opipramol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| substances of the imipramine group | 1993 | 315-72-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A tricyclic antidepressant with actions similar to AMITRIPTYLINE.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.15 | g | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| General physical health deterioration | 203.65 | 34.92 | 113 | 2246 | 201289 | 63285374 |
| Product prescribing error | 70.48 | 34.92 | 29 | 2330 | 26260 | 63460403 |
| Product monitoring error | 57.14 | 34.92 | 16 | 2343 | 4500 | 63482163 |
| Patient uncooperative | 40.55 | 34.92 | 7 | 2352 | 205 | 63486458 |
| Labelled drug-drug interaction medication error | 40.07 | 34.92 | 16 | 2343 | 13383 | 63473280 |
| Delirium | 39.13 | 34.92 | 24 | 2335 | 50517 | 63436146 |
| Skin irritation | 37.58 | 34.92 | 14 | 2345 | 9727 | 63476936 |
| Pneumobilia | 36.76 | 34.92 | 6 | 2353 | 124 | 63486539 |
| Tachycardia | 36.12 | 34.92 | 32 | 2327 | 118124 | 63368539 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| General physical health deterioration | 199.38 | 30.36 | 123 | 2738 | 275115 | 79466412 |
| Product prescribing error | 74.62 | 30.36 | 35 | 2826 | 44778 | 79696749 |
| Product monitoring error | 46.98 | 30.36 | 16 | 2845 | 8890 | 79732637 |
| Hypoparathyroidism secondary | 40.28 | 30.36 | 7 | 2854 | 221 | 79741306 |
| Pneumobilia | 33.32 | 30.36 | 6 | 2855 | 233 | 79741294 |
| Tachycardia | 32.84 | 30.36 | 36 | 2825 | 177732 | 79563795 |
| Skin irritation | 32.58 | 30.36 | 13 | 2848 | 11227 | 79730300 |
| Patient uncooperative | 32.31 | 30.36 | 7 | 2854 | 707 | 79740820 |
| Anaemia folate deficiency | 31.78 | 30.36 | 6 | 2855 | 303 | 79741224 |
| Fall | 31.76 | 30.36 | 60 | 2801 | 487569 | 79253958 |
| Femoral neck fracture | 30.52 | 30.36 | 12 | 2849 | 9972 | 79731555 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AA05 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Non-selective monoamine reuptake inhibitors |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018759 | Adrenergic Uptake Inhibitors |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D000929 | Antidepressive Agents, Tricyclic |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
| MeSH PA | D011619 | Psychotropic Drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Depressive disorder | indication | 35489007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.21 | Basic |
| pKa2 | 5.43 | Basic |
| pKa3 | 4.21 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 9.70 | CHEMBL | |||||
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Enzyme | Ki | 7.89 | CHEMBL | |||||
| Voltage-dependent N-type calcium channel subunit alpha-1B | Ion channel | IC50 | 4.62 | CHEMBL | |||||
| C-8 sterol isomerase | Enzyme | Ki | 7.77 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167254 | NUI |
| D08297 | KEGG_DRUG |
| C0029105 | UMLSCUI |
| CHEBI:94614 | CHEBI |
| CHEMBL370753 | ChEMBL_ID |
| CHEMBL1524185 | ChEMBL_ID |
| DB12930 | DRUGBANK_ID |
| D009888 | MESH_DESCRIPTOR_UI |
| 9417 | PUBCHEM_CID |
| 11247 | IUPHAR_LIGAND_ID |
| 1838 | INN_ID |
| D23ZXO613C | UNII |
| 7674 | RXNORM |
| 004149 | NDDF |
| 004150 | NDDF |
| 1156223004 | SNOMEDCT_US |
| 1172808004 | SNOMEDCT_US |
| 1172810002 | SNOMEDCT_US |
Pharmaceutical products:
None