omapatrilat indications/contra

Stem definitionDrug idCAS RN
endopeptidase inhibitors 1989 167305-00-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BMS-186716
  • omapatrilat
  • Molecular weight: 408.53
  • Formula: C19H24N2O4S2
  • CLOGP: 2.84
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 86.71
  • ALOGS: -3.73
  • ROTB: 5

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
MeSH PA D000075563 Vasopeptidase Inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.38 acidic
pKa2 7.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme Ki 8.22 CHEMBL
Neprilysin Enzyme Ki 8.05 CHEMBL
Angiotensin-converting enzyme Enzyme IC50 8.30 CHEMBL
Neprilysin Enzyme IC50 8.10 CHEMBL

External reference:

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IDSource
D01970 KEGG_DRUG
36NLI90E7T UNII
7714 INN_ID
DB00886 DRUGBANK_ID
CHEMBL289556 ChEMBL_ID
4025254 VANDF
N0000171784 NDFRT
N0000179575 NDFRT
656629 PUBCHEM_CID
C106266 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135660 CHEBI

Pharmaceutical products:

None