nifuroxazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5-nitrofuran derivatives 1928 965-52-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nifuroxazide
  • dicoferin
  • nifuroxazid
  • pentofuryl
  • Molecular weight: 275.22
  • Formula: C12H9N3O5
  • CLOGP: 1.90
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 120.65
  • ALOGS: -3.42
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.60 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Trimethylaminuria 147.94 87.52 17 373 156 63488476
Pseudomembranous colitis 105.70 87.52 18 372 3094 63485538
Megacolon 99.79 87.52 16 374 1899 63486733

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Trimethylaminuria 156.32 63.37 18 447 178 79743745
Pseudomembranous colitis 103.16 63.37 19 446 5355 79738568
Megacolon 97.68 63.37 17 448 3478 79740445
Dysbiosis 77.34 63.37 12 453 1207 79742716
Intestinal perforation 75.64 63.37 18 447 17408 79726515
Peritonitis 71.91 63.37 19 446 28017 79715906
Clostridium difficile infection 68.40 63.37 20 445 42665 79701258

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AX03 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Other intestinal antiinfectives
MeSH PA D000890 Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.75 acidic
pKa2 10.28 acidic
pKa3 2.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Signal transducer and activator of transcription 3 Transcription factor EC50 5.52 CHEMBL

External reference:

IDSource
D07111 KEGG_DRUG
C0068742 UMLSCUI
CHEBI:135136 CHEBI
CHEMBL244888 ChEMBL_ID
DB13855 DRUGBANK_ID
C013150 MESH_SUPPLEMENTAL_RECORD_UI
5337997 PUBCHEM_CID
12358 IUPHAR_LIGAND_ID
1578 INN_ID
PM5LI0P38J UNII
31782 RXNORM
005828 NDDF
703471002 SNOMEDCT_US
703472009 SNOMEDCT_US

Pharmaceutical products:

None