nitazoxanide indications/contra

Stem definitionDrug idCAS RN
antiparasitics, salicylanilides and analogues 1943 55981-09-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitazoxanide
  • nitazode
  • nitazoxanida
  • nizonide
a 5-nitrothiazolyl derivative used for a broad range of intestinal parasitic infections including CRYPTOSPORIDIUM and GIARDIA; it is a redox-active nitrothiazolyl-salicylamide prodrug; structure given in first source
  • Molecular weight: 307.28
  • Formula: C12H9N3O5S
  • CLOGP: 1.24
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 114.11
  • ALOGS: -4.61
  • RINGS: 2
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1000 mg O

Approvals:

DateAgencyCompanyOrphan
Nov. 22, 2002 FDA ROMARK

Pharmacologic Action:

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SourceCodeDescription
ATC P01AX11 Antiparasitic Products, Insecticides And Repellents
Antiprotozoals
Agents Against Amoebiasis And Other Protozoal Diseases
Other agents against amoebiasis and other protozoal diseases
FDA EPC N0000175485 Antiprotozoal
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Giardiasis indication 58265007 DOID:10718
Infection by Cryptosporidium indication 58777003 DOID:1733
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409

Bioactivity Summary:

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TargetClassSwissprotActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Pyruvate dehydrogenase [NADP(+)] Enzyme PNO_CRYPV INHIBITOR DRUGBANK CHEMBL
Pyruvate:ferredoxin oxidoreductase Enzyme Q24982_GIAIN INHIBITOR CHEMBL CHEMBL
Aldose reductase Enzyme ALDR_HUMAN IC50 5.09 CHEMBL

External reference:

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IDSource
CHEMBL1401 ChEMBL DB Compound ID
DB00507 DrugBank ID
5007 Sequential number assigned by World Health Organization's International Nonproprietary Name (INN) Programme
D02486 KEGG DRUG Database ID
C041747 Medical Subject Headings (MeSH) Supplemental Record Unique ID
41684 PubChem Compound Id
31819 RxNorm Vocabulary
407148001 US Edition of SNOMED CT
407149009 US Edition of SNOMED CT
SOA12P041N FDA Unique Ingredient Identifier Code

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 27437-106 POWDER, FOR SUSPENSION 100 mg ORAL NDA 17 sections
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 67546-111 TABLET 500 mg ORAL NDA 17 sections
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 67546-212 POWDER, FOR SUSPENSION 100 mg ORAL NDA 17 sections
Alinia HUMAN PRESCRIPTION DRUG LABEL 1 69189-0243 TABLET 500 mg ORAL NDA 17 sections