nesiritide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
natriuretic peptides 1901 124584-08-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nesiritide
  • Brain natriuretic peptide-32
  • Human brain natriuretic factor-32
  • Human brain natriuretic peptide-32
  • Natriuretic peptide type-B
  • nesiritide recombinant
  • Molecular weight: 3464.07
  • Formula: C143H244N50O42S4
  • CLOGP:
  • LIPINSKI: 3
  • HAC: 92
  • HDO: 56
  • TPSA: 1512.74
  • ALOGS: -4.19
  • ROTB: 87

Drug dosage:

DoseUnitRoute
1.50 mg P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.19 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 9.20 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 10, 2001 FDA SCIOS LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01DX19 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Other vasodilators used in cardiac diseases
FDA CS M0447624 Natriuretic Peptides
FDA EPC N0000175593 Natriuretic Peptide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Decompensated cardiac failure indication 195111005
Decompensated chronic heart failure indication 424404003
Cardiac tamponade contraindication 35304003 DOID:115
Low blood pressure contraindication 45007003
Aortic valve stenosis contraindication 60573004 DOID:1712
Constrictive pericarditis contraindication 85598007 DOID:11481
Cardiogenic shock contraindication 89138009
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Azotemia contraindication 445009001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.72 acidic
pKa2 3.79 acidic
pKa3 12.09 acidic
pKa4 12.32 acidic
pKa5 12.47 acidic
pKa6 12.62 acidic
pKa7 12.91 acidic
pKa8 13.0 acidic
pKa9 13.23 acidic
pKa10 13.25 acidic
pKa11 13.46 acidic
pKa12 13.46 acidic
pKa13 13.49 acidic
pKa14 13.57 acidic
pKa15 13.74 acidic
pKa16 13.84 acidic
pKa17 13.89 acidic
pKa18 13.93 acidic
pKa19 11.5 Basic
pKa20 11.27 Basic
pKa21 11.02 Basic
pKa22 10.75 Basic
pKa23 10.54 Basic
pKa24 10.29 Basic
pKa25 9.93 Basic
pKa26 8.08 Basic
pKa27 6.88 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Atrial natriuretic peptide receptor 1 Enzyme AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
4024230 VUID
N0000022235 NUI
D05147 KEGG_DRUG
4021275 VANDF
4024230 VANDF
C0054015 UMLSCUI
CHEBI:135919 CHEBI
CHEMBL1201668 ChEMBL_ID
DB04899 DRUGBANK_ID
7790 INN_ID
P7WI8UL647 UNII
19666 RXNORM
16114 MMSL
d04763 MMSL
009299 NDDF
009300 NDDF
385678006 SNOMEDCT_US
385680000 SNOMEDCT_US
407059007 SNOMEDCT_US

Pharmaceutical products:

None