nialamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1907 51-12-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nialamide
  • nialamid
  • niamid
  • niamidal
  • niamide
  • niaquitil
  • niazin
An MAO inhibitor that is used as an antidepressive agent.
  • Molecular weight: 298.35
  • Formula: C16H18N4O2
  • CLOGP: 0.91
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 83.12
  • ALOGS: -3.53
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
S (Water solubility) 2.27 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AF02 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Monoamine oxidase inhibitors, non-selective
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D008996 Monoamine Oxidase Inhibitors
MeSH PA D011619 Psychotropic Drugs
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:61115 histone deacetylase inhibitors
CHEBI has role CHEBI:62913 PARP
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:71181 Sir2 inhibitors
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:84087 human urinary metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.18 acidic
pKa2 12.9 acidic
pKa3 3.65 Basic
pKa4 0.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167319 NUI
D07337 KEGG_DRUG
C0027999 UMLSCUI
CHEBI:94510 CHEBI
CHEMBL1256841 ChEMBL_ID
DB04820 DRUGBANK_ID
D009526 MESH_DESCRIPTOR_UI
4472 PUBCHEM_CID
899 INN_ID
T2Q0RYM725 UNII
7394 RXNORM
001494 NDDF
49313009 SNOMEDCT_US

Pharmaceutical products:

None