amperozide indications/contra

Stem definitionDrug idCAS RN
193 75558-90-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amperozide
  • Molecular weight: 401.50
  • Formula: C23H29F2N3O
  • CLOGP: 5.37
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 1
  • TPSA: 35.58
  • ALOGS: -4.49
  • ROTB: 7

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.94 acidic
pKa2 8.09 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 6 GPCR Ki 5.80 PDSP
Fatty-acid amide hydrolase 1 Enzyme IC50 6.34 CHEMBL

External reference:

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IDSource
0M2W3TAG39 UNII
5033 INN_ID
73333 PUBCHEM_CID
CHEMBL1079935 ChEMBL_ID
C049058 MESH_SUPPLEMENTAL_RECORD_UI
DB08927 DRUGBANK_ID

Pharmaceutical products:

None