omapatrilat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
endopeptidase inhibitors 1989 167305-00-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BMS-186716
  • omapatrilat
  • Molecular weight: 408.53
  • Formula: C19H24N2O4S2
  • CLOGP: 2.84
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 86.71
  • ALOGS: -3.73
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
MeSH PA D000075563 Vasopeptidase Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.38 acidic
pKa2 7.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme Ki 8.22 CHEMBL
Neprilysin Enzyme Ki 8.05 CHEMBL
Amyloid beta A4 protein Unclassified IC50 6.70 CHEMBL
Angiotensin-converting enzyme Enzyme IC50 8.30 CHEMBL
Neprilysin Enzyme IC50 8.10 CHEMBL

External reference:

IDSource
D01970 KEGG_DRUG
4025254 VANDF
C0663645 UMLSCUI
CHEBI:135660 CHEBI
FT8 PDB_CHEM_ID
CHEMBL289556 ChEMBL_ID
DB00886 DRUGBANK_ID
C106266 MESH_SUPPLEMENTAL_RECORD_UI
656629 PUBCHEM_CID
7714 INN_ID
36NLI90E7T UNII

Pharmaceutical products:

None