bladder cancer 22.19 12.47 9 249807 20283 110319200
Pancreatic failure 22.19 12.47 27 249789 2327 110337156
Teratoma benign 22.12 12.47 8 249808 76 110339407
Acute monocytic leukaemia 22.10 12.47 15 249801 599 110338884
Breast necrosis 22.10 12.47 9 249807 121 110339362
Coordination abnormal 21.97 12.47 15 249801 25213 110314270
Urinary retention 21.95 12.47 82 249734 69601 110269882
Myocardial oedema 21.90 12.47 15 249801 608 110338875
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 21.85 12.47 8 249808 79 110339404
Angiosarcoma recurrent 21.82 12.47 6 249810 20 110339463
Cystitis noninfective 21.81 12.47 23 249793 1695 110337788
Musculoskeletal disorder 21.79 12.47 12 249804 22652 110316831
Endocrine toxicity 21.76 12.47 8 249808 80 110339403
Angiosarcoma metastatic 21.67 12.47 10 249806 185 110339298
Onychalgia 21.59 12.47 19 249797 1118 110338365
Thrombocytosis 21.50 12.47 62 249754 10382 110329101
Hypocalcaemia 21.41 12.47 234 249582 65132 110274351
Haemoglobin 21.39 12.47 9 249807 132 110339351
Device leakage 21.35 12.47 5 249811 16043 110323440
Cerebral ischaemia 21.30 12.47 68 249748 12036 110327447
Miller Fisher syndrome 21.21 12.47 12 249804 345 110339138
Hyperglycaemia 21.09 12.47 289 249527 84801 110254682
Malignant melanoma 21.06 12.47 6 249810 16885 110322598
Post thrombotic syndrome 21.02 12.47 15 249801 650 110338833
Pleurocutaneous fistula 20.98 12.47 7 249809 51 110339432
Ovarian stromal hyperplasia 20.97 12.47 6 249810 24 110339459
Oesophageal stenosis 20.95 12.47 40 249776 5125 110334358
Taeniasis 20.86 12.47 7 249809 52 110339431
Haemorrhage 20.86 12.47 148 249668 106544 110232939
Poor venous access 20.80 12.47 15 249801 24507 110314976
Spinal pain 20.80 12.47 90 249726 18425 110321058
Immune-mediated encephalopathy 20.76 12.47 8 249808 92 110339391
Pustular psoriasis 20.75 12.47 3 249813 13602 110325881
Nasal septum perforation 20.74 12.47 17 249799 907 110338576
Periodontitis 20.72 12.47 40 249776 5168 110334315
Hormone receptor positive breast cancer 20.54 12.47 14 249802 563 110338920
Arteriosclerosis coronary artery 20.49 12.47 16 249800 25102 110314381
Immune-mediated neuropathy 20.47 12.47 10 249806 211 110339272
Peripheral sensorimotor neuropathy 20.45 12.47 34 249782 3909 110335574
Pulmonary cavitation 20.41 12.47 25 249791 2169 110337314
Dysentery 20.40 12.47 20 249796 1351 110338132
Gelastic seizure 20.35 12.47 5 249811 9 110339474
Acute erythroid leukaemia 20.31 12.47 12 249804 375 110339108
Immune-mediated cholestasis 20.30 12.47 7 249809 57 110339426
Peritoneal disorder 20.25 12.47 16 249800 810 110338673
Catheter site injury 20.20 12.47 11 249805 293 110339190
Tracheo-oesophageal fistula 20.16 12.47 15 249801 694 110338789
Ecchymosis 20.12 12.47 7 249809 17331 110322152
Corneal disorder 20.09 12.47 27 249789 2570 110336913
Respiratory depth decreased 20.06 12.47 6 249810 29 110339454
Aortic injury 20.01 12.47 5 249811 10 110339473
Facial pain 19.97 12.47 5 249811 15334 110324149
Tongue disorder 19.95 12.47 4 249812 14294 110325189
Nasal polyps 19.93 12.47 3 249813 13197 110326286
Seronegative arthritis 19.88 12.47 3 249813 13174 110326309
Nail avulsion 19.88 12.47 9 249807 159 110339324
Polyneuropathy in malignant disease 19.87 12.47 13 249803 488 110338995
Keratitis 19.84 12.47 39 249777 5105 110334378
Microvascular coronary artery disease 19.83 12.47 12 249804 392 110339091
Biliary dilatation 19.81 12.47 32 249784 3593 110335890
Productive cough 19.79 12.47 164 249652 114141 110225342
Melaena 19.70 12.47 84 249732 68673 110270810
Thinking abnormal 19.59 12.47 5 249811 15135 110324348
Xeroderma 19.57 12.47 14 249802 609 110338874
Faeces discoloured 19.49 12.47 29 249787 33919 110305564
Scratch 19.48 12.47 3 249813 12976 110326507
Sarcoid-like reaction 19.48 12.47 11 249805 315 110339168
Hormone receptor positive HER2 negative breast cancer 19.46 12.47 10 249806 236 110339247
Chest pain 19.43 12.47 1038 248778 375337 109964146
Glossopharyngeal nerve paralysis 19.40 12.47 7 249809 66 110339417
Vessel puncture site bruise 19.38 12.47 13 249803 509 110338974
Metastases to bone marrow 19.37 12.47 17 249799 997 110338486
Nephrotic syndrome 19.36 12.47 72 249744 13759 110325724
Ureteric fistula 19.27 12.47 6 249810 34 110339449
Hip fracture 19.25 12.47 31 249785 35120 110304363
Respiratory symptom 19.21 12.47 5 249811 14940 110324543
Portal venous gas 19.16 12.47 13 249803 519 110338964
Epilepsy 19.11 12.47 140 249676 100069 110239414
Vaginal cuff dehiscence 19.10 12.47 5 249811 13 110339470
Autoimmune colitis 19.09 12.47 23 249793 1962 110337521
Cytokine storm 19.01 12.47 20 249796 1470 110338013
Cell death 18.92 12.47 41 249775 5750 110333733
Pulmonary fistula 18.91 12.47 8 249808 119 110339364
Aortic embolus 18.86 12.47 7 249809 72 110339411
Blood creatine phosphokinase increased 18.72 12.47 93 249723 72984 110266499
Rash pruritic 18.71 12.47 137 249679 97932 110241551
Double hit lymphoma 18.70 12.47 6 249810 38 110339445
Cerebral infarction 18.59 12.47 189 249627 51649 110287834
Surgery 18.57 12.47 41 249775 41242 110298241
Diabetes mellitus inadequate control 18.53 12.47 24 249792 29751 110309732
Blood uric acid increased 18.48 12.47 13 249803 21516 110317967
Angiosarcoma 18.37 12.47 13 249803 556 110338927
Breast tumour excision 18.34 12.47 5 249811 16 110339467
Orthostatic hypotension 18.33 12.47 82 249734 66167 110273316
Lung disorder 18.32 12.47 291 249525 179756 110159727
Unwanted pregnancy 18.31 12.47 6 249810 41 110339442
Subacute cutaneous lupus erythematosus 18.23 12.47 37 249779 4957 110334526
Right ventricular failure 18.22 12.47 19 249797 25935 110313548
Colitis ischaemic 18.22 12.47 84 249732 17666 110321817
Diverticulitis 18.18 12.47 61 249755 53461 110286022
Pancreatitis 18.16 12.47 130 249686 93403 110246080
Clinomania 18.13 12.47 7 249809 81 110339402
Herpes zoster oticus 18.11 12.47 14 249802 686 110338797
Middle insomnia 18.11 12.47 12 249804 20490 110318993
Pulmonary artery stenosis 18.11 12.47 8 249808 133 110339350
Glycosylated haemoglobin increased 18.09 12.47 16 249800 23603 110315880
Embolism venous 18.08 12.47 37 249779 4986 110334497
Arterial occlusive disease 18.07 12.47 6 249810 15302 110324181
Akathisia 18.06 12.47 8 249808 17105 110322378
Psychotic disorder 18.03 12.47 57 249759 50880 110288603
Splenic artery thrombosis 17.98 12.47 7 249809 83 110339400
Rhinitis allergic 17.95 12.47 9 249807 17913 110321570
Acquired amegakaryocytic thrombocytopenia 17.95 12.47 6 249810 44 110339439
Pharyngitis streptococcal 17.94 12.47 4 249812 13273 110326210
Cannabinoid hyperemesis syndrome 17.90 12.47 7 249809 84 110339399
Retinal phototoxicity 17.89 12.47 5 249811 18 110339465
Omentectomy 17.83 12.47 6 249810 45 110339438
Progressive multifocal leukoencephalopathy 17.83 12.47 18 249798 24938 110314545
Extra dose administered 17.83 12.47 3 249813 12156 110327327
Anaphylactoid shock 17.78 12.47 16 249800 970 110338513
Odynophagia 17.77 12.47 71 249745 14030 110325453
Pericarditis malignant 17.75 12.47 7 249809 86 110339397
Hypertriglyceridaemia 17.75 12.47 78 249738 16076 110323407
Encephalitis autoimmune 17.74 12.47 30 249786 3498 110335985
Foetal death 17.74 12.47 7 249809 16038 110323445
Blood pressure increased 17.72 12.47 446 249370 257927 110081556
Maternal death affecting foetus 17.62 12.47 4 249812 4 110339479
Breast sarcoma 17.62 12.47 4 249812 4 110339479
Confluent and reticulate papillomatosis 17.62 12.47 4 249812 4 110339479
Blood alkaline phosphatase increased 17.61 12.47 241 249575 70694 110268789
Nail discomfort 17.61 12.47 7 249809 88 110339395
HER2 positive breast cancer 17.57 12.47 11 249805 382 110339101
Resuscitation 17.56 12.47 27 249789 2906 110336577
Myiasis 17.50 12.47 6 249810 48 110339435
Renal cancer 17.46 12.47 4 249812 13030 110326453
Hiatus hernia 17.44 12.47 22 249794 27584 110311899
Electrocardiogram QRS complex prolonged 17.43 12.47 4 249812 13017 110326466
Pollakiuria 17.43 12.47 47 249769 44148 110295335
Metastases to ovary 17.40 12.47 11 249805 389 110339094
Aortic dissection 17.36 12.47 36 249780 4897 110334586
Metastases to pancreas 17.34 12.47 14 249802 731 110338752
Aorto-oesophageal fistula 17.33 12.47 7 249809 92 110339391
Laboratory test abnormal 17.29 12.47 47 249769 44032 110295451
Mania 17.28 12.47 13 249803 20783 110318700
Therapeutic response unexpected 17.26 12.47 17 249799 23826 110315657
Pulmonary congestion 17.25 12.47 27 249789 30939 110308544
Obstruction gastric 17.25 12.47 22 249794 1989 110337494
Blood glucose decreased 17.12 12.47 25 249791 29463 110310020
Poor quality sleep 17.10 12.47 23 249793 28054 110311429
Endometrial cancer recurrent 17.09 12.47 5 249811 22 110339461
Pulmonary hypoplasia 17.08 12.47 6 249810 52 110339431
Parkinsonism 17.03 12.47 15 249801 22172 110317311
Increased tendency to bruise 17.02 12.47 3 249813 11755 110327728
Autoimmune dermatitis 17.01 12.47 9 249807 226 110339257
Hepatic neoplasm 17.00 12.47 31 249785 3836 110335647
Pulmonary vein stenosis 17.00 12.47 8 249808 155 110339328
Intestinal ischaemia 16.93 12.47 77 249739 16102 110323381
Median nerve injury 16.91 12.47 5 249811 23 110339460
Rectal haemorrhage 16.86 12.47 181 249635 119652 110219831
Vascular device infection 16.85 12.47 78 249738 16434 110323049
Triple negative breast cancer 16.82 12.47 12 249804 520 110338963
Intervertebral disc degeneration 16.78 12.47 10 249806 18075 110321408
Gastrointestinal disorder 16.77 12.47 417 249399 241535 110097948
Cholecystitis 16.75 12.47 108 249708 25774 110313709
Breast cellulitis 16.74 12.47 11 249805 416 110339067
Therapy cessation 16.73 12.47 49 249767 44808 110294675
Laryngeal discomfort 16.73 12.47 14 249802 769 110338714
Acute motor-sensory axonal neuropathy 16.69 12.47 12 249804 526 110338957
Immediate post-injection reaction 16.65 12.47 11 249805 420 110339063
Lymphatic disorder 16.65 12.47 11 249805 420 110339063
Crying 16.64 12.47 20 249796 25608 110313875
Hepatitis 16.63 12.47 291 249525 89763 110249720
Face oedema 16.62 12.47 131 249685 33338 110306145
Lung squamous cell carcinoma metastatic 16.62 12.47 7 249809 103 110339380
Upper gastrointestinal perforation 16.59 12.47 6 249810 57 110339426
Anorectal malformation 16.59 12.47 6 249810 57 110339426
Neutrophil toxic granulation present 16.55 12.47 9 249807 239 110339244
Blood magnesium decreased 16.53 12.47 89 249727 19907 110319576
Cholangitis acute 16.52 12.47 21 249795 1892 110337591
Apathy 16.50 12.47 8 249808 16231 110323252
Torsade de pointes 16.49 12.47 16 249800 22584 110316899
Muscle rigidity 16.42 12.47 18 249798 24013 110315470
Thrombotic thrombocytopenic purpura 16.40 12.47 44 249772 7067 110332416
Brachiocephalic vein thrombosis 16.38 12.47 10 249806 332 110339151
Carbohydrate antigen 19-9 increased 16.34 12.47 12 249804 544 110338939
Pulmonary artery occlusion 16.32 12.47 6 249810 60 110339423
Skin cancer 16.27 12.47 10 249806 17774 110321709
Generalised oedema 16.26 12.47 122 249694 30582 110308901
Blood triglycerides increased 16.26 12.47 18 249798 23908 110315575
Hypotensive crisis 16.24 12.47 8 249808 172 110339311
Hypercalcaemia of malignancy 16.23 12.47 12 249804 550 110338933
Myxoedema 16.18 12.47 9 249807 250 110339233
Acquired tracheo-oesophageal fistula 16.16 12.47 8 249808 174 110339309
Fistula 16.15 12.47 73 249743 15226 110324257
Scar 16.14 12.47 9 249807 16872 110322611
Pulmonary artery thrombosis 16.13 12.47 19 249797 1583 110337900
Pulmonary hypertension 16.10 12.47 67 249749 55153 110284330
Escherichia test positive 16.10 12.47 29 249787 3555 110335928
Presyncope 16.01 12.47 175 249641 48712 110290771
Penile necrosis 15.98 12.47 6 249810 64 110339419
Blast cells present 15.94 12.47 15 249801 963 110338520
Sneezing 15.89 12.47 30 249786 31954 110307529
Mediastinum neoplasm 15.86 12.47 7 249809 116 110339367
Drug ineffective for unapproved indication 15.84 12.47 152 249664 102686 110236797
Muscle twitching 15.84 12.47 27 249789 29908 110309575
Tubulointerstitial nephritis 15.83 12.47 190 249626 54094 110285389
Biliary tract disorder 15.70 12.47 20 249796 1806 110337677
Peritoneal fibrosis 15.69 12.47 4 249812 9 110339474
Acute pulmonary oedema 15.69 12.47 78 249738 16918 110322565
Henoch-Schonlein purpura 15.68 12.47 29 249787 3628 110335855
Mental status changes 15.67 12.47 104 249712 76018 110263465
Chylothorax 15.62 12.47 16 249800 1140 110338343
Hydrothorax 15.60 12.47 19 249797 1639 110337844
Maculopathy 15.57 12.47 26 249790 3001 110336482
Laryngeal cancer stage III 15.54 12.47 5 249811 32 110339451
Pathological fracture 15.50 12.47 61 249755 11971 110327512
Cyst 15.48 12.47 9 249807 16487 110322996
Kidney transplant rejection 15.43 12.47 4 249812 11983 110327500
Transient psychosis 15.42 12.47 6 249810 71 110339412
Stent malfunction 15.42 12.47 6 249810 71 110339412
Cutaneous lupus erythematosus 15.38 12.47 28 249788 3460 110336023
Pneumocystis jirovecii infection 15.36 12.47 32 249784 4368 110335115
Feeling jittery 15.35 12.47 7 249809 14715 110324768
Panniculitis 15.35 12.47 8 249808 15574 110323909
Pelvic abscess 15.34 12.47 24 249792 2622 110336861
Lividity 15.33 12.47 12 249804 599 110338884
Cystitis-like symptom 15.29 12.47 3 249813 0 110339483
Ankyloglossia acquired 15.29 12.47 3 249813 0 110339483
Radiation pericarditis 15.29 12.47 3 249813 0 110339483
Cancer with a high tumour mutational burden 15.28 12.47 5 249811 34 110339449
Plethoric face 15.28 12.47 5 249811 34 110339449
Papilloedema 15.27 12.47 44 249772 7365 110332118
Tendonitis 15.25 12.47 22 249794 26061 110313422
Vascular pseudoaneurysm 15.24 12.47 31 249785 4159 110335324
Haemolytic anaemia 15.24 12.47 90 249726 20830 110318653
Psychomotor hyperactivity 15.21 12.47 14 249802 20263 110319220
Urethral fistula 15.16 12.47 5 249811 35 110339448
Neuroendocrine breast tumour 15.16 12.47 5 249811 35 110339448
Adrenocortical insufficiency acute 15.16 12.47 32 249784 4408 110335075
HTLV-1 test positive 15.12 12.47 4 249812 11 110339472
Vaginal perforation 15.12 12.47 4 249812 11 110339472
Abnormal dreams 15.10 12.47 5 249811 12775 110326708
Arterial rupture 15.10 12.47 14 249802 882 110338601
Macular degeneration 15.05 12.47 16 249800 21643 110317840
Metastases to abdominal wall 15.01 12.47 8 249808 204 110339279
Breast conserving surgery 14.95 12.47 14 249802 893 110338590
Protein urine 14.92 12.47 18 249798 1538 110337945
Transaminases 14.91 12.47 6 249810 78 110339405
Large intestine infection 14.90 12.47 32 249784 4460 110335023
Hypogammaglobulinaemia 14.90 12.47 14 249802 20062 110319421
Abdominal infection 14.90 12.47 33 249783 4698 110334785
Venous oxygen saturation increased 14.80 12.47 5 249811 38 110339445
IIIrd nerve paralysis 14.78 12.47 17 249799 1380 110338103
Mucormycosis 14.77 12.47 3 249813 10625 110328858
Cytokine release syndrome 14.75 12.47 232 249584 70074 110269409
Microangiopathic haemolytic anaemia 14.72 12.47 20 249796 1923 110337560
Chemotherapy 14.64 12.47 21 249795 2125 110337358
Peritoneal lesion 14.62 12.47 4 249812 13 110339470
Blepharitis 14.61 12.47 32 249784 4520 110334963
Prostatic specific antigen increased 14.60 12.47 5 249811 12506 110326977
Anosmia 14.53 12.47 5 249811 12467 110327016
Glomerular filtration rate decreased 14.52 12.47 27 249789 28929 110310554
Device malfunction 14.51 12.47 22 249794 25536 110313947
Immunoglobulin G4 related disease 14.50 12.47 10 249806 410 110339073
Uterine adhesions 14.47 12.47 5 249811 41 110339442
Obstructive shock 14.45 12.47 7 249809 145 110339338
Hepatic vein thrombosis 14.39 12.47 9 249807 312 110339171
Tidal volume decreased 14.39 12.47 6 249810 86 110339397
Arthritis infective 14.38 12.47 3 249813 10426 110329057
Mental impairment 14.35 12.47 18 249798 22621 110316862
Pyelonephritis 14.33 12.47 102 249714 25148 110314335
Carpal tunnel syndrome 14.31 12.47 18 249798 22592 110316891
COVID-19 pneumonia 14.28 12.47 40 249776 37103 110302380
Injection site induration 14.27 12.47 4 249812 11379 110328104
Coronary artery occlusion 14.25 12.47 9 249807 15763 110323720
Pneumothorax spontaneous 14.22 12.47 19 249797 1798 110337685
Adenocarcinoma of appendix 14.20 12.47 6 249810 89 110339394
Spondylitis 14.19 12.47 4 249812 11334 110328149
Radiotherapy to mediastinum 14.18 12.47 4 249812 15 110339468
Hyperbilirubinaemia 14.12 12.47 118 249698 30553 110308930
Vitamin D decreased 14.05 12.47 5 249811 12210 110327273
Carcinoembryonic antigen 14.02 12.47 6 249810 92 110339391
Meningitis 14.01 12.47 58 249758 11644 110327839
Gastrointestinal fistula 14.00 12.47 14 249802 969 110338514
Epstein-Barr virus infection 13.98 12.47 13 249803 18725 110320758
Female genital tract fistula 13.98 12.47 74 249742 16445 110323038
Hypergeusia 13.98 12.47 4 249812 16 110339467
Radiotherapy to lymph nodes 13.98 12.47 4 249812 16 110339467
Hypomania 13.95 12.47 3 249813 10207 110329276
Pneumoperitoneum 13.93 12.47 29 249787 3955 110335528
TP53 gene mutation 13.90 12.47 7 249809 158 110339325
Embolism arterial 13.88 12.47 19 249797 1840 110337643
Vaginal discharge 13.87 12.47 12 249804 17896 110321587
Tinnitus 13.87 12.47 80 249736 60460 110279023
Deformity 13.85 12.47 3 249813 10157 110329326
Metastases to vagina 13.79 12.47 4 249812 17 110339466
Vascular pseudoaneurysm ruptured 13.78 12.47 11 249805 565 110338918
Small fibre neuropathy 13.76 12.47 14 249802 989 110338494
Electrolyte imbalance 13.76 12.47 136 249680 36892 110302591
Lung infiltration 13.69 12.47 99 249717 24529 110314954
Internal haemorrhage 13.67 12.47 3 249813 10068 110329415
Portal vein thrombosis 13.67 12.47 41 249775 7017 110332466
Immune reconstitution inflammatory syndrome 13.67 12.47 10 249806 16216 110323267
Vision blurred 13.64 12.47 207 249609 128815 110210668
Nocturia 13.64 12.47 11 249805 16979 110322504
Bladder necrosis 13.60 12.47 4 249812 18 110339465
Subclavian artery occlusion 13.59 12.47 7 249809 166 110339317
Osteolysis 13.58 12.47 35 249781 5488 110333995
Haemodialysis 13.57 12.47 12 249804 17707 110321776
Thymus enlargement 13.55 12.47 7 249809 167 110339316
Lymphadenectomy 13.49 12.47 17 249799 1519 110337964
Radiation injury 13.47 12.47 14 249802 1014 110338469
Jaundice cholestatic 13.45 12.47 67 249749 14541 110324942
Haemoglobin abnormal 13.45 12.47 48 249768 8990 110330493
Atypical haemolytic uraemic syndrome 13.45 12.47 17 249799 1523 110337960
Dandy-Walker syndrome 13.43 12.47 5 249811 52 110339431
Toxic epidermal necrolysis 13.38 12.47 191 249625 56536 110282947
Embryonal rhabdomyosarcoma 13.34 12.47 5 249811 53 110339430
Reactive gastropathy 13.31 12.47 12 249804 729 110338754
Infusion site swelling 13.29 12.47 3 249813 9874 110329609
Normal newborn 13.27 12.47 18 249798 21878 110317605
Pseudocyst 13.27 12.47 9 249807 359 110339124
Gastrointestinal haemorrhage 13.23 12.47 279 249537 165239 110174244
Crepitations 13.23 12.47 4 249812 10831 110328652
Faecal vomiting 13.22 12.47 17 249799 1549 110337934
Pancreatic pseudocyst rupture 13.21 12.47 3 249813 3 110339480
Cytoreductive surgery 13.21 12.47 3 249813 3 110339480
Ulcerated haemangioma 13.21 12.47 3 249813 3 110339480
Breast prosthesis removal 13.21 12.47 3 249813 3 110339480
Vulvovaginal inflammation 13.20 12.47 12 249804 737 110338746
Cholecystectomy 13.18 12.47 4 249812 10805 110328678
Brain injury 13.15 12.47 7 249809 13469 110326014
Large intestine polyp 13.15 12.47 9 249807 15108 110324375
Bradykinesia 13.14 12.47 4 249812 10784 110328699
Chronic myelomonocytic leukaemia 13.08 12.47 14 249802 1049 110338434
Drug level below therapeutic 13.06 12.47 5 249811 11668 110327815
BRCA2 gene mutation 13.05 12.47 6 249810 110 110339373
Metastases to oesophagus 13.02 12.47 5 249811 57 110339426
Potentiating drug interaction 13.00 12.47 5 249811 11638 110327845
Catheter site inflammation 12.97 12.47 15 249801 1225 110338258
Discontinued product administered 12.95 12.47 6 249810 112 110339371
Increased appetite 12.92 12.47 9 249807 14968 110324515
Supraventricular tachycardia 12.91 12.47 97 249719 24325 110315158
Arthropod bite 12.89 12.47 3 249813 9668 110329815
Tachypnoea 12.89 12.47 141 249675 39254 110300229
Oral fungal infection 12.85 12.47 30 249786 4422 110335061
Immune-mediated uveitis 12.83 12.47 8 249808 276 110339207
Liver function test abnormal 12.83 12.47 97 249719 68853 110270630
Lymphoma 12.82 12.47 16 249800 20155 110319328
Nephritic syndrome 12.80 12.47 10 249806 498 110338985
CSF white blood cell count decreased 12.79 12.47 4 249812 23 110339460
Perforation 12.77 12.47 18 249798 1792 110337691
Sensory disturbance 12.71 12.47 75 249741 17354 110322129
Seroma 12.70 12.47 25 249791 3276 110336207
Periodontal disease 12.65 12.47 19 249797 2003 110337480
Sickle cell anaemia with crisis 12.65 12.47 3 249813 9542 110329941
Abdominal lymphadenopathy 12.63 12.47 18 249798 1810 110337673
Tenderness 12.62 12.47 30 249786 29407 110310076
Synovial cyst 12.61 12.47 5 249811 11425 110328058
Angiodermatitis 12.60 12.47 7 249809 194 110339289
Porokeratosis 12.60 12.47 8 249808 285 110339198
Pulmonary arterial hypertension 12.57 12.47 35 249781 32533 110306950
Diverticulum 12.53 12.47 10 249806 15516 110323967
Rib fracture 12.52 12.47 37 249779 33733 110305750

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01CD01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Taxanes
ATC L01CD51 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Taxanes
FDA PE N0000175085 Microtubule Inhibition
MeSH PA D000970 Antineoplastic Agents
FDA EPC N0000175592 Microtubule Inhibitor
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D050256 Antimitotic Agents
MeSH PA D050257 Tubulin Modulators
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:25212 metabolite
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:61950 microtubule-stabilising agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77746 human metabolite

Related Drugs by ATC class:

L01CD Taxanes 2 drugs
cabazitaxeldocetaxel

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282
Hypertensive disorder indication 38341003 DOID:10763
Open-angle glaucoma indication 84494001 DOID:1067
Secondary malignant neoplasm of pancreas indication 94459006
Kaposi's sarcoma indication 109385007
Non-small cell lung cancer indication 254637007 DOID:3908
Carcinoma of breast indication 254838004 DOID:3459
Carcinoma of fallopian tube indication 276870001 DOID:1963
Malignant tumor of cervix indication 363354003 DOID:4362
Malignant tumor of ovary indication 363443007 DOID:2394
Malignant tumor of peritoneum indication 363492001
Metastatic Breast Carcinoma indication
Malignant glaucoma off-label use 10100008
Aphakic glaucoma off-label use 15374009
Secondary glaucoma off-label use 95717004
Neoplasm of esophagus off-label use 126817006 DOID:5041
Small cell carcinoma of lung off-label use 254632001 DOID:5409
Endometrial carcinoma off-label use 254878006 DOID:2871
Malignant tumor of head and/or neck off-label use 255056009
Malignant tumor of testis off-label use 363449006 DOID:2998
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Bronchospasm contraindication 4386001
Psoriasis contraindication 9014002 DOID:8893
Hyperbilirubinemia contraindication 14783006 DOID:2741
Myocardial infarction contraindication 22298006 DOID:5844
Complete atrioventricular block contraindication 27885002
Acute cerebrovascular insufficiency contraindication 29322000
Depressive disorder contraindication 35489007
Anaphylaxis contraindication 39579001
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Sinus bradycardia contraindication 49710005
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Diabetes mellitus contraindication 73211009 DOID:9351
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Liver function tests abnormal contraindication 166603001
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Asthma contraindication 195967001 DOID:2841
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Pheochromocytoma contraindication 302835009
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001
Acute exacerbation of asthma contraindication 708038006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.47 acidic
pKa2 12.08 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
100MG/VIAL ABRAXANE BRISTOL-MYERS N021660 Jan. 7, 2005 RX POWDER INTRAVENOUS 7758891 Feb. 21, 2026 TREATMENT OF PANCREATIC CANCER
100MG/VIAL ABRAXANE BRISTOL-MYERS N021660 Jan. 7, 2005 RX POWDER INTRAVENOUS 8268348 Feb. 21, 2026 TREATMENT OF LUNG CANCER
100MG/VIAL ABRAXANE BRISTOL-MYERS N021660 Jan. 7, 2005 RX POWDER INTRAVENOUS 9101543 Feb. 21, 2026 TREATMENT OF PANCREATIC CANCER
100MG/VIAL ABRAXANE BRISTOL-MYERS N021660 Jan. 7, 2005 RX POWDER INTRAVENOUS 8034375 Aug. 13, 2026 TREATMENT OF LUNG CANCER
100MG/VIAL ABRAXANE BRISTOL-MYERS N021660 Jan. 7, 2005 RX POWDER INTRAVENOUS 9393318 March 4, 2032 TREATMENT OF LUNG CANCER
100MG/VIAL ABRAXANE BRISTOL-MYERS N021660 Jan. 7, 2005 RX POWDER INTRAVENOUS 9597409 March 4, 2032 TREATMENT OF LUNG CANCER
100MG/VIAL ABRAXANE BRISTOL-MYERS N021660 Jan. 7, 2005 RX POWDER INTRAVENOUS 9511046 Jan. 12, 2034 TREATMENT OF PANCREATIC CANCER

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tubulin beta Tumour-associated antigen INHIBITOR EC50 8.05 IUPHAR SCIENTIFIC LITERATURE
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor AGONIST EC50 5.30 IUPHAR
Delta-type opioid receptor GPCR Ki 5.83 DRUG MATRIX
Bile salt export pump Transporter WOMBAT-PK
Multidrug resistance-associated protein 7 Transporter WOMBAT-PK
Tubulin beta chain Structural INHIBITOR EC50 8.05 IUPHAR
Tyrosine-protein kinase Fyn Kinase IC50 4.62 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 4.95 DRUG MATRIX
Multidrug resistance protein 1 Transporter IC50 5.59 CHEMBL
Substance-K receptor GPCR Ki 5.69 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 4.79 DRUG MATRIX
Tyrosine-protein kinase Mer Kinase IC50 5.31 CHEMBL
Tubulin beta-3 chain Structural IC50 8.11 CHEMBL
Lysine-specific histone demethylase 1A Enzyme IC50 7.53 CHEMBL
Nucleotide-binding oligomerization domain-containing protein 2 Cytosolic other IC50 5.10 CHEMBL
Cholecystokinin receptor type A GPCR Ki 5.64 DRUG MATRIX
Botulinum neurotoxin type A Enzyme IC50 5.28 CHEMBL

External reference:

IDSource
4020736 VUID
N0000148314 NUI
D00491 KEGG_DRUG
4020736 VANDF
C0144576 UMLSCUI
CHEBI:45863 CHEBI
TA1 PDB_CHEM_ID
CHEMBL428647 ChEMBL_ID
D017239 MESH_DESCRIPTOR_UI
DB01229 DRUGBANK_ID
2770 IUPHAR_LIGAND_ID
7052 INN_ID
P88XT4IS4D UNII
36314 PUBCHEM_CID
196466 RXNORM
19175 MMSL
2296 MMSL
358465 MMSL
42243 MMSL
5224 MMSL
64289 MMSL
d01376 MMSL
d05427 MMSL
004116 NDDF
008823 NDDF
387374002 SNOMEDCT_US
426653008 SNOMEDCT_US
67735003 SNOMEDCT_US
D000068196 MESH_DESCRIPTOR_UI
P88XT4IS4D INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0480-3290 INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 100 mg INTRAVENOUS NDA 32 sections
PACLITAXEL PROTEIN BOUND PARTICLES ALBUMIN BOUND HUMAN PRESCRIPTION DRUG LABEL 1 0517-4300 INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 100 mg INTRAVENOUS NDA 30 sections
PACLITAXEL PROTEIN BOUND PARTICLES ALBUMIN BOUND HUMAN PRESCRIPTION DRUG LABEL 1 0517-4300 INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 100 mg INTRAVENOUS NDA 30 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3213 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3213 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3216 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3216 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3217 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3218 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3218 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0781-3531 INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 100 mg INTRAVENOUS ANDA 32 sections
Paclitaxel Human Prescription Drug Label 1 16714-137 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 21 sections
PACLITAXELPACLITAXEL Human Prescription Drug Label 1 23155-882 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 19 sections
PACLITAXELPACLITAXEL Human Prescription Drug Label 1 23155-882 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 19 sections
PACLITAXELPACLITAXEL Human Prescription Drug Label 1 23155-883 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 19 sections
PACLITAXELPACLITAXEL Human Prescription Drug Label 1 23155-883 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 19 sections
PACLITAXELPACLITAXEL Human Prescription Drug Label 1 23155-884 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 19 sections
PACLITAXELPACLITAXEL Human Prescription Drug Label 1 23155-884 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 19 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 25021-255 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 24 sections
Paclitaxel Human Prescription Drug Label 1 46708-620 INJECTION 6 mg INTRAVENOUS ANDA 21 sections
Paclitaxel Human Prescription Drug Label 1 46708-621 INJECTION 6 mg INTRAVENOUS ANDA 21 sections
Paclitaxel Human Prescription Drug Label 1 46708-622 INJECTION 6 mg INTRAVENOUS ANDA 21 sections
Paclitaxel protein-bound particles for injectable suspension (albumin-bound) HUMAN PRESCRIPTION DRUG LABEL 1 60505-6230 INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 100 mg INTRAVENOUS NDA authorized generic 32 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 61703-015 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 61703-342 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel Human Prescription Drug Label 1 62332-620 INJECTION 6 mg INTRAVENOUS ANDA 21 sections
Paclitaxel Human Prescription Drug Label 1 62332-621 INJECTION 6 mg INTRAVENOUS ANDA 21 sections
Paclitaxel Human Prescription Drug Label 1 62332-622 INJECTION 6 mg INTRAVENOUS ANDA 21 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 63323-763 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 21 sections
PACLITAXEL HUMAN PRESCRIPTION DRUG LABEL 1 67457-937 INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 100 mg INTRAVENOUS ANDA 29 sections