amodiaquine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quinoline derivatives | 186 | 86-42-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A 4-aminoquinoline compound with anti-inflammatory properties.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.50 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 75 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 17.40 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 217 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.10 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 0.02 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | PARKE DAVIS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P01BA06 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS ANTIMALARIALS Aminoquinolines |
| ATC | P01BF03 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS ANTIMALARIALS Artemisinin and derivatives, combinations |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
| CHEBI has role | CHEBI:38068 | antimalarials |
| CHEBI has role | CHEBI:50266 | Prodrugs |
| CHEBI has role | CHEBI:88188 | allergenic drug |
| CHEBI has role | CHEBI:110725 | histamine 1-methyltransferase inhibitor |
| CHEBI has role | CHEBI:149553 | anticoronaviral drug |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000962 | Antimalarials |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000981 | Antiprotozoal Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.85 | acidic |
| pKa2 | 12.0 | Basic |
| pKa3 | 6.97 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.62 | CHEMBL | |||||
| Histamine N-methyltransferase | Enzyme | Ki | 7.72 | CHEMBL | |||||
| Heparanase | Enzyme | Kd | 4.28 | CHEMBL | |||||
| Amyloid beta A4 protein | Unclassified | IC50 | 5.40 | CHEMBL | |||||
| Nuclear receptor subfamily 4 group A member 2 | Nuclear other | EC50 | 4.44 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019610 | VUID |
| N0000147704 | NUI |
| D02466 | KEGG_DRUG |
| 314495 | RXNORM |
| C0002641 | UMLSCUI |
| CHEBI:2674 | CHEBI |
| CQA | PDB_CHEM_ID |
| CHEMBL682 | ChEMBL_ID |
| DB00613 | DRUGBANK_ID |
| CHEMBL1357648 | ChEMBL_ID |
| D000655 | MESH_DESCRIPTOR_UI |
| 2165 | PUBCHEM_CID |
| 10018 | IUPHAR_LIGAND_ID |
| 1116 | INN_ID |
| 6398-98-7 | SECONDARY_CAS_RN |
| 220236ED28 | UNII |
| 387352008 | SNOMEDCT_US |
| 391768005 | SNOMEDCT_US |
| 64115004 | SNOMEDCT_US |
| CHEMBL1630 | ChEMBL_ID |
| 4019272 | VANDF |
| 4019610 | VANDF |
| 002947 | NDDF |
| 004872 | NDDF |
Pharmaceutical products:
None