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amperozide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 193 | 75558-90-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 4.123 | Moderate | 0.66 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.867 | Moderate | 0.66 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 32.211 | 10^-6 cm/s | Moderate | 0.66 |
| dh-clint | Dog hepatocyte intrinsic clearance | 14.125 | uL/min/10^6 cells | Moderate | 0.66 |
| dppb | Dog plasma protein binding (% unbound) | 1.080 | % | Moderate | 0.66 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 4.150 | % | Moderate | 0.66 |
| herg | hERG pIC50 | 6.067 | pIC50 | Moderate | 0.66 |
| hh-clint | Human hepatocyte intrinsic clearance | 7.464 | uL/min/10^6 cells | Moderate | 0.66 |
| hlm-clint | Human liver microsomal intrinsic clearance | 82.414 | uL/min/mg protein | Moderate | 0.66 |
| hppb | Human plasma protein binding (% unbound) | 1.180 | % | Moderate | 0.66 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.998 | Moderate | 0.66 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 45.186 | Moderate | 0.66 | |
| mppb | Mouse plasma protein binding (% unbound) | 1.120 | Moderate | 0.66 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 4.989 | Moderate | 0.66 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 3.030 | % | Moderate | 0.66 |
| rh-clint | Rat hepatocyte intrinsic clearance | 102.565 | uL/min/10^6 cells | Moderate | 0.66 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 12.630 | % | Moderate | 0.66 |
| rppb | Rat plasma protein binding (% unbound) | 0.900 | % | Moderate | 0.66 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 21.184 | uM | Moderate | 0.66 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D012702 | Serotonin Antagonists |
| MeSH PA | D014149 | Tranquilizing Agents |
| MeSH PA | D014150 | Antipsychotic Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018490 | Serotonin Agents |
| CHEBI has role | CHEBI:35474 | anxiolytic drug |
| CHEBI has role | CHEBI:48279 | serotonergic antagonist |
| CHEBI has role | CHEBI:51039 | dopamine uptake inhibitor |
| CHEBI has role | CHEBI:65191 | second generation antipsychotic |
| CHEBI has role | CHEBI:176497 | geroprotector |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.94 | acidic |
| pKa2 | 8.09 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | Enzyme | IC50 | 6.34 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.80 | PDSP |
External reference:
| ID | Source |
|---|---|
| C0051747 | UMLSCUI |
| CHEBI:180480 | CHEBI |
| CHEMBL1079935 | ChEMBL_ID |
| DB08927 | DRUGBANK_ID |
| C049058 | MESH_SUPPLEMENTAL_RECORD_UI |
| 73333 | PUBCHEM_CID |
| 5033 | INN_ID |
| 0M2W3TAG39 | UNII |
| 0M2W3TAG39 | INXIGHT DRUGS |
Pharmaceutical products:
None