nitazoxanide indications/contra

Stem definitionDrug idCAS RN
antiparasitics, salicylanilides and analogues 1943 55981-09-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitazoxanide
  • nitazode
  • nitazoxanida
  • nizonide
a 5-nitrothiazolyl derivative used for a broad range of intestinal parasitic infections including CRYPTOSPORIDIUM and GIARDIA; it is a redox-active nitrothiazolyl-salicylamide prodrug; structure given in first source
  • Molecular weight: 307.28
  • Formula: C12H9N3O5S
  • CLOGP: 1.24
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 114.11
  • ALOGS: -4.61
  • RINGS: 2
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1000 mg O

Approvals:

DateAgencyCompanyOrphan
Nov. 22, 2002 FDA ROMARK

Pharmacologic Action:

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SourceCodeDescription
ATC P01AX11 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
Other agents against amoebiasis and other protozoal diseases
FDA EPC N0000175485 Antiprotozoal
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Giardiasis indication 58265007 DOID:10718
Infection by Cryptosporidium indication 58777003 DOID:1733
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aldose reductase Enzyme IC50 5.09 CHEMBL
Pyruvate dehydrogenase [NADP(+)] Enzyme INHIBITOR DRUGBANK CHEMBL
Pyruvate:ferredoxin oxidoreductase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

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IDSource
4021365 VANDF
N0000010148 NDFRT
N0000148784 NDFRT
006303 NDDF
31819 RXNORM
d04826 MMSL
17040 MMSL
407148001 SNOMEDCT_US
407149009 SNOMEDCT_US
DB00507 DRUGBANK_ID
C041747 MESH_SUPPLEMENTAL_RECORD_UI
D02486 KEGG_DRUG
5007 INN_ID
SOA12P041N UNII
41684 PUBCHEM_CID
CHEMBL1401 ChEMBL_ID
N0000148784 NUI
C0068788 UMLSCUI
4021365 VUID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 27437-106 POWDER, FOR SUSPENSION 100 mg ORAL NDA 17 sections
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 67546-111 TABLET 500 mg ORAL NDA 17 sections
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 67546-212 POWDER, FOR SUSPENSION 100 mg ORAL NDA 17 sections
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 69189-0243 TABLET 500 mg ORAL NDA 17 sections