ondansetron Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
serotonin receptor antagonists (5-HT3) 1992 99614-02-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • GR-38032F
  • GR38032F
  • ondansetron
  • ondansetron hydrochloride
  • ondansetron hydrochloride dihydrate
  • ondansetron HCl
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
  • Molecular weight: 293.37
  • Formula: C18H19N3O
  • CLOGP: 2.72
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 39.82
  • ALOGS: -3.07
  • ROTB: 2

Drug dosage:

DoseUnitRoute
16 mg O
16 mg P
16 mg R

Approvals:

DateAgencyCompanyOrphan
Jan. 4, 1991 FDA NOVARTIS PHARMS CORP

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Maternal exposure during pregnancy 857.55 30.10 228 4239 10043 3371349
Emotional distress 856.72 30.10 207 4260 6153 3375239
Serotonin syndrome 836.64 30.10 197 4270 5226 3376166
Foetal exposure during pregnancy 807.82 30.10 238 4229 15313 3366079
Injury 745.88 30.10 201 4266 9296 3372096
Vomiting 696.36 30.10 340 4127 89191 3292201
Electrocardiogram QT prolonged 634.00 30.10 182 4285 10613 3370779
Nausea 610.01 30.10 352 4115 129293 3252099
Anxiety 568.92 30.10 232 4235 39397 3341995
Cardiac arrest 500.44 30.10 191 4276 27128 3354264
Pain 495.74 30.10 252 4215 71305 3310087
Torsade de pointes 476.55 30.10 112 4355 2917 3378475
Anhedonia 445.92 30.10 99 4368 1982 3379410
Ventricular tachycardia 403.14 30.10 112 4355 5750 3375642
Heart disease congenital 374.78 30.10 75 4392 884 3380508
Congenital anomaly 371.31 30.10 83 4384 1713 3379679
Dystonia 358.18 30.10 93 4374 3674 3377718
Constipation 349.59 30.10 153 4314 30659 3350733
Diarrhoea 319.81 30.10 217 4250 104131 3277261
Product use issue 318.02 30.10 119 4348 15882 3365510
Tachycardia 307.57 30.10 129 4338 23242 3358150
Abdominal pain 301.94 30.10 157 4310 46068 3335324
Exposure during pregnancy 290.29 30.10 130 4337 27433 3353959
Hypotension 286.16 30.10 155 4312 49359 3332033
Premature baby 285.38 30.10 90 4377 7163 3374229
Pyrexia 265.50 30.10 176 4291 80939 3300453
Drug interaction 263.33 30.10 144 4323 46668 3334724
Drug hypersensitivity 258.29 30.10 130 4337 35550 3345842
Atrial septal defect 239.76 30.10 64 4403 2809 3378583
Left-to-right cardiac shunt 238.36 30.10 32 4435 3 3381389
Unresponsive to stimuli 236.54 30.10 80 4387 7928 3373464
Dyspnoea 223.33 30.10 174 4293 102760 3278632
Dilatation intrahepatic duct acquired 221.93 30.10 35 4432 81 3381311
Product use in unapproved indication 218.81 30.10 63 4404 3663 3377729
Neonatal respiratory distress syndrome 196.86 30.10 48 4419 1456 3379936
Cardiac murmur 191.78 30.10 53 4414 2650 3378742
Loss of consciousness 190.18 30.10 98 4369 28049 3353343
Drug ineffective 186.55 30.10 165 4302 115925 3265467
Bradycardia 186.01 30.10 82 4385 16587 3364805
Completed suicide 183.73 30.10 99 4368 31015 3350377
Oculogyric crisis 181.30 30.10 38 4429 569 3380823
Erythema 179.46 30.10 95 4372 28715 3352677
Headache 174.68 30.10 144 4323 91836 3289556
Ventricular septal defect 172.68 30.10 45 4422 1794 3379598
Ventricular fibrillation 167.09 30.10 53 4414 4280 3377112
Extrapyramidal disorder 166.19 30.10 51 4416 3692 3377700
Anaphylactic reaction 164.51 30.10 70 4397 12984 3368408
Ventricular tachyarrhythmia 163.72 30.10 27 4440 91 3381301
Febrile neutropenia 163.50 30.10 78 4389 18897 3362495
Pruritus 163.29 30.10 106 4361 46727 3334665
Malaise 162.57 30.10 120 4347 65057 3316335
Human herpesvirus 6 infection 159.68 30.10 34 4433 551 3380841
Decreased appetite 157.24 30.10 99 4368 41391 3340001
Generalised tonic-clonic seizure 156.51 30.10 59 4408 7983 3373409
Otitis media acute 152.03 30.10 27 4440 155 3381237
Fatigue 151.61 30.10 142 4325 107098 3274294
Tremor 150.73 30.10 84 4383 28060 3353332
Clonus 150.45 30.10 35 4432 863 3380529
Seizure 147.07 30.10 94 4373 40306 3341086
Cardio-respiratory arrest 146.94 30.10 68 4399 15372 3366020
Hepatotoxicity 146.63 30.10 51 4416 5480 3375912
Muscle rigidity 141.76 30.10 43 4424 2991 3378401
Otitis media chronic 139.12 30.10 23 4444 79 3381313
Premature delivery 136.56 30.10 40 4427 2465 3378927
Myoclonus 135.37 30.10 44 4423 3839 3377553
Dyskinesia 132.92 30.10 51 4416 7234 3374158
Developmental delay 128.09 30.10 31 4436 909 3380483
Patent ductus arteriosus 126.14 30.10 33 4434 1334 3380058
Somnolence 124.80 30.10 78 4389 32126 3349266
Agitation 122.61 30.10 65 4402 19641 3361751
Dehydration 121.65 30.10 78 4389 33571 3347821
Jaundice neonatal 121.48 30.10 26 4441 432 3380960
Cough 121.38 30.10 83 4384 39775 3341617
Oxygen saturation decreased 120.12 30.10 52 4415 10039 3371353
Chest discomfort 118.93 30.10 61 4406 17224 3364168
Intestinal obstruction 117.52 30.10 45 4422 6344 3375048
Foetal growth restriction 115.92 30.10 33 4434 1836 3379556
Toxicity to various agents 115.68 30.10 86 4381 46968 3334424
Multiple congenital abnormalities 115.02 30.10 25 4442 448 3380944
Oropharyngeal cancer 114.31 30.10 19 4448 68 3381324
Cardiomegaly 111.11 30.10 39 4428 4299 3377093
Respiratory arrest 111.02 30.10 51 4416 11317 3370075
Alopecia 110.73 30.10 60 4407 18926 3362466
Syncope 109.25 30.10 66 4401 25567 3355825
Hypersensitivity 109.13 30.10 68 4399 27832 3353560
Chest pain 108.92 30.10 78 4389 40197 3341195
Hypertension 107.48 30.10 76 4391 38390 3343002
Venoocclusive liver disease 107.23 30.10 29 4438 1333 3380059
Sinus tachycardia 106.59 30.10 39 4428 4846 3376546
Asthenia 106.29 30.10 94 4373 65571 3315821
Right ventricular hypertrophy 105.49 30.10 21 4446 239 3381153
Upper respiratory tract infection 102.76 30.10 46 4421 9609 3371783
Ventricular arrhythmia 99.32 30.10 26 4441 1053 3380339
Respiratory distress 99.07 30.10 43 4424 8345 3373047
Change of bowel habit 98.33 30.10 21 4446 345 3381047
Apnoea 98.05 30.10 31 4436 2471 3378921
Chills 97.17 30.10 58 4409 21964 3359428
Hypokalaemia 95.74 30.10 49 4418 13756 3367636
Burkholderia cepacia complex infection 95.05 30.10 16 4451 63 3381329
Migraine 94.87 30.10 44 4423 9972 3371420
Rash erythematous 94.63 30.10 41 4426 7921 3373471
Rash 94.44 30.10 91 4376 70730 3310662
Lip and/or oral cavity cancer 93.91 30.10 19 4448 236 3381156
Muscular weakness 93.47 30.10 55 4412 20286 3361106
Sinus bradycardia 92.77 30.10 32 4435 3347 3378045
Arrhythmia 90.23 30.10 43 4424 10354 3371038
Blood pressure decreased 89.87 30.10 47 4420 13789 3367603
Bacteraemia 89.62 30.10 30 4437 2865 3378527
Cleft palate 89.58 30.10 21 4446 535 3380857
Rhinorrhoea 89.44 30.10 39 4428 7650 3373742
Maternal drugs affecting foetus 89.34 30.10 32 4435 3739 3377653
Long QT syndrome 86.42 30.10 21 4446 626 3380766
Oral pain 85.13 30.10 31 4436 3797 3377595
Ill-defined disorder 84.94 30.10 30 4437 3364 3378028
Encephalopathy 84.04 30.10 37 4430 7425 3373967
Hypoglycaemia neonatal 83.71 30.10 20 4447 554 3380838
Hyperhidrosis 83.44 30.10 54 4413 23556 3357836
Flushing 83.36 30.10 45 4422 14068 3367324
Emotional disorder 82.28 30.10 28 4439 2811 3378581
Blister 81.56 30.10 38 4429 8696 3372696
Mydriasis 81.37 30.10 28 4439 2906 3378486
Post procedural complication 80.44 30.10 32 4435 4985 3376407
Neutropenia 79.66 30.10 60 4407 33326 3348066
Selective eating disorder 79.58 30.10 21 4446 877 3380515
Confusional state 79.16 30.10 63 4404 37935 3343457
Metabolic acidosis 78.29 30.10 37 4430 8741 3372651
Ear pain 75.00 30.10 26 4441 2759 3378633
Back pain 74.89 30.10 61 4406 37944 3343448
Dizziness 74.34 30.10 83 4384 76429 3304963
Gastrooesophageal reflux disease 73.88 30.10 39 4428 11652 3369740
Hepatocellular injury 73.85 30.10 29 4438 4366 3377026
Muscle twitching 73.61 30.10 28 4439 3869 3377523
Right ventricular enlargement 73.02 30.10 11 4456 16 3381376
Hypoxia 71.84 30.10 36 4431 9655 3371737
Transmission of an infectious agent via product 71.43 30.10 14 4453 146 3381246
Pulseless electrical activity 71.18 30.10 22 4445 1626 3379766
Neuropathy peripheral 70.83 30.10 43 4424 16764 3364628
Stoma site pain 69.81 30.10 12 4455 55 3381337
Urticaria 69.34 30.10 52 4415 28675 3352717
Discomfort 69.07 30.10 31 4436 6505 3374887
Pallor 69.06 30.10 30 4437 5825 3375567
Failure to thrive 68.62 30.10 22 4445 1833 3379559
Mental status changes 67.39 30.10 35 4432 10112 3371280
Supraventricular tachycardia 67.34 30.10 25 4442 3231 3378161
Hypertonia 67.10 30.10 22 4445 1968 3379424
Pharyngitis 64.95 30.10 23 4444 2597 3378795
Sepsis neonatal 64.92 30.10 14 4453 241 3381151
Gait disturbance 63.86 30.10 49 4418 27943 3353449
Liver function test abnormal 62.17 30.10 36 4431 12865 3368527
Ventricular extrasystoles 62.09 30.10 24 4443 3463 3377929
Speech disorder 62.08 30.10 32 4435 9100 3372292
Alanine aminotransferase increased 62.00 30.10 45 4422 23595 3357797
Off label use 61.95 30.10 64 4403 53913 3327479
Neonatal tachypnoea 61.86 30.10 12 4455 118 3381274
Eustachian tube dysfunction 61.59 30.10 12 4455 121 3381271
Hyperbilirubinaemia neonatal 60.72 30.10 13 4454 216 3381176
Cardiomyopathy 60.59 30.10 26 4441 4900 3376492
Leukopenia 60.36 30.10 38 4429 15785 3365607
Hyperreflexia 60.09 30.10 18 4449 1196 3380196
Right ventricular dilatation 59.78 30.10 9 4458 13 3381379
Mouth ulceration 59.70 30.10 25 4442 4435 3376957
Anticholinergic syndrome 59.70 30.10 14 4453 357 3381035
Wheezing 59.52 30.10 30 4437 8141 3373251
Urinary tract infection 58.99 30.10 49 4418 31279 3350113
Pulmonary artery stenosis congenital 58.93 30.10 13 4454 250 3381142
Multiple organ dysfunction syndrome 58.48 30.10 36 4431 14374 3367018
Low birth weight baby 58.48 30.10 19 4448 1651 3379741
Dysgeusia 58.04 30.10 33 4434 11391 3370001
Depressed level of consciousness 57.93 30.10 33 4434 11432 3369960
Thrombocytopenia 57.93 30.10 51 4416 35217 3346175
Blood potassium decreased 57.41 30.10 27 4440 6303 3375089
Movement disorder 57.40 30.10 23 4444 3648 3377744
Stress cardiomyopathy 57.04 30.10 18 4449 1424 3379968
Atrial fibrillation 57.00 30.10 43 4424 23898 3357494
Muscle spasms 56.82 30.10 45 4422 26858 3354534
Otitis media 56.80 30.10 16 4451 855 3380537
Anaphylactic shock 56.77 30.10 26 4441 5713 3375679
Hypoplastic left heart syndrome 55.90 30.10 12 4455 202 3381190
Congenital anomaly in offspring 55.49 30.10 10 4457 63 3381329
Atelectasis 55.45 30.10 22 4445 3400 3377992
Anorectal disorder 55.03 30.10 14 4453 505 3380887
Right aortic arch 54.96 30.10 10 4457 67 3381325
Electrocardiogram T wave inversion 54.87 30.10 16 4451 968 3380424
Cardiac failure 54.38 30.10 39 4428 20066 3361326
Nasal congestion 53.17 30.10 27 4440 7440 3373952
Toxic epidermal necrolysis 52.66 30.10 23 4444 4522 3376870
Trismus 51.50 30.10 16 4451 1202 3380190
Anaemia 51.07 30.10 58 4409 54275 3327117
Live birth 50.96 30.10 15 4452 938 3380454
Eye movement disorder 49.74 30.10 17 4450 1727 3379665
Caesarean section 49.52 30.10 22 4445 4504 3376888
Muscle spasticity 49.31 30.10 19 4448 2717 3378675
Intentional overdose 49.31 30.10 33 4434 15192 3366200
Craniofacial deformity 49.20 30.10 8 4459 24 3381368
Cholestasis 49.12 30.10 23 4444 5314 3376078
Right atrial enlargement 48.42 30.10 7 4460 6 3381386
Heart rate increased 48.36 30.10 32 4435 14454 3366938
Nodal rhythm 47.70 30.10 13 4454 614 3380778
Extrasystoles 47.62 30.10 16 4451 1543 3379849
Restlessness 47.50 30.10 25 4442 7413 3373979
Bronchospasm 47.39 30.10 21 4446 4273 3377119
Hypomagnesaemia 47.04 30.10 20 4447 3682 3377710
Premature labour 46.95 30.10 17 4450 2046 3379346
Aphasia 46.50 30.10 24 4443 6837 3374555
Pulmonary oedema 46.40 30.10 29 4438 11882 3369510
Dysuria 45.90 30.10 23 4444 6159 3375233
Mucosal inflammation 45.84 30.10 25 4442 7958 3373434
Panic reaction 45.79 30.10 14 4453 997 3380395
Pain in extremity 45.33 30.10 52 4415 49160 3332232
Weight decreased 44.96 30.10 47 4420 40064 3341328
Pulmonary valve incompetence 44.90 30.10 11 4456 339 3381053
Blood bilirubin increased 44.54 30.10 27 4440 10482 3370910
Lower respiratory tract infection 44.25 30.10 23 4444 6646 3374746
Haemoglobin decreased 44.20 30.10 41 4426 30253 3351139
Gastroenteritis 44.16 30.10 20 4447 4281 3377111
Nystagmus 44.14 30.10 16 4451 1931 3379461
Hepatitis 44.09 30.10 26 4441 9599 3371793
Aspartate aminotransferase increased 43.89 30.10 35 4432 21078 3360314
Atrioventricular block second degree 43.61 30.10 14 4453 1170 3380222
Depression 43.51 30.10 46 4421 39724 3341668
Torticollis 43.51 30.10 12 4455 593 3380799
Feeling hot 43.50 30.10 24 4443 7812 3373580
Large intestine perforation 43.42 30.10 16 4451 2023 3379369
Hallucination 43.40 30.10 29 4438 13311 3368081
Atelectasis neonatal 43.30 30.10 7 4460 20 3381372
Tricuspid valve incompetence 43.21 30.10 17 4450 2568 3378824
Phimosis 43.21 30.10 9 4458 130 3381262
Venoocclusive disease 42.91 30.10 12 4455 624 3380768
Lung cancer metastatic 42.58 30.10 13 4454 921 3380471
Cleft lip 42.12 30.10 10 4457 269 3381123
Ear infection 42.09 30.10 18 4449 3361 3378031
C-reactive protein increased 42.07 30.10 25 4442 9358 3372034
Eating disorder 42.02 30.10 17 4450 2762 3378630
Procedural hypertension 41.98 30.10 8 4459 71 3381321
Electrocardiogram abnormal 41.70 30.10 16 4451 2261 3379131
Feeling abnormal 41.60 30.10 38 4429 27487 3353905
Sinus arrhythmia 41.50 30.10 11 4456 467 3380925
Photophobia 41.20 30.10 17 4450 2905 3378487
Respiratory failure 41.07 30.10 35 4432 23106 3358286
Sialoadenitis 41.05 30.10 10 4457 301 3381091
Tryptase increased 40.59 30.10 8 4459 86 3381306
Gaze palsy 40.52 30.10 11 4456 512 3380880
Hypophagia 40.49 30.10 21 4446 6040 3375352
Coma 40.14 30.10 27 4440 12525 3368867
Acute kidney injury 39.97 30.10 49 4418 49634 3331758
Hyperemesis gravidarum 39.94 30.10 8 4459 94 3381298
Hyperthermia malignant 39.89 30.10 11 4456 543 3380849
Vascular pain 39.73 30.10 9 4458 196 3381196
Talipes 38.98 30.10 12 4455 874 3380518
Abdominal pain upper 38.83 30.10 35 4432 24881 3356511
Pulse absent 38.72 30.10 14 4453 1677 3379715
Hepatic steatosis 38.58 30.10 19 4448 4901 3376491
Electrolyte imbalance 38.42 30.10 16 4451 2798 3378594
Pneumothorax 38.40 30.10 18 4449 4166 3377226
Insomnia 38.33 30.10 41 4426 35857 3345535
Toxic encephalopathy 38.32 30.10 13 4454 1291 3380101
Transaminases increased 38.15 30.10 21 4446 6803 3374589
Left ventricular hypertrophy 38.07 30.10 13 4454 1316 3380076
Arthralgia 38.04 30.10 53 4414 60808 3320584
Cognitive disorder 37.99 30.10 22 4445 7852 3373540
Tachypnoea 37.98 30.10 17 4450 3539 3377853
Bronchiolitis 37.78 30.10 12 4455 969 3380423
Pericardial effusion 37.64 30.10 20 4447 6041 3375351
Neuroleptic malignant syndrome 37.38 30.10 18 4449 4423 3376969
Rhinitis allergic 37.26 30.10 12 4455 1013 3380379
Poor weight gain neonatal 36.95 30.10 7 4460 60 3381332
Blood urine present 36.87 30.10 16 4451 3094 3378298
Irregular breathing 36.85 30.10 7 4460 61 3381331
Product quality issue 36.72 30.10 35 4432 26700 3354692
Medication error 36.68 30.10 25 4442 11846 3369546
Pneumonia 36.48 30.10 56 4411 70087 3311305
Therapy non-responder 36.37 30.10 24 4443 10785 3370607
Hyperventilation 36.33 30.10 13 4454 1511 3379881
Pulmonary valve stenosis congenital 36.01 30.10 8 4459 159 3381233
Deformity 35.93 30.10 10 4457 511 3380881
Otorrhoea 35.83 30.10 9 4458 308 3381084
Hypocalcaemia 35.57 30.10 19 4448 5802 3375590
Peritonitis 35.51 30.10 18 4449 4937 3376455
Atrioventricular block 35.36 30.10 14 4453 2150 3379242
Anaemia neonatal 35.06 30.10 8 4459 180 3381212
Ventricular hypoplasia 34.97 30.10 7 4460 82 3381310
Cyanosis neonatal 34.53 30.10 8 4459 193 3381199
Suspected transmission of an infectious agent via product 34.18 30.10 8 4459 202 3381190
Blood lactic acid increased 34.17 30.10 12 4455 1321 3380071
Hyporesponsive to stimuli 34.11 30.10 8 4459 204 3381188
Congestive cardiomyopathy 34.10 30.10 13 4454 1805 3379587
Dermatitis diaper 33.95 30.10 7 4460 96 3381296
Dysarthria 33.89 30.10 22 4445 9612 3371780
Intercepted drug administration error 33.61 30.10 7 4460 101 3381291
Stridor 33.58 30.10 11 4456 980 3380412
Anaemia macrocytic 33.53 30.10 10 4457 654 3380738
Cardiac disorder 33.42 30.10 25 4442 13694 3367698
Overdose 33.13 30.10 37 4430 33941 3347451
Hyperkalaemia 33.04 30.10 23 4444 11271 3370121
Posterior reversible encephalopathy syndrome 32.99 30.10 15 4452 3239 3378153
Infantile apnoea 32.88 30.10 9 4458 432 3380960
Periorbital cellulitis 32.76 30.10 7 4460 115 3381277
Single functional kidney 32.59 30.10 7 4460 118 3381274
Platelet count increased 32.48 30.10 15 4452 3356 3378036
Arteriospasm coronary 32.43 30.10 11 4456 1091 3380301
Feeding disorder 32.43 30.10 12 4455 1534 3379858
Acidosis 32.32 30.10 14 4453 2696 3378696
Sinoatrial block 32.13 30.10 8 4459 264 3381128
Coma scale abnormal 31.83 30.10 11 4456 1154 3380238
Pulmonary valve stenosis 31.81 30.10 8 4459 275 3381117
Neonatal hypotension 31.71 30.10 7 4460 135 3381257
Anuria 31.45 30.10 14 4453 2877 3378515
Myalgia 31.39 30.10 35 4432 32040 3349352
Slow response to stimuli 31.16 30.10 8 4459 299 3381093
Skin abrasion 31.07 30.10 12 4455 1725 3379667
Prothrombin time prolonged 30.73 30.10 14 4453 3036 3378356
Infusion site erythema 30.67 30.10 10 4457 878 3380514
Cardiac output decreased 30.66 30.10 8 4459 319 3381073
Renal failure 30.63 30.10 35 4432 32905 3348487
Fallot's tetralogy 30.10 30.10 8 4459 343 3381049

Pharmacologic Action:

SourceCodeDescription
ATC A04AA01 ALIMENTARY TRACT AND METABOLISM
ANTIEMETICS AND ANTINAUSEANTS
ANTIEMETICS AND ANTINAUSEANTS
Serotonin (5HT3) antagonists
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000932 Antiemetics
MeSH PA D000982 Antipruritics
MeSH PA D014150 Antipsychotic Agents
MeSH PA D001337 Autonomic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D003879 Dermatologic Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014149 Tranquilizing Agents
FDA MoA N0000175817 Serotonin 3 Receptor Antagonists
FDA EPC N0000175818 Serotonin-3 Receptor Antagonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Chemotherapy-induced nausea and vomiting indication 236084000
Prevention of Radiation-Induced Nausea and Vomiting indication
Prevention of Post-Operative Nausea and Vomiting indication
Excessive vomiting in pregnancy off-label use 14094001
Torsades de pointes contraindication 31722008
Hepatic failure contraindication 59927004
Extrapyramidal disease contraindication 76349003
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002 DOID:1826
Congenital long QT syndrome contraindication 442917000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.13 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 3A Ion channel ANTAGONIST Ki 7.80 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 6.34 DRUG MATRIX
Solute carrier family 22 member 3 Transporter IC50 4.76 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.69 CHEMBL
Neuronal acetylcholine receptor; alpha4/beta2 Ion channel Ki 4.34 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 6.80 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 7.52 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.77 CHEMBL
5-hydroxytryptamine receptor 3B Ion channel Ki 8.30 CHEMBL
Aldehyde oxidase Enzyme IC50 5.68 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.09 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel Ki 9.11 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 5 CHEMBL
Serotonin 3 receptor (5HT3) Ion channel Ki 7.92 CHEMBL
5-hydroxytryptamine receptor 1B GPCR Ki 5.43 CHEMBL
5-hydroxytryptamine receptor 1D GPCR Ki 4.70 CHEMBL
Serotonin 3 (5-HT3) receptor Ion channel Ki 9.11 CHEMBL
Gastrin/cholecystokinin type B receptor GPCR Ki 6.17 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5 CHEMBL
Neuronal acetylcholine receptor subunit alpha-7 Ion channel IC50 4.60 CHEMBL
Mu-type opioid receptor GPCR Ki 5.54 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 5.30 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 5.92 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.17 CHEMBL

External reference:

IDSource
2290 IUPHAR_LIGAND_ID
4019865 VUID
N0000147951 NUI
C0061851 UMLSCUI
D00456 KEGG_DRUG
CHEMBL46 ChEMBL_ID
4AF302ESOS UNII
5965 INN_ID
DB00904 DRUGBANK_ID
4595 PUBCHEM_CID
4019865 VANDF
N0000007321 NDFRT
N0000147951 NDFRT
27290 MMSL
004807 NDDF
26225 RXNORM
108418007 SNOMEDCT_US
372487007 SNOMEDCT_US
d00867 MMSL
CHEBI:7773 CHEBI
CHEMBL1201111 ChEMBL_ID
103639-04-9 SECONDARY_CAS_RN
D017294 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ondansetron Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0064 SOLUTION 4 mg ORAL ANDA 17 sections
Ondansetron hydrochloride and dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0069-0700 INJECTION, SOLUTION 32 mg INTRAVENOUS ANDA 15 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0069-1441 INJECTION 2 mg INTRAVENOUS ANDA 18 sections
ZOFRAN HUMAN PRESCRIPTION DRUG LABEL 1 0078-0676 TABLET, FILM COATED 8 mg ORAL NDA 17 sections
ZOFRAN HUMAN PRESCRIPTION DRUG LABEL 1 0078-0679 TABLET, ORALLY DISINTEGRATING 4 mg ORAL NDA 17 sections
ZOFRAN HUMAN PRESCRIPTION DRUG LABEL 1 0078-0680 TABLET, ORALLY DISINTEGRATING 8 mg ORAL NDA 17 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0143-2422 TABLET 4 mg ORAL ANDA 15 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0143-2423 TABLET 8 mg ORAL ANDA 15 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0143-2424 TABLET 24 mg ORAL ANDA 15 sections
Ondansetron Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0143-9771 INJECTION, SOLUTION 32 mg INTRAVENOUS ANDA 14 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0143-9890 INJECTION 2 mg INTRAMUSCULAR ANDA 17 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0143-9891 INJECTION 2 mg INTRAMUSCULAR ANDA 17 sections
ZOFRAN HUMAN PRESCRIPTION DRUG LABEL 1 0173-0446 TABLET, FILM COATED 4 mg ORAL NDA 17 sections
ZOFRAN HUMAN PRESCRIPTION DRUG LABEL 1 0173-0447 TABLET, FILM COATED 8 mg ORAL NDA 17 sections
ZOFRAN HUMAN PRESCRIPTION DRUG LABEL 1 0173-0489 SOLUTION 4 mg ORAL NDA 17 sections
ZOFRAN HUMAN PRESCRIPTION DRUG LABEL 1 0173-0569 TABLET, ORALLY DISINTEGRATING 4 mg ORAL NDA 17 sections
ZOFRAN HUMAN PRESCRIPTION DRUG LABEL 1 0173-0570 TABLET, ORALLY DISINTEGRATING 8 mg ORAL NDA 17 sections
Ondansetron Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0179-0099 TABLET 4 mg ORAL ANDA 15 sections
Ondansetron Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0179-0100 TABLET 8 mg ORAL ANDA 15 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0378-0315 TABLET, FILM COATED 4 mg ORAL ANDA 17 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0378-0344 TABLET, FILM COATED 8 mg ORAL ANDA 17 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0378-7732 TABLET, ORALLY DISINTEGRATING 4 mg ORAL ANDA 17 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0378-7734 TABLET, ORALLY DISINTEGRATING 8 mg ORAL ANDA 17 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0409-1120 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 19 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0409-4755 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 19 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0409-4759 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 19 sections
Ondansetron Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1726 INJECTION 2 mg INTRAMUSCULAR ANDA 18 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0641-6078 INJECTION 2 mg INTRAMUSCULAR ANDA 17 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0641-6079 INJECTION 2 mg INTRAMUSCULAR ANDA 17 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0641-6080 INJECTION 2 mg INTRAMUSCULAR ANDA 17 sections