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omapatrilat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| endopeptidase inhibitors | 1989 | 167305-00-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 30 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1 | 21 | |||
| kinase-selectivity-class | AXL,EIF2AK3,GRK2,MAP2K6 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000075563 | Vasopeptidase Inhibitors |
| MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.38 | acidic |
| pKa2 | 7.71 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Enzyme | Ki | 8.22 | CHEMBL | |||||
| Neprilysin | Enzyme | Ki | 8.05 | CHEMBL | |||||
| Amyloid beta A4 protein | Membrane other | IC50 | 6.70 | CHEMBL | |||||
| Angiotensin-converting enzyme | Enzyme | IC50 | 8.30 | CHEMBL | |||||
| Neprilysin | Enzyme | IC50 | 8.10 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01970 | KEGG_DRUG |
| 4025254 | VANDF |
| C0663645 | UMLSCUI |
| CHEBI:135660 | CHEBI |
| FT8 | PDB_CHEM_ID |
| CHEMBL289556 | ChEMBL_ID |
| DB00886 | DRUGBANK_ID |
| C106266 | MESH_SUPPLEMENTAL_RECORD_UI |
| 656629 | PUBCHEM_CID |
| 7714 | INN_ID |
| 36NLI90E7T | UNII |
| 36NLI90E7T | INXIGHT DRUGS |
Pharmaceutical products:
None