nifedipine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 1922 21829-25-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BAY A1040
  • nifedipine
  • nedipin
  • fedipin
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
  • Molecular weight: 346.34
  • Formula: C17H18N2O6
  • CLOGP: 3.12
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 110.45
  • ALOGS: -4.29
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.01 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 3.71 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.79 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.04 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1981 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 674.67 10.09 404 62990 29877 63395751
Exposure during pregnancy 318.68 10.09 563 62831 154984 63270644
Premature baby 299.83 10.09 211 63183 20524 63405104
Low birth weight baby 206.62 10.09 113 63281 7016 63418612
Pre-eclampsia 178.11 10.09 112 63282 9021 63416607
Pemphigus 147.56 10.09 9 63385 183717 63241911
Foetal exposure during pregnancy 143.09 10.09 168 63226 31794 63393834
Alopecia 136.83 10.09 84 63310 337452 63088176
Glossodynia 124.22 10.09 16 63378 178860 63246768
Maternal exposure during pregnancy 116.90 10.09 482 62912 219580 63206048
Blood pressure inadequately controlled 114.89 10.09 68 63326 4910 63420718
Hypotension 106.86 10.09 546 62848 272058 63153570
Arthropathy 94.28 10.09 59 63335 234733 63190895
Renal impairment 92.64 10.09 244 63150 88111 63337517
Pericarditis 90.78 10.09 12 63382 131567 63294061
Systemic lupus erythematosus 90.29 10.09 48 63346 208870 63216758
Neovascularisation 89.34 10.09 36 63358 1109 63424519
Premature labour 86.75 10.09 83 63311 12421 63413207
Wound 85.84 10.09 28 63366 163235 63262393
Therapeutic product effect decreased 84.04 10.09 44 63350 193143 63232485
Caesarean section 82.06 10.09 93 63301 16939 63408689
Oedema peripheral 79.43 10.09 387 63007 189124 63236504
Discomfort 79.12 10.09 34 63360 167340 63258288
Blood pressure increased 73.77 10.09 339 63055 161723 63263905
Infusion related reaction 72.47 10.09 83 63311 245438 63180190
Foetal growth restriction 72.00 10.09 60 63334 7493 63418135
Helicobacter infection 70.28 10.09 6 63388 92779 63332849
Rheumatoid factor positive 68.14 10.09 4 63390 84402 63341226
Cardiac failure congestive 67.94 10.09 225 63169 92208 63333420
Blood aldosterone increased 67.48 10.09 19 63375 184 63425444
Proteinuria 65.51 10.09 88 63306 19057 63406571
Contraindicated product administered 61.63 10.09 76 63318 217572 63208056
Hypersensitivity 60.46 10.09 126 63268 292559 63133069
Joint swelling 59.67 10.09 151 63243 327515 63098113
Cerebral infarction 58.79 10.09 94 63300 23799 63401829
Aplastic anaemia 54.38 10.09 57 63337 9512 63416116
Scleroderma 53.33 10.09 44 63350 5418 63420210
Pulmonary oedema 51.95 10.09 146 63248 54727 63370901
Abdominal discomfort 51.62 10.09 157 63237 320728 63104900
Anuria 51.29 10.09 63 63331 12488 63413140
Primary hyperaldosteronism 51.08 10.09 12 63382 51 63425577
Transfusion 50.63 10.09 69 63325 15148 63410480
Synovitis 50.09 10.09 68 63326 186850 63238778
Dyspnoea exertional 49.03 10.09 152 63242 60150 63365478
Rash 48.75 10.09 344 63050 560527 62865101
Cardiac failure 48.61 10.09 197 63197 88945 63336683
Blood pressure diastolic abnormal 48.47 10.09 66 63328 14476 63411152
Paradoxical drug reaction 48.14 10.09 37 63357 4115 63421513
Oligohydramnios 47.50 10.09 44 63350 6322 63419306
Polyhydramnios 47.18 10.09 29 63365 2242 63423386
Shock 46.72 10.09 84 63310 23379 63402249
Bradycardia 46.63 10.09 170 63224 73057 63352571
Blood pressure systolic abnormal 46.52 10.09 62 63332 13324 63412304
Wrist deformity 46.30 10.09 28 63366 2102 63423526
Treatment failure 46.06 10.09 80 63314 198963 63226665
Drug intolerance 44.14 10.09 159 63235 308502 63117126
Acute pulmonary oedema 43.53 10.09 47 63347 8111 63417517
Lower respiratory tract infection 43.20 10.09 41 63353 132266 63293362
Blood creatinine increased 43.12 10.09 188 63206 87656 63337972
Heart rate decreased 42.91 10.09 121 63273 45439 63380189
Intestinal angioedema 42.33 10.09 18 63376 637 63424991
Drug ineffective 42.17 10.09 763 62631 1044002 62381626
Pain 41.18 10.09 508 62886 740120 62685508
Hepatic enzyme increased 41.00 10.09 88 63306 202240 63223388
Impaired healing 39.44 10.09 27 63367 102515 63323113
Sinusitis 38.53 10.09 108 63286 226545 63199083
Rectal prolapse 37.86 10.09 24 63370 1959 63423669
Uraemic encephalopathy 37.33 10.09 13 63381 264 63425364
Eclampsia 36.82 10.09 14 63380 368 63425260
Product use issue 36.07 10.09 107 63287 220413 63205215
Hypertensive crisis 36.05 10.09 59 63335 15227 63410401
Bladder prolapse 36.03 10.09 24 63370 2132 63423496
Hypergammaglobulinaemia 35.95 10.09 15 63379 506 63425122
Dialysis 35.78 10.09 48 63346 10379 63415249
Superimposed pre-eclampsia 35.46 10.09 6 63388 0 63425628
Drug dispensed to wrong patient 35.42 10.09 13 63381 309 63425319
Drug interaction 33.96 10.09 364 63030 228767 63196861
Cerebrovascular accident 33.94 10.09 204 63190 107820 63317808
Product complaint 33.74 10.09 52 63342 12757 63412871
Hypocalvaria 33.33 10.09 8 63386 38 63425590
Swelling 32.99 10.09 152 63242 275226 63150402
Dyspnoea 32.86 10.09 878 62516 660435 62765193
Fatigue 32.84 10.09 658 62736 887370 62538258
Knee arthroplasty 32.83 10.09 7 63387 54199 63371429
Psoriatic arthropathy 32.74 10.09 26 63368 91494 63334134
Blood pressure systolic increased 32.71 10.09 113 63281 47284 63378344
Phaeochromocytoma 32.67 10.09 14 63380 505 63425123
Irritable bowel syndrome 32.64 10.09 21 63373 82391 63343237
Fibromyalgia 32.53 10.09 20 63374 80400 63345228
Neonatal respiratory distress syndrome 32.43 10.09 25 63369 2793 63422835
Hyperkalaemia 32.14 10.09 123 63271 54080 63371548
Infection 32.12 10.09 119 63275 229054 63196574
Tubulointerstitial nephritis 31.92 10.09 65 63329 19838 63405790
Peripartum cardiomyopathy 31.84 10.09 10 63384 145 63425483
Premature separation of placenta 31.78 10.09 21 63373 1840 63423788
Blood pressure decreased 31.78 10.09 139 63255 64883 63360745
Renal artery stenosis 31.30 10.09 21 63373 1888 63423740
Respiratory tract inflammation 30.63 10.09 14 63380 590 63425038
Renin decreased 30.53 10.09 9 63385 104 63425524
Hypervolaemia 30.30 10.09 79 63315 28334 63397294
Blister 30.17 10.09 52 63342 129762 63295866
Blood pressure fluctuation 29.88 10.09 108 63286 46209 63379419
Nodular regenerative hyperplasia 29.73 10.09 13 63381 493 63425135
Angina unstable 29.61 10.09 36 63358 7059 63418569
Renal failure 29.53 10.09 210 63184 117442 63308186
Pain in jaw 29.41 10.09 103 63291 43393 63382235
Hypertension 29.39 10.09 416 62978 278887 63146741
Adverse drug reaction 29.33 10.09 22 63372 79692 63345936
Injection site erythema 29.28 10.09 24 63370 83150 63342478
CD30 expression 28.54 10.09 7 63387 37 63425591
Foetal death 28.12 10.09 44 63350 10936 63414692
Foetal distress syndrome 27.58 10.09 17 63377 1321 63424307
Cognitive disorder 26.90 10.09 11 63383 55804 63369824
Product residue present 26.82 10.09 26 63368 3953 63421675
Pulmonary hypertension 26.04 10.09 89 63305 37034 63388594
Peripheral vascular disorder 25.81 10.09 31 63363 6004 63419624
Thermal burn 25.76 10.09 31 63363 6015 63419613
Aortic dissection 25.65 10.09 19 63375 1999 63423629
Swollen joint count increased 25.55 10.09 3 63391 36051 63389577
Drug abuse 25.44 10.09 21 63373 72497 63353131
Patent ductus arteriosus 25.38 10.09 26 63368 4224 63421404
Electrocardiogram PR prolongation 25.29 10.09 13 63381 711 63424917
Maternal condition affecting foetus 25.13 10.09 9 63385 199 63425429
Blood pressure diastolic decreased 25.10 10.09 64 63330 22642 63402986
Drug ineffective for unapproved indication 25.08 10.09 83 63311 33980 63391648
Blood urea increased 24.77 10.09 70 63324 26309 63399319
Liver injury 24.54 10.09 15 63379 60505 63365123
Injection site reaction 24.45 10.09 14 63380 58510 63367118
Acute myocardial infarction 24.30 10.09 79 63315 32045 63393583
Diabetic nephropathy 23.85 10.09 16 63378 1438 63424190
Neutropenia 23.78 10.09 92 63302 174913 63250715
Hip arthroplasty 23.60 10.09 9 63385 47637 63377991
HELLP syndrome 23.41 10.09 14 63380 1030 63424598
Metabolic acidosis 23.29 10.09 98 63296 44971 63380657
Infrequent bowel movements 22.99 10.09 15 63379 1287 63424341
Psoriasis 22.91 10.09 32 63362 86925 63338703
Foetal exposure timing unspecified 22.84 10.09 9 63385 261 63425367
Intentional product use issue 22.42 10.09 60 63334 127832 63297796
Finger amputation 22.35 10.09 11 63383 548 63425080
Preterm premature rupture of membranes 21.91 10.09 15 63379 1394 63424234
Type 2 diabetes mellitus 21.78 10.09 19 63375 63849 63361779
Fluid retention 21.55 10.09 117 63277 59569 63366059
Pulmonary arterial hypertension 21.29 10.09 60 63334 22517 63403111
Endometritis 21.15 10.09 13 63381 1005 63424623
Acute kidney injury 21.13 10.09 375 63019 263040 63162588
BRASH syndrome 21.08 10.09 10 63384 459 63425169
Palpitations 21.01 10.09 188 63206 112582 63313046
Angina pectoris 21.00 10.09 72 63322 30006 63395622
Hepatic function abnormal 20.97 10.09 83 63311 37059 63388569
Myocardial infarction 20.96 10.09 171 63223 99722 63325906
Hepatic rupture 20.96 10.09 6 63388 62 63425566
Therapeutic product effect incomplete 20.93 10.09 60 63334 124996 63300632
Respiratory distress 20.91 10.09 78 63316 33873 63391755
Rheumatoid arthritis 20.85 10.09 158 63236 253661 63171967
Urticaria 20.75 10.09 90 63304 165712 63259916
Left ventricular hypertrophy 20.63 10.09 26 63368 5289 63420339
Urine output decreased 20.49 10.09 39 63355 11331 63414297
Nephrogenic systemic fibrosis 20.47 10.09 24 63370 4532 63421096
Injection site inflammation 20.26 10.09 22 63372 3821 63421807
Renal hypoplasia 20.14 10.09 5 63389 28 63425600
Stomatitis 20.10 10.09 71 63323 138654 63286974
Stillbirth 20.06 10.09 29 63365 6721 63418907
Chronic kidney disease 19.91 10.09 94 63300 45304 63380324
Vitamin D decreased 19.54 10.09 36 63358 10206 63415422
Porphyria acute 19.42 10.09 13 63381 1164 63424464
Haemoglobin decreased 19.20 10.09 226 63168 145259 63280369
Oedema 18.83 10.09 164 63230 97458 63328170
Bradycardia foetal 18.70 10.09 9 63385 427 63425201
Gestational hypertension 18.60 10.09 17 63377 2400 63423228
Extrapyramidal disorder 18.54 10.09 41 63353 13243 63412385
Barotrauma 18.52 10.09 7 63387 181 63425447
Drug titration error 18.36 10.09 11 63383 812 63424816
Frostbite 18.22 10.09 6 63388 102 63425526
Hypertensive emergency 18.04 10.09 15 63379 1867 63423761
Atrial septal defect 18.04 10.09 28 63366 6910 63418718
Vascular resistance systemic increased 17.73 10.09 3 63391 0 63425628
Oxygen saturation decreased 17.71 10.09 150 63244 88435 63337193
Cardiac arrest 17.61 10.09 155 63239 92390 63333238
Myocardial depression 17.46 10.09 9 63385 495 63425133
Hypovolaemic shock 17.38 10.09 26 63368 6215 63419413
Atrioventricular block 17.34 10.09 29 63365 7618 63418010
Hypertension neonatal 17.22 10.09 4 63390 16 63425612
Multiple sclerosis relapse 17.05 10.09 14 63380 48464 63377164
Platelet count decreased 16.96 10.09 184 63210 115938 63309690
Arrhythmia 16.74 10.09 79 63315 38061 63387567
Transferrin decreased 16.70 10.09 7 63387 239 63425389
Spinal cord infarction 16.22 10.09 7 63387 257 63425371
Intentional self-injury 16.22 10.09 3 63391 25684 63399944
Contusion 16.11 10.09 86 63308 149958 63275670
Use of accessory respiratory muscles 16.04 10.09 7 63387 264 63425364
Gastrointestinal disorder 15.95 10.09 72 63322 131167 63294461
Hyperuricaemia 15.86 10.09 23 63371 5347 63420281
Foetal exposure during delivery 15.77 10.09 6 63388 158 63425470
Product substitution error 15.74 10.09 4 63390 25 63425603
Atrioventricular block first degree 15.72 10.09 27 63367 7246 63418382
Coronary artery disease 15.65 10.09 69 63325 32308 63393320
Pseudolymphoma 15.59 10.09 9 63385 620 63425008
Hypertensive encephalopathy 15.47 10.09 9 63385 629 63424999
Laboratory test interference 15.37 10.09 9 63385 637 63424991
Oral herpes 15.31 10.09 59 63335 26015 63399613
Nephrotic syndrome 15.20 10.09 23 63371 5553 63420075
Respiratory failure 15.15 10.09 162 63232 101696 63323932
Macular degeneration 15.06 10.09 3 63391 24373 63401255
Heliotrope rash 15.01 10.09 6 63388 181 63425447
Exposure via breast milk 14.93 10.09 14 63380 2043 63423585
Ileal ulcer 14.88 10.09 8 63386 480 63425148
Cardiomegaly 14.87 10.09 45 63349 17569 63408059
Renin increased 14.79 10.09 6 63388 188 63425440
Altered state of consciousness 14.74 10.09 57 63337 25173 63400455
Injection site pruritus 14.70 10.09 14 63380 45102 63380526
Renal atrophy 14.60 10.09 12 63382 1470 63424158
Foetal heart rate deceleration abnormality 14.56 10.09 8 63386 501 63425127
Scleroderma renal crisis 14.52 10.09 7 63387 333 63425295
Skin induration 14.51 10.09 17 63377 3206 63422422
Malignant hypertension 14.48 10.09 11 63383 1202 63424426
Wheezing 14.47 10.09 48 63346 95547 63330081
Foetal hypokinesia 14.40 10.09 8 63386 512 63425116
Umbilical cord vascular disorder 14.34 10.09 5 63389 102 63425526
Premature rupture of membranes 14.19 10.09 21 63373 4972 63420656
Aortic valve incompetence 13.97 10.09 23 63371 5965 63419663
Therapy partial responder 13.88 10.09 32 63362 10626 63415002
Accidental exposure to product 13.87 10.09 5 63389 27400 63398228
Poikiloderma 13.83 10.09 6 63388 223 63425405
Skin hypertrophy 13.82 10.09 17 63377 3374 63422254
COVID-19 13.78 10.09 62 63332 113041 63312587
Hypoaesthesia teeth 13.75 10.09 4 63390 44 63425584
Human chorionic gonadotropin positive 13.66 10.09 4 63390 45 63425583
Ventricular hypertrophy 13.64 10.09 17 63377 3419 63422209
General physical health deterioration 13.57 10.09 132 63262 201270 63224358
Blood lactate dehydrogenase increased 13.32 10.09 52 63342 23064 63402564
Haemoperitoneum 13.26 10.09 15 63379 2726 63422902
Adverse event 13.16 10.09 30 63364 67529 63358099
Cervical incompetence 13.13 10.09 8 63386 609 63425019
Prescribed overdose 13.12 10.09 9 63385 34144 63391484
Hypoproteinaemia 13.09 10.09 13 63381 2036 63423592
Joint contracture 13.02 10.09 12 63382 1712 63423916
Neonatal hyponatraemia 13.00 10.09 4 63390 54 63425574
Renal impairment neonatal 13.00 10.09 4 63390 54 63425574
Cortisol increased 12.99 10.09 7 63387 422 63425206
Dermatophytosis of nail 12.74 10.09 4 63390 58 63425570
Wrong technique in product usage process 12.70 10.09 27 63367 62313 63363315
Live birth 12.68 10.09 55 63339 25575 63400053
Lacunar infarction 12.66 10.09 16 63378 3264 63422364
Small for dates baby 12.46 10.09 17 63377 3734 63421894
Musculoskeletal stiffness 12.43 10.09 121 63273 184497 63241131
Jaundice neonatal 12.41 10.09 9 63385 916 63424712
Ill-defined disorder 12.41 10.09 41 63353 81714 63343914
Feeling cold 12.39 10.09 52 63342 23836 63401792
Neuromuscular blockade 12.32 10.09 6 63388 292 63425336
Sleep disorder 12.32 10.09 41 63353 81525 63344103
Rheumatic fever 12.24 10.09 15 63379 43096 63382532
Weight increased 12.20 10.09 185 63209 260607 63165021
Skin tightness 12.04 10.09 18 63376 4298 63421330
Nasopharyngitis 12.02 10.09 180 63214 254077 63171551
Hypoglycaemia neonatal 11.99 10.09 9 63385 966 63424662
Amniotic cavity infection 11.97 10.09 10 63384 1253 63424375
Systemic scleroderma 11.94 10.09 9 63385 972 63424656
Hypoxia 11.82 10.09 101 63293 59691 63365937
Haemodialysis 11.80 10.09 27 63367 8920 63416708
Antibody test positive 11.73 10.09 14 63380 2693 63422935
Transient ischaemic attack 11.66 10.09 71 63323 37682 63387946
Ductus arteriosus premature closure 11.64 10.09 6 63388 330 63425298
Iron binding capacity total decreased 11.61 10.09 6 63388 332 63425296
Anaemia 11.60 10.09 379 63015 293051 63132577
Pancreatitis haemorrhagic 11.57 10.09 7 63387 526 63425102
Carotid artery disease 11.54 10.09 11 63383 1638 63423990
Microvillous inclusion disease 11.51 10.09 3 63391 21 63425607
Blood corticotrophin decreased 11.49 10.09 6 63388 339 63425289
Mental status changes 11.31 10.09 73 63321 39526 63386102
Sinus bradycardia 11.20 10.09 36 63358 14515 63411113
Stevens-Johnson syndrome 11.18 10.09 52 63342 24898 63400730
Device expulsion 11.18 10.09 11 63383 34911 63390717
Platelet transfusion 11.18 10.09 8 63386 798 63424830
Foot deformity 11.16 10.09 7 63387 27846 63397782
Febrile neutropenia 11.06 10.09 71 63323 118378 63307250
Cough 11.03 10.09 376 63018 292367 63133261
Muscle spasticity 10.99 10.09 4 63390 21790 63403838
Glomerulonephritis membranoproliferative 10.93 10.09 5 63389 211 63425417
End stage renal disease 10.90 10.09 22 63372 6671 63418957
Haemodialysis complication 10.89 10.09 5 63389 213 63425415
Pulmonary embolism 10.86 10.09 70 63324 116614 63309014
Arthralgia 10.82 10.09 462 62932 569248 62856380
Brain natriuretic peptide increased 10.81 10.09 19 63375 5194 63420434
Threatened labour 10.76 10.09 8 63386 846 63424782
Pneumonia 10.71 10.09 558 62836 456209 62969419
Hypoperfusion 10.67 10.09 10 63384 1457 63424171
Hyperplasia adrenal 10.66 10.09 3 63391 29 63425599
Congenital hypothyroidism 10.59 10.09 5 63389 227 63425401
Arteriovenous fistula operation 10.49 10.09 5 63389 232 63425396
Large intestine benign neoplasm 10.42 10.09 4 63390 108 63425520
Pancreatic neuroendocrine tumour metastatic 10.39 10.09 3 63391 32 63425596
Decreased appetite 10.37 10.09 326 63068 250726 63174902
Mallory-Weiss syndrome 10.37 10.09 10 63384 1511 63424117
Abdominal distension 10.32 10.09 132 63262 86483 63339145
Histiocytic necrotising lymphadenitis 10.31 10.09 3 63391 33 63425595
Intestinal pseudo-obstruction 10.30 10.09 8 63386 904 63424724
Electrocardiogram abnormal 10.28 10.09 26 63368 9153 63416475
Hospitalisation 10.28 10.09 130 63264 84951 63340677
Hyporeflexia 10.26 10.09 11 63383 1884 63423744
Gastrooesophageal reflux disease 10.25 10.09 143 63251 95496 63330132
Blood chloride increased 10.21 10.09 13 63381 2671 63422957
Renal tubular dysfunction 10.19 10.09 6 63388 429 63425199
Renal disorder 10.17 10.09 62 63332 32912 63392716
Pyuria 10.16 10.09 11 63383 1903 63423725

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 234.26 10.73 194 42916 19439 34894382
Low birth weight baby 154.42 10.73 105 43005 7800 34906021
Foetal exposure during pregnancy 126.91 10.73 193 42917 37908 34875913
Photodermatosis 99.01 10.73 34 43076 529 34913292
Solar lentigo 92.07 10.73 32 43078 517 34913304
Dysplastic naevus 91.31 10.73 31 43079 465 34913356
Off label use 77.18 10.73 263 42847 419261 34494560
Polydactyly 70.60 10.73 33 43077 1180 34912641
Foetal growth restriction 69.46 10.73 50 43060 4067 34909754
Gingival hypertrophy 66.14 10.73 36 43074 1785 34912036
Bradycardia 61.74 10.73 219 42891 75199 34838622
Drug abuse 59.26 10.73 24 43086 99072 34814749
Cerebral infarction 58.33 10.73 114 42996 27341 34886480
Renal impairment 55.26 10.73 247 42863 94266 34819555
Drug ineffective 53.77 10.73 337 42773 456414 34457407
Hyperkalaemia 52.15 10.73 196 42914 69193 34844628
Completed suicide 48.95 10.73 245 42865 97923 34815898
Atrioventricular septal defect 48.54 10.73 16 43094 218 34913603
Blood creatinine increased 48.04 10.73 238 42872 94738 34819083
Dandy-Walker syndrome 45.53 10.73 15 43095 204 34913617
Aplastic anaemia 45.47 10.73 58 43052 9658 34904163
Kidney transplant rejection 45.36 10.73 51 43059 7446 34906375
Blood urea increased 44.97 10.73 109 43001 30255 34883566
Trisomy 21 40.57 10.73 18 43092 569 34913252
Bezoar 39.61 10.73 22 43088 1135 34912686
Pulmonary hypertension 38.65 10.73 82 43028 20842 34892979
Neutropenia 37.81 10.73 86 43024 156692 34757129
Shock 37.09 10.73 88 43022 24091 34889730
Cardiac failure congestive 36.79 10.73 201 42909 83069 34830752
Neurodevelopmental disorder 35.44 10.73 15 43095 422 34913399
Protein urine present 34.11 10.73 37 43073 5191 34908630
Macrocephaly 33.26 10.73 15 43095 493 34913328
Oesophageal obstruction 33.26 10.73 15 43095 493 34913328
Actinic keratosis 32.77 10.73 34 43076 4533 34909288
Proteinuria 32.08 10.73 71 43039 18571 34895250
Hepatic function abnormal 30.60 10.73 122 42988 44241 34869580
Congenital central nervous system anomaly 30.37 10.73 15 43095 607 34913214
Phospholipidosis 30.09 10.73 8 43102 48 34913773
Speech disorder developmental 28.88 10.73 23 43087 2177 34911644
Drug interaction 28.38 10.73 413 42697 225533 34688288
Cardiac arrest 28.12 10.73 209 42901 95950 34817871
Aplasia pure red cell 27.75 10.73 36 43074 6096 34907725
Chronic kidney disease 26.58 10.73 111 42999 41099 34872722
Gene mutation 25.83 10.73 18 43092 1390 34912431
Incision site pain 25.82 10.73 20 43090 1818 34912003
Foetal exposure timing unspecified 25.54 10.73 10 43100 229 34913592
Pre-eclampsia 25.28 10.73 7 43103 50 34913771
Hypotonic-hyporesponsive episode 24.77 10.73 6 43104 23 34913798
Endoscopy upper gastrointestinal tract abnormal 24.48 10.73 7 43103 57 34913764
Systemic scleroderma 24.38 10.73 11 43099 362 34913459
Thrombotic cerebral infarction 24.18 10.73 11 43099 369 34913452
Oedema 24.08 10.73 116 42994 45625 34868196
Blood pressure decreased 23.86 10.73 126 42984 51389 34862432
Blood pressure increased 23.26 10.73 187 42923 87915 34825906
Haemodilution 22.29 10.73 6 43104 38 34913783
Pyelocaliectasis 22.04 10.73 15 43095 1115 34912706
Death 21.05 10.73 355 42755 397694 34516127
Acute kidney injury 21.02 10.73 508 42602 304480 34609341
Oedema peripheral 20.97 10.73 233 42877 119579 34794242
Hypertensive crisis 20.63 10.73 38 43072 8713 34905108
Hypertension 20.63 10.73 258 42852 136185 34777636
Myocardial infarction 20.52 10.73 234 42876 120851 34792970
Interstitial lung disease 20.29 10.73 144 42966 65138 34848683
Atrioventricular block 20.27 10.73 36 43074 8027 34905794
Anti-erythropoietin antibody positive 20.17 10.73 13 43097 882 34912939
Malignant hypertension 20.10 10.73 12 43098 710 34913111
Attention deficit hyperactivity disorder 20.09 10.73 20 43090 2539 34911282
Drug dependence 19.98 10.73 3 43107 24214 34889607
Procedural hypertension 19.88 10.73 6 43104 60 34913761
Treatment failure 19.87 10.73 17 43093 46680 34867141
Renal failure 19.79 10.73 247 42863 130310 34783511
Hypotension 19.67 10.73 383 42727 221266 34692555
Cutaneous lupus erythematosus 19.39 10.73 12 43098 758 34913063
HIV associated nephropathy 19.20 10.73 9 43101 324 34913497
Congenital cystic lung 18.87 10.73 8 43102 226 34913595
Lymphocyte count decreased 18.75 10.73 66 43044 22556 34891265
Lacunar infarction 18.66 10.73 21 43089 3069 34910752
Neonatal respiratory failure 18.34 10.73 9 43101 359 34913462
Intestinal pseudo-obstruction 18.17 10.73 16 43094 1740 34912081
Mixed connective tissue disease 18.02 10.73 5 43105 36 34913785
Photosensitivity reaction 17.83 10.73 40 43070 10554 34903267
Supernumerary nipple 17.79 10.73 5 43105 38 34913783
Blood pressure inadequately controlled 17.78 10.73 19 43091 2621 34911200
Atrioventricular block complete 17.76 10.73 37 43073 9282 34904539
Metabolic acidosis 17.66 10.73 103 43007 43577 34870244
Joint range of motion decreased 17.55 10.73 32 43078 7280 34906541
Product use in unapproved indication 17.43 10.73 80 43030 117419 34796402
Renal ischaemia 17.27 10.73 10 43100 559 34913262
Patent ductus arteriosus 17.26 10.73 21 43089 3333 34910488
Apnoeic attack 17.09 10.73 9 43101 417 34913404
Cell marker increased 16.90 10.73 9 43101 427 34913394
Renal disorder 16.71 10.73 69 43041 25411 34888410
Rickets 16.66 10.73 5 43105 49 34913772
Hyperuricaemia 16.59 10.73 33 43077 8010 34905811
Febrile neutropenia 16.49 10.73 100 43010 136749 34777072
Crepitations 16.43 10.73 20 43090 3176 34910645
Myocardial ischaemia 16.38 10.73 53 43057 17355 34896466
Prinzmetal angina 16.34 10.73 12 43098 1007 34912814
Complications of transplanted kidney 16.26 10.73 24 43086 4585 34909236
Congenital pulmonary valve atresia 16.14 10.73 5 43105 55 34913766
Squamous cell carcinoma of skin 16.04 10.73 39 43071 10842 34902979
Brain stem infarction 15.97 10.73 13 43097 1269 34912552
Eating disorder symptom 15.82 10.73 4 43106 19 34913802
Nausea 15.79 10.73 310 42800 339598 34574223
Meningitis staphylococcal 15.75 10.73 5 43105 60 34913761
Thrombocytopenia 15.45 10.73 121 42989 156126 34757695
Therapeutic product effect incomplete 15.44 10.73 24 43086 50517 34863304
Caesarean section 15.33 10.73 16 43094 2148 34911673
Polyhydramnios 15.30 10.73 7 43103 238 34913583
Pulmonary eosinophilia 15.19 10.73 7 43103 242 34913579
Abdominal symptom 15.09 10.73 9 43101 532 34913289
Vomiting 15.03 10.73 215 42895 247406 34666415
Post procedural urine leak 14.95 10.73 6 43104 147 34913674
Azotaemia 14.90 10.73 24 43086 4943 34908878
Cerebrovascular accident 14.86 10.73 165 42945 84646 34829175
Putamen haemorrhage 14.73 10.73 7 43103 260 34913561
Retinopathy of prematurity 14.61 10.73 6 43104 156 34913665
Hyphaema 14.41 10.73 9 43101 578 34913243
Nephrogenic systemic fibrosis 14.34 10.73 21 43089 3984 34909837
Bronchopulmonary dysplasia 14.25 10.73 9 43101 589 34913232
Chorioretinopathy 14.25 10.73 13 43097 1480 34912341
Wrong technique in product usage process 14.24 10.73 14 43096 35972 34877849
Agitation 14.21 10.73 31 43079 57368 34856453
Product dose omission issue 14.14 10.73 88 43022 119623 34794198
Neonatal respiratory distress 13.96 10.73 9 43101 611 34913210
Red blood cells urine positive 13.95 10.73 14 43096 1795 34912026
Palatal swelling 13.83 10.73 4 43106 34 34913787
Cerebral hyperperfusion syndrome 13.78 10.73 5 43105 92 34913729
Lupus-like syndrome 13.77 10.73 17 43093 2739 34911082
Maternal exposure during pregnancy 13.73 10.73 23 43087 4895 34908926
Pulmonary oedema 13.70 10.73 103 43007 47426 34866395
Oesophageal haemorrhage 13.62 10.73 12 43098 1306 34912515
Ventricular extrasystoles 13.58 10.73 39 43071 11969 34901852
Blindness 13.54 10.73 45 43065 14941 34898880
Intentional product use issue 13.45 10.73 34 43076 59782 34854039
Naevus flammeus 13.43 10.73 6 43104 193 34913628
Congenital hearing disorder 13.40 10.73 5 43105 100 34913721
Pituitary tumour recurrent 13.40 10.73 5 43105 100 34913721
Neuropathy peripheral 13.37 10.73 55 43055 83208 34830613
Hydrocele male infected 13.26 10.73 4 43106 40 34913781
Exposure during pregnancy 13.14 10.73 32 43078 8902 34904919
Cytokine release syndrome 12.93 10.73 6 43104 22871 34890950
Sclerodactylia 12.83 10.73 4 43106 45 34913776
Neonatal cholestasis 12.83 10.73 4 43106 45 34913776
Renal failure neonatal 12.83 10.73 5 43105 113 34913708
Neonatal respiratory distress syndrome 12.80 10.73 20 43090 4014 34909807
Altered state of consciousness 12.73 10.73 59 43051 22834 34890987
Bradycardia foetal 12.68 10.73 7 43103 357 34913464
Acute myocardial infarction 12.56 10.73 111 42999 53608 34860213
Infantile apnoea 12.51 10.73 10 43100 951 34912870
Fatigue 12.48 10.73 355 42755 370298 34543523
BRASH syndrome 12.47 10.73 8 43102 538 34913283
Hypocalcaemia 12.35 10.73 61 43049 24228 34889593
White blood cell count increased 12.33 10.73 90 43020 41061 34872760
Product residue present 12.23 10.73 16 43094 2730 34911091
Acute lung injury 12.22 10.73 12 43098 1498 34912323
Transplant rejection 12.16 10.73 34 43076 10277 34903544
Chronic allograft nephropathy 12.11 10.73 11 43099 1246 34912575
Cardiac cirrhosis 12.03 10.73 4 43106 56 34913765
Spinal cord abscess 11.96 10.73 6 43104 251 34913570
Hypertensive emergency 11.82 10.73 10 43100 1030 34912791
Vertebral artery stenosis 11.74 10.73 5 43105 143 34913678
Papillary renal cell carcinoma 11.72 10.73 6 43104 262 34913559
Maternal drugs affecting foetus 11.68 10.73 19 43091 3946 34909875
Serotonin syndrome 11.62 10.73 5 43105 19928 34893893
Drug level increased 11.60 10.73 56 43054 22040 34891781
Blood pressure systolic 11.58 10.73 3 43107 16 34913805
Tubulointerstitial nephritis 11.56 10.73 54 43056 20970 34892851
Haemoglobin decreased 11.48 10.73 211 42899 120561 34793260
Angina unstable 11.44 10.73 36 43074 11617 34902204
Angina pectoris 11.43 10.73 72 43038 31291 34882530
Skin tightness 11.42 10.73 14 43096 2239 34911582
Hot flush 11.41 10.73 4 43106 18062 34895759
Renal artery stenosis 11.38 10.73 14 43096 2247 34911574
Hydrops foetalis 11.24 10.73 9 43101 858 34912963
Postrenal failure 11.23 10.73 7 43103 448 34913373
Skin hypertrophy 11.22 10.73 15 43095 2614 34911207
Clonic convulsion 11.16 10.73 8 43102 646 34913175
Sedation 11.13 10.73 6 43104 21000 34892821
Kidney infection 10.97 10.73 22 43088 5372 34908449
Adverse drug reaction 10.95 10.73 12 43098 29330 34884491
Neutrophil count increased 10.91 10.73 46 43064 17100 34896721
Cerebrovascular insufficiency 10.89 10.73 3 43107 21 34913800
Hepatocellular injury 10.85 10.73 7 43103 22204 34891617
Peripheral arterial occlusive disease 10.82 10.73 23 43087 5851 34907970
Nodal rhythm 10.82 10.73 11 43099 1432 34912389
Anaemia neonatal 10.78 10.73 6 43104 311 34913510

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 504.76 9.64 322 91074 23145 79629847
Exposure during pregnancy 260.76 9.64 438 90958 100694 79552298
Pre-eclampsia 142.45 9.64 93 91303 6948 79646044
Renal impairment 137.84 9.64 446 90950 157337 79495655
Maternal exposure during pregnancy 116.58 9.64 383 91013 136155 79516837
Cerebral infarction 112.58 9.64 194 91202 45482 79607510
Bradycardia 102.36 9.64 365 91031 135192 79517800
Cardiac failure congestive 99.58 9.64 374 91022 142028 79510964
Hypotension 99.52 9.64 852 90544 439465 79213527
Alopecia 93.14 9.64 77 91319 231278 79421714
Dysplastic naevus 88.01 9.64 31 91365 564 79652428
Photodermatosis 87.06 9.64 35 91361 929 79652063
Aplastic anaemia 86.97 9.64 105 91291 17800 79635192
Blood creatinine increased 85.98 9.64 379 91017 154678 79498314
Shock 83.48 9.64 166 91230 43382 79609610
Hyperkalaemia 82.09 9.64 303 91093 114095 79538897
Drug abuse 81.97 9.64 42 91354 162649 79490343
Blood pressure inadequately controlled 81.81 9.64 63 91333 6114 79646878
Neovascularisation 81.64 9.64 36 91360 1209 79651783
Proteinuria 81.34 9.64 139 91257 32363 79620629
Oedema peripheral 78.19 9.64 526 90870 251762 79401230
Premature labour 76.61 9.64 69 91327 8321 79644671
Therapeutic product effect decreased 74.43 9.64 48 91348 163815 79489177
Solar lentigo 71.85 9.64 32 91364 1101 79651891
Pericarditis 71.36 9.64 16 91380 104220 79548772
Pemphigus 70.81 9.64 14 91382 99568 79553424
Drug interaction 66.13 9.64 747 90649 414436 79238556
Blood urea increased 65.24 9.64 161 91235 48629 79604363
Glossodynia 64.72 9.64 19 91377 103318 79549674
Blood pressure increased 63.87 9.64 438 90958 210922 79442070
Duodenal ulcer perforation 63.22 9.64 3 91393 66208 79586784
Wound 63.13 9.64 27 91369 116152 79536840
Neutropenia 62.56 9.64 149 91247 287561 79365431
Gingival hypertrophy 62.34 9.64 41 91355 3101 79649891
Hypersensitivity 58.46 9.64 134 91262 262105 79390887
Arthropathy 56.46 9.64 72 91324 177039 79475953
Hepatic function abnormal 53.57 9.64 195 91201 72912 79580080
Pulmonary oedema 52.95 9.64 221 91175 88033 79564959
Discomfort 52.80 9.64 40 91356 125577 79527415
Blood pressure decreased 52.75 9.64 240 91156 99226 79553766
Joint swelling 52.60 9.64 163 91233 288483 79364509
Primary hyperaldosteronism 51.62 9.64 15 91381 141 79652851
Rheumatoid factor positive 50.51 9.64 5 91391 59834 79593158
Completed suicide 49.45 9.64 464 90932 245303 79407689
Infusion related reaction 49.43 9.64 120 91276 230117 79422875
Cardiac failure 49.23 9.64 325 91071 154517 79498475
Helicobacter infection 49.14 9.64 10 91386 69694 79583298
Caesarean section 49.02 9.64 66 91330 12469 79640523
Foetal growth restriction 47.85 9.64 30 91366 2089 79650903
Off label use 47.23 9.64 744 90652 906471 78746521
Cerebrovascular accident 47 9.64 322 91074 154970 79498022
Kidney transplant rejection 46.39 9.64 58 91338 10188 79642804
Cardiac arrest 45.26 9.64 345 91051 171751 79481241
Hypertensive crisis 44.49 9.64 83 91313 20687 79632305
Muscle injury 43.91 9.64 3 91393 48558 79604434
Myocardial infarction 43.43 9.64 360 91036 183769 79469223
Wrist deformity 42.91 9.64 28 91368 2089 79650903
Drug ineffective 42.70 9.64 930 90466 1079983 78573009
Angina unstable 41.77 9.64 71 91325 16456 79636536
Treatment failure 41.40 9.64 83 91313 170403 79482589
Renal failure 41.21 9.64 381 91015 200587 79452405
Polyhydramnios 40.48 9.64 25 91371 1695 79651297
Metabolic acidosis 40.00 9.64 194 91202 82335 79570657
Hypertension 39.22 9.64 564 90832 330428 79322564
Chronic kidney disease 39.17 9.64 165 91231 65989 79587003
Bladder prolapse 39.14 9.64 23 91373 1424 79651568
Synovitis 38.68 9.64 71 91325 150663 79502329
Adverse drug reaction 38.41 9.64 14 91382 66378 79586614
Scleroderma 38.33 9.64 39 91357 5471 79647521
Blood aldosterone increased 38.05 9.64 13 91383 215 79652777
Tubulointerstitial nephritis 37.89 9.64 113 91283 38122 79614870
Pulmonary hypertension 37.58 9.64 131 91265 47949 79605043
Bezoar 36.88 9.64 28 91368 2660 79650332
Impaired healing 36.72 9.64 28 91368 87627 79565365
Renal artery stenosis 36.55 9.64 31 91365 3451 79649541
Drug intolerance 36.48 9.64 167 91229 263952 79389040
Acute kidney injury 36.26 9.64 814 90582 518590 79134402
Systemic lupus erythematosus 35.82 9.64 52 91344 121097 79531895
Lower respiratory tract infection 35.77 9.64 58 91338 129162 79523830
Hyperuricaemia 35.69 9.64 55 91341 11744 79641248
Anuria 35.56 9.64 76 91320 20887 79632105
Angina pectoris 35.40 9.64 135 91261 51597 79601395
Atrioventricular block 35.06 9.64 60 91336 13981 79639011
Oedema 35.02 9.64 246 91150 119334 79533658
Intestinal angioedema 34.83 9.64 18 91378 865 79652127
Superimposed pre-eclampsia 34.64 9.64 6 91390 0 79652992
Blood pressure systolic abnormal 34.57 9.64 67 91329 17180 79635812
Malignant hypertension 34.22 9.64 22 91374 1600 79651392
Dialysis 33.73 9.64 69 91327 18393 79634599
Actinic keratosis 33.62 9.64 38 91358 6004 79646988
Phaeochromocytoma 33.43 9.64 16 91380 651 79652341
Rectal prolapse 32.82 9.64 24 91372 2154 79650838
Psoriatic arthropathy 32.56 9.64 25 91371 77974 79575018
BRASH syndrome 32.44 9.64 18 91378 999 79651993
Contraindicated product administered 32.33 9.64 84 91312 157454 79495538
Fatigue 31.90 9.64 817 90579 928910 78724082
Wrong technique in product usage process 31.72 9.64 23 91373 73852 79579140
Acute myocardial infarction 31.70 9.64 173 91223 76863 79576129
Transfusion 31.32 9.64 73 91323 21257 79631735
Intentional product use issue 31.30 9.64 81 91315 152031 79500961
Hepatic enzyme increased 31.24 9.64 106 91290 182504 79470488
Sinusitis 31.11 9.64 117 91279 195384 79457608
Oligohydramnios 31.03 9.64 28 91368 3384 79649608
Eclampsia 30.98 9.64 11 91385 205 79652787
Blood pressure diastolic abnormal 30.73 9.64 68 91328 19134 79633858
Fibromyalgia 30.38 9.64 18 91378 64322 79588670
Aortic dissection 29.86 9.64 30 91366 4145 79648847
Systemic scleroderma 29.71 9.64 18 91378 1179 79651813
Acute pulmonary oedema 29.40 9.64 56 91340 14174 79638818
Product use issue 29.37 9.64 132 91264 209690 79443302
Incision site pain 29.30 9.64 25 91371 2805 79650187
Lacunar infarction 29.04 9.64 35 91361 5922 79647070
Protein urine present 29.01 9.64 46 91350 10066 79642926
Intestinal pseudo-obstruction 28.98 9.64 24 91372 2585 79650407
Knee arthroplasty 28.88 9.64 7 91389 43241 79609751
Hypergammaglobulinaemia 28.81 9.64 15 91381 732 79652260
Blood pressure systolic increased 28.62 9.64 152 91244 66834 79586158
Haemoglobin decreased 28.51 9.64 384 91012 221735 79431257
Renin decreased 28.34 9.64 9 91387 117 79652875
Irritable bowel syndrome 27.21 9.64 19 91377 62222 79590770
Rash 27.15 9.64 483 90913 577875 79075117
Uraemic encephalopathy 27.08 9.64 14 91382 673 79652319
Atrioventricular block first degree 26.86 9.64 50 91346 12441 79640551
Peripartum cardiomyopathy 26.85 9.64 9 91387 140 79652852
Febrile neutropenia 26.84 9.64 155 91241 230844 79422148
Paradoxical drug reaction 26.83 9.64 37 91359 7148 79645844
Injection site erythema 26.81 9.64 30 91366 78167 79574825
Aplasia pure red cell 25.90 9.64 38 91358 7772 79645220
Altered state of consciousness 25.70 9.64 109 91287 43713 79609279
Heart rate decreased 25.70 9.64 153 91243 70163 79582829
CD30 expression 25.67 9.64 7 91389 51 79652941
Dyspnoea exertional 25.41 9.64 179 91217 86894 79566098
White blood cell count increased 25.14 9.64 159 91237 74474 79578518
Therapeutic product effect incomplete 25.06 9.64 81 91315 141564 79511428
Psoriasis 24.99 9.64 40 91356 89547 79563445
Coronary artery disease 24.92 9.64 144 91252 65330 79587662
Drug dependence 24.62 9.64 8 91388 40761 79612231
Atrioventricular block complete 24.56 9.64 57 91339 16553 79636439
Diabetic nephropathy 24.50 9.64 23 91373 2924 79650068
Oesophageal obstruction 24.37 9.64 15 91381 1011 79651981
Abdominal discomfort 24.17 9.64 178 91218 250549 79402443
Infection 24.08 9.64 170 91226 241542 79411450
Drug dispensed to wrong patient 23.91 9.64 13 91383 693 79652299
Peripheral vascular disorder 23.69 9.64 37 91359 7993 79644999
Thrombotic cerebral infarction 23.54 9.64 12 91384 560 79652432
Sleep disorder 23.20 9.64 39 91357 85638 79567354
Renal hypoplasia 23.06 9.64 5 91391 11 79652981
Azotaemia 22.85 9.64 37 91359 8239 79644753
Low birth weight baby 22.58 9.64 12 91384 611 79652381
Endometritis 22.27 9.64 13 91383 795 79652197
Pain in jaw 22.01 9.64 108 91288 46043 79606949
Hypervolaemia 21.88 9.64 102 91294 42588 79610404
Pain 21.60 9.64 628 90768 703174 78949818
Premature baby 21.42 9.64 24 91372 3756 79649236
Finger amputation 21.36 9.64 12 91384 682 79652310
Umbilical cord vascular disorder 21.25 9.64 5 91391 18 79652974
Myocardial ischaemia 21.23 9.64 71 91325 25448 79627544
Sedation 21.20 9.64 17 91379 51878 79601114
Product complaint 21.05 9.64 47 91349 13302 79639690
Platelet transfusion 20.87 9.64 19 91377 2323 79650669
Intentional self-injury 20.22 9.64 6 91390 32413 79620579
Hypertensive encephalopathy 19.93 9.64 13 91383 969 79652023
Hypertensive emergency 19.90 9.64 20 91376 2765 79650227
Endoscopy upper gastrointestinal tract abnormal 19.80 9.64 6 91390 66 79652926
Wheezing 19.75 9.64 68 91328 116596 79536396
HIV associated nephropathy 19.72 9.64 9 91387 328 79652664
Weight increased 19.67 9.64 213 91183 277173 79375819
Foetal death 19.60 9.64 34 91362 8010 79644982
Left ventricular hypertrophy 19.48 9.64 41 91355 11150 79641842
Phospholipidosis 19.37 9.64 8 91388 228 79652764
Brain stem infarction 19.35 9.64 17 91379 1984 79651008
General physical health deterioration 19.26 9.64 212 91184 275026 79377966
Preterm premature rupture of membranes 19.12 9.64 14 91382 1259 79651733
Oesophageal haemorrhage 19.10 9.64 16 91380 1751 79651241
Dyspnoea 19.09 9.64 1181 90215 855844 78797148
Stillbirth 18.89 9.64 23 91373 3932 79649060
Respiratory tract inflammation 18.88 9.64 12 91384 856 79652136
Putamen haemorrhage 18.85 9.64 10 91386 507 79652485
Injection site inflammation 18.79 9.64 23 91373 3953 79649039
Cognitive disorder 18.78 9.64 32 91364 69894 79583098
Arthralgia 18.61 9.64 506 90890 571297 79081695
Pulmonary arterial hypertension 18.57 9.64 73 91323 28293 79624699
Electrocardiogram PR prolongation 18.50 9.64 15 91381 1568 79651424
Interstitial lung disease 18.50 9.64 204 91192 112396 79540596
Sclerodactylia 18.43 9.64 7 91389 159 79652833
Vascular resistance systemic increased 18.39 9.64 4 91392 9 79652983
Nephrotic syndrome 18.37 9.64 40 91356 11134 79641858
Maternal condition affecting foetus 18.35 9.64 7 91389 161 79652831
Hip arthroplasty 18.34 9.64 9 91387 35747 79617245
Thrombocytopenia 18.29 9.64 205 91191 265054 79387938
Multiple sclerosis relapse 18.08 9.64 16 91380 46517 79606475
Neuropathy peripheral 17.95 9.64 92 91304 141213 79511779
Pemphigoid 17.85 9.64 48 91348 15267 79637725
Injection site reaction 17.73 9.64 22 91374 54763 79598229
COVID-19 17.67 9.64 107 91289 157567 79495425
Renal disorder 17.62 9.64 95 91301 42010 79610982
Product residue present 17.60 9.64 21 91375 3515 79649477
Urticaria 17.59 9.64 132 91264 185069 79467923
Ventricular extrasystoles 17.45 9.64 56 91340 19648 79633344
Scleroderma renal crisis 17.44 9.64 10 91386 591 79652401
Prinzmetal angina 17.41 9.64 15 91381 1705 79651287
Haemodialysis 17.34 9.64 53 91343 18115 79634877
Blood pressure fluctuation 17.29 9.64 134 91262 67011 79585981
HELLP syndrome 17.17 9.64 11 91385 795 79652197
Barotrauma 17.16 9.64 7 91389 193 79652799
Thermal burn 17.10 9.64 30 91366 7130 79645862
Photosensitivity reaction 16.88 9.64 58 91338 21069 79631923
Injection site pain 16.80 9.64 84 91312 129754 79523238
Small for dates baby 16.78 9.64 9 91387 467 79652525
Swollen joint count increased 16.77 9.64 3 91393 22924 79630068
Condition aggravated 16.67 9.64 442 90954 500682 79152310
Skin hypertrophy 16.37 9.64 24 91372 4904 79648088
Squamous cell carcinoma of skin 16.37 9.64 44 91352 13989 79639003
Nephrogenic systemic fibrosis 16.28 9.64 27 91369 6133 79646859
Gestational hypertension 16.27 9.64 15 91381 1864 79651128
Nodal rhythm 16.24 9.64 19 91377 3116 79649876
Vitamin D decreased 16.20 9.64 35 91361 9690 79643302
Arrhythmia 16.18 9.64 123 91273 61149 79591843
Nodular regenerative hyperplasia 16.13 9.64 13 91383 1348 79651644
Platelet count decreased 16.12 9.64 313 91083 194351 79458641
Hypocalcaemia 15.98 9.64 105 91291 49819 79603173
Nephrogenic anaemia 15.95 9.64 21 91375 3881 79649111
Myocardial depression 15.89 9.64 9 91387 520 79652472
Tricuspid valve incompetence 15.65 9.64 54 91342 19658 79633334
Complications of transplanted kidney 15.63 9.64 27 91369 6339 79646653
Product use in unapproved indication 15.52 9.64 198 91198 250161 79402831
Hepatocellular injury 15.52 9.64 19 91377 47574 79605418
Telangiectasia 15.41 9.64 13 91383 1436 79651556
Diabetes mellitus 15.24 9.64 147 91249 78243 79574749
Peritoneal dialysis complication 15.18 9.64 16 91380 2338 79650654
Haemodilution 15.04 9.64 6 91390 156 79652836
Gastroenteritis 15.01 9.64 78 91318 34004 79618988
Hyperventilation 15.00 9.64 30 91366 7869 79645123
Premature separation of placenta 14.97 9.64 12 91384 1234 79651758
Neutrophil count increased 14.89 9.64 70 91326 29326 79623666
Urine output decreased 14.86 9.64 50 91346 17972 79635020
Incorrect route of product administration 14.83 9.64 11 91385 34918 79618074
Blood lactate dehydrogenase increased 14.81 9.64 86 91310 39084 79613908
Porphyria acute 14.76 9.64 13 91383 1522 79651470
Renal atrophy 14.71 9.64 14 91382 1811 79651181
Amniotic cavity infection 14.51 9.64 10 91386 817 79652175
Accidental exposure to product 14.45 9.64 9 91387 31313 79621679
Cytokine release syndrome 14.44 9.64 12 91384 35986 79617006
Swelling 14.34 9.64 169 91227 216542 79436450
Lymphocyte count decreased 14.26 9.64 98 91298 47191 79605801
Nasopharyngitis 14.22 9.64 205 91191 253676 79399316
Peritoneal dialysis 14.20 9.64 10 91386 846 79652146
Foot deformity 14.05 9.64 5 91391 24069 79628923
Diverticulum intestinal haemorrhagic 14.01 9.64 20 91376 3991 79649001
Aggression 13.98 9.64 23 91373 50935 79602057
Ventricular hypertrophy 13.96 9.64 27 91369 6911 79646081
Accidental exposure to product by child 13.95 9.64 17 91379 2909 79650083
End stage renal disease 13.94 9.64 38 91358 12182 79640810
Hot flush 13.94 9.64 26 91370 54851 79598141
Blood pressure diastolic decreased 13.90 9.64 70 91326 30146 79622846
Human chorionic gonadotropin positive 13.82 9.64 4 91392 37 79652955
Heliotrope rash 13.76 9.64 6 91390 196 79652796
Procedural hypertension 13.75 9.64 7 91389 326 79652666
Hyphaema 13.71 9.64 10 91386 894 79652098
Hyperplasia adrenal 13.64 9.64 4 91392 39 79652953
Mucosal erosion 13.62 9.64 15 91381 2303 79650689
Neutropenic sepsis 13.60 9.64 7 91389 27057 79625935
Renal ischaemia 13.56 9.64 11 91385 1151 79651841
Meningitis staphylococcal 13.53 9.64 5 91391 105 79652887
Hepatic rupture 13.53 9.64 5 91391 105 79652887
Palpitations 13.50 9.64 212 91184 126398 79526594
Hypoaesthesia teeth 13.46 9.64 4 91392 41 79652951
Anti-erythropoietin antibody positive 13.36 9.64 9 91387 708 79652284
Peritonitis bacterial 13.24 9.64 32 91364 9535 79643457
Blood albumin decreased 13.22 9.64 59 91337 24184 79628808
Diabetic retinopathy 13.14 9.64 17 91379 3089 79649903
Fluid retention 13.12 9.64 130 91266 69679 79583313
Shunt occlusion 13.01 9.64 12 91384 1492 79651500
Sinus arrhythmia 13.00 9.64 14 91382 2096 79650896
Intracardiac mass 12.99 9.64 6 91390 225 79652767
Hypermagnesaemia 12.90 9.64 11 91385 1233 79651759
Decreased appetite 12.89 9.64 497 90899 341921 79311071
Paranasal sinus inflammation 12.89 9.64 6 91390 229 79652763
Live birth 12.89 9.64 49 91347 18695 79634297
Arteriosclerosis 12.83 9.64 48 91348 18179 79634813
Haemoperitoneum 12.80 9.64 20 91376 4323 79648669
Illness 12.75 9.64 21 91375 46490 79606502
Transferrin decreased 12.69 9.64 7 91389 384 79652608
Cerebral hyperperfusion syndrome 12.64 9.64 5 91391 127 79652865
Injection site pruritus 12.64 9.64 18 91378 42265 79610727
Cardiac failure acute 12.62 9.64 49 91347 18880 79634112
Product substitution error 12.59 9.64 4 91392 52 79652940
Bradycardia foetal 12.57 9.64 5 91391 129 79652863
Brain natriuretic peptide increased 12.57 9.64 30 91366 8870 79644122
Device expulsion 12.54 9.64 7 91389 25854 79627138
Prescribed overdose 12.48 9.64 15 91381 37868 79615124
Hypoproteinaemia 12.44 9.64 19 91377 4027 79648965
Chorioretinopathy 12.36 9.64 14 91382 2217 79650775
Post transplant distal limb syndrome 12.32 9.64 8 91388 592 79652400
Hydronephrosis 12.31 9.64 46 91350 17408 79635584
Pleural effusion 12.17 9.64 234 91162 145028 79507964
Rheumatoid arthritis 12.14 9.64 167 91229 208303 79444689
Cerebral haemorrhage 12.14 9.64 110 91286 57563 79595429
Red blood cells urine positive 12.12 9.64 21 91375 4942 79648050
Low density lipoprotein increased 12.11 9.64 29 91367 8593 79644399
Ileus paralytic 12.08 9.64 31 91365 9589 79643403
Ear infection 12.03 9.64 13 91383 34419 79618573
Papillary renal cell carcinoma 11.99 9.64 6 91390 269 79652723
Immunodeficiency 11.91 9.64 5 91391 21763 79631229
Post procedural urine leak 11.90 9.64 5 91391 149 79652843
Vomiting 11.88 9.64 633 90763 665195 78987797
Shunt stenosis 11.84 9.64 11 91385 1380 79651612
Peripheral arterial occlusive disease 11.84 9.64 28 91368 8230 79644762
Muscle spasticity 11.65 9.64 5 91391 21470 79631522
Renal-limited thrombotic microangiopathy 11.59 9.64 5 91391 159 79652833
Apnoeic attack 11.47 9.64 8 91388 666 79652326
Glomerular filtration rate decreased 11.45 9.64 54 91342 22648 79630344
Ill-defined disorder 11.42 9.64 38 91358 65837 79587155
Cardiomegaly 11.39 9.64 60 91336 26292 79626700
Peripheral ischaemia 11.38 9.64 30 91366 9427 79643565
Blood glucose increased 11.32 9.64 190 91206 114785 79538207
Pulmonary embolism 11.30 9.64 134 91262 171520 79481472
Loss of personal independence in daily activities 11.28 9.64 70 91326 102510 79550482
Renal cyst haemorrhage 11.28 9.64 8 91388 684 79652308
Crepitations 11.28 9.64 31 91365 9986 79643006
Sinus bradycardia 11.27 9.64 58 91338 25189 79627803
Joint range of motion decreased 11.26 9.64 71 91325 33211 79619781
Dehydration 11.26 9.64 368 91028 247819 79405173
Lip haemorrhage 11.26 9.64 10 91386 1184 79651808
Frostbite 11.25 9.64 5 91391 171 79652821
Laboratory test interference 11.21 9.64 10 91386 1191 79651801
Cardiac failure chronic 11.12 9.64 33 91363 11102 79641890
Chest discomfort 11.10 9.64 221 91175 137823 79515169
Musculoskeletal stiffness 11.00 9.64 138 91258 174870 79478122
Liver injury 10.99 9.64 31 91365 56583 79596409
Gastric cancer 10.96 9.64 31 91365 10148 79642844
Periodontitis 10.95 9.64 19 91377 4477 79648515
Blister 10.95 9.64 86 91310 119390 79533602
Cholangitis acute 10.94 9.64 11 91385 1521 79651471
Electrocardiogram QRS complex shortened 10.90 9.64 8 91388 722 79652270
Lactic acidosis 10.88 9.64 126 91270 70233 79582759
Pneumonia 10.88 9.64 888 90508 659358 78993634
Dermatophytosis of nail 10.86 9.64 5 91391 186 79652806
Poisoning deliberate 10.84 9.64 4 91392 18824 79634168
Pituitary tumour recurrent 10.81 9.64 5 91391 188 79652804
Vertebral artery stenosis 10.79 9.64 5 91391 189 79652803
Use of accessory respiratory muscles 10.76 9.64 7 91389 520 79652472
Cervical incompetence 10.76 9.64 7 91389 520 79652472
Nausea 10.74 9.64 948 90448 956248 78696744
Bradyarrhythmia 10.73 9.64 18 91378 4128 79648864
Influenza like illness 10.70 9.64 44 91352 71663 79581329
Atrioventricular dissociation 10.70 9.64 6 91390 340 79652652
Restrictive cardiomyopathy 10.63 9.64 9 91387 999 79651993
Carotid artery disease 10.54 9.64 13 91383 2251 79650741
Skin tightness 10.52 9.64 21 91375 5501 79647491
Fibroadenoma of breast 10.51 9.64 6 91390 352 79652640
Abdominal symptom 10.49 9.64 8 91388 765 79652227
Parkinsonism 10.47 9.64 3 91393 16581 79636411
High density lipoprotein decreased 10.47 9.64 19 91377 4636 79648356
Gastric ileus 10.44 9.64 3 91393 27 79652965
Acantholysis 10.44 9.64 3 91393 27 79652965
Foetal hypokinesia 10.41 9.64 6 91390 358 79652634
Peripheral embolism 10.32 9.64 12 91384 1954 79651038
Clostridium difficile infection 10.17 9.64 21 91375 42664 79610328
Dyslalia 10.15 9.64 9 91387 1063 79651929
Pyuria 10.15 9.64 13 91383 2339 79650653
Withdrawal hypertension 10.12 9.64 6 91390 378 79652614
Vascular resistance systemic decreased 10.08 9.64 5 91391 220 79652772
Urticaria pigmentosa 10.07 9.64 3 91393 31 79652961
Pancreatitis haemorrhagic 9.99 9.64 8 91388 822 79652170
Colon gangrene 9.98 9.64 3 91393 32 79652960
Memory impairment 9.97 9.64 81 91315 111653 79541339
Intentional product misuse 9.93 9.64 66 91330 95099 79557893
Iron binding capacity total decreased 9.90 9.64 6 91390 393 79652599
Oliguria 9.90 9.64 41 91355 16268 79636724
Hypothermia 9.87 9.64 7 91389 22739 79630253
Poikiloderma 9.85 9.64 6 91390 397 79652595
Mobility decreased 9.82 9.64 91 91305 122084 79530908
Hepatic cytolysis 9.77 9.64 10 91386 27141 79625851
Ileal ulcer 9.74 9.64 9 91387 1121 79651871
Mydriasis 9.74 9.64 4 91392 17639 79635353
Glomerulonephritis membranoproliferative 9.69 9.64 7 91389 616 79652376
Spinal cord infarction 9.69 9.64 7 91389 616 79652376
Threatened labour 9.68 9.64 7 91389 617 79652375
Product dose omission issue 9.68 9.64 213 91183 247324 79405668
Hypogonadism 9.68 9.64 11 91385 1749 79651243
Cerebellar infarction 9.66 9.64 16 91380 3631 79649361

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07FB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C08CA05 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C08CA55 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C08GA01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
CALCIUM CHANNEL BLOCKERS AND DIURETICS
Calcium channel blockers and diuretics
FDA CS M0006414 Dihydropyridines
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175421 Dihydropyridine Calcium Channel Blocker
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D012102 Reproductive Control Agents
MeSH PA D015149 Tocolytic Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:38215 calcium channel blockers
CHEBI has role CHEBI:66993 tocolytic drugs
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Premature labor off-label use 6383007
Raynaud's phenomenon off-label use 266261006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Stenosis of intestine contraindication 23065003
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Chronic idiopathic constipation contraindication 82934008
Left heart failure contraindication 85232009
Cardiogenic shock contraindication 89138009
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Disease of liver contraindication 235856003 DOID:409
Pyloric obstruction contraindication 244815007
Peripheral edema contraindication 271809000
Continent ileostomy - stoma contraindication 311414006
Non-Q wave myocardial infarction contraindication 314207007
Acute coronary syndrome contraindication 394659003
Porphyria contraindication 418470004
Severe Aortic Valve Stenosis contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel GATING INHIBITOR IC50 7.70 IUPHAR CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER Kd 9.40 CHEMBL SCIENTIFIC LITERATURE
Sodium/nucleoside cotransporter 1 Transporter Ki 5.09 DRUG MATRIX
Adenosine receptor A2a GPCR Ki 4.65 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.30 WOMBAT-PK
Cytochrome P450 3A4 Enzyme IC50 5.26 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.50 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 5.02 DRUG MATRIX
Adenosine receptor A1 GPCR Ki 5.35 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 5.08 CHEMBL
Glutathione reductase, mitochondrial Enzyme Ki 4.76 CHEMBL
Transthyretin Secreted IC50 5.66 WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter IC50 4.30 CHEMBL
Glycine receptor subunit alpha-1 Ion channel IC50 5.48 CHEMBL
Bile salt export pump Transporter IC50 4.51 CHEMBL
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 4.67 WOMBAT-PK
Cytochrome P450 1A2 Enzyme IC50 6.52 DRUG MATRIX
Potassium voltage-gated channel subfamily A member 1 Ion channel IC50 4.02 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1S Ion channel INHIBITOR IC50 6.30 IUPHAR
Potassium voltage-gated channel subfamily A member 5 Ion channel IC50 5.21 CHEMBL
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Enzyme IC50 4.36 DRUG MATRIX
Glycine receptor subunit beta Ion channel ANTAGONIST IC50 5.90 IUPHAR
Potassium voltage-gated channel subfamily A member 2 Ion channel Kd 4.70 WOMBAT-PK
Myosin light chain kinase, smooth muscle Kinase IC50 5.69 CHEMBL
Thromboxane-A synthase Enzyme IC50 4.73 DRUG MATRIX
C-C chemokine receptor type 2 GPCR Ki 6.07 DRUG MATRIX
Voltage-dependent L-type calcium channel subunit alpha-1F Ion channel GATING INHIBITOR IC50 6 IUPHAR
Glycine receptor subunit alpha-3 Ion channel ANTAGONIST IC50 4.50 IUPHAR
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.43 CHEMBL
Acetylcholinesterase Enzyme Ki 5.40 CHEMBL
Adenosine receptor A2a GPCR Ki 4.74 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 9 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel Ki 8.46 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel Ki 8.92 CHEMBL
Cholinesterase Enzyme Ki 5.92 CHEMBL
Indoleamine 2,3-dioxygenase 2 Enzyme IC50 5.82 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 8.59 CHEMBL
Voltage-gated L-type calcium channel Ion channel Ki 8.33 CHEMBL
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 4.34 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 4.82 DRUG MATRIX
Potassium voltage-gated channel subfamily A member 7 Ion channel BLOCKER IC50 4.90 IUPHAR
Potassium voltage-gated channel subfamily A member 1 Ion channel BLOCKER IC50 4 IUPHAR
Potassium voltage-gated channel subfamily A member 2 Ion channel BLOCKER Kd 4.70 IUPHAR
Potassium channel subfamily K member 2 Ion channel IC50 5.09 CHEMBL
Bile salt export pump Transporter IC50 4.34 CHEMBL
Adenosine receptor A1 GPCR Ki 5.54 CHEMBL

External reference:

IDSource
4018390 VUID
N0000146717 NUI
D00437 KEGG_DRUG
4018390 VANDF
C0028066 UMLSCUI
CHEBI:7565 CHEBI
C5U PDB_CHEM_ID
CHEMBL193 ChEMBL_ID
DB01115 DRUGBANK_ID
D009543 MESH_DESCRIPTOR_UI
4485 PUBCHEM_CID
2514 IUPHAR_LIGAND_ID
3222 INN_ID
I9ZF7L6G2L UNII
7417 RXNORM
2302 MMSL
5175 MMSL
d00051 MMSL
000710 NDDF
017700 NDDF
387490003 SNOMEDCT_US
85272000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Procardia XL HUMAN PRESCRIPTION DRUG LABEL 1 0069-2650 TABLET, FILM COATED, EXTENDED RELEASE 30 mg ORAL NDA 20 sections
Procardia XL HUMAN PRESCRIPTION DRUG LABEL 1 0069-2660 TABLET, FILM COATED, EXTENDED RELEASE 60 mg ORAL NDA 20 sections
Procardia XL HUMAN PRESCRIPTION DRUG LABEL 1 0069-2670 TABLET, FILM COATED, EXTENDED RELEASE 90 mg ORAL NDA 20 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2497 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2530 CAPSULE, LIQUID FILLED 20 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7080 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7080 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7081 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7081 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7082 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7082 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7208 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 12 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7229 CAPSULE 10 mg ORAL ANDA 19 sections
NIFEDIPINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-319 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 19 sections
NIFEDIPINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-948 TABLET, FILM COATED, EXTENDED RELEASE 60 mg ORAL ANDA 11 sections
nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 21695-807 TABLET, FILM COATED, EXTENDED RELEASE 90 mg ORAL ANDA 20 sections
nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 21695-908 TABLET, FILM COATED, EXTENDED RELEASE 30 mg ORAL ANDA 20 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 21695-909 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 14 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 23155-194 CAPSULE 10 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 23155-194 CAPSULE 10 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 23155-194 CAPSULE 10 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 23155-195 CAPSULE 20 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 23155-195 CAPSULE 20 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 23155-195 CAPSULE 20 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-009 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-009 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-009 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-009 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-010 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-010 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 11 sections