nitazoxanide indications/contra

Stem definitionDrug idCAS RN
antiparasitics, salicylanilides and analogues 1943 55981-09-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitazoxanide
  • nitazode
  • nitazoxanida
  • nizonide
a 5-nitrothiazolyl derivative used for a broad range of intestinal parasitic infections including CRYPTOSPORIDIUM and GIARDIA; it is a redox-active nitrothiazolyl-salicylamide prodrug; structure given in first source
  • Molecular weight: 307.28
  • Formula: C12H9N3O5S
  • CLOGP: 1.24
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 114.11
  • ALOGS: -4.61
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1 g O

Approvals:

DateAgencyCompanyOrphan
Nov. 22, 2002 FDA ROMARK

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC P01AX11 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
Other agents against amoebiasis and other protozoal diseases
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents
FDA EPC N0000175485 Antiprotozoal

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Giardiasis indication 58265007 DOID:10718
Infection by Cryptosporidium indication 58777003 DOID:1733
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:2527
Disease of liver contraindication 235856003 DOID:409

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.29 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aldose reductase Enzyme IC50 5.09 CHEMBL
Pyruvate dehydrogenase [NADP(+)] Enzyme INHIBITOR DRUGBANK CHEMBL
Pyruvate:ferredoxin oxidoreductase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

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IDSource
DB00507 DRUGBANK_ID
4021365 VUID
N0000148784 NUI
C0068788 UMLSCUI
D02486 KEGG_DRUG
N0000010148 NDFRT
N0000148784 NDFRT
d04826 MMSL
17040 MMSL
31819 RXNORM
4021365 VANDF
407148001 SNOMEDCT_US
407149009 SNOMEDCT_US
006303 NDDF
CHEMBL1401 ChEMBL_ID
41684 PUBCHEM_CID
C041747 MESH_SUPPLEMENTAL_RECORD_UI
SOA12P041N UNII
5007 INN_ID
NTI PDB_CHEM_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 27437-106 POWDER, FOR SUSPENSION 100 mg ORAL NDA 17 sections
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 67546-111 TABLET 500 mg ORAL NDA 17 sections
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 67546-212 POWDER, FOR SUSPENSION 100 mg ORAL NDA 17 sections
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 69189-0243 TABLET 500 mg ORAL NDA 17 sections