ozagrel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
platelet aggregation inhibitors 2043 82571-53-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ozagrel sodium
  • ozagrel
  • sodium ozagrel
  • xanbon
  • ozagrel hydrochloride
  • ozagrel hydrochloride hydrate
  • domenan
  • pulmoza
  • OKY-046
  • ozagrel HCl
  • Molecular weight: 228.25
  • Formula: C13H12N2O2
  • CLOGP: 1.60
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 55.12
  • ALOGS: -2.73
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
CL (Clearance) 8.38 mL/min/kg Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
Vd (Volume of distribution) 0.62 L/kg Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK12,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 41
kinase-selectivity-class GRK2,MAP2K6,MAPK7,PRKDC 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018494 Histamine Agents
CHEBI has role CHEBI:66981 ophthalmology drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Spasm of cerebral arteries indication 73173006
Asthma indication 195967001 DOID:2841




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.37 acidic
pKa2 6.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thromboxane-A synthase Enzyme IC50 7.96 CHEMBL
Thromboxane-A synthase Enzyme IC50 6.70 CHEMBL

External reference:

IDSource
D01683 KEGG_DRUG
189224-26-8 SECONDARY_CAS_RN
C0069392 UMLSCUI
CHEBI:134938 CHEBI
CHEMBL11662 ChEMBL_ID
DB12017 DRUGBANK_ID
5282440 PUBCHEM_CID
C034364 MESH_SUPPLEMENTAL_RECORD_UI
9866 IUPHAR_LIGAND_ID
5918 INN_ID
78712-43-3 SECONDARY_CAS_RN
L256JB984D UNII

Pharmaceutical products:

None