amodiaquine indications/contra

Stem definitionDrug idCAS RN
quinoline derivatives 186 86-42-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amodiaquine
  • amodiaquin
  • camochin
  • camoquin
  • camoquinal
  • camoquine
  • flavoquine
  • sunoquine
  • amodiaquine hydrochloride
  • amodiaquin dihydrochloride dihydrate
  • Amodiaquin dihydrochloride
  • amodiaquine HCl
  • camoquin hydrochloride
  • camoquin HCl
A 4-aminoquinoline compound with anti-inflammatory properties.
  • Molecular weight: 355.87
  • Formula: C20H22ClN3O
  • CLOGP: 5.32
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 2
  • TPSA: 48.39
  • ALOGS: -4.61
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.50 g O

Approvals:

DateAgencyCompanyOrphan
None FDA PARKE DAVIS

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Stillbirth 61.76 57.91 8 15 1567 3384269

Pharmacologic Action:

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SourceCodeDescription
ATC P01BA06 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Aminoquinolines
ATC P01BF03 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:50266 prodrug

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.85 acidic
pKa2 12.0 Basic
pKa3 6.97 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Heparanase Enzyme Kd 4.28 CHEMBL
Histamine N-methyltransferase Enzyme Ki 7.72 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.62 CHEMBL

External reference:

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IDSource
4019610 VUID
N0000147704 NUI
C0002641 UMLSCUI
D02466 KEGG_DRUG
CHEMBL682 ChEMBL_ID
220236ED28 UNII
1116 INN_ID
DB00613 DRUGBANK_ID
4019610 VANDF
720 RXNORM
387352008 SNOMEDCT_US
64115004 SNOMEDCT_US
N0000147704 NDFRT
N0000005832 NDFRT
004872 NDDF
2165 PUBCHEM_CID
CHEMBL1630 ChEMBL_ID
6398-98-7 SECONDARY_CAS_RN
D000655 MESH_DESCRIPTOR_UI
CHEBI:2674 CHEBI
CQA PDB_CHEM_ID

Pharmaceutical products:

None