ampiroxicam indications/contra

Stem definitionDrug idCAS RN
anti-inflammatory, isoxicam derivatives 199 99464-64-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • flucam
  • ampiroxicam
  • CP-65703
  • CP 65703
prodrug of piroxicam; structure given in first source
  • Molecular weight: 447.46
  • Formula: C20H21N3O7S
  • CLOGP: 2.51
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 1
  • TPSA: 124.13
  • ALOGS: -4.03
  • ROTB: 8

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Liver disorder 17.39 0 3 6 10220 3375630

Pharmacologic Action:

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SourceCodeDescription
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50266 prodrug

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.27 acidic
pKa2 4.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
D01397 KEGG_DRUG
0PV32JZB1J UNII
6047 INN_ID
2176 PUBCHEM_CID
CHEMBL1566249 ChEMBL_ID
C065946 MESH_SUPPLEMENTAL_RECORD_UI
DB00554 DRUGBANK_ID
CHEBI:31210 CHEBI

Pharmaceutical products:

None