mycophenolate mofetil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1859 128794-94-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • linfonex
  • RS-61443
  • myclausen
  • mycophenolate mofetil
  • mycophenolate mofetil hydrochloride
  • myfenax
  • mycophenolate mofetil HCl
Mycophenolate mofetil is a prodrug of mycophenolic acid, an inhibitor of inosine-5'-monophosphate dehydrogenase. MPA depletes guanosine nucleotides preferentially in T and B lymphocytes and inhibits their proliferation.
  • Molecular weight: 433.50
  • Formula: C23H31NO7
  • CLOGP: 2.78
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 94.53
  • ALOGS: -3.66
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 47.45 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
June 25, 2021 PMDA CHUGAI PHARMACEUTICAL Co., Ltd
May 3, 1995 FDA ROCHE PALO
Feb. 14, 1998 EMA Roche Registration GmbH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 3185.11 10.81 1085 126786 9695 63351456
Cytomegalovirus infection 2651.60 10.81 1136 126735 19816 63341335
Post transplant lymphoproliferative disorder 1602.26 10.81 536 127335 4495 63356656
Off label use 1512.15 10.81 3820 124051 670642 62690509
Product use in unapproved indication 1491.66 10.81 1818 126053 177262 63183889
Transplant dysfunction 1452.66 10.81 494 127377 4378 63356773
Kidney transplant rejection 1083.83 10.81 384 127487 3887 63357264
Epstein-Barr virus infection 1029.33 10.81 440 127431 7610 63353541
Thrombotic microangiopathy 875.69 10.81 427 127444 10134 63351017
Cytomegalovirus viraemia 729.57 10.81 311 127560 5338 63355813
Polyomavirus-associated nephropathy 689.54 10.81 222 127649 1626 63359525
Complications of transplanted kidney 640.19 10.81 226 127645 2260 63358891
BK virus infection 618.36 10.81 237 127634 3042 63358109
Acute graft versus host disease in skin 574.92 10.81 228 127643 3224 63357927
Acute graft versus host disease 556.04 10.81 239 127632 4189 63356962
Posterior reversible encephalopathy syndrome 510.44 10.81 358 127513 16987 63344164
Multiple organ dysfunction syndrome 488.62 10.81 587 127284 56165 63304986
Ovarian cyst 485.34 10.81 336 127535 15609 63345542
Immunosuppressant drug level increased 449.06 10.81 194 127677 3444 63357707
Acne 439.38 10.81 369 127502 22924 63338227
Chronic graft versus host disease 434.67 10.81 181 127690 2921 63358230
Transplant failure 434.62 10.81 151 127720 1434 63359717
Varicella zoster virus infection 428.33 10.81 172 127699 2517 63358634
Cytomegalovirus infection reactivation 414.05 10.81 188 127683 3775 63357376
Graft versus host disease 408.62 10.81 221 127650 6542 63354609
Fatigue 391.00 10.81 750 127121 887278 62473873
Trichodysplasia spinulosa 382.65 10.81 108 127763 469 63360682
Aspergillus infection 382.08 10.81 225 127646 7868 63353283
Smooth muscle cell neoplasm 380.26 10.81 117 127754 724 63360427
Fall 379.43 10.81 158 127713 392176 62968975
Pain 373.78 10.81 573 127298 740055 62621096
Graft versus host disease in gastrointestinal tract 368.11 10.81 163 127708 3078 63358073
Human herpesvirus 6 infection 362.74 10.81 157 127714 2800 63358351
Pneumocystis jirovecii pneumonia 356.84 10.81 286 127585 16628 63344523
Graft versus host disease in skin 355.57 10.81 154 127717 2751 63358400
Nocardiosis 341.27 10.81 134 127737 1842 63359309
Diffuse large B-cell lymphoma 333.76 10.81 193 127678 6519 63354632
Nephropathy toxic 322.42 10.81 214 127657 9265 63351886
Adenovirus infection 319.01 10.81 152 127719 3419 63357732
Chronic allograft nephropathy 315.33 10.81 98 127773 630 63360521
Renal transplant failure 306.77 10.81 97 127774 665 63360486
Liver transplant rejection 304.20 10.81 113 127758 1322 63359829
COVID-19 295.57 10.81 683 127188 112420 63248731
Polyomavirus viraemia 289.55 10.81 92 127779 642 63360509
Klebsiella infection 285.60 10.81 191 127680 8375 63352776
Leukopenia 284.19 10.81 537 127334 76753 63284398
Epstein-Barr virus associated lymphoproliferative disorder 273.77 10.81 113 127758 1781 63359370
Completed suicide 272.54 10.81 4 127867 145669 63215482
Acute graft versus host disease in intestine 268.67 10.81 109 127762 1640 63359511
Mucormycosis 268.10 10.81 126 127745 2745 63358406
Cytomegalovirus colitis 265.23 10.81 118 127753 2254 63358897
Renal impairment 262.82 10.81 562 127309 87793 63273358
Heart transplant rejection 246.39 10.81 78 127793 537 63360614
Delayed graft function 242.49 10.81 89 127782 1004 63360147
Constipation 240.15 10.81 77 127794 224866 63136285
Bronchopulmonary aspergillosis 239.63 10.81 172 127699 8463 63352688
Haemophagocytic lymphohistiocytosis 233.36 10.81 184 127687 10443 63350708
JC virus infection 232.44 10.81 103 127768 1948 63359203
Drug ineffective for unapproved indication 227.89 10.81 311 127560 33752 63327399
Dyspnoea 226.23 10.81 638 127233 660675 62700476
Dizziness 225.54 10.81 323 127548 429602 62931549
Sciatica 224.54 10.81 310 127561 34014 63327137
Central nervous system lymphoma 221.81 10.81 91 127780 1411 63359740
Aplasia pure red cell 220.38 10.81 128 127743 4359 63356792
Cystitis haemorrhagic 216.90 10.81 123 127748 4000 63357151
Hypogammaglobulinaemia 215.88 10.81 150 127721 7005 63354146
Escherichia infection 213.99 10.81 189 127682 12565 63348586
Lupus nephritis 212.19 10.81 107 127764 2732 63358419
Pseudomonas infection 206.00 10.81 175 127696 11038 63350113
Nausea 205.86 10.81 955 126916 853516 62507635
Proteinuria 205.30 10.81 222 127649 18923 63342228
Progressive multifocal leukoencephalopathy 203.36 10.81 185 127686 12786 63348365
Septic shock 198.31 10.81 424 127447 66205 63294946
Arthralgia 198.11 10.81 545 127326 569165 62791986
Back pain 193.95 10.81 149 127722 263996 63097155
Mycobacterial infection 190.75 10.81 86 127785 1697 63359454
Injection site pain 190.25 10.81 20 127851 129780 63231371
Headache 190.17 10.81 648 127223 632593 62728558
Herpes simplex 187.65 10.81 146 127725 8125 63353026
Brain abscess 185.68 10.81 89 127782 2029 63359122
Enterococcal infection 183.43 10.81 141 127730 7707 63353444
Chronic graft versus host disease in skin 180.80 10.81 65 127806 688 63360463
Pain in extremity 179.75 10.81 243 127628 331243 63029908
Malacoplakia 177.16 10.81 46 127825 134 63361017
Malaise 177.15 10.81 357 127514 415597 62945554
Sepsis 176.24 10.81 692 127179 152431 63208720
Strongyloidiasis 175.45 10.81 73 127798 1175 63359976
Cerebral toxoplasmosis 174.82 10.81 68 127803 910 63360241
Histoplasmosis disseminated 174.33 10.81 76 127795 1380 63359771
Focal segmental glomerulosclerosis 173.73 10.81 76 127795 1392 63359759
Pneumonia cytomegaloviral 172.99 10.81 86 127785 2128 63359023
Bacteraemia 170.18 10.81 192 127679 17156 63343995
Disease recurrence 169.74 10.81 244 127627 27786 63333365
Toxoplasmosis 167.84 10.81 75 127796 1448 63359703
Haemolytic uraemic syndrome 165.87 10.81 87 127784 2416 63358735
Graft loss 164.87 10.81 51 127820 322 63360829
Cryptococcosis 160.38 10.81 67 127804 1090 63360061
Feeling abnormal 159.71 10.81 50 127821 148342 63212809
Human polyomavirus infection 158.10 10.81 48 127823 282 63360869
Parvovirus B19 infection 156.24 10.81 54 127817 504 63360647
Acute respiratory distress syndrome 156.09 10.81 214 127657 23320 63337831
Anti-erythropoietin antibody negative 155.82 10.81 39 127832 93 63361058
Respiratory failure 155.42 10.81 505 127366 101353 63259798
Epstein-Barr viraemia 155.33 10.81 63 127808 947 63360204
Lung transplant rejection 153.56 10.81 61 127810 866 63360285
Disseminated cryptococcosis 153.10 10.81 50 127821 385 63360766
Microtia 152.98 10.81 49 127822 352 63360799
Meningitis cryptococcal 152.35 10.81 68 127803 1309 63359842
Viraemia 148.85 10.81 66 127805 1250 63359901
Drug resistance 146.79 10.81 205 127666 22728 63338423
Phaeohyphomycosis 144.28 10.81 44 127827 263 63360888
Histoplasmosis 143.55 10.81 73 127798 1898 63359253
Lymphocele 143.19 10.81 56 127815 761 63360390
Hepatitis E 142.98 10.81 66 127805 1378 63359773
Acute graft versus host disease in liver 142.83 10.81 53 127818 618 63360533
Vaccination failure 142.42 10.81 55 127816 721 63360430
Atypical haemolytic uraemic syndrome 141.71 10.81 54 127817 681 63360470
Renal tubular necrosis 138.46 10.81 144 127727 11734 63349417
Encephalitis viral 137.47 10.81 68 127803 1664 63359487
West Nile viral infection 136.73 10.81 45 127826 356 63360795
Injection site erythema 132.30 10.81 9 127862 83165 63277986
Rash 131.57 10.81 632 127239 560239 62800912
Drug abuse 131.48 10.81 3 127868 72515 63288636
Cytomegalovirus test positive 129.71 10.81 79 127792 2939 63358212
Scedosporium infection 129.19 10.81 47 127824 516 63360635
Infection reactivation 128.80 10.81 58 127813 1141 63360010
Cytomegalovirus gastrointestinal infection 127.03 10.81 40 127831 270 63360881
Product dose omission issue 125.66 10.81 173 127698 234140 63127011
Blood creatinine increased 124.62 10.81 425 127446 87419 63273732
Kidney fibrosis 123.56 10.81 65 127806 1816 63359335
Nephrotic syndrome 119.11 10.81 95 127776 5481 63355670
Hypersensitivity 118.73 10.81 258 127613 292427 63068724
Therapy partial responder 118.51 10.81 126 127745 10532 63350619
Renal tubular atrophy 117.95 10.81 48 127823 728 63360423
Epidermodysplasia verruciformis 116.79 10.81 31 127840 101 63361050
Peripheral swelling 116.73 10.81 224 127647 265718 63095433
Pruritus 116.44 10.81 358 127513 361095 63000056
Viral haemorrhagic cystitis 116.03 10.81 49 127822 820 63360331
Psoriasis 114.03 10.81 19 127852 86938 63274213
Renal graft infection 112.34 10.81 35 127836 227 63360924
Graft versus host disease in liver 111.51 10.81 44 127827 613 63360538
Venoocclusive liver disease 111.10 10.81 86 127785 4749 63356402
Pathogen resistance 109.70 10.81 96 127775 6302 63354849
Systemic candida 107.31 10.81 72 127799 3173 63357978
Cytomegalovirus chorioretinitis 106.65 10.81 58 127813 1735 63359416
Hyperhidrosis 106.30 10.81 42 127829 107794 63253357
Asthenia 105.91 10.81 406 127465 383198 62977953
Inappropriate schedule of product administration 104.96 10.81 39 127832 103926 63257225
Acute kidney injury 104.61 10.81 896 126975 262519 63098632
Renal phospholipidosis 103.65 10.81 27 127844 80 63361071
Nasopharyngitis 103.20 10.81 224 127647 254033 63107118
Pneumonia bacterial 101.90 10.81 110 127761 9355 63351796
Adenoviral hepatitis 101.51 10.81 36 127835 365 63360786
Syncope 101.34 10.81 55 127816 117330 63243821
Lymphoproliferative disorder 101.24 10.81 69 127802 3121 63358030
Glomerulonephritis 100.76 10.81 56 127815 1750 63359401
Treatment failure 100.56 10.81 716 127155 198327 63162824
Blood iron abnormal 100.26 10.81 74 127797 3802 63357349
Microsporidia infection 99.95 10.81 33 127838 264 63360887
Death 99.67 10.81 402 127469 373979 62987172
Drug level increased 98.84 10.81 170 127701 22566 63338585
Chest discomfort 98.68 10.81 49 127822 109920 63251231
Immunosuppressant drug level decreased 98.44 10.81 45 127826 918 63360233
Pulmonary nocardiosis 97.84 10.81 34 127837 323 63360828
Anxiety 97.39 10.81 181 127690 217360 63143791
Chronic graft versus host disease in liver 96.92 10.81 32 127839 256 63360895
Muscle spasms 95.59 10.81 104 127767 156046 63205105
Loss of consciousness 95.38 10.81 60 127811 118061 63243090
Abdominal discomfort 94.87 10.81 330 127541 320555 63040596
Joint swelling 94.19 10.81 341 127530 327325 63033826
Swelling 93.50 10.81 266 127605 275112 63086039
Epstein-Barr virus associated lymphoma 92.53 10.81 36 127835 482 63360669
Systemic mycosis 92.06 10.81 46 127825 1151 63360000
Arthropathy 91.88 10.81 211 127660 234581 63126570
Diabetes mellitus 91.75 10.81 284 127587 55526 63305625
Intentional product use issue 90.78 10.81 502 127369 127390 63233761
Cryptosporidiosis infection 89.81 10.81 31 127840 288 63360863
Infusion related reaction 88.71 10.81 230 127641 245291 63115860
Palpitations 88.71 10.81 59 127812 112711 63248440
Hepatitis C 88.15 10.81 78 127793 5196 63355955
Ureaplasma infection 87.90 10.81 37 127834 614 63360537
Obliterative bronchiolitis 87.89 10.81 54 127817 2041 63359110
Squamous cell carcinoma of skin 87.50 10.81 83 127788 6049 63355102
Deep vein thrombosis postoperative 87.14 10.81 111 127760 11258 63349893
Vomiting 86.90 10.81 716 127155 558901 62802250
External auditory canal atresia 86.88 10.81 22 127849 56 63361095
Injection site reaction 85.77 10.81 9 127862 58515 63302636
End stage renal disease 85.02 10.81 85 127786 6608 63354543
SARS-CoV-2 RNA increased 85.01 10.81 22 127849 63 63361088
Haemolytic anaemia 84.23 10.81 103 127768 10022 63351129
Pre-engraftment immune reaction 82.32 10.81 27 127844 211 63360940
Glomerulonephritis membranoproliferative 80.79 10.81 26 127845 190 63360961
Glossodynia 80.78 10.81 148 127723 178728 63182423
Autoimmune disorder 80.73 10.81 133 127738 17044 63344107
Immune reconstitution inflammatory syndrome 80.50 10.81 79 127792 6005 63355146
Oesophageal atresia 79.83 10.81 33 127838 522 63360629
Depression 79.79 10.81 173 127698 196319 63164832
Erythema 79.73 10.81 145 127726 175606 63185545
Gait disturbance 79.70 10.81 155 127716 183023 63178128
Bacterial sepsis 79.39 10.81 65 127806 3893 63357258
Injection site swelling 79.14 10.81 4 127867 47568 63313583
Flushing 77.77 10.81 27 127844 75060 63286091
Pyelonephritis 77.37 10.81 133 127738 17645 63343506
Therapy non-responder 76.93 10.81 330 127541 75571 63285580
Pancreas transplant rejection 76.50 10.81 23 127848 130 63361021
Locked-in syndrome 76.29 10.81 30 127841 414 63360737
Hypotension 76.14 10.81 287 127584 272317 63088834
Cardiac failure congestive 75.94 10.81 46 127825 92387 63268764
Chronic obstructive pulmonary disease 75.21 10.81 17 127854 62669 63298482
Balance disorder 75.16 10.81 38 127833 84384 63276767
Emphysematous pyelonephritis 74.44 10.81 26 127845 251 63360900
New onset diabetes after transplantation 74.07 10.81 21 127850 93 63361058
Cytomegalovirus enteritis 73.19 10.81 26 127845 265 63360886
Pancytopenia 73.18 10.81 387 127484 96546 63264605
Body tinea 72.55 10.81 46 127825 1839 63359312
Multiple sclerosis relapse 72.22 10.81 7 127864 48471 63312680
Drug ineffective 71.80 10.81 2672 125199 1042093 62319058
Electrocardiogram QT prolonged 71.72 10.81 16 127855 59514 63301637
Intentional overdose 71.25 10.81 30 127841 74122 63287029
Myocardial infarction 71.13 10.81 58 127813 99835 63261316
Bacillary angiomatosis 70.46 10.81 20 127851 89 63361062
Penicillium infection 70.40 10.81 21 127850 115 63361036
Pemphigus 70.33 10.81 167 127704 183559 63177592
SLE arthritis 70.17 10.81 32 127839 649 63360502
Graft versus host disease in lung 69.84 10.81 27 127844 355 63360796
Graft complication 68.69 10.81 24 127847 232 63360919
Injection site bruising 68.24 10.81 4 127867 41906 63319245
Neutrophil Pelger-Huet anomaly present 67.97 10.81 19 127852 79 63361072
Necrotising retinitis 67.86 10.81 27 127844 385 63360766
Babesiosis 67.38 10.81 23 127848 206 63360945
Malignant neoplasm progression 67.27 10.81 41 127830 82080 63279071
Encephalitis 66.96 10.81 86 127785 8794 63352357
Biopsy lung abnormal 66.78 10.81 21 127850 141 63361010
Dysplasia 66.44 10.81 34 127837 896 63360255
Visceral leishmaniasis 66.14 10.81 29 127842 534 63360617
Complications of transplanted heart 65.86 10.81 17 127854 48 63361103
Stress 64.81 10.81 27 127844 67140 63294011
Human herpesvirus 8 infection 64.70 10.81 23 127848 235 63360916
Vision blurred 64.67 10.81 54 127817 91870 63269281
Abortion spontaneous 63.99 10.81 225 127646 46970 63314181
Ascites 63.94 10.81 204 127667 40524 63320627
Insomnia 63.80 10.81 221 127650 215031 63146120
Nephrectomy 63.60 10.81 39 127832 1469 63359682
Encephalitis cytomegalovirus 63.02 10.81 28 127843 533 63360618
Ureteric stenosis 62.97 10.81 29 127842 602 63360549
Neuropathy peripheral 62.83 10.81 82 127789 113585 63247566
Papilloma viral infection 62.15 10.81 39 127832 1531 63359620
Glomerulosclerosis 61.38 10.81 25 127846 380 63360771
Encapsulating peritoneal sclerosis 61.37 10.81 24 127847 326 63360825
Donor specific antibody present 61.01 10.81 20 127851 156 63360995
Candida infection 60.97 10.81 159 127712 28192 63332959
Herpes zoster 60.72 10.81 327 127544 82135 63279016
Cerebrovascular accident 60.67 10.81 77 127794 107947 63253204
Glucose tolerance impaired 59.79 10.81 70 127801 6507 63354644
Influenza like illness 59.60 10.81 30 127841 66794 63294357
Pulmonary mucormycosis 58.98 10.81 23 127848 310 63360841
Swelling face 58.90 10.81 27 127844 63448 63297703
Mycoplasma infection 58.85 10.81 26 127845 488 63360663
Coloboma 58.78 10.81 17 127854 82 63361069
Mycobacterium abscessus infection 58.50 10.81 28 127843 636 63360515
Lymphopenia 58.41 10.81 120 127751 18207 63342944
Central nervous system fungal infection 58.41 10.81 18 127853 112 63361039
Hypokalaemia 58.28 10.81 74 127797 103730 63257421
Pneumonia fungal 58.02 10.81 63 127808 5392 63355759
Nasal congestion 57.78 10.81 30 127841 65630 63295521
Disseminated mycobacterium avium complex infection 57.74 10.81 18 127853 117 63361034
Hepatic enzyme increased 57.12 10.81 212 127659 202116 63159035
Cryptococcal meningoencephalitis 56.86 10.81 17 127854 94 63361057
Peritonitis 56.67 10.81 114 127757 17040 63344111
Humoral immune defect 56.66 10.81 21 127850 244 63360907
Complications of transplanted lung 56.35 10.81 21 127850 248 63360903
Hand deformity 56.32 10.81 151 127720 159306 63201845
Bronchial polyp 55.69 10.81 16 127855 75 63361076
Multifocal micronodular pneumocyte hyperplasia 55.69 10.81 16 127855 75 63361076
Steroid diabetes 55.60 10.81 34 127837 1274 63359877
Dehydration 55.49 10.81 172 127699 173182 63187969
Anogenital warts 55.32 10.81 25 127846 496 63360655
Paraesthesia 55.17 10.81 149 127722 156817 63204334
Renal tubular injury 55.14 10.81 25 127846 500 63360651
Agranulocytosis 55.12 10.81 142 127729 24992 63336159
Venoocclusive disease 54.83 10.81 40 127831 2018 63359133
IgA nephropathy 54.79 10.81 26 127845 579 63360572
Hypertelorism 54.64 10.81 24 127847 444 63360707
Rash pruritic 54.62 10.81 26 127845 59773 63301378
Legionella infection 54.54 10.81 24 127847 446 63360705
Wound 54.40 10.81 159 127712 163104 63198047
Bone pain 54.30 10.81 21 127850 54620 63306531
Encephalitis autoimmune 54.07 10.81 35 127836 1451 63359700
Reversible cerebral vasoconstriction syndrome 54.04 10.81 44 127827 2614 63358537
Alveolar proteinosis 53.51 10.81 22 127849 343 63360808
Inhibitory drug interaction 53.42 10.81 45 127826 2804 63358347
Hallucination 52.95 10.81 22 127849 54795 63306356
Infection susceptibility increased 52.81 10.81 49 127822 3472 63357679
Suicidal ideation 52.77 10.81 30 127841 62391 63298760
Pleural mesothelioma malignant 52.65 10.81 14 127857 46 63361105
Pneumonia aspiration 52.40 10.81 171 127700 34369 63326782
Discomfort 52.22 10.81 168 127703 167206 63193945
Symptom masked 52.06 10.81 27 127844 732 63360419
Acinetobacter infection 52.05 10.81 35 127836 1548 63359603
Pneumocystis jirovecii infection 51.66 10.81 34 127837 1450 63359701
Chronic graft versus host disease oral 51.60 10.81 17 127854 135 63361016
Atrial fibrillation 51.31 10.81 98 127773 116538 63244613
Citrobacter infection 51.19 10.81 23 127848 450 63360701
Microangiopathic haemolytic anaemia 51.06 10.81 25 127846 598 63360553
Eye infection toxoplasmal 50.92 10.81 20 127851 275 63360876
Urinary tract infection viral 50.32 10.81 14 127857 57 63361094
Mycobacterium avium complex infection 50.28 10.81 45 127826 3043 63358108
Orf 50.06 10.81 12 127859 22 63361129
Tuberculosis gastrointestinal 49.69 10.81 21 127850 352 63360799
Rebound effect 49.42 10.81 53 127818 4473 63356678
Disseminated toxoplasmosis 49.13 10.81 16 127855 122 63361029
Pneumonia klebsiella 49.09 10.81 40 127831 2379 63358772
COVID-19 pneumonia 48.83 10.81 96 127775 14113 63347038
Vesicoureteric reflux 48.81 10.81 18 127853 206 63360945
Lactic acidosis 48.80 10.81 9 127862 38278 63322873
Coccidioidomycosis 48.67 10.81 28 127843 936 63360215
Disseminated varicella zoster virus infection 48.59 10.81 19 127852 258 63360893
Interstitial lung disease 47.97 10.81 249 127622 61659 63299492
Bradycardia 47.93 10.81 46 127825 73181 63287970
Atypical mycobacterial infection 47.80 10.81 29 127842 1071 63360080
Tubulointerstitial nephritis 47.37 10.81 116 127755 19787 63341364
Wrong technique in product usage process 47.17 10.81 34 127837 62306 63298845
Escherichia bacteraemia 46.92 10.81 48 127823 3835 63357316
Alternaria infection 46.81 10.81 18 127853 233 63360918
Cytomegalovirus hepatitis 46.75 10.81 20 127851 346 63360805
Polyomavirus test positive 46.59 10.81 14 127857 79 63361072
Chronic myeloid leukaemia 46.35 10.81 38 127833 2280 63358871
Osteonecrosis 46.18 10.81 131 127740 24399 63336752
Gastroenteritis norovirus 45.81 10.81 36 127835 2032 63359119
Trichophytosis 45.77 10.81 13 127858 58 63361093
Blastomycosis 45.77 10.81 19 127852 304 63360847
Cytopenia 45.59 10.81 83 127788 11518 63349633
Neoplasm progression 45.50 10.81 9 127862 36419 63324732
Liver abscess 45.31 10.81 41 127830 2813 63358338
Pneumonia cryptococcal 45.25 10.81 25 127846 772 63360379
Graft versus host disease in eye 45.24 10.81 13 127858 61 63361090
Orthostatic hypotension 45.03 10.81 9 127862 36151 63325000
Pneumatosis intestinalis 45.01 10.81 38 127833 2375 63358776
Vertigo 44.88 10.81 33 127838 59854 63301297
Psoriatic arthropathy 44.86 10.81 327 127544 91193 63269958
Complications of transplanted liver 44.81 10.81 20 127851 385 63360766
Apoptosis 44.78 10.81 14 127857 92 63361059
Arthritis bacterial 44.71 10.81 60 127811 6403 63354748
Cough 44.64 10.81 376 127495 292367 63068784
Unevaluable event 44.44 10.81 24 127847 51362 63309789
Bone marrow failure 44.42 10.81 145 127726 29145 63332006
Cushingoid 44.40 10.81 69 127802 8416 63352735
Micrognathia 44.17 10.81 18 127853 274 63360877
Renal transplant 44.15 10.81 30 127841 1350 63359801
Cognitive disorder 44.15 10.81 29 127842 55786 63305365
Abdominal pain upper 44.02 10.81 240 127631 206204 63154947
Synovitis 43.99 10.81 210 127661 186708 63174443
Oedema peripheral 43.97 10.81 214 127657 189297 63171854
Elbow deformity 43.93 10.81 31 127840 1484 63359667
Staphylococcal infection 43.83 10.81 182 127689 41074 63320077
Idiopathic pneumonia syndrome 43.78 10.81 19 127852 341 63360810
Opportunistic infection 43.64 10.81 34 127837 1895 63359256
Bacterial infection 43.62 10.81 111 127760 19388 63341763
Human herpesvirus 6 encephalitis 43.53 10.81 17 127854 230 63360921
Renal tubular disorder 43.50 10.81 39 127832 2643 63358508
Confusional state 43.46 10.81 288 127583 236092 63125059
Escherichia sepsis 43.38 10.81 52 127819 4955 63356196
Anti-cyclic citrullinated peptide antibody positive 43.37 10.81 107 127764 116105 63245046
Mycobacterium chelonae infection 43.32 10.81 21 127850 491 63360660
Q fever 43.21 10.81 15 127856 142 63361009
Liver function test abnormal 43.18 10.81 202 127669 47979 63313172
Somnolence 43.08 10.81 199 127672 178486 63182665
Reticulocytopenia 43.02 10.81 13 127858 75 63361076
Haemodynamic instability 42.97 10.81 71 127800 9119 63352032
Angiosarcoma 42.88 10.81 17 127854 240 63360911
Cystitis viral 42.84 10.81 15 127856 146 63361005
Hot flush 42.66 10.81 25 127846 51134 63310017
Enterococcal bacteraemia 42.64 10.81 30 127841 1429 63359722
Myopathy 42.63 10.81 79 127792 11112 63350039
Suicide attempt 42.58 10.81 36 127835 60882 63300269
Vasogenic cerebral oedema 42.52 10.81 25 127846 871 63360280
Abdominal distension 42.43 10.81 68 127803 86547 63274604
Lymphocytic infiltration 42.16 10.81 25 127846 885 63360266
Splenic abscess 42.13 10.81 15 127856 154 63360997
Acute myeloid leukaemia recurrent 42.01 10.81 31 127840 1592 63359559
Metastatic squamous cell carcinoma 42.01 10.81 17 127854 254 63360897
Remission not achieved 41.87 10.81 14 127857 117 63361034
Sedation 41.86 10.81 13 127858 38796 63322355
Renal artery stenosis 41.79 10.81 33 127838 1876 63359275
Blood pressure increased 41.79 10.81 176 127695 161886 63199265
Blood calcium decreased 41.65 10.81 3 127868 26448 63334703
Urticaria 41.56 10.81 182 127689 165620 63195531
Full blood count abnormal 41.42 10.81 7 127864 31710 63329441
Enterobacter infection 41.40 10.81 35 127836 2192 63358959
Pulmonary alveolar haemorrhage 41.30 10.81 49 127822 4619 63356532
C-reactive protein 41.16 10.81 50 127821 4832 63356319
White blood cell count decreased 41.07 10.81 143 127728 138961 63222190
Hyponatraemia 41.00 10.81 104 127767 111796 63249355
Cerebral aspergillosis 40.89 10.81 19 127852 403 63360748
Accidental exposure to product 40.71 10.81 4 127867 27401 63333750
Nodular regenerative hyperplasia 40.56 10.81 20 127851 486 63360665
Engraftment syndrome 40.48 10.81 20 127851 488 63360663
Sleep disorder due to general medical condition, insomnia type 40.44 10.81 210 127661 52007 63309144
Cytomegalovirus gastritis 40.34 10.81 15 127856 176 63360975
Disseminated blastomycosis 40.20 10.81 10 127861 23 63361128
Contraindicated product administered 40.10 10.81 265 127606 217383 63143768
Bronchitis 39.94 10.81 124 127747 124811 63236340
Hepatic cyst infection 39.93 10.81 13 127858 99 63361052
Neutrophil count decreased 39.84 10.81 33 127838 56373 63304778
Dermatomyositis 39.59 10.81 38 127833 2810 63358341
Passenger lymphocyte syndrome 39.45 10.81 12 127859 71 63361080
Epstein-Barr virus test positive 39.36 10.81 21 127850 604 63360547
Infection in an immunocompromised host 39.05 10.81 22 127849 706 63360445
Foot deformity 39.02 10.81 5 127866 27848 63333303
Hypoglycaemia 39.00 10.81 38 127833 60027 63301124
Drug hypersensitivity 38.86 10.81 419 127452 310268 63050883
Sarcoma of skin 38.80 10.81 10 127861 28 63361123
Cytomegalovirus oesophagitis 38.77 10.81 16 127855 252 63360899
Rhodococcus infection 38.73 10.81 13 127858 110 63361041
Actinic keratosis 38.60 10.81 36 127835 2568 63358583
Hepatic fibrosis 38.53 10.81 42 127829 3610 63357541
Chronic graft versus host disease in eye 38.53 10.81 13 127858 112 63361039
Myalgia 38.48 10.81 158 127713 146371 63214780
Transient ischaemic attack 38.36 10.81 14 127857 37739 63323412
Lupus vasculitis 38.34 10.81 20 127851 549 63360602
Urate nephropathy 38.33 10.81 13 127858 114 63361037
Haematochezia 38.22 10.81 31 127840 53513 63307638
Human ehrlichiosis 38.14 10.81 14 127857 158 63360993
Full blood count decreased 38.13 10.81 4 127867 26020 63335131
Angioedema 37.83 10.81 25 127846 47940 63313211
Drug withdrawal syndrome 37.81 10.81 5 127866 27189 63333962
Therapeutic product effect decreased 37.75 10.81 231 127640 192956 63168195
Injection site haemorrhage 37.60 10.81 3 127868 24311 63336840
Serum sickness 37.58 10.81 37 127834 2823 63358328
Neutropenia 37.57 10.81 527 127344 174478 63186673
Feeling hot 37.40 10.81 28 127843 50326 63310825
Periostitis 37.36 10.81 17 127854 343 63360808
Proteus infection 37.23 10.81 25 127846 1103 63360048
Complications of transplant surgery 37.22 10.81 14 127857 170 63360981
Swollen tongue 36.92 10.81 12 127859 34788 63326363
Cytomegalovirus urinary tract infection 36.91 10.81 11 127860 60 63361091
Vascular graft complication 36.91 10.81 10 127861 36 63361115
Bronchiolitis obliterans syndrome 36.90 10.81 13 127858 129 63361022
Femur fracture 36.85 10.81 19 127852 41737 63319414
Drug level decreased 36.79 10.81 61 127810 7858 63353293
Rectal haemorrhage 36.76 10.81 27 127844 49003 63312148
Pneumonia adenoviral 36.64 10.81 13 127858 132 63361019
Dermatophytosis 36.64 10.81 14 127857 178 63360973
Hepatic necrosis 36.63 10.81 51 127820 5636 63355515
Incorrect dose administered 36.60 10.81 40 127831 59928 63301223
Laryngeal disorder 36.58 10.81 24 127847 1018 63360133
Cerebral fungal infection 36.45 10.81 12 127859 95 63361056
Haemodialysis 36.42 10.81 65 127806 8882 63352269
Drug interaction 36.36 10.81 656 127215 228475 63132676
Post transplant distal limb syndrome 36.24 10.81 15 127856 238 63360913
Staphylococcal bacteraemia 36.23 10.81 50 127821 5480 63355671
Blood potassium decreased 35.81 10.81 20 127851 42006 63319145
Type 1 diabetes mellitus 35.56 10.81 41 127830 3749 63357402
Squamous cell carcinoma 35.51 10.81 63 127808 8569 63352582
Perinephric abscess 35.48 10.81 14 127857 195 63360956
Urinary tract infection enterococcal 35.47 10.81 35 127836 2678 63358473
Central nervous system viral infection 35.40 10.81 12 127859 105 63361046
Chest pain 35.37 10.81 272 127599 215687 63145464
Anorexia nervosa 35.30 10.81 15 127856 255 63360896
Scleroderma 35.21 10.81 49 127822 5413 63355738
Asthma 35.11 10.81 135 127736 127426 63233725
Respiratory arrest 35.09 10.81 11 127860 32634 63328517
Disease progression 35.08 10.81 390 127481 122368 63238783
Overlap syndrome 34.82 10.81 22 127849 874 63360277
Kaposi's sarcoma 34.77 10.81 13 127858 155 63360996
Dysphonia 34.70 10.81 27 127844 47587 63313564
Cholangitis 34.52 10.81 49 127822 5512 63355639
Presyncope 34.42 10.81 7 127864 27778 63333373
Skin squamous cell carcinoma metastatic 34.37 10.81 8 127863 12 63361139
Exposure via partner 34.34 10.81 12 127859 116 63361035
Pneumonia influenzal 34.31 10.81 28 127843 1669 63359482
Necrotising fasciitis 33.89 10.81 36 127835 3005 63358146
Disseminated tuberculosis 33.85 10.81 35 127836 2832 63358319
Chills 33.83 10.81 116 127755 113262 63247889
Hepatitis B 33.71 10.81 40 127831 3772 63357379
Cleft lip and palate 33.55 10.81 19 127852 616 63360535
Hypertrophic osteoarthropathy 33.52 10.81 9 127862 31 63361120
Capillaritis 33.29 10.81 12 127859 128 63361023
Clostridium difficile colitis 33.17 10.81 104 127767 20465 63340686
Escherichia urinary tract infection 33.14 10.81 74 127797 11888 63349263
Central nervous system infection 33.03 10.81 20 127851 736 63360415
Malacoplakia gastrointestinal 32.90 10.81 10 127861 59 63361092
Disseminated aspergillosis 32.78 10.81 11 127860 93 63361058
Drug effective for unapproved indication 32.59 10.81 37 127834 3327 63357824
Oropharyngeal pain 32.21 10.81 91 127780 94396 63266755
Gastroenteritis rotavirus 32.18 10.81 12 127859 142 63361009
Overdose 32.18 10.81 121 127750 114957 63246194
Dysgeusia 32.16 10.81 28 127843 46682 63314469
Orbital apex syndrome 32.09 10.81 9 127862 38 63361113
Epstein-Barr virus infection reactivation 32.03 10.81 20 127851 778 63360373
Herpes simplex hepatitis 31.96 10.81 16 127855 402 63360749
Brain oedema 31.95 10.81 81 127790 14114 63347037
Biliary anastomosis complication 31.90 10.81 9 127862 39 63361112
Serositis 31.85 10.81 19 127852 680 63360471
Pneumomediastinum 31.82 10.81 25 127846 1411 63359740
Granuloma 31.77 10.81 48 127823 5713 63355438
International normalised ratio increased 31.76 10.81 28 127843 46397 63314754
Infectious pleural effusion 31.75 10.81 26 127845 1557 63359594
Urinary tract infection bacterial 31.60 10.81 45 127826 5077 63356074
Restlessness 31.53 10.81 10 127861 29443 63331708
Prophylaxis against transplant rejection 31.42 10.81 8 127863 21 63361130
Disturbance in attention 31.36 10.81 19 127852 38170 63322981
Herpes simplex meningitis 31.19 10.81 9 127862 43 63361108
Urosepsis 31.11 10.81 95 127776 18429 63342722
Pleocytosis 30.98 10.81 20 127851 825 63360326
Cardiac disorder 30.90 10.81 34 127837 50782 63310369
Hyperammonaemia 30.87 10.81 45 127826 5187 63355964
Lip swelling 30.76 10.81 12 127859 31051 63330100
American trypanosomiasis 30.73 10.81 10 127861 76 63361075
Necrosis 30.66 10.81 46 127825 5441 63355710
Haemorrhage intracranial 30.65 10.81 77 127794 13342 63347809
Product quality issue 30.65 10.81 17 127854 35848 63325303
Human herpesvirus 6 infection reactivation 30.63 10.81 15 127856 359 63360792
Gingival hypertrophy 30.53 10.81 26 127845 1645 63359506
Macular degeneration 30.49 10.81 6 127865 24370 63336781
Staphylococcal sepsis 30.49 10.81 57 127814 8071 63353080
Secondary immunodeficiency 30.48 10.81 24 127847 1359 63359792
Pyelonephritis acute 30.46 10.81 42 127829 4599 63356552
Dry skin 30.45 10.81 42 127829 56845 63304306
Rheumatic disorder 30.12 10.81 34 127837 3038 63358113
Calciphylaxis 30.12 10.81 34 127837 3038 63358113
Norovirus infection 29.98 10.81 18 127853 652 63360499
Urine protein/creatinine ratio increased 29.98 10.81 18 127853 652 63360499
Septic embolus 29.89 10.81 20 127851 877 63360274
Delayed engraftment 29.74 10.81 11 127860 127 63361024
Cytomegalovirus enterocolitis 29.71 10.81 18 127853 663 63360488
Renal failure 29.71 10.81 365 127506 117287 63243864
Feeling cold 29.63 10.81 6 127865 23882 63337269
BK polyomavirus test positive 29.62 10.81 9 127862 53 63361098
Myocardial necrosis 29.55 10.81 12 127859 181 63360970
Lysozyme increased 29.50 10.81 7 127864 12 63361139
Shock haemorrhagic 29.45 10.81 63 127808 9832 63351319
Cardio-respiratory arrest 29.43 10.81 47 127824 59912 63301239
Renal necrosis 29.34 10.81 9 127862 55 63361096
Autoimmune haemolytic anaemia 29.24 10.81 41 127830 4560 63356591
Abdominal wall infection 29.15 10.81 10 127861 91 63361060
Glomerulonephritis proliferative 29.02 10.81 12 127859 190 63360961
Encephalopathy 28.99 10.81 154 127717 38466 63322685
Lung infiltration 28.96 10.81 79 127792 14384 63346767
Flatulence 28.87 10.81 17 127854 34685 63326466
Congenital nail disorder 28.87 10.81 10 127861 94 63361057
Forced vital capacity decreased 28.81 10.81 21 127850 1058 63360093
Acquired plagiocephaly 28.81 10.81 7 127864 14 63361137
Fibromatosis colli of infancy 28.81 10.81 7 127864 14 63361137
Central nervous system vasculitis 28.78 10.81 20 127851 934 63360217
Sinus disorder 28.77 10.81 7 127864 24546 63336605
General physical health deterioration 28.76 10.81 263 127608 201139 63160012
Crying 28.67 10.81 6 127865 23337 63337814
Listeriosis 28.47 10.81 24 127847 1497 63359654
Nephritis 28.42 10.81 30 127841 2486 63358665
Candida sepsis 28.39 10.81 23 127848 1357 63359794
Lethargy 28.35 10.81 43 127828 55964 63305187
Lacrimation increased 28.20 10.81 4 127867 20627 63340524
Neck pain 28.13 10.81 61 127810 69257 63291894
Stenotrophomonas infection 28.09 10.81 27 127844 2000 63359151
Lower respiratory tract infection 28.08 10.81 154 127717 132153 63228998
Nephrogenic systemic fibrosis 28.07 10.81 40 127831 4516 63356635
Skin graft rejection 27.88 10.81 7 127864 17 63361134
Trichosporon infection 27.83 10.81 13 127858 279 63360872
Intentional product misuse 27.83 10.81 50 127821 60867 63300284
Graft thrombosis 27.83 10.81 11 127860 154 63360997
Parvovirus infection 27.71 10.81 13 127858 282 63360869
Fungal skin infection 27.63 10.81 40 127831 4582 63356569
Mycobacterium fortuitum infection 27.59 10.81 8 127863 39 63361112
Unresponsive to stimuli 27.52 10.81 17 127854 33799 63327352
Nervousness 27.48 10.81 14 127857 30965 63330186
Cat scratch disease 27.42 10.81 12 127859 220 63360931
Hydronephrosis 27.37 10.81 64 127807 10598 63350553
Complications of bone marrow transplant 27.36 10.81 15 127856 456 63360695
Agitation 27.34 10.81 49 127822 59708 63301443
Gallbladder disorder 27.34 10.81 3 127868 18839 63342312
Graft ischaemia 27.26 10.81 8 127863 41 63361110
Fluid retention 27.26 10.81 49 127822 59637 63301514
Body temperature increased 27.21 10.81 21 127850 37171 63323980
Hepatic artery thrombosis 27.15 10.81 9 127862 73 63361078
Nephropathy 27.02 10.81 47 127824 6294 63354857
Disseminated intravascular coagulation 26.84 10.81 92 127779 18959 63342192
Oesophageal candidiasis 26.81 10.81 44 127827 5619 63355532
Liver transplant failure 26.81 10.81 7 127864 21 63361130
Gouty tophus 26.79 10.81 12 127859 233 63360918
Musculoskeletal chest pain 26.77 10.81 5 127866 21078 63340073
Restless legs syndrome 26.76 10.81 3 127868 18528 63342623
Incorrect route of product administration 26.76 10.81 118 127753 27334 63333817
Renal cortical necrosis 26.69 10.81 10 127861 120 63361031
Accidental overdose 26.63 10.81 7 127864 23302 63337849
Throat irritation 26.61 10.81 22 127849 37625 63323526
Anuria 26.58 10.81 70 127801 12481 63348670
Colitis 26.47 10.81 178 127693 48350 63312801
Meningoencephalitis herpetic 26.45 10.81 21 127850 1203 63359948
Status epilepticus 26.41 10.81 79 127792 15154 63345997
Microangiopathy 26.39 10.81 21 127850 1207 63359944
Musculoskeletal stiffness 26.39 10.81 241 127630 184377 63176774
Burning sensation 26.37 10.81 43 127828 54364 63306787
Epistaxis 26.32 10.81 68 127803 72657 63288494
Gastroenteritis adenovirus 26.15 10.81 12 127859 247 63360904
Frequent bowel movements 26.14 10.81 7 127864 23015 63338136
Apoptotic colonopathy 26.10 10.81 7 127864 24 63361127
Herpes virus infection 26.08 10.81 43 127828 5513 63355638
Fungaemia 25.99 10.81 28 127843 2375 63358776
Myelitis 25.98 10.81 22 127849 1381 63359770
Haematuria 25.94 10.81 122 127749 29035 63332116
Angiocentric lymphoma 25.80 10.81 16 127855 615 63360536
Necrotising herpetic retinopathy 25.76 10.81 9 127862 87 63361064
Glomerulonephritis rapidly progressive 25.74 10.81 19 127852 976 63360175
Blood pressure decreased 25.74 10.81 58 127813 64964 63296187
Myopathy toxic 25.71 10.81 15 127856 515 63360636
Irritability 25.70 10.81 16 127855 31678 63329473
Photodermatosis 25.68 10.81 14 127857 421 63360730
Laboratory test abnormal 25.67 10.81 11 127860 26901 63334250
Aspergillosis oral 25.66 10.81 8 127863 52 63361099
Acanthamoeba infection 25.66 10.81 8 127863 52 63361099
Viral vasculitis 25.66 10.81 8 127863 52 63361099
Breast cancer 25.61 10.81 36 127835 48347 63312804
Superinfection bacterial 25.52 10.81 16 127855 627 63360524
Splenomegaly 25.46 10.81 64 127807 11093 63350058
Cleft palate 25.45 10.81 19 127852 993 63360158
Moraxella infection 25.32 10.81 14 127857 433 63360718
Multiple allergies 25.29 10.81 73 127798 13729 63347422
Cytomegalovirus gastroenteritis 25.27 10.81 11 127860 199 63360952
Rash erythematous 25.24 10.81 29 127842 42481 63318670
Pulmonary embolism 25.21 10.81 135 127736 116549 63244602
Swollen joint count increased 25.20 10.81 141 127730 35913 63325238
Skin mass 25.19 10.81 44 127827 5911 63355240
Memory impairment 25.18 10.81 116 127755 104142 63257009
Mediastinitis 25.17 10.81 11 127860 201 63360950
Haematemesis 25.16 10.81 15 127856 30397 63330754
Heart rate decreased 25.03 10.81 33 127838 45527 63315624
Endocarditis 24.99 10.81 43 127828 5707 63355444
Head injury 24.88 10.81 12 127859 27384 63333767
Malacoplakia vesicae 24.79 10.81 8 127863 59 63361092
Drug level fluctuating 24.77 10.81 14 127857 452 63360699
Myelosuppression 24.73 10.81 104 127767 23599 63337552
Arteriovenous fistula occlusion 24.62 10.81 13 127858 366 63360785
Bronchiectasis 24.56 10.81 80 127791 16062 63345089
Illness 24.51 10.81 38 127833 49021 63312130
Hepatitis viral 24.47 10.81 14 127857 463 63360688
Eye irritation 24.35 10.81 7 127864 21964 63339187
Pneumococcal sepsis 24.28 10.81 16 127855 684 63360467
Hepatitis cholestatic 24.28 10.81 47 127824 6831 63354320
Propionibacterium infection 24.16 10.81 7 127864 34 63361117
Limb discomfort 24.10 10.81 15 127856 29701 63331450
Aplastic anaemia 24.09 10.81 57 127814 9512 63351639
Renal artery thrombosis 23.95 10.81 9 127862 109 63361042
Blood pressure diastolic abnormal 23.89 10.81 74 127797 14468 63346683
Mood swings 23.89 10.81 4 127867 18244 63342907
Perihepatic abscess 23.77 10.81 6 127865 15 63361136
Fungal endocarditis 23.73 10.81 11 127860 232 63360919
Disorder of globe 23.70 10.81 5 127866 3 63361148
Urinary tract infection pseudomonal 23.68 10.81 17 127854 836 63360315
Oesophageal stenosis 23.64 10.81 31 127840 3235 63357916
Anaphylactic shock 23.61 10.81 9 127862 23624 63337527
Disseminated trichosporonosis 23.50 10.81 8 127863 71 63361080
Endocarditis Q fever 23.49 10.81 6 127865 16 63361135
Colorectal adenocarcinoma 23.37 10.81 9 127862 117 63361034
Iris coloboma 23.22 10.81 7 127864 40 63361111
Respiratory distress 23.22 10.81 132 127739 33819 63327332
Panic attack 23.17 10.81 8 127863 22323 63338828
Pseudomonal bacteraemia 23.16 10.81 22 127849 1606 63359545
Neurotoxicity 23.02 10.81 81 127790 16909 63344242
Plasma cell myeloma 22.98 10.81 23 127848 35882 63325269
Withdrawal syndrome 22.86 10.81 6 127865 19991 63341160
Ocular hyperaemia 22.85 10.81 11 127860 25133 63336018
Rhesus antigen positive 22.83 10.81 9 127862 125 63361026
Philadelphia positive chronic myeloid leukaemia 22.79 10.81 7 127864 43 63361108
Tuberculosis of central nervous system 22.79 10.81 12 127859 336 63360815
Dementia 22.74 10.81 5 127866 18789 63342362
Cutaneous malacoplakia 22.73 10.81 6 127865 19 63361132
Pallor 22.70 10.81 17 127854 30551 63330600
Chronic kidney disease 22.69 10.81 163 127708 45235 63315916
Blood glucose decreased 22.63 10.81 7 127864 20945 63340206
Pulmonary tuberculosis 22.62 10.81 36 127835 4481 63356670
Granulicatella bacteraemia 22.59 10.81 5 127866 5 63361146
Procedural failure 22.59 10.81 5 127866 5 63361146
Condition aggravated 22.57 10.81 1008 126863 401209 62959942
Malignant catatonia 22.52 10.81 10 127861 190 63360961
Eye pruritus 22.52 10.81 5 127866 18666 63342485
Wound infection 22.38 10.81 94 127777 21316 63339835
Urinary retention 22.31 10.81 17 127854 30284 63330867
Muscle spasticity 22.28 10.81 8 127863 21786 63339365
Jaw fracture 22.24 10.81 27 127844 2607 63358544
Weight decreased 22.21 10.81 408 127463 276390 63084761
Tendonitis 22.20 10.81 6 127865 19609 63341542
Depressed mood 22.19 10.81 29 127842 40162 63320989
Conjunctival melanoma 22.12 10.81 5 127866 6 63361145
Angina pectoris 21.98 10.81 17 127854 30061 63331090
Hiatus hernia 21.95 10.81 8 127863 21586 63339565
Osteonecrosis of jaw 21.91 10.81 23 127848 35100 63326051
Sleep apnoea syndrome 21.89 10.81 16 127855 29117 63332034
Leukoencephalopathy 21.86 10.81 35 127836 4378 63356773
Pulmonary hypoplasia 21.77 10.81 11 127860 282 63360869
Meningitis 21.71 10.81 46 127825 7131 63354020
Disseminated cytomegaloviral infection 21.70 10.81 10 127861 208 63360943
Congenital diaphragmatic hernia 21.70 10.81 10 127861 208 63360943
Normocytic anaemia 21.68 10.81 23 127848 1917 63359234
Chronic graft versus host disease in intestine 21.66 10.81 8 127863 92 63361059
Soft tissue sarcoma 21.51 10.81 9 127862 147 63361004
Tinnitus 21.48 10.81 24 127847 35604 63325547
Muir-Torre syndrome 21.46 10.81 6 127865 25 63361126
Viral myelitis 21.46 10.81 6 127865 25 63361126
Hypersomnia 21.45 10.81 5 127866 18050 63343101
Cutaneous tuberculosis 21.40 10.81 9 127862 149 63361002
Xanthoma 21.31 10.81 7 127864 55 63361096
Heart disease congenital 21.29 10.81 19 127852 1280 63359871
Tracheal atresia 21.27 10.81 6 127865 26 63361125
Granulomatous dermatitis 21.24 10.81 9 127862 152 63360999
Skin discolouration 21.19 10.81 27 127844 37801 63323350
Enterocolitis 21.09 10.81 48 127823 7810 63353341
Cutaneous nocardiosis 21.08 10.81 6 127865 27 63361124
Enterobacter pneumonia 21.08 10.81 6 127865 27 63361124
Neurofibrosarcoma 21.08 10.81 9 127862 155 63360996
Cervicitis 21.07 10.81 13 127858 495 63360656
Blue toe syndrome 21.03 10.81 12 127859 395 63360756
Cholelithiasis 21.02 10.81 35 127836 43890 63317261
Rhinorrhoea 21.01 10.81 65 127806 65512 63295639
Myositis 20.99 10.81 53 127818 9213 63351938
Hospitalisation 20.94 10.81 94 127777 84987 63276164
Dialysis 20.92 10.81 57 127814 10370 63350781
Leukaemia in remission 20.92 10.81 5 127866 9 63361142
Pelvic deformity 20.90 10.81 10 127861 227 63360924
Red blood cell count decreased 20.77 10.81 31 127840 40614 63320537
Klebsiella bacteraemia 20.74 10.81 21 127850 1657 63359494
Therapeutic response decreased 20.65 10.81 202 127669 61323 63299828
Ureteric obstruction 20.60 10.81 22 127849 1848 63359303
Fryns syndrome 20.58 10.81 7 127864 62 63361089
Immunosuppressant drug level 20.58 10.81 5 127866 10 63361141
Actinomycotic sepsis 20.57 10.81 8 127863 107 63361044
Systemic inflammatory response syndrome 20.56 10.81 39 127832 5582 63355569
Skin laceration 20.54 10.81 10 127861 22698 63338453
Sputum discoloured 20.50 10.81 4 127867 16343 63344808
C-reactive protein abnormal 20.49 10.81 161 127710 45935 63315216
Liver injury 20.46 10.81 199 127672 60321 63300830
Musculoskeletal disorder 20.40 10.81 8 127863 20636 63340515
Germ cell cancer 20.38 10.81 7 127864 64 63361087
Hypoaesthesia 20.27 10.81 229 127642 168164 63192987
Decreased appetite 20.15 10.81 370 127501 250682 63110469
Spinal stenosis 20.15 10.81 3 127868 14922 63346229
Dysmorphism 20.15 10.81 24 127847 2272 63358879
Fluorosis 20.10 10.81 7 127864 67 63361084
Bone density decreased 20.09 10.81 70 127801 14542 63346609
Vulval ulceration 20.08 10.81 11 127860 334 63360817
Rash macular 20.07 10.81 11 127860 23353 63337798
Lung transplant 20.07 10.81 28 127843 3100 63358051
Hepatitis B reactivation 20.01 10.81 28 127843 3109 63358042
Perinephric collection 19.98 10.81 8 127863 116 63361035
Fungal infection 19.96 10.81 135 127736 36739 63324412
Morphoea 19.96 10.81 11 127860 338 63360813
Dry eye 19.96 10.81 32 127839 40729 63320422
Cutaneous blastomycosis 19.95 10.81 5 127866 12 63361139
Rheumatoid nodule 19.89 10.81 5 127866 17150 63344001
Hip fracture 19.89 10.81 18 127853 29456 63331695
Parainfluenzae virus infection 19.89 10.81 24 127847 2303 63358848
Computerised tomogram thorax abnormal 19.88 10.81 21 127850 1742 63359409
Bacterial pyelonephritis 19.87 10.81 11 127860 341 63360810
Rhinovirus infection 19.86 10.81 34 127837 4495 63356656
Speech disorder 19.79 10.81 32 127839 40597 63320554
Skin hypertrophy 19.77 10.81 29 127842 3362 63357789
Hyperparathyroidism 19.75 10.81 26 127845 2723 63358428
Surgery 19.74 10.81 26 127845 35886 63325265
Intensive care unit acquired weakness 19.73 10.81 15 127856 806 63360345
Alpha haemolytic streptococcal infection 19.72 10.81 18 127853 1249 63359902
Purpura 19.70 10.81 59 127812 11326 63349825
Trichostasis spinulosa 19.67 10.81 5 127866 13 63361138
Tremor 19.60 10.81 171 127700 132068 63229083
Lung diffusion test decreased 19.59 10.81 14 127857 684 63360467
Neuropsychiatric lupus 19.58 10.81 9 127862 186 63360965
Pericarditis constrictive 19.55 10.81 11 127860 352 63360799
Gastric ulcer 19.53 10.81 98 127773 23939 63337212
Oliguria 19.52 10.81 51 127820 9050 63352101
Viral diarrhoea 19.49 10.81 9 127862 188 63360963
Multiple congenital abnormalities 19.49 10.81 13 127858 567 63360584
Gastrointestinal disorder 19.49 10.81 372 127499 130867 63230284
Engraft failure 19.47 10.81 11 127860 355 63360796
Coinfection 19.40 10.81 5 127866 14 63361137
Acid fast bacilli infection 19.31 10.81 7 127864 76 63361075
Exostosis 19.23 10.81 6 127865 17856 63343295
Ankle fracture 19.22 10.81 6 127865 17849 63343302
Pulmonary cavitation 19.21 10.81 15 127856 839 63360312
Urinary tract candidiasis 19.19 10.81 13 127858 582 63360569
Osteoarthritis 19.13 10.81 113 127758 95230 63265921
Blood immunoglobulin A decreased 19.12 10.81 18 127853 1299 63359852
Acanthosis nigricans 19.12 10.81 6 127865 40 63361111
Drug reaction with eosinophilia and systemic symptoms 19.11 10.81 24 127847 33812 63327339
Vasculitis 19.08 10.81 80 127791 18129 63343022
Human herpesvirus 7 infection 19.05 10.81 8 127863 132 63361019
Subcutaneous emphysema 19.02 10.81 15 127856 851 63360300
Pollakiuria 18.93 10.81 17 127854 27920 63333231
Migraine 18.93 10.81 126 127745 103220 63257931
Serratia bacteraemia 18.91 10.81 5 127866 16 63361135
Biopsy kidney abnormal 18.87 10.81 6 127865 42 63361109
Epstein-Barr virus antigen positive 18.87 10.81 6 127865 42 63361109
Meningism 18.85 10.81 12 127859 483 63360668
Growth retardation 18.84 10.81 18 127853 1323 63359828
Muscle twitching 18.82 10.81 8 127863 19660 63341491
Cellulitis staphylococcal 18.72 10.81 14 127857 734 63360417
Hyphaema 18.70 10.81 10 127861 289 63360862
Blood sodium decreased 18.64 10.81 13 127858 24239 63336912
Genital herpes simplex 18.64 10.81 10 127861 291 63360860
Visual impairment 18.63 10.81 97 127774 84349 63276802
Organising pneumonia 18.62 10.81 38 127833 5738 63355413
Pyelonephritis fungal 18.62 10.81 8 127863 140 63361011
Complement fixation abnormal 18.61 10.81 4 127867 3 63361148
Herpes sepsis 18.61 10.81 4 127867 3 63361148
Nosocomial infection 18.52 10.81 20 127851 1701 63359450
Immunosuppression 18.51 10.81 49 127822 8765 63352386
Arthritis 18.50 10.81 147 127724 115774 63245377
Post procedural bile leak 18.46 10.81 8 127863 143 63361008
Pancreas transplant 18.45 10.81 5 127866 18 63361133
Haemophilus infection 18.26 10.81 17 127854 1210 63359941
Oral herpes 18.24 10.81 102 127769 25972 63335179
Diffuse alveolar damage 18.24 10.81 15 127856 904 63360247
Fusarium infection 18.22 10.81 13 127858 633 63360518
Poikiloderma 18.20 10.81 9 127862 220 63360931
Depressed level of consciousness 18.19 10.81 64 127807 62014 63299137
Campylobacter infection 18.16 10.81 16 127855 1060 63360091
Eczema 18.14 10.81 23 127848 32268 63328883
Blood stem cell transplant failure 18.11 10.81 8 127863 150 63361001
Arthritis reactive 18.11 10.81 11 127860 407 63360744
Sneezing 18.10 10.81 7 127864 18211 63342940
Viral acanthoma 18.07 10.81 4 127867 4 63361147
Fascioliasis 18.07 10.81 4 127867 4 63361147
Desmoplastic melanoma 18.07 10.81 4 127867 4 63361147
Acute allograft nephropathy 18.07 10.81 4 127867 4 63361147
Infective uveitis 18.07 10.81 4 127867 4 63361147
Tooth abscess 18.07 10.81 4 127867 14965 63346186
Aortitis salmonella 18.04 10.81 5 127866 20 63361131
Burkholderia cepacia complex infection 18.02 10.81 8 127863 152 63360999
Enterococcal sepsis 17.99 10.81 18 127853 1400 63359751
Microphthalmos 17.92 10.81 8 127863 154 63360997
Acute myocardial infarction 17.92 10.81 23 127848 32101 63329050
Bile duct stenosis 17.92 10.81 17 127854 1239 63359912
Wound dehiscence 17.91 10.81 34 127837 4869 63356282
Respiratory syncytial virus infection 17.88 10.81 42 127829 6976 63354175
Transitional cell carcinoma 17.85 10.81 13 127858 654 63360497
Intervertebral disc protrusion 17.84 10.81 13 127858 23696 63337455
Natural killer-cell leukaemia 17.84 10.81 7 127864 96 63361055
Lip dry 17.82 10.81 70 127801 15400 63345751
Ear infection 17.78 10.81 31 127840 38182 63322969
Urinary incontinence 17.78 10.81 23 127848 31991 63329160
Hepatic steatosis 17.76 10.81 19 127852 28750 63332401
Wrist fracture 17.74 10.81 3 127868 13584 63347567
Pneumoperitoneum 17.73 10.81 18 127853 1425 63359726
Mucosal inflammation 17.72 10.81 158 127713 46770 63314381
Breast cancer female 17.69 10.81 3 127868 13556 63347595
Optic atrophy 17.67 10.81 17 127854 1261 63359890
Ureteral necrosis 17.65 10.81 6 127865 53 63361098
Pelvic pain 17.61 10.81 3 127868 13516 63347635
Herpes simplex viraemia 17.61 10.81 10 127861 326 63360825
Acanthoma 17.61 10.81 4 127867 5 63361146
Klebsiella sepsis 17.61 10.81 18 127853 1437 63359714
Carpal tunnel syndrome 17.60 10.81 10 127861 20807 63340344
Hyperaldosteronism 17.59 10.81 9 127862 237 63360914
Aggression 17.53 10.81 13 127858 23485 63337666
Corynebacterium infection 17.52 10.81 12 127859 547 63360604
Scleroderma renal crisis 17.50 10.81 10 127861 330 63360821
Superinfection viral 17.48 10.81 5 127866 23 63361128
Anomaly of external ear congenital 17.42 10.81 8 127863 165 63360986
Lung disorder 17.41 10.81 197 127674 62064 63299087
Abdominal pain 17.36 10.81 454 127417 293002 63068149
Blood immunoglobulin M increased 17.32 10.81 16 127855 1127 63360024
Prescribed overdose 17.28 10.81 123 127748 34030 63327121
Lupus pneumonitis 17.26 10.81 6 127865 57 63361094
Oxygen saturation decreased 17.25 10.81 106 127765 88479 63272672
Pulmonary haemorrhage 17.24 10.81 42 127829 7139 63354012
Jejunal perforation 17.21 10.81 7 127864 106 63361045
Hypoacusis 17.21 10.81 14 127857 24137 63337014
Disseminated coccidioidomycosis 17.17 10.81 6 127865 58 63361093
Mycoplasma test positive 17.08 10.81 6 127865 59 63361092
Subcutaneous abscess 17.08 10.81 36 127835 5560 63355591
Pericarditis 17.01 10.81 176 127695 131403 63229748
Japanese spotted fever 16.98 10.81 5 127866 26 63361125
Treatment noncompliance 16.94 10.81 131 127740 37194 63323957
X-ray abnormal 16.94 10.81 45 127826 8065 63353086
Tooth disorder 16.94 10.81 19 127852 28138 63333013
Globulins decreased 16.83 10.81 9 127862 260 63360891
Disseminated Bacillus Calmette-Guerin infection 16.82 10.81 5 127866 27 63361124
Skin hyperpigmentation 16.82 10.81 37 127834 5884 63355267
Hypoaesthesia oral 16.74 10.81 3 127868 13030 63348121
Anal ulcer 16.74 10.81 12 127859 589 63360562
Sleep disorder 16.72 10.81 96 127775 81470 63279681
Nail disorder 16.71 10.81 3 127868 13012 63348139
Disseminated mucormycosis 16.70 10.81 8 127863 182 63360969
Neuromyelitis optica spectrum disorder 16.70 10.81 15 127856 1019 63360132
Intracranial infection 16.67 10.81 5 127866 28 63361123
Reperfusion injury 16.56 10.81 6 127865 65 63361086
Oesophagitis 16.56 10.81 67 127804 14941 63346210
Stomatococcal infection 16.53 10.81 7 127864 118 63361033
Bronchial anastomosis complication 16.52 10.81 5 127866 29 63361122
Sebaceous carcinoma 16.52 10.81 5 127866 29 63361122
Thyroid disorder 16.49 10.81 5 127866 15157 63345994
Fibrosis 16.48 10.81 30 127841 4162 63356989
Gonorrhoea 16.48 10.81 7 127864 119 63361032
Parapox virus infection 16.46 10.81 4 127867 8 63361143
Meningitis histoplasma 16.46 10.81 4 127867 8 63361143
Idiopathic interstitial pneumonia 16.38 10.81 5 127866 30 63361121
Malignant ascites 16.35 10.81 14 127857 892 63360259
Hypertrophic cardiomyopathy 16.31 10.81 18 127853 1569 63359582
Mucocutaneous leishmaniasis 16.27 10.81 10 127861 378 63360773
Thrombosis 16.26 10.81 71 127800 64684 63296467
Cryptococcal cutaneous infection 16.24 10.81 6 127865 69 63361082
Urticaria cholinergic 16.24 10.81 5 127866 31 63361120
Rib fracture 16.23 10.81 13 127858 22584 63338567
Renal ischaemia 16.18 10.81 12 127859 621 63360530
Product storage error 16.15 10.81 5 127866 14951 63346200
Neuralgia 16.14 10.81 17 127854 25909 63335242
Removal of renal transplant 16.14 10.81 4 127867 9 63361142
Post herpetic neuralgia 16.11 10.81 21 127850 2178 63358973
Hypothyroidism 16.09 10.81 39 127832 42593 63318558
Angiosarcoma metastatic 16.09 10.81 6 127865 71 63361080
B-cell lymphoma 16.08 10.81 26 127845 3279 63357872
Procedural pain 16.01 10.81 12 127859 21557 63339594
Aphthous ulcer 16.00 10.81 63 127808 13875 63347276
Adjustment disorder with depressed mood 15.91 10.81 51 127820 10153 63350998
Acute disseminated encephalomyelitis 15.87 10.81 8 127863 204 63360947
Evans syndrome 15.87 10.81 8 127863 204 63360947
Hypoplastic anaemia 15.85 10.81 4 127867 10 63361141
Pleomorphism 15.85 10.81 4 127867 10 63361141
Retinal toxicity 15.84 10.81 16 127855 1259 63359892
Infective aneurysm 15.79 10.81 10 127861 399 63360752
Thrombotic thrombocytopenic purpura 15.78 10.81 28 127843 3808 63357343
Spinal cord disorder 15.78 10.81 16 127855 1265 63359886
Jejunal ulcer perforation 15.72 10.81 5 127866 35 63361116
Eye swelling 15.68 10.81 15 127856 23903 63337248
Large intestine perforation 15.67 10.81 45 127826 8437 63352714
Gastroenteritis cryptosporidial 15.65 10.81 6 127865 77 63361074
Angiopathy 15.65 10.81 31 127840 4582 63356569
Ureteral catheterisation 15.63 10.81 3 127868 0 63361151
Stenotrophomonas bacteraemia 15.63 10.81 3 127868 0 63361151
Bartonella test positive 15.63 10.81 3 127868 0 63361151
Glycosylated haemoglobin increased 15.62 10.81 3 127868 12395 63348756
Pancreatic pseudoaneurysm 15.58 10.81 6 127865 78 63361073
Transplant abscess 15.57 10.81 4 127867 11 63361140
Plasma cells decreased 15.48 10.81 5 127866 37 63361114
T-lymphocyte count decreased 15.48 10.81 9 127862 307 63360844
Retinal vasculitis 15.48 10.81 14 127857 960 63360191
Sinus bradycardia 15.47 10.81 5 127866 14546 63346605
Deep vein thrombosis 15.43 10.81 102 127769 83698 63277453
Parathyroid hyperplasia 15.39 10.81 7 127864 141 63361010
Infective keratitis 15.37 10.81 5 127866 38 63361113
Post procedural urine leak 15.37 10.81 5 127866 38 63361113
Secretion discharge 15.32 10.81 3 127868 12228 63348923
Respiratory papilloma 15.32 10.81 4 127867 12 63361139
Pseudallescheria infection 15.32 10.81 4 127867 12 63361139
Eye pain 15.27 10.81 28 127843 33826 63327325
Adenovirus reactivation 15.26 10.81 7 127864 144 63361007
Pneumonia acinetobacter 15.25 10.81 5 127866 39 63361112
Necrotising myositis 15.23 10.81 11 127860 546 63360605
Blast crisis in myelogenous leukaemia 15.23 10.81 11 127860 546 63360605
Epiglottic erythema 15.14 10.81 5 127866 40 63361111
Molluscum contagiosum 15.13 10.81 8 127863 226 63360925
Tuberous sclerosis complex 15.11 10.81 6 127865 85 63361066
Epstein Barr virus positive mucocutaneous ulcer 14.98 10.81 10 127861 437 63360714
Chronic myeloid leukaemia recurrent 14.97 10.81 8 127863 231 63360920
Breast cancer metastatic 14.94 10.81 3 127868 12015 63349136
Bladder hypertrophy 14.94 10.81 8 127863 232 63360919
Transient hypogammaglobulinaemia of infancy 14.93 10.81 5 127866 42 63361109
Acinetobacter bacteraemia 14.93 10.81 6 127865 88 63361063
Blood glucose increased 14.89 10.81 103 127768 83653 63277498
Substance-induced psychotic disorder 14.87 10.81 19 127852 1932 63359219
Ischaemic nephropathy 14.85 10.81 4 127867 14 63361137
Lymphocele marsupialisation 14.85 10.81 4 127867 14 63361137
Genitourinary tract infection 14.84 10.81 8 127863 235 63360916
Upper limb fracture 14.80 10.81 10 127861 18958 63342193
Double stranded DNA antibody positive 14.77 10.81 9 127862 335 63360816
Drug level above therapeutic 14.77 10.81 31 127840 4774 63356377
Heart rate irregular 14.77 10.81 14 127857 22407 63338744
Adenoviral haemorrhagic cystitis 14.75 10.81 7 127864 156 63360995
Clonic convulsion 14.74 10.81 12 127859 713 63360438
Arteritis infective 14.73 10.81 5 127866 44 63361107
Acute myeloid leukaemia 14.71 10.81 71 127800 17076 63344075
Rheumatic fever 14.69 10.81 142 127729 42969 63318182
Herpes zoster reactivation 14.68 10.81 6 127865 92 63361059
Musculoskeletal discomfort 14.67 10.81 9 127862 17958 63343193
Tracheo-oesophageal fistula 14.64 10.81 11 127860 581 63360570
Intestinal villi atrophy 14.63 10.81 8 127863 242 63360909
Adenoma benign 14.63 10.81 13 127858 871 63360280
Aspartate aminotransferase increased 14.62 10.81 114 127757 90163 63270988
Tooth infection 14.60 10.81 9 127862 17911 63343240
Abnormal behaviour 14.56 10.81 13 127858 21413 63339738
Joint dislocation 14.55 10.81 10 127861 18790 63342361
Bacteriuria 14.54 10.81 14 127857 1039 63360112
Upper respiratory tract infection 14.54 10.81 101 127770 81946 63279205
Encephalitis Japanese B 14.53 10.81 5 127866 46 63361105
Localised infection 14.52 10.81 24 127847 30186 63330965
Foreign body reaction 14.51 10.81 6 127865 95 63361056
Hepatic haematoma 14.46 10.81 10 127861 463 63360688
Erythema infectiosum 14.45 10.81 6 127865 96 63361055
Wheezing 14.44 10.81 123 127748 95472 63265679
Orbital infection 14.43 10.81 5 127866 47 63361104
Small cell lung cancer recurrent 14.43 10.81 4 127867 16 63361135
Tonsillar exudate 14.43 10.81 4 127867 16 63361135
Rhinitis allergic 14.43 10.81 3 127868 11724 63349427
Graft infection 14.43 10.81 7 127864 164 63360987
Bronchostenosis 14.37 10.81 10 127861 468 63360683
Genital lesion 14.36 10.81 8 127863 251 63360900
Product complaint 14.34 10.81 4 127867 12805 63348346
Phospholipidosis 14.27 10.81 7 127864 168 63360983
Respiratory tract infection fungal 14.26 10.81 10 127861 474 63360677
Skin burning sensation 14.22 10.81 4 127867 12730 63348421
Fungal sepsis 14.09 10.81 15 127856 1255 63359896
Achromobacter infection 14.07 10.81 5 127866 51 63361100
Skin papilloma 14.06 10.81 31 127840 4938 63356213
Histoplasmosis cutaneous 14.06 10.81 4 127867 18 63361133
Chronic cutaneous lupus erythematosus 13.95 10.81 9 127862 371 63360780
Retching 13.94 10.81 6 127865 14639 63346512
Cervical dysplasia 13.92 10.81 24 127847 3190 63357961
Lower limb fracture 13.91 10.81 90 127781 24131 63337020
Herpes simplex oesophagitis 13.91 10.81 7 127864 178 63360973
Catatonia 13.90 10.81 29 127842 4448 63356703
Hypothermia 13.86 10.81 5 127866 13576 63347575
Melaena 13.80 10.81 25 127846 30340 63330811
Myasthenia gravis crisis 13.75 10.81 10 127861 502 63360649
Adjusted calcium decreased 13.73 10.81 7 127864 183 63360968
Movement disorder 13.72 10.81 14 127857 21647 63339504
Hepatic amoebiasis 13.71 10.81 4 127867 20 63361131
Mesothelioma malignant 13.65 10.81 5 127866 56 63361095
Mechanical ventilation 13.63 10.81 15 127856 1303 63359848
White blood cell count increased 13.61 10.81 51 127820 48510 63312641
Blood albumin increased 13.60 10.81 13 127858 956 63360195
Pulmonary pneumatocele 13.56 10.81 3 127868 3 63361148
Right atrial hypertrophy 13.56 10.81 3 127868 3 63361148
Retroviral infection 13.56 10.81 3 127868 3 63361148
Cytomegalovirus myocarditis 13.56 10.81 3 127868 3 63361148
C3 glomerulopathy 13.56 10.81 3 127868 3 63361148
Erysipelothrix infection 13.56 10.81 3 127868 3 63361148
Dacryocystitis 13.55 10.81 4 127867 21 63361130
Hyperuricaemia 13.53 10.81 32 127839 5338 63355813
Emotional disorder 13.53 10.81 5 127866 13374 63347777
Lipohypertrophy 13.50 10.81 11 127860 654 63360497
Feeding disorder 13.50 10.81 5 127866 13357 63347794
Adrenal mass 13.43 10.81 13 127858 971 63360180
Plasmapheresis 13.42 10.81 8 127863 286 63360865
Renal vessel disorder 13.40 10.81 4 127867 22 63361129
Blood immunoglobulin M decreased 13.39 10.81 13 127858 975 63360176
Kidney enlargement 13.39 10.81 11 127860 662 63360489
Epileptic encephalopathy 13.35 10.81 8 127863 289 63360862
Endocarditis enterococcal 13.34 10.81 5 127866 60 63361091
Cleft lip 13.32 10.81 6 127865 118 63361033
Ecthyma 13.32 10.81 8 127863 290 63360861
Exfoliative rash 13.32 10.81 22 127849 2825 63358326
Sleep disorder due to a general medical condition 13.29 10.81 4 127867 12184 63348967
Toxic epidermal necrolysis 13.26 10.81 19 127852 25315 63335836
HCoV-HKU1 infection 13.25 10.81 4 127867 23 63361128
Pseudomonal sepsis 13.23 10.81 20 127851 2381 63358770
Neoplasm malignant 13.20 10.81 25 127846 29836 63331315
Productive cough 13.17 10.81 74 127797 63134 63298017
Histology abnormal 13.14 10.81 6 127865 122 63361029
Tuberculosis 13.14 10.81 51 127820 11160 63349991
Lupus myocarditis 13.13 10.81 5 127866 63 63361088
Enterovirus infection 13.10 10.81 13 127858 1001 63360150
Choriomeningitis lymphocytic 13.10 10.81 4 127867 24 63361127
Lymphadenitis bacterial 13.10 10.81 4 127867 24 63361127
Tuberculosis of genitourinary system 13.10 10.81 4 127867 24 63361127
Infective scleritis 13.10 10.81 4 127867 24 63361127
Hemivertebra 13.10 10.81 6 127865 123 63361028
Kidney anastomosis 13.10 10.81 3 127868 4 63361147
Blood urine present 13.08 10.81 7 127864 15062 63346089
Skin disorder 13.08 10.81 103 127768 29404 63331747
Blood immunoglobulin G increased 13.07 10.81 20 127851 2407 63358744
Vaginal haemorrhage 13.06 10.81 22 127849 27465 63333686
Pulmonary sepsis 13.06 10.81 16 127855 1560 63359591
Septal panniculitis 13.05 10.81 5 127866 64 63361087
Erythropoiesis abnormal 13.05 10.81 8 127863 301 63360850
Infusion site pain 13.02 10.81 9 127862 16860 63344291
Intracranial pressure increased 13.01 10.81 31 127840 5196 63355955
Colorectal cancer 12.98 10.81 25 127846 3620 63357531
Thymoma 12.98 10.81 7 127864 206 63360945
Hirsutism 12.94 10.81 15 127856 1380 63359771
Mycobacterium kansasii infection 12.92 10.81 6 127865 127 63361024
Emotional distress 12.91 10.81 29 127842 32520 63328631
Thrombocytopenia 12.86 10.81 397 127474 150760 63210391
Bone marrow transplant rejection 12.85 10.81 5 127866 67 63361084
Hairy cell leukaemia 12.85 10.81 5 127866 67 63361084
Brain herniation 12.82 10.81 25 127846 3652 63357499
Chromaturia 12.80 10.81 9 127862 16708 63344443
Pharyngitis 12.78 10.81 13 127858 20130 63341021
Hydrocephalus 12.73 10.81 31 127840 5269 63355882
Coronary artery disease 12.72 10.81 29 127842 32348 63328803
Burning feet syndrome 12.71 10.81 5 127866 69 63361082
Disorientation 12.71 10.81 39 127832 39413 63321738
Paraesthesia oral 12.71 10.81 12 127859 19244 63341907
Lacrimal haemorrhage 12.70 10.81 4 127867 27 63361124
Choroidal coloboma 12.70 10.81 3 127868 5 63361146
Tracheobronchitis 12.68 10.81 14 127857 1221 63359930
Intervertebral disc degeneration 12.68 10.81 8 127863 15724 63345427
Chronic sinusitis 12.65 10.81 5 127866 12838 63348313
Encephalitis brain stem 12.63 10.81 6 127865 134 63361017
Hallucination, auditory 12.62 10.81 5 127866 12819 63348332
Abdominal wound dehiscence 12.62 10.81 7 127864 218 63360933
Leiomyosarcoma 12.62 10.81 7 127864 218 63360933
Protein-losing gastroenteropathy 12.62 10.81 7 127864 218 63360933
Haemolysis 12.60 10.81 36 127835 6732 63354419
Craniofacial deformity 12.59 10.81 6 127865 135 63361016
Dysarthria 12.53 10.81 44 127827 42667 63318484
Blood test abnormal 12.52 10.81 8 127863 15621 63345530
Pneumonia 12.48 10.81 1075 126796 455692 62905459
Pharyngeal oedema 12.47 10.81 6 127865 13715 63347436
Total lung capacity abnormal 12.46 10.81 5 127866 73 63361078
Foot fracture 12.45 10.81 18 127853 23896 63337255
Gastroenteritis 12.45 10.81 94 127777 26496 63334655
Tonsil cancer 12.44 10.81 7 127864 224 63360927
Laryngeal stenosis 12.44 10.81 13 127858 1065 63360086
Infusion site erythema 12.44 10.81 4 127867 11675 63349476
Meningitis aseptic 12.43 10.81 29 127842 4794 63356357
Acarodermatitis 12.39 10.81 13 127858 1070 63360081
Contusion 12.38 10.81 220 127651 149824 63211327
Oral pain 12.35 10.81 24 127847 28370 63332781
Viral oesophagitis 12.35 10.81 3 127868 6 63361145
Meningitis aspergillus 12.35 10.81 3 127868 6 63361145
Hepatitis G 12.35 10.81 3 127868 6 63361145
Mycotic endophthalmitis 12.34 10.81 5 127866 75 63361076
Uveitis 12.27 10.81 54 127817 12499 63348652
Reticulocyte count decreased 12.23 10.81 9 127862 460 63360691
Urticaria aquagenic 12.23 10.81 4 127867 31 63361120
Antisynthetase syndrome 12.22 10.81 5 127866 77 63361074
Tachycardia 12.21 10.81 166 127705 117990 63243161
Renal atrophy 12.20 10.81 15 127856 1467 63359684
Rash maculo-papular 12.18 10.81 29 127842 31867 63329284
Synovial cyst 12.17 10.81 3 127868 10430 63350721
Immunoglobulins decreased 12.16 10.81 14 127857 1278 63359873
Biopsy muscle abnormal 12.11 10.81 4 127867 32 63361119
Palatal ulcer 12.10 10.81 5 127866 79 63361072
Varicella 12.03 10.81 17 127854 1904 63359247
Hyperlipidaemia 12.03 10.81 74 127797 19497 63341654
Anger 12.02 10.81 5 127866 12451 63348700
Renal haemorrhage 12.01 10.81 12 127859 932 63360219
Keratoacanthoma 12.00 10.81 9 127862 474 63360677
Head discomfort 11.99 10.81 6 127865 13409 63347742
Mycobacterium haemophilum infection 11.90 10.81 4 127867 34 63361117
Cerebral ventricle collapse 11.90 10.81 4 127867 34 63361117
Hepatic vein stenosis 11.90 10.81 4 127867 34 63361117
Ultrasound kidney abnormal 11.90 10.81 4 127867 34 63361117
Respiratory tract congestion 11.90 10.81 11 127860 17821 63343330
Tooth extraction 11.88 10.81 3 127868 10261 63350890
Mania 11.88 10.81 5 127866 12362 63348789
Meningoencephalitis bacterial 11.88 10.81 5 127866 83 63361068
Renal abscess 11.86 10.81 11 127860 779 63360372
Atrophy 11.86 10.81 16 127855 1716 63359435
Skin hypopigmentation 11.85 10.81 11 127860 780 63360371
Nephrolithiasis 11.82 10.81 44 127827 41940 63319211
Exposure during pregnancy 11.80 10.81 403 127468 155144 63206007
Hepatic infection bacterial 11.80 10.81 4 127867 35 63361116
Cardiogenic shock 11.79 10.81 69 127802 17863 63343288
Heart rate increased 11.79 10.81 127 127744 94111 63267040
Skin squamous cell carcinoma recurrent 11.75 10.81 3 127868 8 63361143
Pancreatic pseudocyst haemorrhage 11.75 10.81 3 127868 8 63361143
Erythema multiforme 11.72 10.81 3 127868 10166 63350985
Pneumothorax 11.63 10.81 64 127807 16197 63344954
Cyst 11.60 10.81 7 127864 14092 63347059
Pulmonary function test decreased 11.60 10.81 25 127846 3922 63357229
Enterococcus test positive 11.53 10.81 13 127858 1160 63359991
Meningitis bacterial 11.52 10.81 14 127857 1353 63359798
Fat necrosis 11.51 10.81 10 127861 650 63360501
Drug specific antibody absent 11.51 10.81 5 127866 90 63361061
Influenza 11.50 10.81 152 127719 108570 63252581
Fibrodysplasia ossificans progressiva 11.49 10.81 3 127868 9 63361142
Pharyngeal necrosis 11.49 10.81 3 127868 9 63361142
Pancreatitis viral 11.49 10.81 3 127868 9 63361142
Blister 11.47 10.81 188 127683 129626 63231525
Acute respiratory failure 11.46 10.81 113 127758 34372 63326779
Enterocolitis viral 11.45 10.81 7 127864 262 63360889
Respiratory tract infection viral 11.44 10.81 18 127853 2219 63358932
Clostridium difficile infection 11.43 10.81 101 127770 29821 63331330
Salmonella sepsis 11.41 10.81 7 127864 264 63360887
CSF protein increased 11.39 10.81 9 127862 512 63360639
Hypergammaglobulinaemia 11.39 10.81 9 127862 512 63360639
Secondary hypertension 11.36 10.81 6 127865 169 63360982
Impaired healing 11.35 10.81 142 127729 102400 63258751
Pain in jaw 11.34 10.81 47 127824 43449 63317702
Salmonellosis 11.34 10.81 13 127858 1181 63359970
Nerve injury 11.34 10.81 3 127868 9943 63351208
Granulomatosis with polyangiitis 11.27 10.81 18 127853 2247 63358904
Antibody test negative 11.24 10.81 4 127867 41 63361110
CSF white blood cell count increased 11.24 10.81 4 127867 41 63361110
Vasculitic ulcer 11.20 10.81 6 127865 174 63360977
Tonsillitis 11.16 10.81 31 127840 5704 63355447
Sinus congestion 11.15 10.81 12 127859 18111 63343040
Bronchospasm 11.14 10.81 11 127860 17269 63343882
Renal vein thrombosis 11.14 10.81 8 127863 394 63360757
Cryptitis 11.07 10.81 4 127867 43 63361108
Autoimmune hepatitis 11.04 10.81 40 127831 8470 63352681
Ageusia 11.04 10.81 7 127864 13721 63347430
Parainfluenzae viral bronchitis 11.03 10.81 3 127868 11 63361140
Graft haemorrhage 11.03 10.81 3 127868 11 63361140
Orthobunyavirus test positive 11.03 10.81 3 127868 11 63361140
Drug eruption 11.03 10.81 26 127845 28668 63332483
Shock 11.01 10.81 83 127788 23380 63337771
DNA antibody 10.99 10.81 4 127867 44 63361107
Heliotrope rash 10.99 10.81 6 127865 181 63360970
Adverse drug reaction 10.97 10.81 105 127766 79609 63281542
Anastomotic stenosis 10.97 10.81 7 127864 283 63360868
Dysstasia 10.95 10.81 16 127855 21150 63340001
Fracture 10.95 10.81 14 127857 19570 63341581
Weight increased 10.93 10.81 422 127449 260370 63100781
Anaphylactic reaction 10.92 10.81 83 127788 66017 63295134
Meningomyelitis herpes 10.91 10.81 4 127867 45 63361106
Skin lesion 10.87 10.81 102 127769 30619 63330532
Systemic lupus erythematosus 10.86 10.81 329 127542 208589 63152562
Throat tightness 10.86 10.81 21 127850 24866 63336285
Endophthalmitis 10.84 10.81 23 127848 3569 63357582
CSF culture positive 10.83 10.81 3 127868 12 63361139
Platelet glycoprotein gene mutation 10.83 10.81 3 127868 12 63361139
Skin flap necrosis 10.83 10.81 3 127868 12 63361139
Panencephalitis 10.83 10.81 3 127868 12 63361139
Renal cell carcinoma 10.82 10.81 22 127849 3313 63357838
Venous haemorrhage 10.82 10.81 7 127864 290 63360861

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 2741.07 11.78 1484 121695 24651 34809101
Transplant rejection 2647.94 11.78 1087 122092 9224 34824528
Product use in unapproved indication 1533.11 11.78 1974 121205 115525 34718227
Post transplant lymphoproliferative disorder 1420.45 11.78 612 122567 5916 34827836
Kidney transplant rejection 1310.89 11.78 603 122576 6894 34826858
Polyomavirus-associated nephropathy 1300.76 11.78 495 122684 3349 34830403
Complications of transplanted kidney 914.48 11.78 405 122774 4204 34829548
BK virus infection 896.31 11.78 427 122752 5311 34828441
Acute graft versus host disease 770.23 11.78 401 122778 6102 34827650
Epstein-Barr virus infection 753.80 11.78 417 122762 7211 34826541
Cytomegalovirus viraemia 747.49 11.78 411 122768 7019 34826733
Adenovirus infection 727.13 11.78 360 122819 4897 34828855
Off label use 700.65 11.78 3121 120058 416403 34417349
Transplant dysfunction 678.53 11.78 279 122900 2370 34831382
Acute graft versus host disease in skin 616.74 11.78 321 122858 4880 34828872
Aspergillus infection 599.80 11.78 429 122750 11825 34821927
Graft versus host disease 580.27 11.78 397 122782 10172 34823580
Immunosuppressant drug level increased 546.65 11.78 312 122867 5743 34828009
Chronic graft versus host disease 541.85 11.78 278 122901 4095 34829657
Pneumocystis jirovecii pneumonia 533.60 11.78 488 122691 19222 34814530
Thrombotic microangiopathy 515.32 11.78 370 122809 10260 34823492
Nocardiosis 515.24 11.78 260 122919 3691 34830061
COVID-19 510.10 11.78 951 122228 76599 34757153
Fatigue 464.18 11.78 377 122802 370276 34463476
Graft versus host disease in skin 444.71 11.78 235 122944 3690 34830062
Mucormycosis 436.43 11.78 268 122911 5674 34828078
Bronchopulmonary aspergillosis 436.43 11.78 383 122796 14276 34819476
Chronic allograft nephropathy 429.23 11.78 163 123016 1094 34832658
Graft versus host disease in gastrointestinal tract 427.20 11.78 224 122955 3459 34830293
Nephropathy toxic 426.02 11.78 354 122825 12234 34821518
Liver transplant rejection 422.86 11.78 187 122992 1932 34831820
Cytomegalovirus infection reactivation 417.67 11.78 247 122932 4871 34828881
Transplant failure 409.00 11.78 215 122964 3338 34830414
Acute respiratory distress syndrome 394.44 11.78 472 122707 25497 34808255
Fall 380.41 11.78 121 123058 202764 34630988
Dizziness 379.51 11.78 148 123031 218373 34615379
Heart transplant rejection 347.34 11.78 139 123040 1092 34832660
Phaeohyphomycosis 346.20 11.78 126 123053 738 34833014
Cystitis haemorrhagic 325.19 11.78 219 122960 5460 34828292
Polyomavirus viraemia 324.32 11.78 123 123056 822 34832930
Acute graft versus host disease in intestine 323.51 11.78 168 123011 2540 34831212
Drug abuse 319.28 11.78 6 123173 99090 34734662
Klebsiella infection 309.82 11.78 250 122929 8281 34825471
Dyspnoea 291.92 11.78 554 122625 376228 34457524
Completed suicide 290.71 11.78 13 123166 98155 34735597
Hepatitis E 288.86 11.78 143 123036 1943 34831809
Focal segmental glomerulosclerosis 283.92 11.78 140 123039 1885 34831867
Strongyloidiasis 283.78 11.78 154 123025 2557 34831195
Enterococcal infection 282.70 11.78 246 122933 9060 34824692
Pseudomonas infection 278.82 11.78 277 122902 12105 34821647
Pain 277.59 11.78 191 122988 204484 34629268
Constipation 276.29 11.78 71 123108 136911 34696841
Cryptococcosis 271.68 11.78 144 123035 2275 34831477
Death 271.64 11.78 629 122550 397420 34436332
Cytomegalovirus colitis 268.97 11.78 150 123029 2634 34831118
Nausea 260.32 11.78 503 122676 339405 34494347
Multiple organ dysfunction syndrome 256.37 11.78 719 122460 75847 34757905
Escherichia infection 246.52 11.78 216 122963 8029 34825723
Pneumatosis intestinalis 245.72 11.78 160 123019 3763 34829989
Renal impairment 245.66 11.78 812 122367 93701 34740051
Rash 245.49 11.78 254 122925 222498 34611254
Delayed graft function 243.19 11.78 130 123049 2091 34831661
Renal tubular necrosis 242.98 11.78 288 122891 15392 34818360
Brain abscess 239.86 11.78 145 123034 2980 34830772
Product dose omission issue 239.56 11.78 63 123116 119648 34714104
Septic shock 237.97 11.78 672 122507 71162 34762590
Chronic graft versus host disease in skin 233.94 11.78 98 123081 876 34832876
Acute graft versus host disease in liver 233.75 11.78 113 123066 1453 34832299
Renal transplant failure 231.68 11.78 101 123078 1005 34832747
Leukopenia 231.11 11.78 611 122568 62245 34771507
COVID-19 pneumonia 224.78 11.78 288 122891 16679 34817073
Asthenia 222.54 11.78 325 122854 244926 34588826
Diffuse large B-cell lymphoma 220.19 11.78 193 122986 7177 34826575
Meningitis cryptococcal 219.98 11.78 125 123054 2279 34831473
Renal tubular atrophy 219.68 11.78 99 123080 1073 34832679
Epstein-Barr virus associated lymphoproliferative disorder 215.17 11.78 115 123064 1849 34831903
Kidney fibrosis 209.69 11.78 118 123061 2110 34831642
Pruritus 202.51 11.78 125 123054 141856 34691896
Parvovirus B19 infection 201.92 11.78 85 123094 770 34832982
Blood creatinine increased 199.56 11.78 761 122418 94215 34739537
Pulmonary nocardiosis 197.00 11.78 85 123094 823 34832929
Pneumonia cytomegaloviral 194.81 11.78 126 123053 2928 34830824
JC virus infection 191.85 11.78 111 123068 2097 34831655
Disease recurrence 191.70 11.78 302 122877 21188 34812564
Human herpesvirus 6 infection 187.18 11.78 107 123072 1974 34831778
Graft loss 186.14 11.78 81 123098 802 34832950
Malaise 185.95 11.78 229 122950 185596 34648156
Arthralgia 185.95 11.78 195 122984 169846 34663906
Proteinuria 184.62 11.78 275 122904 18367 34815385
Cytomegalovirus test positive 183.12 11.78 133 123046 3753 34829999
Posterior reversible encephalopathy syndrome 181.61 11.78 199 122980 9755 34823997
Human herpesvirus 8 infection 181.61 11.78 82 123097 893 34832859
Hypotension 179.07 11.78 317 122862 221332 34612420
Lung transplant rejection 177.95 11.78 76 123103 716 34833036
Candida infection 177.84 11.78 263 122916 17452 34816300
Malacoplakia 176.30 11.78 65 123114 397 34833355
Fungal skin infection 173.77 11.78 111 123068 2523 34831229
Alternaria infection 173.57 11.78 62 123117 341 34833411
End stage renal disease 171.92 11.78 183 122996 8678 34825074
Staphylococcal infection 170.87 11.78 365 122814 32395 34801357
Syncope 170.30 11.78 55 123124 91396 34742356
Varicella zoster virus infection 168.20 11.78 95 123084 1711 34832041
Immunosuppressant drug level decreased 164.88 11.78 83 123096 1171 34832581
Aplasia pure red cell 162.31 11.78 150 123029 5982 34827770
Respiratory failure 161.74 11.78 784 122395 107788 34725964
Lymphopenia 160.37 11.78 240 122939 16095 34817657
Viraemia 160.02 11.78 81 123098 1157 34832595
West Nile viral infection 159.02 11.78 69 123110 678 34833074
Muscle spasms 158.74 11.78 35 123144 74966 34758786
Cryptosporidiosis infection 158.67 11.78 61 123118 425 34833327
Blastomycosis 157.81 11.78 60 123119 404 34833348
Pain in extremity 157.24 11.78 129 123050 126384 34707368
Back pain 156.62 11.78 120 123059 121669 34712083
Infection reactivation 156.52 11.78 85 123094 1413 34832339
Drug hypersensitivity 154.30 11.78 46 123133 80483 34753269
Haemophagocytic lymphohistiocytosis 151.46 11.78 207 122972 12766 34820986
Anxiety 151.03 11.78 81 123098 99347 34734405
Somnolence 148.68 11.78 105 123074 111011 34722741
Chest pain 146.97 11.78 138 123041 126624 34707128
Progressive multifocal leukoencephalopathy 145.77 11.78 176 123003 9588 34824164
Hypogammaglobulinaemia 145.14 11.78 157 123022 7583 34826169
Neutrophil Pelger-Huet anomaly present 143.86 11.78 48 123131 207 34833545
Vaccination failure 142.37 11.78 73 123106 1073 34832679
Histoplasmosis 141.78 11.78 80 123099 1438 34832314
Complications of transplanted heart 141.35 11.78 50 123129 266 34833486
Hyperhidrosis 140.07 11.78 46 123133 75646 34758106
Urticaria 136.34 11.78 27 123152 62350 34771402
Trichodysplasia spinulosa 135.95 11.78 46 123133 209 34833543
Cerebral toxoplasmosis 135.04 11.78 81 123098 1640 34832112
Feeling abnormal 134.84 11.78 29 123150 63206 34770546
Lymphocele 133.51 11.78 74 123105 1283 34832469
Actinic keratosis 133.23 11.78 118 123061 4449 34829303
Toxoplasmosis 132.87 11.78 73 123106 1243 34832509
Mycobacterial infection 132.21 11.78 90 123089 2284 34831468
Pneumocystis jirovecii infection 130.38 11.78 80 123099 1690 34832062
Herpes simplex 130.03 11.78 127 123052 5432 34828320
Inappropriate schedule of product administration 129.95 11.78 30 123149 62266 34771486
Myocardial infarction 129.88 11.78 141 123038 120944 34712808
Lymphoproliferative disorder 129.03 11.78 94 123085 2665 34831087
Hepatitis C 128.84 11.78 166 123013 9664 34824088
Epstein-Barr viraemia 127.59 11.78 71 123108 1241 34832511
Peripheral swelling 125.86 11.78 56 123123 76485 34757267
Endophthalmitis 123.55 11.78 101 123078 3407 34830345
Malignant neoplasm progression 123.40 11.78 79 123100 87967 34745785
Depression 123.12 11.78 97 123082 97001 34736751
Dermatophytosis 122.53 11.78 42 123137 200 34833552
Cardiac failure congestive 121.88 11.78 71 123108 83199 34750553
Fungal infection 120.62 11.78 208 122971 15727 34818025
Nasopharyngitis 120.16 11.78 48 123131 69920 34763832
Squamous cell carcinoma of skin 118.62 11.78 168 123011 10713 34823039
Insomnia 118.22 11.78 115 123064 103792 34729960
Bradycardia 118.13 11.78 59 123120 75359 34758393
Human polyomavirus infection 115.03 11.78 55 123124 689 34833063
Renal graft infection 114.96 11.78 42 123137 249 34833503
Demodicidosis 114.42 11.78 39 123140 182 34833570
Intentional overdose 113.96 11.78 11 123168 43663 34790089
Pulmonary mucormycosis 112.35 11.78 55 123124 728 34833024
Drug level increased 111.54 11.78 243 122936 21853 34811899
Hypoglycaemia 110.66 11.78 28 123151 54612 34779140
Drug ineffective for unapproved indication 109.84 11.78 252 122927 23463 34810289
Chronic graft versus host disease in liver 109.63 11.78 46 123133 413 34833339
Psoriasis 109.03 11.78 7 123172 38805 34794947
Atrial fibrillation 109.00 11.78 164 123015 122229 34711523
Alveolar proteinosis 107 11.78 46 123133 441 34833311
Papilloma viral infection 106.55 11.78 46 123133 446 34833306
Bacillary angiomatosis 105.97 11.78 33 123146 108 34833644
Stenotrophomonas infection 105.80 11.78 75 123104 2035 34831717
Chronic obstructive pulmonary disease 105.18 11.78 22 123157 48896 34784856
Pathogen resistance 104.25 11.78 147 123032 9335 34824417
Injection site pain 103.98 11.78 9 123170 38996 34794756
Complications of transplanted lung 103.27 11.78 36 123143 182 34833570
Choroiditis 102.70 11.78 60 123119 1155 34832597
Graft versus host disease in liver 102.22 11.78 61 123118 1223 34832529
Tubulointerstitial nephritis 101.36 11.78 227 122952 20797 34812955
Vomiting 99.83 11.78 491 122688 247130 34586622
Trichophytosis 97.97 11.78 38 123141 272 34833480
Drug resistance 97.19 11.78 254 122925 25673 34808079
Gait disturbance 97.09 11.78 94 123085 85046 34748706
Nephrotic syndrome 96.76 11.78 124 123055 7179 34826573
Disseminated varicella zoster virus infection 96.68 11.78 38 123141 283 34833469
Encephalitis 95.54 11.78 123 123056 7154 34826598
Neurotoxicity 95.42 11.78 202 122977 17808 34815944
IgA nephropathy 95.37 11.78 58 123121 1205 34832547
Acinetobacter infection 95.20 11.78 57 123122 1150 34832602
Renal tubular injury 95.05 11.78 53 123126 930 34832822
International normalised ratio increased 94.41 11.78 25 123154 47302 34786450
Joint swelling 93.56 11.78 47 123132 59843 34773909
Asthma 92.08 11.78 19 123160 42637 34791115
Suicide attempt 91.88 11.78 14 123165 39102 34794650
Disseminated tuberculosis 91.66 11.78 70 123109 2135 34831617
Headache 91.50 11.78 380 122799 200255 34633497
Suicidal ideation 91.41 11.78 16 123163 40372 34793380
Loss of consciousness 91.14 11.78 94 123085 82573 34751179
Decreased appetite 90.42 11.78 293 122886 166099 34667653
Gastroenteritis norovirus 90.12 11.78 60 123119 1466 34832286
Cytomegalovirus gastrointestinal infection 90.00 11.78 33 123146 198 34833554
Intentional product misuse 89.28 11.78 25 123154 45586 34788166
Scedosporium infection 89.25 11.78 49 123130 833 34832919
Human ehrlichiosis 87.91 11.78 37 123142 335 34833417
Gingival hypertrophy 87.34 11.78 63 123116 1758 34831994
Drug reaction with eosinophilia and systemic symptoms 86.96 11.78 8 123171 33004 34800748
Wrong technique in product usage process 86.57 11.78 12 123167 35974 34797778
Viral haemorrhagic cystitis 86.07 11.78 53 123126 1127 34832625
Dermoid cyst 85.53 11.78 30 123149 155 34833597
Disseminated cryptococcosis 85.50 11.78 56 123123 1330 34832422
Haemolytic uraemic syndrome 85.13 11.78 68 123111 2218 34831534
Pyelonephritis acute 84.79 11.78 65 123114 1994 34831758
Disseminated blastomycosis 84.79 11.78 29 123150 137 34833615
Encephalitis viral 84.76 11.78 53 123126 1159 34832593
Pancreas transplant rejection 84.13 11.78 30 123149 164 34833588
Cytomegalovirus chorioretinitis 83.95 11.78 82 123097 3507 34830245
Pneumonia fungal 83.94 11.78 114 123065 6986 34826766
Hypersensitivity 83.82 11.78 56 123123 60979 34772773
Graft versus host disease in lung 83.73 11.78 41 123138 543 34833209
Pneumonia cryptococcal 82.70 11.78 47 123132 857 34832895
Cat scratch disease 81.87 11.78 29 123150 155 34833597
Histoplasmosis disseminated 81.48 11.78 54 123125 1309 34832443
Glomerulonephritis 80.49 11.78 62 123117 1916 34831836
Mycobacterium abscessus infection 80.42 11.78 39 123140 505 34833247
Cytomegalovirus oesophagitis 80.04 11.78 38 123141 468 34833284
Nodular regenerative hyperplasia 79.48 11.78 47 123132 926 34832826
Stress 78.23 11.78 8 123171 30339 34803413
Obliterative bronchiolitis 78.21 11.78 51 123128 1202 34832550
Renal tubular acidosis 77.98 11.78 65 123114 2254 34831498
Epistaxis 77.92 11.78 55 123124 58196 34775556
Blood pressure increased 77.49 11.78 119 123060 87983 34745769
Ureteric stenosis 76.19 11.78 49 123130 1127 34832625
Angiosarcoma metastatic 76.13 11.78 21 123158 38 34833714
Erythema infectiosum 76.12 11.78 27 123152 145 34833607
American trypanosomiasis 75.92 11.78 30 123149 227 34833525
Platelet count decreased 75.82 11.78 196 122983 119521 34714231
Angiosarcoma 75.81 11.78 31 123148 259 34833493
Epstein-Barr virus associated lymphoma 75.67 11.78 40 123139 628 34833124
Enterobacter infection 75.33 11.78 65 123114 2365 34831387
Adverse drug reaction 74.96 11.78 8 123171 29334 34804418
Balance disorder 74.67 11.78 25 123154 40629 34793123
Hydronephrosis 74.34 11.78 132 123047 10214 34823538
Smooth muscle cell neoplasm 74.20 11.78 27 123152 158 34833594
Complications of transplanted liver 74.01 11.78 29 123150 214 34833538
Graft complication 73.93 11.78 33 123146 349 34833403
Overdose 73.56 11.78 130 123049 90929 34742823
Hypoaesthesia 73.39 11.78 65 123114 61379 34772373
White blood cell count decreased 72.91 11.78 141 123038 95304 34738448
Cerebrovascular accident 72.27 11.78 117 123062 84694 34749058
Wheezing 71.73 11.78 28 123151 41374 34792378
Infusion related reaction 71.09 11.78 50 123129 53007 34780745
Microsporidia infection 70.83 11.78 39 123140 667 34833085
Electrocardiogram QT prolonged 70.45 11.78 28 123151 40924 34792828
Epstein-Barr virus test positive 69.74 11.78 36 123143 537 34833215
Erythema 69.70 11.78 129 123050 88651 34745101
Squamous cell carcinoma 69.44 11.78 136 123043 11339 34822413
Musculoskeletal stiffness 69.42 11.78 39 123140 46641 34787111
Renal transplant 68.85 11.78 55 123124 1794 34831958
Confusional state 68.84 11.78 268 122911 143892 34689860
Neutrophil count decreased 68.68 11.78 48 123131 51056 34782696
Adenoviral hepatitis 68.58 11.78 35 123144 509 34833243
Anogenital warts 68.34 11.78 36 123143 561 34833191
Mycobacterium chelonae infection 68.23 11.78 40 123139 775 34832977
General physical health deterioration 67.49 11.78 229 122950 128040 34705712
Atypical mycobacterial infection 67.41 11.78 41 123138 852 34832900
Dry skin 67.39 11.78 14 123165 31273 34802479
Sepsis 67.00 11.78 888 122291 165673 34668079
Sleep disorder 66.59 11.78 15 123164 31673 34802079
Pyelonephritis 66.32 11.78 95 123084 6120 34827632
Basal cell carcinoma 66.06 11.78 185 122994 19473 34814279
Rheumatoid arthritis 66.01 11.78 26 123153 38212 34795540
Hallucination 65.80 11.78 51 123128 51447 34782305
Blood glucose increased 65.78 11.78 83 123096 66635 34767117
Apoptosis 65.42 11.78 31 123148 380 34833372
Loss of personal independence in daily activities 65.28 11.78 18 123161 33161 34800591
Haemodialysis 65.21 11.78 126 123053 10400 34823352
Cytomegalovirus enteritis 65.03 11.78 33 123146 474 34833278
Therapeutic product effect decreased 64.44 11.78 21 123158 34722 34799030
Drug interaction 64.44 11.78 1136 122043 224810 34608942
Venoocclusive liver disease 64.28 11.78 107 123072 7859 34825893
Paraesthesia 64.13 11.78 79 123100 64093 34769659
Pancytopenia 63.76 11.78 562 122617 94595 34739157
Memory impairment 63.26 11.78 37 123142 43281 34790471
Bacteraemia 62.80 11.78 182 122997 19535 34814217
C3 glomerulopathy 62.49 11.78 19 123160 56 34833696
Febrile neutropenia 62.44 11.78 259 122920 136590 34697162
Agitation 62.42 11.78 66 123113 57333 34776419
Chest discomfort 62.39 11.78 60 123119 54470 34779282
Epstein-Barr virus infection reactivation 61.82 11.78 42 123137 1062 34832690
Aggression 61.72 11.78 30 123149 38934 34794818
Unevaluable event 61.69 11.78 19 123160 32571 34801181
Bacterial sepsis 61.62 11.78 84 123095 5166 34828586
Dehydration 61.16 11.78 243 122936 129726 34704026
Blood pressure decreased 60.92 11.78 55 123124 51460 34782292
Skin papilloma 60.67 11.78 54 123125 2049 34831703
Pneumonia klebsiella 60.23 11.78 66 123113 3234 34830518
Wound dehiscence 60.05 11.78 66 123113 3245 34830507
Dysplastic naevus 59.90 11.78 31 123148 465 34833287
Pulmonary embolism 59.87 11.78 143 123036 89603 34744149
Hepatic artery thrombosis 59.72 11.78 25 123154 223 34833529
Mycoplasma infection 59.36 11.78 29 123150 382 34833370
Malacoplakia gastrointestinal 59.26 11.78 20 123159 90 34833662
Ureaplasma infection 59.11 11.78 28 123151 343 34833409
Pneumomediastinum 58.99 11.78 56 123123 2311 34831441
Photodermatosis 58.97 11.78 32 123147 531 34833221
Treatment failure 58.82 11.78 322 122857 46375 34787377
Chronic graft versus host disease in intestine 58.30 11.78 25 123154 238 34833514
Dry mouth 58.17 11.78 17 123162 30148 34803604
Urinary tract infection bacterial 58.15 11.78 51 123128 1897 34831855
Arthropathy 58.04 11.78 12 123167 26895 34806857
Gastroenteritis sapovirus 57.98 11.78 21 123158 121 34833631
Kaposi's sarcoma 57.72 11.78 37 123142 846 34832906
Fusarium infection 57.62 11.78 41 123138 1119 34832633
Psoriatic arthropathy 57.34 11.78 3 123176 19795 34813957
Glomerulonephritis membranoproliferative 57.12 11.78 29 123150 417 34833335
Solar lentigo 56.94 11.78 31 123148 518 34833234
Dysgeusia 56.78 11.78 12 123167 26485 34807267
Parvovirus infection 56.69 11.78 29 123150 424 34833328
Organising pneumonia 56.05 11.78 86 123093 5893 34827859
Large intestinal ulcer 55.70 11.78 50 123129 1919 34831833
Fungal endocarditis 55.45 11.78 27 123152 353 34833399
Myalgia 55.33 11.78 135 123044 83975 34749777
Pericarditis fungal 55.28 11.78 21 123158 141 34833611
Oedema peripheral 55.11 11.78 226 122953 119586 34714166
Scleroderma 54.81 11.78 45 123134 1527 34832225
Endocarditis 54.61 11.78 89 123090 6422 34827330
Palpitations 54.47 11.78 37 123142 39949 34793803
Rhinovirus infection 53.84 11.78 71 123108 4228 34829524
Hypokalaemia 53.74 11.78 76 123103 58138 34775614
Cutaneous T-cell lymphoma 53.57 11.78 44 123135 1494 34832258
Cardiac disorder 53.48 11.78 44 123135 43082 34790670
Emphysematous pyelonephritis 53.44 11.78 16 123163 44 34833708
Corynebacterium infection 53.18 11.78 31 123148 594 34833158
Contusion 53.18 11.78 31 123148 36333 34797419
Diabetes mellitus 52.98 11.78 314 122865 46559 34787193
Mediastinitis 52.65 11.78 32 123147 664 34833088
Central nervous system lymphoma 52.61 11.78 37 123142 991 34832761
Epidermodysplasia verruciformis 52.48 11.78 23 123156 232 34833520
Transient ischaemic attack 52.44 11.78 16 123163 27597 34806155
Post transplant distal limb syndrome 52.39 11.78 24 123155 271 34833481
Neuropathy peripheral 51.41 11.78 138 123041 83125 34750627
Periostitis 51.40 11.78 24 123155 284 34833468
Chronic graft versus host disease in eye 51.16 11.78 18 123161 94 34833658
Pneumonia pseudomonal 51.02 11.78 66 123113 3856 34829896
Post procedural bile leak 50.74 11.78 24 123155 293 34833459
Acute myocardial infarction 50.72 11.78 69 123110 53650 34780102
Therapy non-responder 50.70 11.78 272 122907 38874 34794878
Necrotising oesophagitis 50.63 11.78 29 123150 537 34833215
Rash pruritic 50.47 11.78 16 123163 26925 34806827
Human herpesvirus 6 encephalitis 50.47 11.78 25 123154 340 34833412
Enterococcal sepsis 50.37 11.78 44 123135 1628 34832124
Herpes zoster meningoencephalitis 50.31 11.78 24 123155 299 34833453
Hepatic cancer recurrent 50.31 11.78 24 123155 299 34833453
Skin lesion 50.23 11.78 181 122998 21780 34811972
Venoocclusive disease 50.02 11.78 56 123123 2811 34830941
Fungaemia 49.74 11.78 53 123126 2515 34831237
Contraindicated product administered 49.73 11.78 8 123171 21473 34812279
Polyomavirus test positive 49.65 11.78 18 123161 104 34833648
Heart rate decreased 49.43 11.78 25 123154 31720 34802032
Graft versus host disease in eye 49.34 11.78 22 123157 232 34833520
Rhodococcus infection 49.15 11.78 21 123158 198 34833554
Drug ineffective 49.09 11.78 2020 121159 454731 34379021
Coronary artery disease 48.75 11.78 59 123120 48246 34785506
Glomerulonephropathy 48.69 11.78 21 123158 203 34833549
Full blood count decreased 48.68 11.78 4 123175 18084 34815668
Therapeutic product effect incomplete 48.65 11.78 64 123115 50477 34783275
Cytomegalovirus nephritis 48.54 11.78 18 123161 112 34833640
Cutaneous mucormycosis 48.01 11.78 20 123159 176 34833576
Abdominal discomfort 47.78 11.78 86 123093 59749 34774003
Graft infection 47.67 11.78 26 123153 436 34833316
Tularaemia 47.52 11.78 17 123162 94 34833658
Encapsulating peritoneal sclerosis 46.94 11.78 28 123151 561 34833191
Opportunistic infection 46.69 11.78 42 123137 1616 34832136
Presyncope 46.68 11.78 6 123173 19053 34814699
Cytomegalovirus gastritis 46.56 11.78 21 123158 228 34833524
Uveitis 46.43 11.78 90 123089 7445 34826307
Cerebral fungal infection 46.41 11.78 22 123157 270 34833482
Bacterial infection 46.38 11.78 149 123030 16914 34816838
Skin squamous cell carcinoma recurrent 46.11 11.78 14 123165 41 34833711
Hyponatraemia 45.98 11.78 144 123035 82547 34751205
Cryptococcal cutaneous infection 45.72 11.78 16 123163 82 34833670
Musculoskeletal pain 45.69 11.78 28 123151 31935 34801817
Diarrhoea haemorrhagic 45.66 11.78 84 123095 6680 34827072
Full blood count abnormal 45.43 11.78 6 123173 18662 34815090
Respiratory depression 45.41 11.78 3 123176 16242 34817510
Malignant fibrous histiocytoma 45.35 11.78 20 123159 205 34833547
Hepatitis B reactivation 45.28 11.78 62 123117 3829 34829923
Disseminated cytomegaloviral infection 45.27 11.78 20 123159 206 34833546
Drug level fluctuating 45.03 11.78 26 123153 489 34833263
Glomerulosclerosis 45.01 11.78 31 123148 802 34832950
Abdominal distension 45.00 11.78 86 123093 58406 34775346
Meningoencephalitis herpetic 44.94 11.78 31 123148 804 34832948
Penicillium infection 44.64 11.78 17 123162 115 34833637
Drug withdrawal syndrome 44.57 11.78 8 123171 19826 34813926
Locked-in syndrome 44.57 11.78 21 123158 254 34833498
Mycobacterium haemophilum infection 44.35 11.78 16 123163 91 34833661
Heart rate increased 44.28 11.78 59 123120 46284 34787468
Injection site erythema 44.25 11.78 3 123176 15896 34817856
Biliary anastomosis complication 44.20 11.78 16 123163 92 34833660
Lupus nephritis 44.15 11.78 23 123156 350 34833402
Mycetoma mycotic 44.06 11.78 16 123163 93 34833659
Epstein Barr virus positive mucocutaneous ulcer 43.91 11.78 23 123156 354 34833398
Disseminated mucormycosis 43.89 11.78 26 123153 514 34833238
Haemodynamic instability 43.87 11.78 101 123078 9422 34824330
Viral test positive 43.58 11.78 19 123160 189 34833563
Escherichia urinary tract infection 43.54 11.78 58 123121 3488 34830264
Disseminated mycobacterium avium complex infection 43.33 11.78 15 123164 74 34833678
Glomerulonephritis proliferative 43.32 11.78 19 123160 192 34833560
Norovirus infection 43.25 11.78 18 123161 158 34833594
Encephalitis cytomegalovirus 43.16 11.78 27 123152 591 34833161
Weight increased 43.07 11.78 175 123004 92858 34740894
Chills 43.06 11.78 144 123035 80899 34752853
Granuloma 42.75 11.78 55 123124 3196 34830556
Complications of transplant surgery 42.62 11.78 25 123154 485 34833267
Product quality issue 42.61 11.78 5 123174 17030 34816722
Fungal abscess central nervous system 42.56 11.78 16 123163 104 34833648
Sedation 42.07 11.78 11 123168 20995 34812757
Pneumoperitoneum 42.06 11.78 41 123138 1749 34832003
Hospitalisation 41.76 11.78 86 123093 56816 34776936
Flushing 41.55 11.78 32 123147 32388 34801364
Ureteral necrosis 41.19 11.78 13 123166 45 34833707
H1N1 influenza 41.00 11.78 31 123148 931 34832821
Visceral leishmaniasis 40.89 11.78 26 123153 586 34833166
Respiratory arrest 40.87 11.78 24 123155 28019 34805733
Tachycardia 40.81 11.78 157 123022 84615 34749137
Blood potassium decreased 40.75 11.78 7 123172 17908 34815844
Cystitis viral 40.66 11.78 25 123154 530 34833222
Chronic graft versus host disease oral 40.38 11.78 16 123163 122 34833630
Meningitis viral 40.38 11.78 30 123149 877 34832875
Superinfection bacterial 40.35 11.78 30 123149 878 34832874
Mycobacterium avium complex infection 40.34 11.78 47 123132 2464 34831288
Skin squamous cell carcinoma metastatic 39.93 11.78 13 123166 51 34833701
Angioedema 39.49 11.78 44 123135 37330 34796422
Swelling 39.40 11.78 55 123124 42311 34791441
Abdominal pain upper 39.38 11.78 125 123054 71365 34762387
Immune reconstitution inflammatory syndrome 39.36 11.78 92 123087 8667 34825085
Respiratory tract infection fungal 39.15 11.78 27 123152 700 34833052
Urinary tract infection enterococcal 39.14 11.78 29 123150 844 34832908
Haemoglobin decreased 39.07 11.78 257 122922 120515 34713237
Cushingoid 39.01 11.78 48 123131 2666 34831086
External auditory canal atresia 38.92 11.78 17 123162 170 34833582
Clostridium difficile colitis 38.86 11.78 133 123046 15597 34818155
Herpes virus infection 38.82 11.78 49 123130 2793 34830959
Nephrolithiasis 38.79 11.78 30 123149 30303 34803449
Drug eruption 38.76 11.78 11 123168 19887 34813865
Scrotal ulcer 38.59 11.78 23 123156 460 34833292
Peritonitis pneumococcal 38.52 11.78 11 123168 24 34833728
Steroid diabetes 38.51 11.78 43 123136 2152 34831600
Rhabdomyolysis 38.38 11.78 118 123061 68045 34765707
Urinoma 38.33 11.78 18 123161 216 34833536
Renal tubular disorder 38.31 11.78 63 123116 4580 34829172
Choriomeningitis lymphocytic 38.22 11.78 11 123168 25 34833727
Wound infection 38.19 11.78 80 123099 6999 34826753
Enterovirus infection 38.15 11.78 30 123149 956 34832796
Thrombosis 38.11 11.78 75 123104 50383 34783369
Microtia 37.87 11.78 19 123160 266 34833486
Disseminated Bacillus Calmette-Guerin infection 37.82 11.78 17 123162 183 34833569
Rectal haemorrhage 37.69 11.78 52 123127 40197 34793555
Gastroenteritis cryptosporidial 37.58 11.78 17 123162 186 34833566
Cough 37.55 11.78 343 122836 149797 34683955
Prostatic specific antigen increased 37.50 11.78 4 123175 14676 34819076
Prostate cancer 37.35 11.78 51 123128 39598 34794154
Migraine 37.27 11.78 8 123171 17470 34816282
Haematemesis 37.26 11.78 26 123153 27685 34806067
Oropharyngeal pain 37.25 11.78 42 123137 35443 34798309
Intentional self-injury 37.18 11.78 3 123176 13768 34819984
Blood creatine phosphokinase increased 37.15 11.78 63 123116 44794 34788958
Dysphonia 37.03 11.78 18 123161 23365 34810387
Central nervous system fungal infection 36.96 11.78 20 123159 330 34833422
Systemic mycosis 36.90 11.78 36 123143 1537 34832215
Stevens-Johnson syndrome 36.87 11.78 10 123169 18629 34815123
Vision blurred 36.75 11.78 66 123113 45897 34787855
Bile duct stenosis 36.74 11.78 32 123147 1179 34832573
Cutaneous tuberculosis 36.73 11.78 14 123165 95 34833657
Plasma cell myeloma 36.73 11.78 57 123122 41980 34791772
Emphysematous cystitis 36.60 11.78 14 123165 96 34833656
Nightmare 36.56 11.78 4 123175 14387 34819365
Propionibacterium infection 36.13 11.78 18 123161 248 34833504
Central nervous system infection 36.02 11.78 25 123154 655 34833097
Atypical mycobacterial pneumonia 35.91 11.78 15 123164 133 34833619
Pneumonia influenzal 35.90 11.78 35 123144 1493 34832259
Idiopathic pneumonia syndrome 35.88 11.78 18 123161 252 34833500
Therapy partial responder 35.81 11.78 94 123085 9522 34824230
Adverse event 35.74 11.78 11 123168 18866 34814886
Cutaneous blastomycosis 35.60 11.78 10 123169 20 34833732
Coccidioidomycosis 35.57 11.78 26 123153 741 34833011
Head injury 35.44 11.78 10 123169 18150 34815602
Pneumonia bacterial 35.34 11.78 107 123072 11765 34821987
Incorrect dose administered 35.33 11.78 55 123124 40460 34793292
Pneumonia acinetobacter 35.31 11.78 14 123165 107 34833645
Hot flush 35.16 11.78 10 123169 18056 34815696
Dysphagia 35.12 11.78 108 123071 62273 34771479
Lymphadenitis bacterial 35.09 11.78 11 123168 37 34833715
Multiple sclerosis relapse 35.08 11.78 3 123176 13130 34820622
Dyspepsia 34.85 11.78 47 123132 36685 34797067
Complications of bone marrow transplant 34.79 11.78 17 123162 224 34833528
Sinusitis aspergillus 34.77 11.78 13 123166 83 34833669
Enterococcal bacteraemia 34.73 11.78 38 123141 1859 34831893
Transitional cell carcinoma metastatic 34.65 11.78 11 123168 39 34833713
Cutaneous malacoplakia 34.64 11.78 13 123166 84 34833668
Pre-engraftment immune reaction 34.38 11.78 13 123166 86 34833666
Sporotrichosis 34.37 11.78 12 123167 61 34833691
Cholangitis sclerosing 34.24 11.78 33 123146 1388 34832364
Heart rate irregular 34.19 11.78 7 123172 15800 34817952
Orf 34.08 11.78 10 123169 25 34833727
Paternal exposure before pregnancy 34.02 11.78 11 123168 42 34833710
Apoptotic colonopathy 34.01 11.78 13 123166 89 34833663
Foetal exposure during pregnancy 33.92 11.78 51 123128 38050 34795702
Hyperplasia 33.87 11.78 23 123156 581 34833171
Cardio-respiratory arrest 33.81 11.78 92 123087 55181 34778571
Heartland virus infection 33.80 11.78 10 123169 26 34833726
Escherichia sepsis 33.77 11.78 60 123119 4644 34829108
Intestinal tuberculosis 33.63 11.78 14 123165 123 34833629
Herpes zoster 33.59 11.78 222 122957 34177 34799575
Abscess fungal 33.57 11.78 17 123162 243 34833509
Gastrooesophageal reflux disease 33.54 11.78 51 123128 37873 34795879
Lactic acidosis 33.49 11.78 44 123135 34728 34799024
Chronic hepatitis 33.42 11.78 24 123155 665 34833087
Rebound effect 33.41 11.78 49 123130 3225 34830527
Subcapsular renal haematoma 33.38 11.78 20 123159 404 34833348
Myopathy 33.33 11.78 103 123076 11451 34822301
Pleocytosis 33.31 11.78 22 123157 530 34833222
Removal of renal transplant 33.27 11.78 10 123169 28 34833724
Scopulariopsis infection 33.17 11.78 13 123166 96 34833656
Ileal ulcer 33.00 11.78 23 123156 607 34833145
Seroconversion test negative 32.76 11.78 8 123171 6 34833746
Atypical haemolytic uraemic syndrome 32.73 11.78 18 123161 307 34833445
Orthostatic hypotension 32.68 11.78 26 123153 25893 34807859
Swollen tongue 32.58 11.78 6 123173 14599 34819153
Central nervous system lesion 32.52 11.78 71 123108 6392 34827360
Erectile dysfunction 32.51 11.78 16 123163 20621 34813131
Pyogenic granuloma 32.44 11.78 17 123162 262 34833490
Aphthous ulcer 32.43 11.78 61 123118 4934 34828818
Hypocalcaemia 32.38 11.78 23 123156 24266 34809486
Oliguria 32.32 11.78 83 123096 8297 34825455
Irritability 32.11 11.78 24 123155 24666 34809086
Reversible cerebral vasoconstriction syndrome 32.00 11.78 20 123159 437 34833315
Transitional cell carcinoma 31.92 11.78 39 123140 2150 34831602
Colitis 31.80 11.78 235 122944 37515 34796237
Medication error 31.79 11.78 26 123153 25539 34808213
Cytomegalovirus hepatitis 31.76 11.78 20 123159 443 34833309
Retinitis 31.75 11.78 19 123160 383 34833369
Capillaritis 31.65 11.78 13 123166 110 34833642
Postoperative wound infection 31.41 11.78 59 123120 4767 34828985
Diabetic cardiomyopathy 31.41 11.78 9 123170 20 34833732
Neuroleptic malignant syndrome 31.27 11.78 12 123167 17922 34815830
Epstein-Barr virus antibody positive 31.23 11.78 17 123162 284 34833468
Pharyngeal polyp 31.22 11.78 8 123171 9 34833743
White blood cell count increased 31.21 11.78 61 123118 41090 34792662
Oxygen saturation decreased 31.13 11.78 92 123087 53726 34780026
Osteomyelitis fungal 31.09 11.78 16 123163 237 34833515
Lung transplant 31.05 11.78 37 123142 1987 34831765
Pleural adhesion 31.02 11.78 15 123164 193 34833559
Drug dependence 30.91 11.78 24 123155 24193 34809559
Klebsiella sepsis 30.86 11.78 37 123142 2000 34831752
Oesophageal ulcer 30.81 11.78 48 123131 3333 34830419
Bacterial pyelonephritis 30.80 11.78 16 123163 242 34833510
Inferior vena cava stenosis 30.53 11.78 9 123170 23 34833729
Lymphocytic infiltration 30.38 11.78 23 123156 692 34833060
Anuria 30.35 11.78 93 123086 10292 34823460
Bronchitis 30.30 11.78 64 123115 41899 34791853
Infertility 30.28 11.78 15 123164 204 34833548
Renal and pancreas transplant rejection 30.26 11.78 9 123170 24 34833728
Dyskinesia 30.17 11.78 21 123158 22392 34811360
Intentional product use issue 30.13 11.78 333 122846 59483 34774269
Respiratory syncytial virus infection 29.94 11.78 57 123122 4652 34829100
Disseminated varicella zoster vaccine virus infection 29.81 11.78 10 123169 44 34833708
Non-cirrhotic portal hypertension 29.78 11.78 16 123163 260 34833492
Varicella 29.67 11.78 33 123146 1644 34832108
Chromoblastomycosis 29.63 11.78 10 123169 45 34833707
Osteoarthritis 29.61 11.78 18 123161 20624 34813128
Urinary tract infection viral 29.49 11.78 9 123170 27 34833725
Aspergilloma 29.43 11.78 17 123162 320 34833432
Discomfort 29.35 11.78 15 123164 18923 34814829
Renal haematoma 29.33 11.78 20 123159 509 34833243
Klebsiella bacteraemia 29.31 11.78 30 123149 1358 34832394
Incorrect route of product administration 29.30 11.78 8 123171 14837 34818915
Muir-Torre syndrome 29.17 11.78 8 123171 14 34833738
Proteus infection 29.16 11.78 27 123152 1079 34832673
Meningitis fungal 29.06 11.78 12 123167 103 34833649
Burkholderia cepacia complex infection 29.03 11.78 14 123165 179 34833573
Toxic optic neuropathy 28.94 11.78 24 123155 826 34832926
Pneumonia viral 28.84 11.78 45 123134 3129 34830623
Adenoviral haemorrhagic cystitis 28.69 11.78 18 123161 396 34833356
Cerebral aspergillosis 28.53 11.78 30 123149 1402 34832350
Hepatic fibrosis 28.35 11.78 55 123124 4552 34829200
Graft thrombosis 28.33 11.78 16 123163 288 34833464
Lactobacillus infection 28.24 11.78 16 123163 290 34833462
Gastrointestinal haemorrhage 28.23 11.78 189 122990 88288 34745464
Tinnitus 28.23 11.78 18 123161 20100 34813652
Seizure 28.22 11.78 235 122944 104622 34729130
Skin necrosis 27.98 11.78 63 123116 5790 34827962
Serratia infection 27.93 11.78 24 123155 868 34832884
Pericarditis constrictive 27.92 11.78 17 123162 354 34833398
Acute disseminated encephalomyelitis 27.86 11.78 11 123168 83 34833669
Pancreatitis necrotising 27.74 11.78 41 123138 2717 34831035
Serotonin syndrome 27.74 11.78 18 123161 19915 34813837
Enteritis 27.72 11.78 77 123102 8065 34825687
Product prescribing error 27.67 11.78 24 123155 22903 34810849
Glomerulonephritis rapidly progressive 27.60 11.78 21 123158 637 34833115
Skin mass 27.55 11.78 50 123129 3935 34829817
Metastatic carcinoma of the bladder 27.47 11.78 14 123165 203 34833549
Renal vein thrombosis 27.46 11.78 13 123166 159 34833593
Guillain-Barre syndrome 27.42 11.78 64 123115 6023 34827729
Lepromatous leprosy 27.41 11.78 10 123169 59 34833693
Necrotising fasciitis 27.40 11.78 48 123131 3674 34830078
Human herpesvirus 6 infection reactivation 27.39 11.78 13 123166 160 34833592
Transplantation associated food allergy 27.31 11.78 9 123170 37 34833715
Anaphylactic shock 27.24 11.78 11 123168 15930 34817822
Sphincter of Oddi dysfunction 27.13 11.78 12 123167 124 34833628
Mouth ulceration 27.09 11.78 98 123081 11812 34821940
Flatulence 27.06 11.78 21 123158 21177 34812575
Blindness cortical 27.02 11.78 17 123162 376 34833376
Upper gastrointestinal haemorrhage 27.00 11.78 30 123149 25488 34808264
Synovitis 26.98 11.78 8 123171 14058 34819694
Intraocular pressure increased 26.93 11.78 59 123120 5324 34828428
Product administration error 26.78 11.78 12 123167 16332 34817420
Osmotic demyelination syndrome 26.77 11.78 23 123156 832 34832920
Pyelonephritis chronic 26.58 11.78 9 123170 41 34833711
Cystitis escherichia 26.43 11.78 13 123166 174 34833578
Nephropathy 26.42 11.78 62 123117 5855 34827897
Phaeohyphomycotic brain abscess 26.40 11.78 9 123170 42 34833710
Blood pressure fluctuation 26.37 11.78 30 123149 25219 34808533
Dehiscence 26.29 11.78 11 123168 98 34833654
Acid fast bacilli infection 26.29 11.78 11 123168 98 34833654
Laboratory test abnormal 26.29 11.78 20 123159 20371 34813381
Staphylococcal scalded skin syndrome 26.18 11.78 15 123164 278 34833474
Skin laceration 26.12 11.78 6 123173 12503 34821249
Nephrectomy 26.07 11.78 22 123157 776 34832976
Ureteric anastomosis complication 26.06 11.78 9 123170 44 34833708
Coronavirus infection 26.00 11.78 51 123128 4256 34829496
Muscular weakness 25.69 11.78 151 123028 72746 34761006
Nasal congestion 25.64 11.78 26 123153 23031 34810721
Hepatocellular carcinoma 25.55 11.78 71 123108 7438 34826314
Parainfluenzae virus infection 25.54 11.78 40 123139 2790 34830962
B-cell lymphoma 25.54 11.78 51 123128 4312 34829440
Neck pain 25.53 11.78 31 123148 25318 34808434
Lymphangiectasia 25.50 11.78 8 123171 27 34833725
Haematotoxicity 25.47 11.78 75 123104 8119 34825633
Optic atrophy 25.44 11.78 23 123156 891 34832861
Oropharyngeal squamous cell carcinoma 25.30 11.78 13 123166 192 34833560
Microsporum infection 25.28 11.78 8 123171 28 34833724
Trichophytic granuloma 25.27 11.78 9 123170 49 34833703
Tuberculosis 25.24 11.78 77 123102 8500 34825252
Bone marrow transplant rejection 25.18 11.78 13 123166 194 34833558
Zoonotic bacterial infection 25.12 11.78 9 123170 50 34833702
Angina pectoris 25.10 11.78 45 123134 31318 34802434
Escherichia bacteraemia 25.06 11.78 43 123136 3237 34830515
Feeling hot 24.97 11.78 19 123160 19353 34814399
Morganella infection 24.90 11.78 18 123161 504 34833248
IIIrd nerve paralysis 24.90 11.78 18 123161 504 34833248
Restlessness 24.79 11.78 32 123147 25450 34808302
Paranoia 24.78 11.78 6 123173 12062 34821690
Melaena 24.68 11.78 55 123124 35325 34798427
Obstructive nephropathy 24.65 11.78 8 123171 31 34833721
Swelling face 24.63 11.78 27 123152 23078 34810674
Drug level decreased 24.57 11.78 72 123107 7774 34825978
Bone pain 24.55 11.78 22 123157 20664 34813088
Squamous cell carcinoma of the oral cavity 24.43 11.78 13 123166 207 34833545
Fluoride increased 24.41 11.78 9 123170 55 34833697
Underdose 24.39 11.78 9 123170 13771 34819981
Mobility decreased 24.32 11.78 43 123136 30085 34803667
Ecthyma 24.18 11.78 17 123162 455 34833297
Skin exfoliation 24.15 11.78 37 123142 27395 34806357
Cytokine release syndrome 24.09 11.78 27 123152 22850 34810902
Cytomegalovirus gastroenteritis 24.05 11.78 13 123166 214 34833538
Road traffic accident 23.96 11.78 16 123163 17434 34816318
Injection site reaction 23.95 11.78 8 123171 13025 34820727
Spermatozoa progressive motility decreased 23.95 11.78 11 123168 125 34833627
Herpes zoster cutaneous disseminated 23.92 11.78 12 123167 168 34833584
Hypersomnia 23.90 11.78 7 123172 12400 34821352
Disturbance in attention 23.81 11.78 34 123145 25911 34807841
Norovirus test positive 23.75 11.78 9 123170 60 34833692
Pericarditis infective 23.75 11.78 9 123170 60 34833692
Chronic myeloid leukaemia 23.74 11.78 34 123145 2190 34831562
Odynophagia 23.73 11.78 57 123122 5464 34828288
Renal vessel disorder 23.73 11.78 13 123166 220 34833532
Mycobacterium fortuitum infection 23.73 11.78 12 123167 171 34833581
Perinephric collection 23.73 11.78 12 123167 171 34833581
Iris coloboma 23.72 11.78 7 123172 18 34833734
Pulmonary tuberculosis 23.66 11.78 52 123127 4702 34829050
Ophthalmic herpes zoster 23.62 11.78 22 123157 886 34832866
Acanthamoeba infection 23.61 11.78 16 123163 403 34833349
Mucosal hypertrophy 23.53 11.78 8 123171 37 34833715
Depressed level of consciousness 23.52 11.78 75 123104 42766 34790986
Serum sickness 23.47 11.78 32 123147 1968 34831784
Pneumonia respiratory syncytial viral 23.31 11.78 22 123157 901 34832851
Pathergy reaction 23.30 11.78 6 123173 7 34833745
Gastroenteritis adenovirus 23.28 11.78 11 123168 134 34833618
Eye infection toxoplasmal 23.27 11.78 13 123166 229 34833523
Serpiginous choroiditis 23.26 11.78 5 123174 0 34833752
Urinary retention 23.25 11.78 59 123120 36229 34797523
Legionella infection 23.21 11.78 17 123162 486 34833266
Injection site swelling 23.15 11.78 6 123173 11521 34822231
Humoral immune defect 23.07 11.78 12 123167 182 34833570
Necrotising retinitis 23.07 11.78 21 123158 821 34832931
Infection in an immunocompromised host 23.01 11.78 19 123160 650 34833102
Stomatitis 22.94 11.78 75 123104 42439 34791313
Osteoporosis 22.93 11.78 97 123082 12571 34821181
Arterial rupture 22.91 11.78 17 123162 496 34833256
Cutaneous sporotrichosis 22.86 11.78 8 123171 41 34833711
Pallor 22.78 11.78 34 123145 25446 34808306
Faeces discoloured 22.74 11.78 12 123167 14866 34818886
Neutrophil morphology abnormal 22.67 11.78 9 123170 69 34833683
Hepatic artery stenosis 22.64 11.78 11 123168 143 34833609
Schistosomiasis 22.55 11.78 8 123171 43 34833709
Sleep apnoea syndrome 22.50 11.78 23 123156 20298 34813454
Feeling cold 22.42 11.78 5 123174 10634 34823118
Hepatosplenomegaly 22.35 11.78 47 123132 4122 34829630
Arrhythmia 22.35 11.78 59 123120 35749 34798003
Candida sepsis 22.34 11.78 25 123154 1254 34832498
Tuberculosis of central nervous system 22.34 11.78 12 123167 195 34833557
Ventricular tachycardia 22.31 11.78 37 123142 26542 34807210
Extranodal marginal zone B-cell lymphoma (MALT type) 22.28 11.78 12 123167 196 34833556
Glucose tolerance impaired 22.26 11.78 41 123138 3263 34830489
Abdominal pain 22.03 11.78 425 122754 163193 34670559
Deep vein thrombosis 22.02 11.78 137 123042 65111 34768641
Tracheitis 21.93 11.78 19 123160 695 34833057
Engraftment syndrome 21.87 11.78 22 123157 975 34832777
Renal artery stenosis 21.87 11.78 33 123146 2228 34831524
Phospholipidosis 21.82 11.78 8 123171 48 34833704
Oxalosis 21.80 11.78 7 123172 26 34833726
Pneumocephalus 21.80 11.78 11 123168 156 34833596
Cutaneous nocardiosis 21.80 11.78 11 123168 156 34833596
Lip swelling 21.73 11.78 15 123164 16065 34817687
Benign prostatic hyperplasia 21.70 11.78 12 123167 14483 34819269
Staphylococcal mediastinitis 21.68 11.78 8 123171 49 34833703
Chronic papillomatous dermatitis 21.68 11.78 8 123171 49 34833703
Abnormal behaviour 21.67 11.78 34 123145 24935 34808817
Haemorrhagic cyst 21.43 11.78 9 123170 81 34833671
Gastrointestinal disorder 21.42 11.78 198 122981 33750 34800002
HIV infection 21.41 11.78 25 123154 1314 34832438
Cognitive disorder 21.36 11.78 43 123136 28650 34805102
Adenovirus reactivation 21.35 11.78 12 123167 214 34833538
Staphylococcal bacteraemia 21.35 11.78 72 123107 8380 34825372
Rhinorrhoea 21.29 11.78 36 123143 25632 34808120
Skin discolouration 21.15 11.78 19 123160 17826 34815926
Pneumopericardium 21.15 11.78 10 123169 122 34833630
Appendicitis 21.12 11.78 13 123166 14794 34818958
Protein-losing gastroenteropathy 21.10 11.78 14 123165 340 34833412
Hypertensive emergency 21.10 11.78 22 123157 1018 34832734
Gynaecomastia 21.02 11.78 5 123174 10175 34823577
Acanthoma 21.01 11.78 7 123172 30 34833722
Hypoacusis 21.00 11.78 16 123163 16285 34817467
Pulmonary air leakage 20.96 11.78 11 123168 170 34833582
Pollakiuria 20.96 11.78 23 123156 19651 34814101
Influenza like illness 20.92 11.78 41 123138 27593 34806159
Metastases to peritoneum 20.88 11.78 29 123150 1815 34831937
Cow pox 20.83 11.78 7 123172 31 34833721
Anastomotic stenosis 20.76 11.78 13 123166 285 34833467
Pain in jaw 20.71 11.78 10 123169 13030 34820722
Body temperature decreased 20.69 11.78 10 123169 13024 34820728
Oesophageal candidiasis 20.66 11.78 47 123132 4349 34829403
Withdrawal syndrome 20.63 11.78 9 123170 12446 34821306
Urine output decreased 20.62 11.78 80 123099 9969 34823783
Paradoxical drug reaction 20.62 11.78 40 123139 3311 34830441
Bronchitis bacterial 20.59 11.78 19 123160 756 34832996
Tuberculosis gastrointestinal 20.49 11.78 12 123167 232 34833520
Endocarditis bacterial 20.45 11.78 21 123158 954 34832798
Encephalitis fungal 20.41 11.78 11 123168 180 34833572
Oesophageal carcinoma 20.37 11.78 4 123175 9300 34824452
Alpha haemolytic streptococcal infection 20.28 11.78 23 123156 1171 34832581
Dyspnoea exertional 20.27 11.78 81 123098 43198 34790554
Osteomyelitis chronic 20.25 11.78 13 123166 298 34833454
Lung abscess 20.25 11.78 35 123144 2650 34831102
Meningitis bacterial 20.23 11.78 24 123155 1283 34832469
Burning sensation 20.16 11.78 21 123158 18373 34815379
Muscle rigidity 20.14 11.78 6 123173 10512 34823240
Pneumoretroperitoneum 20.12 11.78 10 123169 137 34833615
Osteonecrosis of jaw 20.08 11.78 20 123159 17869 34815883
Limb injury 20.08 11.78 8 123171 11681 34822071
Hepatitis C virus test 20.08 11.78 8 123171 62 34833690
Acute myeloid leukaemia recurrent 20.04 11.78 31 123148 2139 34831613
Acute allograft nephropathy 19.98 11.78 7 123172 36 34833716
Sinus tachycardia 19.96 11.78 19 123160 17341 34816411
Coma 19.84 11.78 88 123091 45590 34788162
Transplantation complication 19.81 11.78 10 123169 142 34833610
Meningoencephalitis viral 19.81 11.78 10 123169 142 34833610
Microangiopathic haemolytic anaemia 19.78 11.78 20 123159 892 34832860
Post procedural urine leak 19.74 11.78 10 123169 143 34833609
Renal haemorrhage 19.71 11.78 25 123154 1432 34832320
Gastroenteritis rotavirus 19.68 11.78 11 123168 194 34833558
Bronchiolitis obliterans syndrome 19.63 11.78 11 123168 195 34833557
Pneumococcal infection 19.60 11.78 15 123164 459 34833293
Alanine aminotransferase increased 19.59 11.78 186 122993 80629 34753123
Pyrexia 19.56 11.78 1393 121786 331620 34502132
Respiratory distress 19.56 11.78 202 122977 35463 34798289
Human anaplasmosis 19.55 11.78 8 123171 67 34833685
Disseminated strongyloidiasis 19.53 11.78 11 123168 197 34833555
B-lymphocyte count decreased 19.53 11.78 17 123162 626 34833126
Ageusia 19.52 11.78 6 123173 10302 34823450
Papillary renal cell carcinoma 19.45 11.78 12 123167 256 34833496
Mycobacterium kansasii infection 19.44 11.78 13 123166 320 34833432
Myelodysplastic syndrome unclassifiable 19.42 11.78 6 123173 19 34833733
Granulomatous dermatitis 19.41 11.78 12 123167 257 34833495
Retinopathy haemorrhagic 19.37 11.78 7 123172 40 34833712
Peritonitis 19.37 11.78 111 123068 16254 34817498
Engraft failure 19.24 11.78 15 123164 472 34833280
Herpes zoster oticus 19.24 11.78 11 123168 203 34833549
Renal infarct 19.24 11.78 24 123155 1352 34832400
Tumour lysis syndrome 19.24 11.78 19 123160 17040 34816712
Passenger lymphocyte syndrome 19.23 11.78 7 123172 41 34833711
Cytomegalovirus syndrome 19.16 11.78 9 123170 108 34833644
Viral load increased 19.14 11.78 33 123146 2494 34831258
Seborrhoeic keratosis 19.11 11.78 23 123156 1248 34832504
Biopsy kidney abnormal 19.09 11.78 9 123170 109 34833643
Miosis 19.08 11.78 5 123174 9530 34824222
Dysarthria 19.02 11.78 61 123118 34721 34799031
Obstructive airways disorder 18.97 11.78 16 123163 15478 34818274
Metastases to lung 18.96 11.78 74 123105 9246 34824506
Renal adenoma 18.96 11.78 6 123173 21 34833731
Anomalous pulmonary venous connection 18.86 11.78 8 123171 74 34833678
Fungal sepsis 18.84 11.78 19 123160 845 34832907
Hepatotoxicity 18.81 11.78 135 123044 21350 34812402
Isosporiasis 18.80 11.78 9 123170 113 34833639
Arteritis infective 18.75 11.78 6 123173 22 34833730
Papilloma 18.73 11.78 12 123167 274 34833478
Pneumonia necrotising 18.70 11.78 18 123161 756 34832996
Hepatitis infectious mononucleosis 18.68 11.78 7 123172 45 34833707
Lung adenocarcinoma stage IV 18.66 11.78 9 123170 115 34833637
Polymorphonuclear chromatin clumping 18.61 11.78 4 123175 0 34833752
Citrobacter infection 18.55 11.78 15 123164 498 34833254
Calciphylaxis 18.49 11.78 21 123158 1071 34832681
Disseminated intravascular coagulation 18.48 11.78 136 123043 21680 34812072
Emphysematous cholecystitis 18.43 11.78 7 123172 47 34833705
Neuroendocrine carcinoma of the skin 18.36 11.78 18 123161 773 34832979
Dementia 18.35 11.78 13 123166 13735 34820017
Haemoperitoneum 18.32 11.78 27 123152 1785 34831967
Lung infiltration 18.31 11.78 92 123087 12813 34820939
Unresponsive to stimuli 18.31 11.78 44 123135 27525 34806227
Antiviral drug level above therapeutic 18.30 11.78 7 123172 48 34833704
Fear 18.28 11.78 7 123172 10469 34823283
Localised infection 18.25 11.78 21 123158 17566 34816186
T-cell lymphoma 18.23 11.78 20 123159 981 34832771
Inflammatory bowel disease 18.14 11.78 35 123144 2885 34830867
Anaphylactic reaction 18.12 11.78 56 123123 32245 34801507
Ureteric obstruction 18.10 11.78 22 123157 1206 34832546
Arteritis coronary 18.06 11.78 7 123172 50 34833702
Depressed mood 18.04 11.78 25 123154 19292 34814460
Hyperoxaluria 18.00 11.78 9 123170 125 34833627
Joint injury 18.00 11.78 5 123174 9168 34824584
Haemosiderosis 17.99 11.78 12 123167 294 34833458
Vascular hyalinosis 17.97 11.78 8 123171 84 34833668
Bladder transitional cell carcinoma 17.96 11.78 33 123146 2622 34831130
Varicella zoster pneumonia 17.89 11.78 8 123171 85 34833667
Mesangioproliferative glomerulonephritis 17.82 11.78 7 123172 52 34833700
Bile duct necrosis 17.80 11.78 5 123174 10 34833742
Delirium 17.78 11.78 87 123092 43904 34789848
Dystonia 17.71 11.78 8 123171 10837 34822915
Bulbar palsy 17.69 11.78 11 123168 238 34833514
Leukaemia recurrent 17.69 11.78 25 123154 1590 34832162
Blood urine present 17.68 11.78 8 123171 10826 34822926
Hip fracture 17.67 11.78 10 123169 11915 34821837
Gastric haemorrhage 17.67 11.78 7 123172 10254 34823498
Diverticulitis intestinal perforated 17.65 11.78 8 123171 88 34833664
Colon dysplasia 17.63 11.78 9 123170 131 34833621
Oesophagitis ulcerative 17.62 11.78 18 123161 813 34832939
Subdural haematoma 17.54 11.78 28 123151 20393 34813359
Portal hypertension 17.53 11.78 42 123137 4020 34829732
Gastrointestinal mucormycosis 17.47 11.78 10 123169 185 34833567
Renal cell carcinoma 17.44 11.78 48 123131 5000 34828752
Nephrocalcinosis 17.44 11.78 16 123163 632 34833120
Influenza 17.43 11.78 103 123076 49563 34784189
Bronchospasm 17.39 11.78 8 123171 10723 34823029
T-cell lymphoma stage IV 17.39 11.78 9 123170 135 34833617
Vascular pseudoaneurysm 17.34 11.78 29 123150 2138 34831614
Prescribed underdose 17.28 11.78 5 123174 8928 34824824
Hepatic infection fungal 17.28 11.78 10 123169 189 34833563
Endoscopy upper gastrointestinal tract abnormal 17.27 11.78 7 123172 57 34833695
Hyperfibrinogenaemia 17.27 11.78 7 123172 57 34833695
Microangiopathy 17.27 11.78 19 123160 935 34832817
Sebaceous gland disorder 17.27 11.78 6 123173 30 34833722
Dengue fever 17.26 11.78 11 123168 249 34833503
Accidental exposure to product 17.23 11.78 12 123167 12790 34820962
Superinfection viral 17.18 11.78 5 123174 12 34833740
Anaplastic large cell lymphoma T- and null-cell types 17.18 11.78 8 123171 94 34833658
Intracranial pressure increased 17.18 11.78 41 123138 3914 34829838
Poor quality sleep 17.16 11.78 4 123175 8252 34825500
Agranulocytosis 17.14 11.78 143 123036 23678 34810074
Cyanosis 17.13 11.78 12 123167 12752 34821000
Arthritis 17.12 11.78 55 123124 31291 34802461
Corneal graft rejection 17.11 11.78 6 123173 31 34833721
Pleomorphic malignant fibrous histiocytoma 17.11 11.78 6 123173 31 34833721
Nosocomial infection 17.01 11.78 21 123158 1170 34832582
Acute hepatic failure 17.01 11.78 96 123083 13978 34819774
Hepatic haematoma 17.01 11.78 13 123166 397 34833355
Cardiac failure 16.97 11.78 223 122956 91025 34742727
Severe acute respiratory syndrome 16.96 11.78 7 123172 60 34833692
Oesophageal injury 16.95 11.78 6 123173 32 34833720
Cyclosporidium infection 16.90 11.78 5 123174 13 34833739
Lethargy 16.81 11.78 81 123098 41041 34792711
Viral cardiomyopathy 16.80 11.78 6 123173 33 34833719
Pseudomembranous colitis 16.79 11.78 33 123146 2758 34830994
Meningeal neoplasm 16.76 11.78 7 123172 62 34833690
Antiphospholipid syndrome 16.76 11.78 14 123165 487 34833265
Disseminated aspergillosis 16.73 11.78 17 123162 763 34832989
Hypothyroidism 16.72 11.78 30 123149 20872 34812880
Achromobacter infection 16.67 11.78 7 123172 63 34833689
Anal ulcer 16.66 11.78 18 123161 868 34832884
Lung squamous cell carcinoma stage IV 16.65 11.78 6 123173 34 34833718
Cytomegalovirus enterocolitis 16.63 11.78 19 123160 975 34832777
Red blood cell count decreased 16.62 11.78 50 123129 29040 34804712
Haemophilus infection 16.60 11.78 21 123158 1200 34832552
Chronic hepatitis C 16.59 11.78 13 123166 412 34833340
Central nervous system vasculitis 16.56 11.78 14 123165 495 34833257
Pityriasis rubra pilaris 16.54 11.78 8 123171 103 34833649
Coronary artery occlusion 16.52 11.78 9 123170 10953 34822799
Growth retardation 16.51 11.78 26 123153 1822 34831930
Leiomyosarcoma 16.50 11.78 9 123170 151 34833601
Toxic epidermal necrolysis 16.49 11.78 32 123147 21614 34812138
Oesophageal atresia 16.47 11.78 14 123165 499 34833253
Pulmonary haemorrhage 16.46 11.78 76 123103 10228 34823524
Arteriosclerosis coronary artery 16.41 11.78 12 123167 12473 34821279
Bordetella infection 16.40 11.78 8 123171 105 34833647
Infective aneurysm 16.40 11.78 15 123164 590 34833162
Opsoclonus myoclonus 16.38 11.78 7 123172 66 34833686
Central nervous system immune reconstitution inflammatory response 16.38 11.78 5 123174 15 34833737
Biliary hamartoma 16.38 11.78 5 123174 15 34833737
Nephritis haemorrhagic 16.38 11.78 5 123174 15 34833737
Wound evisceration 16.33 11.78 8 123171 106 34833646
Pyuria 16.31 11.78 17 123162 786 34832966
Rib fracture 16.28 11.78 16 123163 14384 34819368
Chest wall abscess 16.24 11.78 9 123170 156 34833596
Wound infection pseudomonas 16.23 11.78 11 123168 277 34833475
Viral sepsis 16.20 11.78 8 123171 108 34833644
Neutrophil count increased 16.20 11.78 22 123157 17124 34816628
Blood immunoglobulin A decreased 16.20 11.78 11 123168 278 34833474
Skin induration 16.17 11.78 28 123151 2123 34831629
Extrapyramidal disorder 16.14 11.78 13 123166 12867 34820885
Limbic encephalitis 16.12 11.78 13 123166 430 34833322
Clostridium difficile infection 16.11 11.78 118 123061 18780 34814972
Arterial disorder 16.09 11.78 21 123158 1238 34832514
Right ventricular diastolic collapse 16.02 11.78 7 123172 70 34833682
Urinary fistula 16.01 11.78 8 123171 111 34833641
Hepatitis C RNA increased 15.99 11.78 11 123168 284 34833468
Nocturia 15.95 11.78 8 123171 10202 34823550
Donor specific antibody present 15.95 11.78 8 123171 112 34833640
Metastasis 15.93 11.78 41 123138 4103 34829649
Mycobacterium marinum infection 15.92 11.78 11 123168 286 34833466
Metastases to skin 15.89 11.78 13 123166 439 34833313
Insulin resistant diabetes 15.85 11.78 4 123175 4 34833748
Acute pulmonary histoplasmosis 15.84 11.78 9 123170 164 34833588
Anastomotic haemorrhage 15.84 11.78 9 123170 164 34833588
Infectious pleural effusion 15.83 11.78 30 123149 2440 34831312
Pancreatic fistula 15.77 11.78 7 123172 73 34833679
Eosinophilia 15.76 11.78 44 123135 26178 34807574
Vascular graft complication 15.76 11.78 8 123171 115 34833637
Eye pain 15.73 11.78 91 123088 13371 34820381
Necrotising herpetic retinopathy 15.69 11.78 5 123174 18 34833734
Meningitis candida 15.68 11.78 7 123172 74 34833678
Ectropion 15.64 11.78 8 123171 117 34833635
Neoplasm progression 15.62 11.78 37 123142 23263 34810489
Oral herpes 15.58 11.78 49 123130 5498 34828254
Blood phosphorus increased 15.54 11.78 4 123175 7717 34826035
Gait inability 15.54 11.78 31 123148 20727 34813025
Splenic peliosis 15.48 11.78 5 123174 19 34833733
Purtscher retinopathy 15.48 11.78 5 123174 19 34833733
Psychotic disorder 15.48 11.78 40 123139 24412 34809340
Cholelithiasis 15.48 11.78 32 123147 21116 34812636
Lymphadenopathy mediastinal 15.46 11.78 30 123149 2483 34831269
Disseminated coccidioidomycosis 15.44 11.78 7 123172 77 34833675
Injury 15.40 11.78 31 123148 20656 34813096
Hypertrophic osteoarthropathy 15.36 11.78 7 123172 78 34833674
Glomerulonephritis membranous 15.35 11.78 20 123159 1177 34832575
Plasmodium falciparum infection 15.34 11.78 6 123173 44 34833708
Cholangitis 15.32 11.78 66 123113 8623 34825129
Reperfusion injury 15.28 11.78 7 123172 79 34833673
Blood test abnormal 15.26 11.78 3 123176 6968 34826784
Vascular pseudoaneurysm ruptured 15.20 11.78 7 123172 80 34833672
Blood sodium decreased 15.20 11.78 21 123158 16230 34817522
Incisional hernia 15.18 11.78 21 123158 1309 34832443
Aspartate aminotransferase increased 15.17 11.78 159 123020 67624 34766128
Accidental overdose 15.14 11.78 30 123149 20110 34813642
Enterocolitis haemorrhagic 15.13 11.78 18 123161 965 34832787
Bladder transitional cell carcinoma stage III 15.12 11.78 6 123173 46 34833706
Retinal coloboma 15.09 11.78 5 123174 21 34833731
Systemic inflammatory response syndrome 15.09 11.78 55 123124 6654 34827098
Serratia sepsis 15.05 11.78 7 123172 82 34833670
Hyperparathyroidism 15.00 11.78 20 123159 1204 34832548
Neurosarcoidosis 14.97 11.78 9 123170 183 34833569
Intestinal metastasis 14.96 11.78 10 123169 246 34833506
Parvovirus B19 test positive 14.95 11.78 8 123171 129 34833623
Papule 14.94 11.78 40 123139 4099 34829653
Kaposi sarcoma inflammatory cytokine syndrome 14.90 11.78 5 123174 22 34833730
Troponin increased 14.90 11.78 11 123168 11378 34822374
Anger 14.88 11.78 12 123167 11872 34821880
Urinary tract infection pseudomonal 14.87 11.78 18 123161 983 34832769
Asphyxia 14.84 11.78 3 123176 6832 34826920
Gastritis fungal 14.83 11.78 7 123172 85 34833667
Ventricular remodelling 14.83 11.78 7 123172 85 34833667
Electrocardiogram abnormal 14.82 11.78 7 123172 9240 34824512
Portal fibrosis 14.79 11.78 11 123168 322 34833430
Human herpes virus 8 test positive 14.73 11.78 5 123174 23 34833729
Biopsy kidney 14.69 11.78 6 123173 50 34833702
Nerve conduction studies abnormal 14.69 11.78 6 123173 50 34833702
Pneumonia aspiration 14.65 11.78 87 123092 41816 34791936
Blood glucose decreased 14.63 11.78 15 123164 13222 34820530
Chronic kidney disease 14.61 11.78 215 122964 40995 34792757
Pulmonary thrombosis 14.60 11.78 4 123175 7403 34826349
Vestibular nystagmus 14.59 11.78 4 123175 7 34833745
Restrictive allograft syndrome 14.55 11.78 5 123174 24 34833728
Abscess 14.54 11.78 81 123098 11736 34822016
Vertigo 14.51 11.78 44 123135 25492 34808260
Eosinophil count increased 14.51 11.78 6 123173 8566 34825186
Orchitis 14.46 11.78 23 123156 1626 34832126
Device related bacteraemia 14.45 11.78 12 123167 414 34833338
Immunosuppression 14.45 11.78 52 123127 6252 34827500
Hypoproteinaemia 14.41 11.78 27 123152 2177 34831575
Urinary bladder toxicity 14.39 11.78 5 123174 25 34833727
Biliary tract disorder 14.34 11.78 18 123161 1020 34832732
Weight decreased 14.32 11.78 493 122686 175808 34657944
Prescribed overdose 14.30 11.78 10 123169 10637 34823115
Urinary incontinence 14.29 11.78 28 123151 18846 34814906
Disseminated trichosporonosis 14.29 11.78 6 123173 54 34833698
Endothelial dysfunction 14.29 11.78 6 123173 54 34833698
Back disorder 14.27 11.78 3 123176 6648 34827104
Pulmonary cavitation 14.26 11.78 17 123162 913 34832839
Cytomegalovirus myocarditis 14.24 11.78 4 123175 8 34833744
Skin graft rejection 14.24 11.78 4 123175 8 34833744
Amnesia 14.23 11.78 47 123132 26516 34807236
Babesiosis 14.22 11.78 8 123171 143 34833609
Malabsorption 14.21 11.78 28 123151 2344 34831408
Renal arteriosclerosis 14.15 11.78 9 123170 203 34833549
Kidney rupture 14.15 11.78 9 123170 203 34833549
Aortic valve disease mixed 14.14 11.78 7 123172 95 34833657
Throat irritation 14.14 11.78 10 123169 10575 34823177
Fluid retention 14.11 11.78 48 123131 26839 34806913
Femoral nerve palsy 14.10 11.78 6 123173 56 34833696
Acute hepatitis C 14.08 11.78 7 123172 96 34833656
Speech disorder 14.07 11.78 45 123134 25641 34808111
Serositis 14.07 11.78 9 123170 205 34833547
Hepatic necrosis 14.04 11.78 37 123142 3757 34829995
Limb discomfort 14.03 11.78 11 123168 11036 34822716
Renal abscess 13.99 11.78 10 123169 275 34833477
Sinus bradycardia 13.98 11.78 15 123164 12948 34820804
Granulomatous rosacea 13.97 11.78 8 123171 148 34833604
Endotoxaemia 13.96 11.78 3 123176 0 34833752
Trichosporon infection 13.95 11.78 15 123164 719 34833033
Intra-abdominal haemorrhage 13.95 11.78 28 123151 2376 34831376
Eye swelling 13.94 11.78 9 123170 9986 34823766
Anorectal infection bacterial 13.92 11.78 4 123175 9 34833743
Cutaneous T-cell lymphoma stage II 13.92 11.78 5 123174 28 34833724
Myocarditis toxoplasmal 13.91 11.78 6 123173 58 34833694
Visual field defect 13.90 11.78 41 123138 4442 34829310
Therapy cessation 13.90 11.78 24 123155 16949 34816803
CNS ventriculitis 13.89 11.78 10 123169 278 34833474
Ocular hyperaemia 13.80 11.78 12 123167 11440 34822312
Disorientation 13.78 11.78 65 123114 33123 34800629
Chronic inflammatory demyelinating polyradiculoneuropathy 13.77 11.78 15 123164 730 34833022
Granulomatosis with polyangiitis 13.72 11.78 19 123160 1186 34832566
Bronchostenosis 13.71 11.78 10 123169 284 34833468
Rash macular 13.69 11.78 15 123164 12827 34820925
Thrombotic thrombocytopenic purpura 13.64 11.78 34 123145 3336 34830416
Necrotising bronchiolitis 13.63 11.78 4 123175 10 34833742
Endotoxic shock 13.63 11.78 4 123175 10 34833742
Infection 13.60 11.78 418 122761 90497 34743255
Pneumonia adenoviral 13.58 11.78 11 123168 366 34833386
Lymphocyte count decreased 13.57 11.78 38 123141 22584 34811168
Chronic myelomonocytic leukaemia 13.56 11.78 14 123165 640 34833112
Renal necrosis 13.51 11.78 8 123171 158 34833594
Typhoid fever 13.50 11.78 5 123174 31 34833721
External ear disorder 13.50 11.78 5 123174 31 34833721
Feeding disorder 13.42 11.78 4 123175 7006 34826746
Liver abscess 13.42 11.78 37 123142 3858 34829894
Renal cancer recurrent 13.36 11.78 5 123174 32 34833720
Histology abnormal 13.35 11.78 10 123169 296 34833456
Urosepsis 13.35 11.78 84 123095 12715 34821037
Bronchiectasis 13.30 11.78 69 123110 9732 34824020
Renal artery occlusion 13.29 11.78 7 123172 109 34833643
Femur fracture 13.25 11.78 6 123173 8118 34825634
Capnocytophaga infection 13.24 11.78 7 123172 110 34833642
Prostatic abscess 13.23 11.78 12 123167 467 34833285
Staphylococcal skin infection 13.15 11.78 16 123163 878 34832874
Wound 13.13 11.78 20 123159 14844 34818908
Skin bacterial infection 13.13 11.78 7 123172 112 34833640
Angina unstable 13.11 11.78 13 123166 11640 34822112
Prostatitis 13.11 11.78 46 123133 5461 34828291
Schwannoma 13.11 11.78 5 123174 34 34833718
BK polyomavirus test positive 13.11 11.78 5 123174 34 34833718
Adhesiolysis 13.10 11.78 4 123175 12 34833740
Ovarian cancer metastatic 13.10 11.78 4 123175 12 34833740
Pterygium colli 13.10 11.78 4 123175 12 34833740
Large intestine infection 13.07 11.78 21 123158 1497 34832255
Surgical procedure repeated 13.06 11.78 11 123168 387 34833365
Large intestine perforation 13.05 11.78 62 123117 8441 34825311
Vanishing bile duct syndrome 13.04 11.78 17 123162 1001 34832751
Transfusion 13.01 11.78 7 123172 8578 34825174
Bone disorder 12.94 11.78 3 123176 6212 34827540
Liver disorder 12.91 11.78 66 123113 32931 34800821
Autoimmune haemolytic anaemia 12.89 11.78 40 123139 4456 34829296
Dermatitis allergic 12.89 11.78 4 123175 6826 34826926
Gamma-glutamyltransferase increased 12.89 11.78 56 123123 29175 34804577
Gastrointestinal fungal infection 12.87 11.78 8 123171 173 34833579
Splenic artery aneurysm 12.87 11.78 4 123175 13 34833739
Bronchial anastomosis complication 12.87 11.78 4 123175 13 34833739
Fungating wound 12.87 11.78 5 123174 36 34833716
Iliac artery disease 12.87 11.78 4 123175 13 34833739
Blood calcium decreased 12.86 11.78 10 123169 10074 34823678
Cardiac arrest 12.86 11.78 250 122929 95909 34737843
Glomerular vascular disorder 12.85 11.78 7 123172 117 34833635
Bone tuberculosis 12.85 11.78 11 123168 396 34833356
Ventricular extrasystoles 12.83 11.78 14 123165 11994 34821758
Intestinal ulcer 12.81 11.78 16 123163 902 34832850
Reticulocyte count decreased 12.81 11.78 14 123165 684 34833068
Ascites 12.80 11.78 233 122946 46338 34787414
Anaemia 12.78 11.78 682 122497 232653 34601099
Nephrogenic systemic fibrosis 12.78 11.78 37 123142 3968 34829784
Reticulocytopenia 12.75 11.78 7 123172 119 34833633
Histoplasmosis cutaneous 12.75 11.78 5 123174 37 34833715
Acute generalised exanthematous pustulosis 12.73 11.78 4 123175 6772 34826980
Lacrimation increased 12.73 11.78 7 123172 8475 34825277
Neurological symptom 12.72 11.78 38 123141 4147 34829605
Steatohepatitis 12.63 11.78 10 123169 322 34833430
Thirst 12.62 11.78 6 123173 7889 34825863
Intervertebral disc protrusion 12.53 11.78 10 123169 9946 34823806
Exposure during pregnancy 12.52 11.78 8 123171 8926 34824826
Keloid scar 12.52 11.78 5 123174 39 34833713
Uraemic encephalopathy 12.52 11.78 10 123169 326 34833426
Frequent bowel movements 12.50 11.78 16 123163 12771 34820981
Pharyngeal oedema 12.43 11.78 3 123176 6044 34827708
Metastases to salivary gland 12.43 11.78 4 123175 15 34833737
Tooth disorder 12.41 11.78 12 123167 10870 34822882
Peripheral coldness 12.40 11.78 5 123174 7246 34826506
Keratitis 12.39 11.78 20 123159 1431 34832321
VIth nerve paralysis 12.39 11.78 15 123164 819 34832933
Soft tissue necrosis 12.37 11.78 10 123169 332 34833420
Epididymitis 12.35 11.78 27 123152 2432 34831320
Cytomegalovirus gastrointestinal ulcer 12.31 11.78 5 123174 41 34833711
Complement factor C3 decreased 12.31 11.78 5 123174 41 34833711
Spindle cell sarcoma 12.30 11.78 7 123172 128 34833624
Oral pain 12.27 11.78 12 123167 10815 34822937
Drug-induced liver injury 12.25 11.78 56 123123 28776 34804976
Nephrosclerosis 12.23 11.78 16 123163 945 34832807
Renal artery perforation 12.23 11.78 4 123175 16 34833736
Pneumonia toxoplasmal 12.23 11.78 4 123175 16 34833736
Ischaemic stroke 12.22 11.78 29 123150 18221 34815531
Amyloidosis senile 12.20 11.78 5 123174 42 34833710
Intracranial infection 12.20 11.78 5 123174 42 34833710
Inflammatory myofibroblastic tumour 12.20 11.78 7 123172 130 34833622
Brain oedema 12.19 11.78 87 123092 13734 34820018
Aspiration 12.19 11.78 15 123164 12179 34821573
Haematochezia 12.18 11.78 105 123074 46429 34787323
Hepatic failure 12.18 11.78 180 122999 34351 34799401
Osteomyelitis acute 12.18 11.78 9 123170 261 34833491
Necrotising soft tissue infection 12.09 11.78 6 123173 82 34833670
Renal aneurysm 12.06 11.78 7 123172 133 34833619
Hepatitis B surface antigen positive 12.02 11.78 7 123172 134 34833618
Anorectal varices 12.00 11.78 5 123174 44 34833708
Pemphigus 11.96 11.78 21 123158 1610 34832142
Paraspinal abscess 11.96 11.78 6 123173 84 34833668
Sinusitis 11.95 11.78 91 123088 41311 34792441
Gastrointestinal stromal tumour 11.94 11.78 16 123163 968 34832784
Sinus disorder 11.93 11.78 5 123174 7080 34826672
Gastrointestinal wall thickening 11.92 11.78 20 123159 1478 34832274
Myocarditis mycotic 11.89 11.78 3 123176 3 34833749
Solid organ transplant rejection 11.89 11.78 3 123176 3 34833749
Congenital acrochordon 11.89 11.78 3 123176 3 34833749
Transfusion associated graft versus host disease 11.89 11.78 3 123176 3 34833749
Vascular graft infection 11.89 11.78 3 123176 3 34833749
Sialocele 11.89 11.78 3 123176 3 34833749
Hyperparathyroidism tertiary 11.89 11.78 3 123176 3 34833749
Splenic neoplasm malignancy unspecified 11.85 11.78 4 123175 18 34833734
Progressive bulbar palsy 11.85 11.78 4 123175 18 34833734
Abdominal abscess 11.84 11.78 37 123142 4138 34829614
Adenovirus test positive 11.81 11.78 5 123174 46 34833706
Cytomegalovirus test 11.81 11.78 5 123174 46 34833706
Aortic pseudoaneurysm 11.81 11.78 5 123174 46 34833706
Liver transplant 11.81 11.78 27 123152 2507 34831245
Dyslipidaemia 11.79 11.78 55 123124 7433 34826319
Herpes simplex test positive 11.79 11.78 8 123171 202 34833550

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 5297.46 10.40 2021 226948 17416 79498003
Cytomegalovirus infection 5055.09 10.40 2460 226509 40184 79475235
Product use in unapproved indication 3166.89 10.40 3740 225229 246619 79268800
Post transplant lymphoproliferative disorder 2837.64 10.40 1112 227857 10352 79505067
Kidney transplant rejection 2053.42 10.40 854 228115 9392 79506027
Polyomavirus-associated nephropathy 2027.22 10.40 719 228250 4908 79510511
Transplant dysfunction 1934.45 10.40 742 228227 6479 79508940
Off label use 1913.56 10.40 6316 222653 900899 78614520
Epstein-Barr virus infection 1617.79 10.40 802 228167 13614 79501805
BK virus infection 1532.33 10.40 664 228305 8140 79507279
Complications of transplanted kidney 1444.20 10.40 580 228389 5786 79509633
Acute graft versus host disease 1428.16 10.40 660 228309 9507 79505912
Cytomegalovirus viraemia 1423.07 10.40 708 228261 12113 79503306
Thrombotic microangiopathy 1227.27 10.40 749 228220 19420 79495999
Acute graft versus host disease in skin 1131.65 10.40 515 228454 7143 79508276
Adenovirus infection 1101.79 10.40 521 228448 7926 79507493
Graft versus host disease 1010.10 10.40 595 228374 14431 79500988
Aspergillus infection 973.95 10.40 635 228334 18526 79496893
Immunosuppressant drug level increased 962.03 10.40 485 228484 8542 79506877
Pneumocystis jirovecii pneumonia 905.07 10.40 749 228220 31759 79483660
Chronic graft versus host disease 895.95 10.40 422 228547 6359 79509060
Nocardiosis 826.78 10.40 378 228591 5301 79510118
Cytomegalovirus infection reactivation 823.94 10.40 432 228537 8284 79507135
COVID-19 800.66 10.40 1540 227429 156134 79359285
Fall 764.97 10.40 226 228743 487403 79028016
Transplant failure 758.74 10.40 335 228634 4306 79511113
Graft versus host disease in skin 756.69 10.40 363 228606 5710 79509709
Mucormycosis 722.41 10.40 392 228577 8077 79507342
Graft versus host disease in gastrointestinal tract 708.23 10.40 352 228617 6004 79509415
Nephropathy toxic 700.40 10.40 532 228437 19887 79495532
Fatigue 699.71 10.40 994 227975 928733 78586686
Chronic allograft nephropathy 698.35 10.40 240 228729 1471 79513948
Multiple organ dysfunction syndrome 687.31 10.40 1236 227733 119010 79396409
Liver transplant rejection 658.31 10.40 273 228696 2975 79512444
Completed suicide 649.95 10.40 11 228958 245756 79269663
Bronchopulmonary aspergillosis 644.25 10.40 525 228444 21769 79493650
Polyomavirus viraemia 629.53 10.40 222 228747 1485 79513934
Pain 609.63 10.40 675 228294 703127 78812292
Klebsiella infection 589.24 10.40 432 228537 15288 79500131
Posterior reversible encephalopathy syndrome 582.93 10.40 532 228437 25749 79489670
Acute respiratory distress syndrome 575.61 10.40 671 228298 43396 79472023
Acute graft versus host disease in intestine 569.54 10.40 263 228706 3778 79511641
Dizziness 560.17 10.40 417 228552 526024 78989395
Renal transplant failure 539.60 10.40 204 228765 1703 79513716
Cystitis haemorrhagic 538.44 10.40 333 228636 8839 79506580
Diffuse large B-cell lymphoma 531.81 10.40 367 228602 11782 79503637
Phaeohyphomycosis 520.22 10.40 176 228793 1021 79514398
Nausea 518.50 10.40 1250 227719 955946 78559473
Varicella zoster virus infection 515.78 10.40 253 228716 4188 79511231
Leukopenia 512.10 10.40 1072 227897 115441 79399978
Dyspnoea 509.81 10.40 1063 227906 855962 78659457
Heart transplant rejection 506.30 10.40 183 228786 1327 79514092
Renal impairment 502.95 10.40 1279 227690 156504 79358915
Cytomegalovirus colitis 485.41 10.40 247 228722 4438 79510981
Pseudomonas infection 482.97 10.40 433 228536 20470 79494949
Trichodysplasia spinulosa 472.32 10.40 148 228821 644 79514775
Delayed graft function 471.76 10.40 221 228748 3286 79512133
Human herpesvirus 6 infection 462.01 10.40 250 228719 5120 79510299
Focal segmental glomerulosclerosis 461.37 10.40 214 228755 3107 79512312
Strongyloidiasis 452.50 10.40 222 228747 3676 79511743
Constipation 451.01 10.40 127 228842 282923 79232496
Ovarian cyst 443.45 10.40 334 228635 12321 79503098
Escherichia infection 439.73 10.40 385 228584 17632 79497787
Septic shock 439.63 10.40 1041 227928 121760 79393659
Epstein-Barr virus associated lymphoproliferative disorder 436.63 10.40 210 228759 3322 79512097
Cryptococcosis 432.78 10.40 208 228761 3285 79512134
Hepatitis E 432.29 10.40 198 228771 2788 79512631
Enterococcal infection 431.99 10.40 359 228610 15301 79500118
Arthralgia 425.24 10.40 615 228354 571188 78944231
Brain abscess 425.23 10.40 230 228739 4706 79510713
Drug abuse 423.05 10.40 9 228960 162682 79352737
JC virus infection 400.31 10.40 204 228765 3677 79511742
Malaise 386.05 10.40 505 228464 489364 79026055
Meningitis cryptococcal 384.21 10.40 192 228777 3314 79512105
Smooth muscle cell neoplasm 373.49 10.40 130 228839 832 79514587
Death 369.73 10.40 664 228305 565850 78949569
Haemophagocytic lymphohistiocytosis 367.61 10.40 380 228589 21457 79493962
Renal tubular necrosis 363.80 10.40 403 228566 24636 79490783
Hypogammaglobulinaemia 361.60 10.40 299 228670 12652 79502767
Parvovirus B19 infection 353.57 10.40 140 228829 1340 79514079
Acne 349.98 10.40 411 228558 26779 79488640
Chronic graft versus host disease in skin 345.22 10.40 140 228829 1434 79513985
Pneumonia cytomegaloviral 345.05 10.40 201 228768 4768 79510651
Acute graft versus host disease in liver 343.39 10.40 148 228821 1787 79513632
Malacoplakia 338.57 10.40 109 228860 527 79514892
Back pain 337.41 10.40 230 228739 303950 79211469
Pain in extremity 332.30 10.40 334 228635 364204 79151215
Proteinuria 326.63 10.40 434 228535 32068 79483351
Rash 325.98 10.40 738 228231 577620 78937799
Disease recurrence 324.61 10.40 508 228461 43601 79471818
Respiratory failure 323.56 10.40 1198 227771 179713 79335706
Pruritus 318.86 10.40 399 228570 394249 79121170
Mycobacterial infection 316.21 10.40 171 228798 3497 79511922
Kidney fibrosis 313.70 10.40 168 228801 3367 79512052
Epstein-Barr viraemia 309.15 10.40 143 228826 2062 79513357
Renal tubular atrophy 303.47 10.40 134 228835 1722 79513697
Progressive multifocal leukoencephalopathy 301.77 10.40 333 228636 20267 79495152
Aplasia pure red cell 300.31 10.40 218 228751 7592 79507827
Cerebral toxoplasmosis 299.77 10.40 143 228826 2219 79513200
Herpes simplex 298.56 10.40 261 228708 11926 79503493
Lung transplant rejection 297.88 10.40 125 228844 1406 79514013
Headache 296.68 10.40 929 228040 652843 78862576
Histoplasmosis 296.55 10.40 142 228827 2223 79513196
Asthenia 296.37 10.40 643 228326 511046 79004373
Pulmonary nocardiosis 295.77 10.40 119 228850 1192 79514227
Vaccination failure 294.03 10.40 131 228838 1722 79513697
COVID-19 pneumonia 288.01 10.40 384 228585 28465 79486954
Toxoplasmosis 284.68 10.40 144 228825 2553 79512866
Drug ineffective for unapproved indication 282.71 10.40 519 228450 50719 79464700
Injection site pain 280.51 10.40 25 228944 129813 79385606
Infection reactivation 275.02 10.40 140 228829 2517 79512902
Human polyomavirus infection 272.55 10.40 107 228862 999 79514420
Graft loss 271.51 10.40 105 228864 938 79514481
End stage renal disease 270.22 10.40 247 228722 11973 79503446
Blood creatinine increased 266.55 10.40 1014 227955 154043 79361376
Feeling abnormal 265.66 10.40 65 228904 159134 79356285
Pneumatosis intestinalis 263.05 10.40 186 228783 6211 79509208
Viraemia 262.05 10.40 139 228830 2730 79512689
Cytomegalovirus test positive 261.09 10.40 180 228789 5767 79509652
Product dose omission issue 252.68 10.40 204 228765 247333 79268086
Central nervous system lymphoma 249.78 10.40 125 228844 2164 79513255
Histoplasmosis disseminated 249.44 10.40 126 228843 2227 79513192
Syncope 248.42 10.40 102 228867 179347 79336072
Drug resistance 247.42 10.40 439 228530 41774 79473645
Hypotension 246.90 10.40 563 228406 439754 79075665
Human herpesvirus 8 infection 245.40 10.40 102 228867 1118 79514301
Cryptosporidiosis infection 245.20 10.40 89 228880 654 79514765
Immunosuppressant drug level decreased 241.22 10.40 117 228852 1887 79513532
Peripheral swelling 235.45 10.40 256 228713 269361 79246058
West Nile viral infection 233.15 10.40 93 228876 909 79514510
Vomiting 231.80 10.40 1054 227915 664774 78850645
Hepatitis C 227.30 10.40 222 228747 11703 79503716
Candida infection 223.44 10.40 397 228572 37817 79477602
Alternaria infection 222.49 10.40 81 228888 601 79514818
Hyperhidrosis 219.79 10.40 80 228889 151412 79364007
Anxiety 219.16 10.40 234 228735 248278 79267141
Sepsis 217.57 10.40 1421 227548 268007 79247412
Disseminated cryptococcosis 217.52 10.40 106 228863 1728 79513691
Pathogen resistance 215.55 10.40 235 228734 14107 79501312
Inappropriate schedule of product administration 212.59 10.40 60 228909 133568 79381851
Neutrophil Pelger-Huet anomaly present 212.27 10.40 67 228902 300 79515119
Lymphoproliferative disorder 211.96 10.40 155 228814 5460 79509959
Blastomycosis 211.00 10.40 79 228890 640 79514779
Lymphocele 210.99 10.40 101 228868 1580 79513839
Staphylococcal infection 210.42 10.40 496 228473 57799 79457620
Renal graft infection 208.44 10.40 73 228896 477 79514942
Haemolytic uraemic syndrome 208.00 10.40 140 228829 4309 79511110
Nasopharyngitis 207.67 10.40 254 228715 253627 79261792
Complications of transplanted heart 207.60 10.40 66 228903 304 79515115
Squamous cell carcinoma of skin 207.53 10.40 228 228741 13805 79501614
Drug ineffective 205.49 10.40 4290 224679 1076623 78438796
Scedosporium infection 204.56 10.40 95 228874 1383 79514036
Drug level increased 202.98 10.40 389 228580 39262 79476157
Encephalitis viral 202.38 10.40 113 228856 2466 79512953
Cytomegalovirus gastrointestinal infection 201.90 10.40 70 228899 442 79514977
Muscle spasms 200.53 10.40 127 228842 174603 79340816
Hypersensitivity 200.46 10.40 276 228693 261963 79253456
Venoocclusive liver disease 200.20 10.40 206 228763 11565 79503854
Lupus nephritis 196.58 10.40 117 228852 2891 79512528
Bacteraemia 195.77 10.40 344 228625 32480 79482939
Injection site erythema 193.35 10.40 7 228962 78190 79437229
Lymphopenia 192.38 10.40 328 228641 30229 79485190
Actinic keratosis 190.96 10.40 150 228819 5892 79509527
Graft versus host disease in liver 189.09 10.40 95 228874 1659 79513760
Loss of consciousness 188.73 10.40 125 228844 167818 79347601
Nephrotic syndrome 187.25 10.40 194 228775 10980 79504439
Pulmonary mucormycosis 186.90 10.40 83 228886 1082 79514337
Fungal skin infection 186.79 10.40 148 228821 5888 79509531
Joint swelling 186.36 10.40 340 228629 288306 79227113
Viral haemorrhagic cystitis 185.84 10.40 99 228870 1962 79513457
Pneumocystis jirovecii infection 185.06 10.40 111 228858 2783 79512636
Intentional overdose 183.24 10.40 40 228929 105920 79409499
Psoriasis 181.25 10.40 22 228947 89565 79425854
Depression 180.34 10.40 214 228755 216576 79298843
Bacillary angiomatosis 178.15 10.40 54 228915 205 79515214
Bradycardia 173.58 10.40 86 228883 135471 79379948
Cardiac failure congestive 172.54 10.40 97 228872 142305 79373114
Somnolence 171.36 10.40 263 228706 238718 79276701
Urticaria 170.48 10.40 168 228801 185033 79330386
Myocardial infarction 168.37 10.40 168 228801 183961 79331458
Chest discomfort 163.02 10.40 97 228872 137947 79377472
Palpitations 162.60 10.40 80 228889 126530 79388889
Diabetes mellitus 162.26 10.40 545 228424 77845 79437574
Cytomegalovirus chorioretinitis 162.19 10.40 131 228838 5359 79510060
Epstein-Barr virus associated lymphoma 160.12 10.40 73 228896 1016 79514403
Chronic graft versus host disease in liver 159.00 10.40 63 228906 604 79514815
Infusion related reaction 158.80 10.40 260 228709 229977 79285442
Chronic obstructive pulmonary disease 158.79 10.40 27 228942 85392 79430027
Microsporidia infection 158.77 10.40 70 228899 896 79514523
Adenoviral hepatitis 158.28 10.40 69 228900 858 79514561
Glomerulonephritis 155.65 10.40 106 228863 3327 79512092
Erythema 155.08 10.40 251 228718 223039 79292380
Epidermodysplasia verruciformis 153.90 10.40 53 228916 327 79515092
Complications of transplanted lung 153.53 10.40 56 228913 418 79515001
Renal tubular injury 151.32 10.40 78 228891 1441 79513978
Drug hypersensitivity 151.07 10.40 403 228566 298513 79216906
Papilloma viral infection 149.92 10.40 81 228888 1653 79513766
Dermatophytosis 149.48 10.40 55 228914 422 79514997
Insomnia 149.29 10.40 299 228670 244871 79270548
Gait disturbance 149.09 10.40 228 228741 207278 79308141
Balance disorder 148.89 10.40 49 228920 98808 79416611
Cerebrovascular accident 148.61 10.40 136 228833 155156 79360263
Encephalitis 148.13 10.40 197 228772 14563 79500856
Malignant neoplasm progression 147.74 10.40 105 228864 135885 79379534
Hypoglycaemia 146.74 10.40 54 228915 101540 79413879
Tubulointerstitial nephritis 146.40 10.40 333 228636 37902 79477517
Alveolar proteinosis 145.45 10.40 62 228907 727 79514692
Gastroenteritis norovirus 143.44 10.40 97 228872 3009 79512410
Chest pain 143.10 10.40 380 228589 281924 79233495
Pancreas transplant rejection 142.08 10.40 48 228921 277 79515142
Pneumonia cryptococcal 141.98 10.40 75 228894 1460 79513959
Disseminated varicella zoster virus infection 141.22 10.40 57 228912 576 79514843
Trichophytosis 141.07 10.40 50 228919 340 79515079
Obliterative bronchiolitis 140.88 10.40 95 228874 2933 79512486
Ureaplasma infection 140.71 10.40 66 228903 984 79514435
Treatment failure 140.42 10.40 904 228065 169582 79345837
Stress 139.80 10.40 29 228940 79583 79435836
Electrocardiogram QT prolonged 139.33 10.40 43 228926 90343 79425076
Atypical haemolytic uraemic syndrome 138.70 10.40 65 228904 967 79514452
Bacterial sepsis 138.57 10.40 143 228826 8055 79507364
Pneumonia fungal 138.54 10.40 166 228803 11044 79504375
Disseminated tuberculosis 134.69 10.40 105 228864 4078 79511341
Mycobacterium abscessus infection 134.13 10.40 67 228902 1155 79514264
Graft versus host disease in lung 133.67 10.40 61 228908 851 79514568
Fungal infection 131.32 10.40 337 228632 41411 79474008
Squamous cell carcinoma 129.18 10.40 190 228779 15432 79499987
Acinetobacter infection 128.90 10.40 87 228882 2690 79512729
Hypokalaemia 128.73 10.40 134 228835 143906 79371513
Atrial fibrillation 128.63 10.40 232 228737 197654 79317765
Pancytopenia 127.49 10.40 864 228105 164881 79350538
Human ehrlichiosis 127.18 10.40 51 228918 506 79514913
Disseminated blastomycosis 126.87 10.40 39 228930 157 79515262
IgA nephropathy 126.69 10.40 73 228896 1695 79513724
Anogenital warts 126.06 10.40 59 228910 875 79514544
Arthropathy 125.88 10.40 196 228773 176915 79338504
Systemic mycosis 124.89 10.40 84 228885 2582 79512837
Cytomegalovirus enteritis 124.22 10.40 56 228913 758 79514661
Endophthalmitis 123.13 10.40 120 228849 6308 79509111
Stenotrophomonas infection 122.12 10.40 95 228874 3678 79511741
Dehydration 122.06 10.40 339 228630 247848 79267571
Immune reconstitution inflammatory syndrome 121.25 10.40 173 228796 13668 79501751
Ureteric stenosis 120.28 10.40 65 228904 1327 79514092
Angiosarcoma 120.26 10.40 47 228922 433 79514986
Sciatica 120.22 10.40 283 228686 32939 79482480
Blood pressure increased 120.08 10.40 268 228701 211092 79304327
Demodicidosis 119.90 10.40 39 228930 196 79515223
Injection site reaction 119.80 10.40 10 228959 54775 79460644
Atypical mycobacterial infection 119.68 10.40 70 228899 1673 79513746
Mycoplasma infection 119.52 10.40 54 228915 735 79514684
Graft complication 119.00 10.40 53 228916 696 79514723
Suicide attempt 118.23 10.40 45 228924 82887 79432532
Anti-erythropoietin antibody negative 118.07 10.40 42 228927 289 79515130
Flushing 117.59 10.40 53 228916 88215 79427204
International normalised ratio increased 117.44 10.40 48 228921 84673 79430746
Neurotoxicity 116.58 10.40 276 228693 32242 79483177
Paraesthesia 116.14 10.40 205 228764 176118 79339301
Choroiditis 115.20 10.40 63 228906 1318 79514101
American trypanosomiasis 115.09 10.40 42 228927 314 79515105
Cytomegalovirus oesophagitis 115.08 10.40 52 228917 708 79514711
Swelling 113.39 10.40 287 228682 216424 79298995
Apoptosis 113.18 10.40 46 228923 474 79514945
Suicidal ideation 112.94 10.40 39 228930 76301 79439118
Glomerulosclerosis 112.88 10.40 58 228911 1064 79514355
Penicillium infection 112.52 10.40 39 228930 246 79515173
Wrong technique in product usage process 112.33 10.40 36 228933 73839 79441580
Intentional product misuse 112.16 10.40 67 228902 95098 79420321
Epstein-Barr virus test positive 112.06 10.40 58 228911 1081 79514338
Emphysematous pyelonephritis 111.95 10.40 41 228928 310 79515109
Pyelonephritis 111.77 10.40 206 228763 20182 79495237
Neutrophil count decreased 110.95 10.40 66 228903 93893 79421526
Drug interaction 110.77 10.40 1740 227229 413443 79101976
Locked-in syndrome 110.11 10.40 50 228919 689 79514730
Hydronephrosis 109.39 10.40 187 228782 17267 79498152
Pre-engraftment immune reaction 109.38 10.40 40 228929 301 79515118
Enterobacter infection 108.33 10.40 96 228873 4466 79510953
Gingival hypertrophy 108.02 10.40 82 228887 3060 79512359
Pneumonia bacterial 106.83 10.40 196 228773 19135 79496284
White blood cell count decreased 106.74 10.40 239 228730 188049 79327370
Angioedema 105.52 10.40 43 228926 75992 79439427
Abdominal discomfort 105.24 10.40 368 228601 250359 79265060
Glomerulonephritis membranoproliferative 105.16 10.40 46 228923 577 79514842
Injection site swelling 104.74 10.40 8 228961 47124 79468295
Pneumonia klebsiella 103.71 10.40 98 228871 4956 79510463
Confusional state 103.50 10.40 515 228454 317482 79197937
Multiple sclerosis relapse 103.12 10.40 8 228961 46525 79468894
Cat scratch disease 103.07 10.40 40 228929 361 79515058
Encephalitis cytomegalovirus 103.01 10.40 55 228914 1095 79514324
Epistaxis 101.61 10.40 102 228867 111413 79404006
Visceral leishmaniasis 101.41 10.40 54 228915 1069 79514350
Asthma 101.33 10.40 144 228825 134951 79380468
Post transplant distal limb syndrome 100.30 10.40 44 228925 556 79514863
Overdose 100.24 10.40 239 228730 183967 79331452
Rash pruritic 100.23 10.40 40 228929 71589 79443830
Injection site bruising 100.23 10.40 4 228965 40998 79474421
Haemodialysis 100.14 10.40 184 228785 17984 79497435
Myalgia 100.12 10.40 242 228727 185399 79330020
Kaposi's sarcoma 99.53 10.40 47 228922 712 79514707
Epstein-Barr virus infection reactivation 99.30 10.40 64 228905 1828 79513591
Disseminated mycobacterium avium complex infection 98.62 10.40 33 228936 184 79515235
Therapy non-responder 98.36 10.40 524 228445 91781 79423638
Drug reaction with eosinophilia and systemic symptoms 98.23 10.40 31 228938 64213 79451206
Mycobacterium avium complex infection 97.86 10.40 91 228878 4509 79510910
Nasal congestion 97.32 10.40 49 228920 76503 79438916
Oedema peripheral 96.29 10.40 385 228584 251903 79263516
Renal phospholipidosis 95.95 10.40 28 228941 90 79515329
Hyponatraemia 95.00 10.40 233 228736 177615 79337804
Abdominal pain upper 93.59 10.40 329 228640 223490 79291929
Graft versus host disease in eye 93.43 10.40 35 228934 284 79515135
Hallucination 93.38 10.40 66 228903 85679 79429740
Pneumomediastinum 92.77 10.40 80 228889 3587 79511832
Malacoplakia gastrointestinal 91.87 10.40 30 228939 153 79515266
Cytomegalovirus syndrome 91.72 10.40 34 228935 267 79515152
Cardio-respiratory arrest 91.37 10.40 106 228863 108404 79407015
Cough 90.81 10.40 648 228321 366141 79149278
General physical health deterioration 89.98 10.40 445 228524 274793 79240626
Bacterial infection 89.73 10.40 244 228725 31036 79484383
Vision blurred 89.65 10.40 103 228866 105795 79409624
Cystitis viral 89.12 10.40 43 228926 685 79514734
Systemic candida 89.00 10.40 103 228866 6603 79508816
Human herpesvirus 6 encephalitis 88.95 10.40 42 228927 636 79514783
Renal transplant 88.73 10.40 67 228902 2480 79512939
Chills 88.69 10.40 206 228763 160028 79355391
Swelling face 88.42 10.40 47 228922 71165 79444254
Therapeutic product effect decreased 88.05 10.40 214 228755 163649 79351770
Central nervous system fungal infection 87.63 10.40 37 228932 423 79514996
Cytomegalovirus gastritis 87.25 10.40 37 228932 428 79514991
Dermoid cyst 86.91 10.40 33 228936 279 79515140
Sedation 86.89 10.40 21 228948 51874 79463545
Polyomavirus test positive 86.19 10.40 30 228939 192 79515227
Photodermatosis 86.06 10.40 46 228923 918 79514501
Angiosarcoma metastatic 85.34 10.40 27 228942 122 79515297
Full blood count abnormal 84.21 10.40 9 228960 40465 79474954
Pyelonephritis acute 84.14 10.40 95 228874 5928 79509491
Periostitis 83.88 10.40 40 228929 620 79514799
Haemodynamic instability 83.44 10.40 166 228803 17216 79498203
Bronchitis 83.23 10.40 155 228814 130489 79384930
Erythema infectiosum 83.00 10.40 29 228940 188 79515231
Orthostatic hypotension 82.55 10.40 29 228940 56135 79459284
Acute kidney injury 82.43 10.40 2012 226957 517392 78998027
Lactic acidosis 82.25 10.40 50 228919 70309 79445110
Chronic graft versus host disease in intestine 81.89 10.40 33 228936 332 79515087
Blood pressure decreased 81.79 10.40 99 228870 99367 79416052
Orf 81.50 10.40 22 228947 48 79515371
Blood iron abnormal 81.16 10.40 50 228919 1317 79514102
Drug level fluctuating 80.49 10.40 41 228928 738 79514681
Fungal endocarditis 80.45 10.40 38 228931 576 79514843
Swollen tongue 80.12 10.40 13 228956 42557 79472862
Intentional self-injury 79.80 10.40 3 228966 32416 79483003
Oropharyngeal pain 79.61 10.40 119 228850 109234 79406185
Transient ischaemic attack 79.55 10.40 26 228943 52669 79462750
Humoral immune defect 79.51 10.40 34 228935 402 79515017
Musculoskeletal stiffness 78.81 10.40 249 228720 174759 79340660
Complications of transplant surgery 78.68 10.40 40 228929 717 79514702
Dry skin 78.54 10.40 49 228920 67946 79447473
Decreased appetite 78.53 10.40 618 228351 341800 79173619
Presyncope 78.49 10.40 12 228957 41042 79474377
Opportunistic infection 77.98 10.40 66 228903 2884 79512535
Coccidioidomycosis 77.93 10.40 48 228921 1264 79514155
New onset diabetes after transplantation 77.85 10.40 26 228943 144 79515275
Steroid diabetes 77.77 10.40 71 228898 3435 79511984
Necrotising retinitis 77.66 10.40 47 228922 1198 79514221
Complications of transplanted liver 77.57 10.40 33 228936 385 79515034
Respiratory arrest 77.52 10.40 34 228935 57516 79457903
Neuropathy peripheral 77.13 10.40 183 228786 141122 79374297
Abdominal distension 77.07 10.40 141 228828 119509 79395910
Rhodococcus infection 77.00 10.40 31 228938 311 79515108
Joint injury 76.79 10.40 3 228966 31332 79484087
Mediastinitis 76.49 10.40 41 228928 823 79514596
Endocarditis 76.48 10.40 121 228848 10476 79504943
Organising pneumonia 76.33 10.40 123 228846 10816 79504603
Hot flush 76.20 10.40 31 228938 54846 79460573
Biliary anastomosis complication 75.97 10.40 26 228943 157 79515262
Fungaemia 75.65 10.40 79 228890 4512 79510907
Mycobacterium chelonae infection 75.52 10.40 60 228909 2396 79513023
Cerebral fungal infection 75.44 10.40 33 228936 414 79515005
Heart rate decreased 75.42 10.40 55 228914 70261 79445158
Babesiosis 75.21 10.40 31 228938 332 79515087
Glucose tolerance impaired 75.20 10.40 104 228865 7980 79507439
Dysgeusia 75.11 10.40 35 228934 57142 79458277
Synovitis 74.72 10.40 205 228764 150529 79364890
Unevaluable event 74.62 10.40 33 228936 55552 79459867
Agitation 74.07 10.40 107 228862 99608 79415811
Renal tubular acidosis 74.01 10.40 70 228899 3544 79511875
Serotonin syndrome 73.88 10.40 19 228950 45008 79470411
Wheezing 73.80 10.40 139 228830 116525 79398894
Pulmonary embolism 73.30 10.40 250 228719 171404 79344015
Intentional product use issue 72.88 10.40 712 228257 151400 79364019
Therapy partial responder 72.77 10.40 157 228812 17240 79498179
Skin papilloma 72.47 10.40 87 228882 5799 79509620
Idiopathic pneumonia syndrome 72.35 10.40 35 228934 561 79514858
Autoimmune haemolytic anaemia 72.31 10.40 104 228865 8276 79507143
BK polyomavirus test positive 72.30 10.40 24 228945 130 79515289
Bone pain 71.88 10.40 35 228934 55707 79459712
Feeling hot 71.88 10.40 41 228928 59693 79455726
Nodular regenerative hyperplasia 71.33 10.40 46 228923 1315 79514104
Gastroenteritis sapovirus 70.96 10.40 24 228945 139 79515280
Legionella infection 70.48 10.40 38 228931 772 79514647
Haematemesis 70.21 10.40 31 228938 52233 79463186
Blood potassium decreased 70.12 10.40 23 228946 46489 79468930
Nephrectomy 70.08 10.40 54 228915 2061 79513358
Memory impairment 69.91 10.40 134 228835 111600 79403819
Cryptococcal cutaneous infection 69.67 10.40 25 228944 177 79515242
Influenza like illness 69.52 10.40 62 228907 71645 79443774
Hypoaesthesia 69.48 10.40 272 228697 179080 79336339
Rectal haemorrhage 69.26 10.40 70 228899 76230 79439189
SARS-CoV-2 RNA increased 69.26 10.40 22 228947 101 79515318
Urinary tract infection bacterial 69.18 10.40 89 228880 6367 79509052
Cytomegalovirus hepatitis 68.84 10.40 37 228932 747 79514672
Granuloma 68.73 10.40 101 228868 8196 79507223
Meningoencephalitis herpetic 68.58 10.40 52 228917 1937 79513482
Glomerulonephritis proliferative 68.46 10.40 30 228939 378 79515041
Lymphocytic infiltration 68.16 10.40 47 228922 1506 79513913
Fusarium infection 67.86 10.40 50 228919 1782 79513637
Lip swelling 67.63 10.40 17 228952 40894 79474525
Pericarditis fungal 67.61 10.40 24 228945 164 79515255
Tuberculosis gastrointestinal 67.55 10.40 33 228936 541 79514878
Skin squamous cell carcinoma metastatic 67.37 10.40 19 228950 52 79515367
Aggression 67.24 10.40 31 228938 50927 79464492
Disseminated cytomegaloviral infection 67.20 10.40 31 228938 444 79514975
Peritonitis 67.16 10.40 205 228764 27831 79487588
Dysphonia 67.06 10.40 40 228929 56832 79458587
Drug withdrawal syndrome 66.71 10.40 10 228959 34708 79480711
Biopsy lung abnormal 66.37 10.40 23 228946 145 79515274
Infection in an immunocompromised host 66.24 10.40 44 228925 1324 79514095
Rhinovirus infection 66.15 10.40 97 228872 7856 79507563
Central nervous system infection 65.98 10.40 44 228925 1333 79514086
Eye infection toxoplasmal 65.75 10.40 32 228937 520 79514899
Proteus infection 65.68 10.40 52 228917 2066 79513353
Urinary tract infection viral 65.60 10.40 19 228950 59 79515360
Venoocclusive disease 65.37 10.40 73 228896 4500 79510919
Donor specific antibody present 65.19 10.40 26 228943 254 79515165
Body tinea 65.09 10.40 49 228920 1805 79513614
Colitis 64.83 10.40 396 228573 72911 79442508
Hepatic artery thrombosis 64.63 10.40 27 228942 300 79515119
Wound dehiscence 64.61 10.40 87 228882 6508 79508911
Renal tubular disorder 64.21 10.40 86 228883 6400 79509019
Cytomegalovirus nephritis 63.71 10.40 22 228947 137 79515282
Myopathy 63.64 10.40 165 228804 20398 79495021
Post procedural bile leak 63.52 10.40 29 228940 405 79515014
Escherichia bacteraemia 63.42 10.40 86 228883 6476 79508943
Herpes zoster 63.23 10.40 471 228498 92612 79422807
Herpes virus infection 63.06 10.40 89 228880 6960 79508459
Acute myocardial infarction 62.99 10.40 77 228892 76959 79438460
Cardiac disorder 62.39 10.40 58 228911 65699 79449720
Corynebacterium infection 62.30 10.40 42 228927 1296 79514123
Disseminated mucormycosis 62.06 10.40 34 228935 714 79514705
Enterococcal sepsis 62.03 10.40 56 228913 2670 79512749
Parvovirus infection 61.67 10.40 33 228936 660 79514759
Blood calcium decreased 61.52 10.40 9 228960 31810 79483609
Haemolytic anaemia 61.45 10.40 149 228820 17671 79497748
Cutaneous mucormycosis 61.25 10.40 23 228946 188 79515231
Renal artery stenosis 61.14 10.40 62 228907 3420 79511999
Solar lentigo 61.13 10.40 39 228930 1094 79514325
Graft infection 60.88 10.40 33 228936 678 79514741
Discomfort 60.66 10.40 173 228796 125444 79389975
Dysplastic naevus 60.56 10.40 31 228938 564 79514855
Escherichia urinary tract infection 60.41 10.40 127 228842 13698 79501721
Chronic myeloid leukaemia 60.29 10.40 63 228906 3601 79511818
Cognitive disorder 60.28 10.40 67 228902 69859 79445560
Femur fracture 60.26 10.40 18 228951 38634 79476785
Serum sickness 60.26 10.40 63 228906 3603 79511816
Rebound effect 59.91 10.40 88 228881 7138 79508281
Superinfection bacterial 59.64 10.40 43 228926 1481 79513938
Necrotising fasciitis 59.56 10.40 80 228889 5970 79509449
Apoptotic colonopathy 59.55 10.40 20 228949 113 79515306
Pneumoperitoneum 59.49 10.40 58 228911 3050 79512369
Deep vein thrombosis postoperative 59.39 10.40 109 228860 10643 79504776
Skin lesion 59.36 10.40 258 228711 41586 79473833
Pneumonia influenzal 59.00 10.40 56 228913 2848 79512571
Mycobacterium haemophilum infection 58.97 10.40 20 228949 117 79515302
Hospitalisation 58.96 10.40 113 228856 94123 79421296
Platelet count decreased 58.93 10.40 323 228646 194341 79321078
Citrobacter infection 58.92 10.40 36 228933 934 79514485
Pulmonary tuberculosis 58.42 10.40 91 228878 7774 79507645
Norovirus infection 58.41 10.40 32 228937 672 79514747
Abdominal pain 58.35 10.40 778 228191 388791 79126628
Full blood count decreased 58.34 10.40 5 228964 26814 79488605
Oxalosis 58.33 10.40 19 228950 96 79515323
Feeling cold 58.23 10.40 7 228962 28722 79486697
Ascites 58.10 10.40 394 228575 75168 79440251
Propionibacterium infection 57.99 10.40 25 228944 302 79515117
Staphylococcal bacteraemia 57.82 10.40 116 228853 12102 79503317
Oxygen saturation decreased 57.81 10.40 184 228785 128863 79386556
SLE arthritis 57.77 10.40 30 228939 563 79514856
Pleocytosis 57.22 10.40 41 228928 1398 79514021
Cutaneous malacoplakia 56.92 10.40 19 228950 105 79515314
Necrotising oesophagitis 56.82 10.40 37 228932 1076 79514343
Chronic graft versus host disease in eye 56.68 10.40 20 228949 134 79515285
Urinary tract infection enterococcal 56.64 10.40 58 228911 3237 79512182
Cutaneous T-cell lymphoma 56.59 10.40 53 228916 2650 79512769
Reversible cerebral vasoconstriction syndrome 56.56 10.40 56 228913 3001 79512418
Enterococcal bacteraemia 56.39 10.40 56 228913 3012 79512407
Graft thrombosis 56.36 10.40 27 228942 423 79514996
Epstein Barr virus positive mucocutaneous ulcer 55.93 10.40 33 228936 802 79514617
Cutaneous blastomycosis 55.80 10.40 15 228954 32 79515387
Nightmare 55.78 10.40 5 228964 25856 79489563
Cutaneous tuberculosis 55.52 10.40 22 228947 211 79515208
Vertigo 55.48 10.40 70 228899 69012 79446407
Skin mass 55.36 10.40 90 228879 7973 79507446
Microangiopathic haemolytic anaemia 55.04 10.40 41 228928 1486 79513933
Neck pain 54.96 10.40 82 228887 75335 79440084
Hepatitis B reactivation 54.46 10.40 77 228892 6031 79509388
Clostridium difficile colitis 54.46 10.40 210 228759 32073 79483346
Illness 54.44 10.40 33 228936 46478 79468941
Sleep disorder 54.25 10.40 102 228867 85575 79429844
Microangiopathy 54.03 10.40 44 228925 1821 79513598
Gastroenteritis cryptosporidial 54.01 10.40 23 228946 269 79515150
Respiratory tract infection fungal 53.92 10.40 37 228932 1176 79514243
Wound 53.92 10.40 163 228806 116016 79399403
Anaphylactic shock 53.91 10.40 18 228951 35978 79479441
Bronchial polyp 53.88 10.40 17 228952 76 79515343
Head injury 53.72 10.40 20 228949 37349 79478070
Acute myeloid leukaemia recurrent 53.58 10.40 57 228912 3326 79512093
Blood glucose increased 53.58 10.40 161 228808 114814 79400605
Heart rate increased 53.47 10.40 173 228796 120551 79394868
Device dislocation 53.46 10.40 6 228963 25964 79489455
Pneumonia pseudomonal 53.42 10.40 75 228894 5836 79509583
Heart rate irregular 53.21 10.40 14 228955 32665 79482754
Cryptococcal meningoencephalitis 53.18 10.40 22 228947 238 79515181
Nervousness 53.12 10.40 15 228954 33400 79482019
Escherichia sepsis 53.11 10.40 91 228878 8417 79507002
Hepatic enzyme increased 53.10 10.40 307 228662 182303 79333116
Engraft failure 52.59 10.40 30 228939 683 79514736
Lung transplant 52.24 10.40 65 228904 4496 79510923
Glomerulonephropathy 52.05 10.40 23 228946 296 79515123
Abdominal infection 52.00 10.40 58 228911 3571 79511848
Contraindicated product administered 51.84 10.40 254 228715 157284 79358135
Toxic skin eruption 51.84 10.40 3 228966 22290 79493129
Cushingoid 51.71 10.40 96 228873 9456 79505963
Agranulocytosis 51.67 10.40 261 228708 44769 79470650
Drug eruption 51.66 10.40 31 228938 43904 79471515
Oliguria 51.64 10.40 132 228837 16177 79499242
Weight increased 51.57 10.40 528 228441 276858 79238561
Incorrect dose administered 51.42 10.40 88 228881 76542 79438877
Lower respiratory tract infection 51.30 10.40 194 228775 129026 79386393
Tuberculosis 51.26 10.40 126 228843 15072 79500347
Capillaritis 51.09 10.40 22 228947 265 79515154
Drug effective for unapproved indication 51.08 10.40 74 228895 5927 79509492
Foot deformity 51 10.40 5 228964 24069 79491350
Fluid retention 50.77 10.40 76 228893 69733 79445686
Bronchiolitis obliterans syndrome 50.71 10.40 23 228946 316 79515103
Tularaemia 50.63 10.40 17 228952 96 79515323
Vesicoureteric reflux 50.58 10.40 18 228951 124 79515295
Choriomeningitis lymphocytic 50.54 10.40 15 228954 52 79515367
Nephropathy 50.39 10.40 96 228873 9642 79505777
Mycetoma mycotic 50.34 10.40 18 228951 126 79515293
Hand deformity 50.25 10.40 143 228826 103776 79411643
Glossodynia 50.12 10.40 142 228827 103195 79412224
Multifocal micronodular pneumocyte hyperplasia 50.10 10.40 16 228953 75 79515344
Anti-cyclic citrullinated peptide antibody positive 50.03 10.40 102 228867 83041 79432378
Tachycardia 50.03 10.40 302 228667 177466 79337953
Tinnitus 49.76 10.40 33 228936 44300 79471119
Mycobacterium fortuitum infection 49.73 10.40 20 228949 200 79515219
Large intestinal ulcer 49.64 10.40 65 228904 4732 79510687
Device malfunction 49.53 10.40 3 228966 21445 79493974
Dysplasia 49.48 10.40 37 228932 1349 79514070
Drug level decreased 49.21 10.40 120 228849 14282 79501137
Skin squamous cell carcinoma recurrent 49.20 10.40 14 228955 40 79515379
Cerebral aspergillosis 49.16 10.40 41 228928 1755 79513664
Product quality issue 49.06 10.40 18 228951 33922 79481497
Anuria 49.02 10.40 152 228817 20811 79494608
Depressed level of consciousness 48.98 10.40 130 228839 96522 79418897
Engraftment syndrome 48.94 10.40 37 228932 1372 79514047
Lung infiltration 48.90 10.40 161 228808 22751 79492668
Muir-Torre syndrome 48.70 10.40 14 228955 42 79515377
Respiratory depression 48.63 10.40 10 228959 27620 79487799
Meningitis bacterial 48.62 10.40 49 228920 2683 79512736
Disseminated toxoplasmosis 48.54 10.40 20 228949 214 79515205
Pneumonia acinetobacter 48.34 10.40 19 228950 178 79515241
Enterovirus infection 48.29 10.40 42 228927 1905 79513514
Gastroenteritis adenovirus 48.15 10.40 23 228946 358 79515061
Accidental exposure to product 48.08 10.40 15 228954 31307 79484112
Chronic kidney disease 47.94 10.40 340 228629 65814 79449605
Transitional cell carcinoma 47.85 10.40 47 228922 2494 79512925
Osteoarthritis 47.69 10.40 113 228856 87196 79428223
Encapsulating peritoneal sclerosis 47.68 10.40 30 228939 821 79514598
Malignant fibrous histiocytoma 47.43 10.40 19 228950 188 79515231
Neoplasm progression 47.38 10.40 47 228922 51635 79463784
Infectious pleural effusion 47.18 10.40 56 228913 3688 79511731
Fungal abscess central nervous system 46.94 10.40 17 228952 124 79515295
Rhinorrhoea 46.92 10.40 92 228877 75982 79439437
Product prescribing error 46.84 10.40 36 228933 44777 79470642
Withdrawal syndrome 46.69 10.40 10 228959 26844 79488575
Respiratory syncytial virus infection 46.59 10.40 91 228878 9311 79506108
Arthritis 46.56 10.40 171 228798 114709 79400710
Restlessness 46.52 10.40 39 228930 46453 79468966
Pallor 46.50 10.40 45 228924 50017 79465402
Burning sensation 46.47 10.40 60 228909 58572 79456847
Skin laceration 46.04 10.40 13 228956 28949 79486470
Respiratory distress 45.93 10.40 306 228663 58033 79457386
Glomerulonephritis rapidly progressive 45.90 10.40 38 228931 1610 79513809
Infection susceptibility increased 45.81 10.40 55 228914 3666 79511753
Burkholderia cepacia complex infection 45.76 10.40 21 228948 297 79515122
Disturbance in attention 45.66 10.40 47 228922 50754 79464665
Disseminated intravascular coagulation 45.61 10.40 214 228755 35628 79479791
Lymphadenitis bacterial 45.54 10.40 15 228954 79 79515340
Scrotal ulcer 45.50 10.40 23 228946 407 79515012
Passenger lymphocyte syndrome 45.50 10.40 16 228953 106 79515313
Tuberculosis of central nervous system 45.35 10.40 24 228945 469 79514950
Throat irritation 45.26 10.40 31 228938 40915 79474504
Therapeutic product effect incomplete 45.10 10.40 231 228738 141414 79374005
Flatulence 45.06 10.40 34 228935 42690 79472729
Bile duct stenosis 45.06 10.40 41 228928 1975 79513444
Acanthamoeba infection 44.81 10.40 24 228945 481 79514938
Hypertrophic osteoarthropathy 44.75 10.40 16 228953 112 79515307
Therapy interrupted 44.67 10.40 17 228952 31324 79484095
Pericarditis constrictive 44.65 10.40 26 228943 616 79514803
Human herpesvirus 6 infection reactivation 44.59 10.40 25 228944 550 79514869
Candida sepsis 44.59 10.40 45 228924 2468 79512951
Pneumonia adenoviral 44.50 10.40 24 228945 488 79514931
Anaphylactic reaction 44.46 10.40 110 228859 83633 79431786
Reticulocytopenia 44.33 10.40 19 228950 226 79515193
Unresponsive to stimuli 44.31 10.40 57 228912 55731 79459688
Encephalitis autoimmune 44.26 10.40 43 228926 2251 79513168
Vascular graft complication 44.24 10.40 17 228952 149 79515270
Ureteral necrosis 43.91 10.40 15 228954 90 79515329
Cytomegalovirus gastroenteritis 43.85 10.40 23 228946 441 79514978
Contusion 43.85 10.40 249 228720 148527 79366892
Chronic hepatitis 43.75 10.40 35 228934 1412 79514007
Wound infection 43.74 10.40 160 228809 23831 79491588
Cholelithiasis 43.73 10.40 52 228917 52612 79462807
Osteonecrosis of jaw 43.58 10.40 36 228933 43190 79472229
Liver abscess 43.51 10.40 69 228900 5985 79509434
Acid fast bacilli infection 43.27 10.40 17 228952 159 79515260
Coronary artery disease 43.19 10.40 76 228893 65398 79450021
Herpes zoster meningoencephalitis 43.07 10.40 27 228942 734 79514685
Disseminated Bacillus Calmette-Guerin infection 42.69 10.40 18 228951 205 79515214
Hepatic necrosis 42.59 10.40 86 228883 9014 79506405
Varicella 42.25 10.40 47 228922 2885 79512534
Autoimmune disorder 42.18 10.40 124 228845 16488 79498931
B-cell lymphoma 42.17 10.40 69 228900 6146 79509273
C3 glomerulopathy 42.16 10.40 13 228956 53 79515366
Bacterial pyelonephritis 42.13 10.40 24 228945 545 79514874
Lacrimation increased 42.00 10.40 7 228962 22470 79492949
Stevens-Johnson syndrome 41.53 10.40 31 228938 39135 79476284
Crying 41.27 10.40 8 228961 23035 79492384
Necrosis 41.24 10.40 87 228882 9406 79506013
Listeriosis 41.23 10.40 41 228928 2209 79513210
Thrombosis 41.20 10.40 115 228854 83985 79431434
Adenoviral haemorrhagic cystitis 41.19 10.40 23 228946 502 79514917
Parainfluenzae virus infection 41.17 10.40 65 228904 5617 79509802
Scopulariopsis infection 41.12 10.40 15 228954 112 79515307
Cholangitis 41.07 10.40 104 228865 12672 79502747
Gallbladder disorder 41.01 10.40 4 228965 19336 79496083
Arthritis bacterial 40.98 10.40 85 228884 9081 79506338
Neuroleptic malignant syndrome 40.89 10.40 14 228955 27545 79487874
Peritonitis pneumococcal 40.75 10.40 11 228958 24 79515395
Fear 40.74 10.40 7 228962 21979 79493440
Ocular hyperaemia 40.70 10.40 15 228954 28191 79487228
Vasogenic cerebral oedema 40.70 10.40 34 228935 1459 79513960
Calciphylaxis 40.44 10.40 52 228917 3718 79511701
White blood cell count increased 40.44 10.40 97 228872 74536 79440883
Abscess fungal 40.29 10.40 20 228949 340 79515079
Granulomatous dermatitis 40.16 10.40 21 228948 400 79515019
Serositis 40.11 10.40 27 228942 831 79514588
Brain oedema 39.92 10.40 161 228808 25102 79490317
Acute disseminated encephalomyelitis 39.87 10.40 19 228950 294 79515125
Accidental overdose 39.86 10.40 33 228936 39548 79475871
Perinephric abscess 39.84 10.40 18 228951 245 79515174
Blood creatine phosphokinase increased 39.83 10.40 81 228888 66009 79449410
Osteonecrosis 39.82 10.40 186 228783 30909 79484510
Diarrhoea haemorrhagic 39.73 10.40 105 228864 13129 79502290
Cytomegalovirus enterocolitis 39.64 10.40 35 228934 1620 79513799
Klebsiella bacteraemia 39.56 10.40 46 228923 2964 79512455
Oesophageal candidiasis 39.49 10.40 84 228885 9134 79506285
Toxic optic neuropathy 39.43 10.40 30 228939 1123 79514296
Renal vein thrombosis 39.39 10.40 23 228946 548 79514871
Eye pruritus 39.35 10.40 6 228963 20564 79494855
Epstein-Barr virus antibody positive 39.27 10.40 24 228945 623 79514796
Haematochezia 39.22 10.40 125 228844 87520 79427899
Hepatic fibrosis 39.20 10.40 73 228896 7207 79508212
Urinoma 38.95 10.40 17 228952 212 79515207
Coronavirus infection 38.91 10.40 74 228895 7423 79507996
Optic atrophy 38.74 10.40 37 228932 1896 79513523
Prophylaxis against transplant rejection 38.34 10.40 13 228956 76 79515343
Migraine 38.31 10.40 126 228843 87367 79428052
Autoimmune neutropenia 38.29 10.40 23 228946 578 79514841
Rhabdomyolysis 38.29 10.40 159 228810 102972 79412447
Osmotic demyelination syndrome 38.26 10.40 33 228936 1480 79513939
Irritability 38.20 10.40 37 228932 41107 79474312
Depressed mood 38.02 10.40 50 228919 48430 79466989
Angina pectoris 37.93 10.40 56 228913 51676 79463743
Remission not achieved 37.88 10.40 20 228949 389 79515030
Alpha haemolytic streptococcal infection 37.80 10.40 40 228929 2320 79513099
Sinus disorder 37.78 10.40 9 228960 22455 79492964
Disseminated varicella zoster vaccine virus infection 37.76 10.40 14 228955 110 79515309
Osteomyelitis fungal 37.69 10.40 18 228951 280 79515139
Hypocalcaemia 37.63 10.40 53 228916 49871 79465548
Haemoglobin decreased 37.58 10.40 432 228537 221687 79293732
Central nervous system viral infection 37.54 10.40 14 228955 112 79515307
Uveitis 37.48 10.40 120 228849 16710 79498709
Necrotising herpetic retinopathy 37.44 10.40 14 228955 113 79515306
Gastroenteritis rotavirus 37.33 10.40 20 228949 401 79515018
Muscle spasticity 37.33 10.40 8 228961 21467 79493952
Renal failure 37.21 10.40 796 228173 200172 79315247
Urinary retention 37.11 10.40 66 228903 56564 79458855
Hepatitis B 36.94 10.40 77 228892 8255 79507164
Cutaneous nocardiosis 36.77 10.40 16 228953 198 79515221
Metastatic squamous cell carcinoma 36.73 10.40 22 228947 550 79514869
Renal vessel disorder 36.69 10.40 18 228951 298 79515121
Renal and pancreas transplant rejection 36.66 10.40 11 228958 40 79515379
Transitional cell carcinoma metastatic 36.66 10.40 11 228958 40 79515379
Pulmonary haemorrhage 36.55 10.40 109 228860 14608 79500811
Pleural mesothelioma malignant 36.45 10.40 15 228954 160 79515259
Human herpes virus 8 test positive 36.45 10.40 11 228958 41 79515378
Skin graft rejection 36.39 10.40 10 228959 24 79515395
Melaena 36.38 10.40 75 228894 60815 79454604
Aphthous ulcer 36.33 10.40 119 228850 16770 79498649
Hypothyroidism 36.23 10.40 59 228910 52333 79463086
Pyogenic granuloma 36.20 10.40 21 228948 494 79514925
Limb discomfort 36.14 10.40 25 228944 32825 79482594
Rheumatoid nodule 35.97 10.40 4 228965 17434 79497985
Adenovirus reactivation 35.96 10.40 19 228950 370 79515049
Restless legs syndrome 35.93 10.40 7 228962 20085 79495334
Splenic abscess 35.90 10.40 22 228947 574 79514845
Stomatitis 35.90 10.40 260 228709 146497 79368922
Dyspepsia 35.88 10.40 175 228794 108512 79406907
Disseminated aspergillosis 35.86 10.40 28 228941 1090 79514329
Heartland virus infection 35.82 10.40 10 228959 26 79515393
Medication error 35.79 10.40 91 228878 68551 79446868
Hip fracture 35.75 10.40 22 228947 30739 79484680
Bone marrow transplant rejection 35.74 10.40 17 228952 262 79515157
Skin discolouration 35.72 10.40 39 228930 40995 79474424
H1N1 influenza 35.65 10.40 40 228929 2479 79512940
Hypersomnia 35.54 10.40 11 228958 23075 79492344
Pulmonary alveolar haemorrhage 35.52 10.40 92 228877 11365 79504054
Rash erythematous 35.50 10.40 70 228899 57699 79457720
Sinus bradycardia 35.48 10.40 14 228955 25233 79490186
Viral load increased 35.36 10.40 43 228926 2905 79512514
Musculoskeletal disorder 35.28 10.40 9 228960 21439 79493980
Sarcoma of skin 35.27 10.40 12 228957 71 79515348
Dystonia 35.16 10.40 9 228960 21390 79494029
Nosocomial infection 35.10 10.40 42 228927 2790 79512629
Nephrolithiasis 35.02 10.40 62 228907 53229 79462190
Seroconversion test negative 34.98 10.40 8 228961 5 79515414
Sleep apnoea syndrome 34.81 10.40 32 228937 36446 79478973
Viral test positive 34.76 10.40 19 228950 397 79515022
Cytopenia 34.72 10.40 133 228836 20250 79495169
Arteritis infective 34.71 10.40 12 228957 75 79515344
Localised infection 34.64 10.40 34 228935 37541 79477878
Chronic graft versus host disease oral 34.55 10.40 14 228955 143 79515276
Phaeohyphomycotic brain abscess 34.54 10.40 11 228958 51 79515368
Frequent bowel movements 34.51 10.40 21 228948 29518 79485901
Disseminated trichosporonosis 34.47 10.40 14 228955 144 79515275
Pancreatitis necrotising 34.45 10.40 49 228920 3859 79511560
Large intestine perforation 34.41 10.40 106 228863 14461 79500958
Sporotrichosis 34.33 10.40 13 228956 109 79515310
Deep vein thrombosis 34.23 10.40 205 228764 120714 79394705
Visual impairment 34.22 10.40 142 228827 91989 79423430
Breast cancer 34.22 10.40 28 228941 33753 79481666
Sputum discoloured 34.12 10.40 10 228959 21733 79493686
Dysphagia 34.08 10.40 208 228761 121928 79393491
Perinephric collection 34.05 10.40 18 228951 351 79515068
Toxic epidermal necrolysis 33.93 10.40 47 228922 44534 79470885
Cytomegalovirus urinary tract infection 33.68 10.40 12 228957 83 79515336
Lethargy 33.60 10.40 120 228849 81172 79434247
Chromoblastomycosis 33.56 10.40 12 228957 84 79515335
Atypical mycobacterial pneumonia 33.48 10.40 14 228955 156 79515263
Ecthyma 33.46 10.40 23 228946 733 79514686
Superinfection viral 33.40 10.40 10 228959 36 79515383
Red blood cell count decreased 33.39 10.40 72 228897 57441 79457978
Pleural adhesion 33.32 10.40 17 228952 307 79515112
Hyperplasia 33.25 10.40 28 228941 1215 79514204
Scleroderma 33.17 10.40 58 228911 5452 79509967
Guillain-Barre syndrome 33.12 10.40 77 228892 8888 79506531
Mobility decreased 33.09 10.40 210 228759 121965 79393454
Haematotoxicity 33.07 10.40 109 228860 15410 79500009
Blood glucose decreased 33.03 10.40 17 228952 26217 79489202
Renal cell carcinoma 33.00 10.40 64 228905 6514 79508905
Fungal sepsis 32.89 10.40 33 228936 1797 79513622
Loss of personal independence in daily activities 32.82 10.40 167 228802 102413 79413006
Intestinal tuberculosis 32.76 10.40 15 228954 211 79515208
Product administration error 32.75 10.40 26 228943 31820 79483599
Oesophageal ulcer 32.74 10.40 66 228903 6909 79508510
Speech disorder 32.58 10.40 67 228902 54378 79461041
Renal necrosis 32.55 10.40 16 228953 266 79515153
Herpes simplex hepatitis 32.52 10.40 20 228949 525 79514894
Dry mouth 32.48 10.40 136 228833 87883 79427536
Rib fracture 32.47 10.40 20 228949 27927 79487492
Mucosal inflammation 32.45 10.40 346 228623 75234 79440185
Lung adenocarcinoma stage IV 32.39 10.40 16 228953 269 79515150
Ankle fracture 32.34 10.40 5 228964 16964 79498455
Dyskinesia 32.31 10.40 49 228920 44724 79470695
Central nervous system lesion 32.25 10.40 98 228871 13270 79502149
Biopsy kidney abnormal 32.19 10.40 14 228955 173 79515246
Phospholipidosis 32.14 10.40 15 228954 221 79515198
Inflammatory bowel disease 32.11 10.40 58 228911 5593 79509826
Mucoepidermoid carcinoma of salivary gland 32.07 10.40 12 228957 97 79515322
Exostosis 32.06 10.40 5 228964 16853 79498566
Klebsiella sepsis 32.01 10.40 43 228926 3209 79512210
Acute allograft nephropathy 32.01 10.40 10 228959 43 79515376
Blood sodium decreased 31.94 10.40 29 228940 33226 79482193
Ear infection 31.92 10.40 31 228938 34401 79481018
Erythema multiforme 31.88 10.40 6 228963 17645 79497774
Pulmonary cavitation 31.88 10.40 31 228938 1625 79513794
Serratia infection 31.87 10.40 32 228937 1744 79513675
Angiocentric lymphoma 31.86 10.40 24 228945 885 79514534
Removal of renal transplant 31.81 10.40 9 228960 25 79515394
Oesophageal stenosis 31.81 10.40 50 228919 4304 79511115
Infective aneurysm 31.80 10.40 25 228944 983 79514436
Trichosporon infection 31.80 10.40 25 228944 983 79514436
Hypoacusis 31.79 10.40 24 228945 30126 79485293
Acanthoma 31.64 10.40 10 228959 45 79515374
Nephritis 31.64 10.40 49 228920 4165 79511254
Miosis 31.63 10.40 4 228965 15785 79499634
Chronic hepatitis C 31.61 10.40 21 228948 632 79514787
Bone marrow failure 31.58 10.40 253 228716 50854 79464565
Emotional distress 31.57 10.40 41 228928 39928 79475491
Lupus vasculitis 31.57 10.40 20 228949 554 79514865
Disseminated coccidioidomycosis 31.56 10.40 13 228956 139 79515280
Herpes zoster reactivation 31.56 10.40 14 228955 182 79515237
Pharyngeal polyp 31.55 10.40 8 228961 12 79515407
Systemic inflammatory response syndrome 31.45 10.40 88 228881 11377 79504042
Metastatic carcinoma of the bladder 31.43 10.40 15 228954 233 79515186
Retching 31.42 10.40 6 228963 17461 79497958
Blood immunoglobulin A decreased 31.40 10.40 29 228940 1424 79513995
Urine protein/creatinine ratio increased 31.38 10.40 27 228942 1207 79514212
Aspartate aminotransferase increased 31.37 10.40 251 228718 138390 79377029
Ileal ulcer 31.36 10.40 26 228943 1104 79514315
Musculoskeletal discomfort 31.35 10.40 9 228960 19826 79495593
Inferior vena cava stenosis 31.29 10.40 10 228959 47 79515372
Blood urine present 31.29 10.40 11 228958 21286 79494133
Hyperammonaemia 31.28 10.40 86 228883 11007 79504412
Urinary incontinence 31.26 10.40 43 228926 40866 79474553
Encephalopathy 31.05 10.40 313 228656 67084 79448335
Hiatus hernia 31.04 10.40 14 228955 23298 79492121
Dementia 31.01 10.40 16 228953 24643 79490776
Splenomegaly 31.01 10.40 130 228839 20624 79494795
Anorexia nervosa 30.97 10.40 15 228954 241 79515178
Gastrooesophageal reflux disease 30.97 10.40 174 228795 104072 79411347
Pain in jaw 30.96 10.40 53 228916 46098 79469321
Cholangitis sclerosing 30.88 10.40 38 228931 2599 79512820
Diabetic cardiomyopathy 30.82 10.40 9 228960 29 79515390
Pollakiuria 30.82 10.40 37 228932 37280 79478139
Tendonitis 30.66 10.40 15 228954 23815 79491604
Meningitis viral 30.61 10.40 33 228936 1955 79513464
Liver transplant failure 30.29 10.40 12 228957 115 79515304
Thirst 30.27 10.40 8 228961 18611 79496808
Odynophagia 30.16 10.40 86 228883 11241 79504178
Immunosuppression 30.09 10.40 93 228876 12710 79502709
Q fever 30.06 10.40 15 228954 258 79515161
Intestinal villi atrophy 30.02 10.40 18 228951 451 79514968
Salivary hypersecretion 30.01 10.40 3 228966 14221 79501198
Obstructive nephropathy 30.00 10.40 10 228959 55 79515364
Aspergilloma 29.93 10.40 20 228949 608 79514811
Elbow deformity 29.85 10.40 29 228940 1518 79513901
Meningitis 29.76 10.40 77 228892 9505 79505914
Body temperature decreased 29.73 10.40 29 228940 32116 79483303
Throat tightness 29.70 10.40 22 228947 27885 79487534
Serpiginous choroiditis 29.68 10.40 7 228962 6 79515413
Renal haematoma 29.64 10.40 22 228947 793 79514626
Arterial rupture 29.62 10.40 22 228947 794 79514625
Influenza 29.62 10.40 234 228735 129372 79386047
Philadelphia positive chronic myeloid leukaemia 29.51 10.40 13 228956 166 79515253
Complications of bone marrow transplant 29.41 10.40 20 228949 626 79514793
HIV infection 29.35 10.40 25 228944 1102 79514317
Spinal stenosis 29.32 10.40 5 228964 15786 79499633
Urate nephropathy 29.30 10.40 13 228956 169 79515250
Hepatitis cholestatic 29.26 10.40 97 228872 13755 79501664
Dehiscence 29.24 10.40 13 228956 170 79515249
Rash macular 29.21 10.40 24 228945 28875 79486544
Sneezing 29.20 10.40 10 228959 19673 79495746
Dysarthria 29.18 10.40 98 228871 67524 79447895
Rheumatoid arthritis 29.14 10.40 422 228547 208048 79307371
Enteritis 28.94 10.40 100 228869 14483 79500936
Renal haemorrhage 28.85 10.40 34 228935 2222 79513197
Achromobacter infection 28.83 10.40 12 228957 132 79515287
Mycobacterium kansasii infection 28.78 10.40 16 228953 346 79515073
Hepatitis viral 28.65 10.40 24 228945 1034 79514385
Symptom masked 28.61 10.40 27 228942 1363 79514056
Haemophilus infection 28.61 10.40 34 228935 2242 79513177
Bronchospasm 28.59 10.40 18 228951 24841 79490578
Musculoskeletal chest pain 28.38 10.40 18 228951 24746 79490673
Subcapsular renal haematoma 28.32 10.40 21 228948 756 79514663
Meningitis fungal 28.26 10.40 13 228956 185 79515234
Anastomotic stenosis 28.12 10.40 18 228951 508 79514911
Adverse drug reaction 28.11 10.40 97 228872 66295 79449124
Intracranial pressure increased 28.07 10.40 69 228900 8253 79507166
Reperfusion injury 28.07 10.40 13 228956 188 79515231
Blood test abnormal 28.06 10.40 8 228961 17702 79497717
Septic embolus 28.06 10.40 32 228937 2019 79513400
Sinus congestion 28.01 10.40 11 228958 19885 79495534
Gastrointestinal disorder 28.01 10.40 500 228469 121705 79393714
Skin exfoliation 28.00 10.40 74 228895 55026 79460393
Eye swelling 27.99 10.40 21 228948 26447 79488972
Chronic papillomatous dermatitis 27.97 10.40 10 228959 70 79515349
Urinary tract infection pseudomonal 27.96 10.40 30 228939 1768 79513651
Middle insomnia 27.90 10.40 6 228963 16063 79499356
Hypertrophic cardiomyopathy 27.85 10.40 34 228935 2306 79513113
Swollen joint count increased 27.80 10.40 135 228834 22792 79492627
Viral vasculitis 27.76 10.40 12 228957 146 79515273
Malacoplakia vesicae 27.72 10.40 10 228959 72 79515347
Product complaint 27.69 10.40 3 228966 13346 79502073
Sleep disorder due to a general medical condition 27.69 10.40 4 228965 14273 79501146
Procedural pain 27.55 10.40 16 228953 23068 79492351
Lactobacillus infection 27.52 10.40 16 228953 378 79515041
Staphylococcal sepsis 27.51 10.40 99 228870 14627 79500792
Lepromatous leprosy 27.49 10.40 10 228959 74 79515345
Nephrogenic systemic fibrosis 27.39 10.40 57 228912 6103 79509316
Bronchiectasis 27.28 10.40 132 228837 22254 79493165
Obstructive airways disorder 27.27 10.40 30 228939 31429 79483990
Pelvic deformity 27.26 10.40 10 228959 76 79515343
Body temperature increased 27.14 10.40 54 228915 44366 79471053
Angina unstable 27.06 10.40 7 228962 16520 79498899
Dry eye 27.05 10.40 40 228929 36891 79478528
External auditory canal atresia 27.04 10.40 7 228962 12 79515407
C-reactive protein 26.90 10.40 50 228919 4929 79510490
Upper limb fracture 26.88 10.40 9 228960 17958 79497461
Adverse event 26.85 10.40 86 228883 60128 79455291
Pneumonia respiratory syncytial viral 26.72 10.40 30 228939 1860 79513559
Ureteric anastomosis complication 26.68 10.40 8 228961 29 79515390
Transplant abscess 26.68 10.40 8 228961 29 79515390
Vascular pseudoaneurysm 26.61 10.40 41 228928 3469 79511950
Pemphigus 26.54 10.40 172 228797 99410 79416009
Troponin increased 26.53 10.40 11 228958 19244 79496175
Hepatic cyst infection 26.52 10.40 12 228957 164 79515255
Bronchial anastomosis complication 26.49 10.40 9 228960 53 79515366
Central nervous system vasculitis 26.43 10.40 26 228943 1382 79514037
Upper gastrointestinal haemorrhage 26.42 10.40 49 228920 41331 79474088
Hepatic haematoma 26.40 10.40 21 228948 840 79514579
Mood swings 26.37 10.40 12 228957 19868 79495551
Emphysematous cystitis 26.35 10.40 15 228954 340 79515079
Trichophytic granuloma 26.35 10.40 9 228960 54 79515365
Fibromatosis colli of infancy 26.34 10.40 7 228962 14 79515405
Acquired plagiocephaly 26.34 10.40 7 228962 14 79515405
Product storage error 26.33 10.40 7 228962 16219 79499200
Leiomyosarcoma 26.31 10.40 15 228954 341 79515078
Tooth disorder 26.25 10.40 22 228947 26211 79489208
Muscular weakness 26.25 10.40 315 228654 160414 79355005
Intracranial infection 26.19 10.40 10 228959 86 79515333
Renal cortical necrosis 26.16 10.40 15 228954 345 79515074
Gouty tophus 26.12 10.40 16 228953 417 79515002
Extranodal marginal zone B-cell lymphoma (MALT type) 26.07 10.40 18 228951 578 79514841
Thrombotic thrombocytopenic purpura 26.05 10.40 57 228912 6319 79509100
Growth retardation 26.05 10.40 30 228939 1913 79513506
Pulmonary air leakage 26.03 10.40 13 228956 224 79515195
Bladder transitional cell carcinoma 26.02 10.40 35 228934 2615 79512804
Oesophagitis ulcerative 25.98 10.40 24 228945 1179 79514240
Plasma cell myeloma 25.96 10.40 73 228896 53186 79462233
Panic attack 25.89 10.40 19 228950 24197 79491222
Gastrointestinal mucormycosis 25.82 10.40 16 228953 426 79514993
Pericarditis 25.81 10.40 184 228785 104052 79411367
Histoplasmosis cutaneous 25.80 10.40 9 228960 58 79515361
Oral pain 25.76 10.40 32 228937 31766 79483653
Inhibitory drug interaction 25.68 10.40 46 228923 4407 79511012
Hepatosplenomegaly 25.65 10.40 55 228914 6014 79509405
Papule 25.61 10.40 62 228907 7345 79508074
Encephalitis fungal 25.58 10.40 12 228957 179 79515240
Zoonotic bacterial infection 25.54 10.40 9 228960 60 79515359
Neutrophil morphology abnormal 25.50 10.40 10 228959 93 79515326
Pleomorphic malignant fibrous histiocytoma 25.49 10.40 8 228961 35 79515384
Blood stem cell transplant failure 25.40 10.40 17 228952 518 79514901
Ureteric obstruction 25.35 10.40 35 228934 2681 79512738
Overlap syndrome 25.22 10.40 22 228947 1002 79514417
Glomerulonephritis membranous 25.19 10.40 27 228942 1589 79513830
Hypoaesthesia oral 25.09 10.40 5 228964 14119 79501300
Anger 24.98 10.40 9 228960 17153 79498266
Normocytic anaemia 24.96 10.40 44 228925 4163 79511256
Shock haemorrhagic 24.96 10.40 119 228850 19941 79495478
Arrhythmia 24.96 10.40 91 228878 61181 79454238
Herpes zoster cutaneous disseminated 24.88 10.40 16 228953 455 79514964
Cytomegalovirus myocarditis 24.86 10.40 7 228962 19 79515400
Muscle rigidity 24.86 10.40 13 228956 19869 79495550
Subcutaneous abscess 24.82 10.40 64 228905 7885 79507534
Post procedural urine leak 24.80 10.40 11 228958 143 79515276
Vascular hyalinosis 24.78 10.40 10 228959 101 79515318
Haemorrhage intracranial 24.76 10.40 144 228825 26049 79489370
Paraesthesia oral 24.70 10.40 14 228955 20457 79494962
Oropharyngeal squamous cell carcinoma 24.61 10.40 13 228956 253 79515166
Pharyngeal oedema 24.61 10.40 8 228961 16264 79499155
Multiple allergies 24.60 10.40 76 228893 10384 79505035
B-lymphocyte count decreased 24.50 10.40 25 228944 1389 79514030
Multiple sclerosis 24.45 10.40 17 228952 22265 79493154
Disorientation 24.42 10.40 95 228874 62681 79452738
Orbital apex syndrome 24.35 10.40 9 228960 70 79515349
Respiratory papilloma 24.35 10.40 7 228962 21 79515398
Molluscum contagiosum 24.34 10.40 16 228953 473 79514946
Microsporum infection 24.31 10.40 8 228961 42 79515377
Spinal pain 24.30 10.40 7 228962 15385 79500034
Sinusitis aspergillus 24.29 10.40 13 228956 260 79515159
Metastases to lung 24.26 10.40 110 228859 18053 79497366
Neuroendocrine carcinoma of the skin 24.21 10.40 24 228945 1288 79514131
Papillary renal cell carcinoma 24.21 10.40 13 228956 262 79515157
Ophthalmic herpes zoster 24.17 10.40 34 228935 2650 79512769
Granulomatous rosacea 24.17 10.40 12 228957 204 79515215
Cyanosis 24.13 10.40 22 228947 25160 79490259
Hepatic cancer recurrent 24.12 10.40 13 228956 264 79515155
Clostridium difficile infection 24.07 10.40 207 228762 42478 79472941
Myocardial necrosis 23.98 10.40 16 228953 485 79514934
Dermatitis allergic 23.96 10.40 11 228958 18119 79497300
Cardiac failure 23.95 10.40 307 228662 154535 79360884
Faeces discoloured 23.92 10.40 29 228940 29098 79486321
Dyspnoea exertional 23.92 10.40 149 228820 86924 79428495
Skin induration 23.90 10.40 45 228924 4480 79510939
Leukoencephalopathy 23.89 10.40 63 228906 7866 79507553
Pneumonia necrotising 23.68 10.40 23 228946 1204 79514215
Viral myelitis 23.63 10.40 10 228959 115 79515304
Human anaplasmosis 23.61 10.40 9 228960 77 79515342
Toothache 23.61 10.40 14 228955 19956 79495463
Respiratory tract congestion 23.57 10.40 14 228955 19940 79495479
Cutaneous sporotrichosis 23.56 10.40 8 228961 47 79515372
Device related bacteraemia 23.43 10.40 18 228951 684 79514735
Hepatotoxicity 23.42 10.40 238 228731 51114 79464305
Evans syndrome 23.35 10.40 15 228954 426 79514993
Urosepsis 23.34 10.40 143 228826 26352 79489067
Leukaemia recurrent 23.31 10.40 34 228935 2740 79512679
Sinus tachycardia 23.31 10.40 44 228925 36864 79478555
Anal ulcer 23.22 10.40 24 228945 1354 79514065
Neutropenia 23.19 10.40 1029 227940 286681 79228738
Pneumoretroperitoneum 23.15 10.40 11 228958 169 79515250
Staphylococcal mediastinitis 23.14 10.40 8 228961 50 79515369
Liver function test abnormal 23.11 10.40 285 228684 64190 79451229
Lung abscess 23.11 10.40 42 228927 4070 79511349
Hepatic infection fungal 23.07 10.40 12 228957 226 79515193
Tuberculosis of genitourinary system 23.01 10.40 8 228961 51 79515368
Bacteriuria 22.99 10.40 23 228946 1248 79514171
Skin burning sensation 22.96 10.40 5 228964 13267 79502152
Jejunal perforation 22.95 10.40 14 228955 362 79515057
Herpes sepsis 22.92 10.40 6 228963 11 79515408
Weight decreased 22.89 10.40 812 228157 354386 79161033
Endocarditis bacterial 22.88 10.40 25 228944 1504 79513915
Aspergillosis oral 22.88 10.40 8 228961 52 79515367
Feeding disorder 22.86 10.40 9 228960 16245 79499174
Oral herpes 22.82 10.40 146 228823 27308 79488111
Joint dislocation 22.82 10.40 10 228959 16929 79498490
Gastrointestinal haemorrhage 22.80 10.40 293 228676 147426 79367993
Cardiac arrest 22.79 10.40 352 228617 171744 79343675
Schistosomiasis 22.75 10.40 8 228961 53 79515366
Moraxella infection 22.73 10.40 17 228952 620 79514799
Breast cancer female 22.72 10.40 3 228966 11458 79503961
Extrapyramidal disorder 22.72 10.40 19 228950 22660 79492759
Epstein-Barr virus antigen positive 22.65 10.40 9 228960 87 79515332
Herpes simplex meningitis 22.62 10.40 8 228961 54 79515365
Lymphadenopathy 22.50 10.40 243 228726 53004 79462415
Prostate cancer 22.50 10.40 38 228931 33230 79482189
Hyperlipidaemia 22.46 10.40 140 228829 25953 79489466
Eye irritation 22.40 10.40 16 228953 20665 79494754
IIIrd nerve paralysis 22.34 10.40 22 228947 1171 79514248
Febrile bone marrow aplasia 22.33 10.40 5 228964 13015 79502404
Hyperoxaluria 22.25 10.40 13 228956 310 79515109
Cow pox 22.24 10.40 7 228962 31 79515388
Intervertebral disc protrusion 22.21 10.40 21 228948 23600 79491819
Disseminated strongyloidiasis 22.20 10.40 12 228957 245 79515174
Fracture 22.17 10.40 18 228951 21783 79493636
Head discomfort 22.16 10.40 7 228962 14495 79500924
Gastritis fungal 22.16 10.40 11 228958 187 79515232
Hyperparathyroidism 22.15 10.40 36 228933 3188 79512231
Hepatic artery stenosis 22.05 10.40 11 228958 189 79515230
Disorder of globe 21.94 10.40 5 228964 3 79515416
Polymorphonuclear chromatin clumping 21.94 10.40 5 228964 3 79515416
Laboratory test abnormal 21.92 10.40 29 228940 28019 79487400
Blindness cortical 21.92 10.40 20 228949 967 79514452
Emotional disorder 21.89 10.40 7 228962 14380 79501039
Histology abnormal 21.88 10.40 13 228956 320 79515099
Taste disorder 21.86 10.40 9 228960 15814 79499605
Diffuse alveolar damage 21.78 10.40 38 228931 3566 79511853
Intraocular pressure increased 21.76 10.40 67 228902 9138 79506281
Rash maculo-papular 21.73 10.40 85 228884 55993 79459426
Enterobacter pneumonia 21.69 10.40 10 228959 143 79515276
Varicella zoster pneumonia 21.69 10.40 10 228959 143 79515276
Eosinophil count increased 21.66 10.40 11 228958 17094 79498325
Dengue fever 21.66 10.40 19 228950 872 79514547
Hypothermia 21.65 10.40 20 228949 22726 79492693
Soft tissue sarcoma 21.59 10.40 11 228958 198 79515221
Abscess 21.58 10.40 126 228843 22825 79492594
Bulbar palsy 21.48 10.40 12 228957 262 79515157
Nail disorder 21.47 10.40 4 228965 11848 79503571
Mydriasis 21.38 10.40 12 228957 17631 79497788
Dysstasia 21.37 10.40 29 228940 27717 79487702
Eczema 21.36 10.40 54 228915 40764 79474655
Productive cough 21.35 10.40 157 228812 88174 79427245
Rheumatic disorder 21.34 10.40 35 228934 3123 79512296
Abdominal wall infection 21.23 10.40 9 228960 104 79515315
Osteomyelitis chronic 21.22 10.40 17 228952 687 79514732
Transfusion 21.21 10.40 18 228951 21312 79494107
Rotator cuff syndrome 21.19 10.40 7 228962 14088 79501331
Fibrosis 21.17 10.40 47 228922 5262 79510157
Tooth infection 21.16 10.40 14 228955 18818 79496601
Biliary tract disorder 21.15 10.40 25 228944 1639 79513780
Coinfection 21.14 10.40 8 228961 67 79515352
Asphyxia 21.13 10.40 4 228965 11716 79503703
Paranoia 21.09 10.40 15 228954 19417 79496002
Electrocardiogram QRS complex prolonged 21.09 10.40 3 228966 10830 79504589
Graft ischaemia 21.08 10.40 7 228962 38 79515381
Face oedema 21.07 10.40 30 228939 28106 79487313
Renal ischaemia 20.97 10.40 21 228948 1141 79514278
Mucosal hypertrophy 20.93 10.40 8 228961 69 79515350
Haemosiderosis 20.92 10.40 15 228954 512 79514907
Tongue disorder 20.91 10.40 7 228962 13968 79501451
Sleep disorder due to general medical condition, insomnia type 20.90 10.40 204 228765 43352 79472067
Type 1 diabetes mellitus 20.88 10.40 55 228914 6864 79508555
Electrocardiogram abnormal 20.84 10.40 11 228958 16726 79498693
Acute hepatitis C 20.83 10.40 11 228958 214 79515205
Granulicatella bacteraemia 20.83 10.40 5 228964 5 79515414
Pyelonephritis chronic 20.81 10.40 12 228957 279 79515140
Abnormal behaviour 20.80 10.40 46 228923 36375 79479044
Delayed engraftment 20.77 10.40 12 228957 280 79515139
Protein-losing gastroenteropathy 20.69 10.40 16 228953 614 79514805
Morphoea 20.68 10.40 14 228955 435 79514984
Cutaneous T-cell lymphoma stage II 20.63 10.40 7 228962 41 79515378
Myelodysplastic syndrome unclassifiable 20.63 10.40 6 228963 19 79515400
Acute generalised exanthematous pustulosis 20.53 10.40 12 228957 17242 79498177
Pulmonary arterial hypertension 20.51 10.40 31 228938 28335 79487084
Papilloma 20.49 10.40 13 228956 361 79515058
Rhinitis allergic 20.47 10.40 5 228964 12264 79503155
Adenovirus test positive 20.44 10.40 8 228961 74 79515345
Basal cell carcinoma 20.42 10.40 180 228789 37195 79478224
Tardive dyskinesia 20.41 10.40 3 228966 10568 79504851
Hypertensive emergency 20.37 10.40 32 228937 2753 79512666
Viral sepsis 20.36 10.40 10 228959 166 79515253
Ventricular remodelling 20.36 10.40 9 228960 116 79515303
Conjunctival melanoma 20.35 10.40 5 228964 6 79515413
Hydrocephalus 20.31 10.40 64 228905 8836 79506583
Arteriovenous fistula occlusion 20.30 10.40 15 228954 537 79514882
Cerebral ventricle collapse 20.22 10.40 9 228960 118 79515301
Brain herniation 20.20 10.40 57 228912 7406 79508013
Renal abscess 20.18 10.40 20 228949 1073 79514346
Pneumonia herpes viral 20.14 10.40 10 228959 170 79515249
Laryngeal disorder 20.13 10.40 20 228949 1076 79514343
Mycobacterium marinum infection 20.13 10.40 14 228955 455 79514964
Myopathy toxic 20.10 10.40 20 228949 1078 79514341
Gastroenteritis viral 20.10 10.40 25 228944 24806 79490613
Vulval ulceration 20.08 10.40 11 228958 231 79515188
Secretion discharge 20.03 10.40 9 228960 15013 79500406
Pyuria 20.02 10.40 29 228940 2323 79513096
Carpal tunnel syndrome 20.01 10.40 16 228953 19512 79495907
Muscle twitching 19.98 10.40 25 228944 24739 79490680
Immunosuppressant drug level 19.96 10.40 6 228963 22 79515397
Kidney rupture 19.95 10.40 11 228958 234 79515185
Portal hypertension 19.94 10.40 55 228914 7053 79508366
Mucocutaneous leishmaniasis 19.83 10.40 14 228955 466 79514953
Nephrocalcinosis 19.81 10.40 23 228946 1479 79513940
Vaginal haemorrhage 19.81 10.40 20 228949 21797 79493622
Stem cell transplant 19.77 10.40 37 228932 3667 79511752
Rhesus antigen positive 19.76 10.40 9 228960 125 79515294
Anal incontinence 19.75 10.40 14 228955 18154 79497265
Infusion site pain 19.69 10.40 8 228961 14168 79501251
Tooth abscess 19.68 10.40 11 228958 16199 79499220
Germ cell cancer 19.63 10.40 10 228959 180 79515239
Cervicitis 19.62 10.40 11 228958 242 79515177
Blood loss anaemia 19.57 10.40 10 228959 15488 79499931
Fluoride increased 19.55 10.40 8 228961 84 79515335
Complications of transplanted pancreas 19.55 10.40 6 228963 24 79515395
Oesophageal carcinoma 19.53 10.40 4 228965 11080 79504339
Wound evisceration 19.50 10.40 9 228960 129 79515290
Mouth ulceration 19.50 10.40 182 228787 38212 79477207
Enterococcus test positive 19.47 10.40 27 228942 2077 79513342
Acarodermatitis 19.44 10.40 22 228947 1376 79514043
Blood pressure fluctuation 19.44 10.40 113 228856 67032 79448387
Pulmonary pneumatocele 19.42 10.40 4 228965 0 79515419
Pneumonia toxoplasmal 19.42 10.40 4 228965 0 79515419
Renal aneurysm 19.39 10.40 10 228959 185 79515234
Bronchostenosis 19.38 10.40 16 228953 675 79514744
Atrophy 19.37 10.40 27 228942 2087 79513332
Lupus myocarditis 19.30 10.40 8 228961 87 79515332
Multi-organ disorder 19.30 10.40 30 228939 2558 79512861
Reticulocyte count decreased 19.29 10.40 18 228951 896 79514523
Hepatitis C RNA increased 19.23 10.40 13 228956 403 79515016
Anaplastic large cell lymphoma T- and null-cell types 19.20 10.40 9 228960 134 79515285
Ageusia 19.18 10.40 12 228957 16620 79498799
Leukaemia in remission 19.16 10.40 5 228964 9 79515410
Meningitis histoplasma 19.16 10.40 5 228964 9 79515410
Peripheral coldness 19.15 10.40 11 228958 15959 79499460
Transplantation complication 19.15 10.40 12 228957 326 79515093
Pneumopericardium 19.15 10.40 10 228959 190 79515229
Arteritis coronary 19.10 10.40 7 228962 53 79515366
Tonsil cancer 19.07 10.40 20 228949 1148 79514271
Febrile neutropenia 19.04 10.40 511 228458 230488 79284931
Acute lymphocytic leukaemia recurrent 19.04 10.40 42 228927 4682 79510737
Status epilepticus 18.90 10.40 130 228839 24911 79490508
Herpes simplex test positive 18.84 10.40 13 228956 417 79515002
Prostatitis 18.82 10.40 39 228930 4163 79511256
Xanthoma 18.82 10.40 10 228959 197 79515222
Blister 18.80 10.40 236 228733 119240 79396179
Skin fissures 18.78 10.40 7 228962 13066 79502353
Hallucination, auditory 18.76 10.40 19 228950 20674 79494745
Sphincter of Oddi dysfunction 18.76 10.40 13 228956 420 79514999
Lymphocyte count decreased 18.76 10.40 71 228898 47218 79468201
Alanine aminotransferase increased 18.75 10.40 341 228628 162229 79353190
Anastomotic haemorrhage 18.73 10.40 11 228958 265 79515154
Plasmablastic lymphoma 18.66 10.40 14 228955 513 79514906
Pneumocephalus 18.64 10.40 12 228957 342 79515077
T-cell lymphoma stage IV 18.62 10.40 9 228960 144 79515275
Gastric haemorrhage 18.58 10.40 10 228959 15040 79500379
Corneal graft rejection 18.56 10.40 7 228962 58 79515361
Musculoskeletal pain 18.51 10.40 196 228773 102158 79413261
Pulmonary sepsis 18.48 10.40 36 228933 3676 79511743
Injection site induration 18.47 10.40 3 228966 9816 79505603
Pelvic fracture 18.45 10.40 6 228963 12198 79503221
Emphysematous cholecystitis 18.45 10.40 7 228962 59 79515360
Postoperative wound infection 18.44 10.40 80 228889 12881 79502538
Cystitis escherichia 18.44 10.40 15 228954 620 79514799
Genitourinary tract infection 18.40 10.40 11 228958 274 79515145
Torsade de pointes 18.36 10.40 17 228952 19295 79496124
X-ray abnormal 18.35 10.40 47 228922 5766 79509653
Endocarditis enterococcal 18.34 10.40 9 228960 149 79515270
Meningoencephalitis viral 18.33 10.40 13 228956 436 79514983
Skin bacterial infection 18.29 10.40 14 228955 529 79514890
Dyslipidaemia 18.27 10.40 74 228895 11559 79503860
Lung squamous cell carcinoma stage IV 18.25 10.40 7 228962 61 79515358
Feeling jittery 18.24 10.40 7 228962 12834 79502585
Myelitis 18.23 10.40 28 228941 2363 79513056
Kidney duplex 18.20 10.40 5 228964 12 79515407
Blood thyroid stimulating hormone increased 18.19 10.40 3 228966 9705 79505714
Blood parathyroid hormone decreased 18.16 10.40 4 228965 10532 79504887
Angiopathy 18.11 10.40 53 228916 7029 79508390
Subcutaneous emphysema 18.08 10.40 24 228945 1770 79513649
CSF protein increased 18.08 10.40 20 228949 1220 79514199
Ligament sprain 18.06 10.40 8 228961 13456 79501963
Pseudomonal bacteraemia 17.98 10.40 32 228937 3050 79512369
Coordination abnormal 17.97 10.40 14 228955 17298 79498121
Skin irritation 17.95 10.40 5 228964 11235 79504184
Herpes simplex oesophagitis 17.95 10.40 12 228957 365 79515054
Foot fracture 17.93 10.40 22 228947 21959 79493460
Skin haemorrhage 17.93 10.40 6 228963 11975 79503444
Trichostasis spinulosa 17.91 10.40 5 228964 13 79515406
Cyclosporidium infection 17.91 10.40 5 228964 13 79515406
Thyroid disorder 17.91 10.40 9 228960 14070 79501349
Bordetella infection 17.90 10.40 8 228961 106 79515313
Lymphangiectasia 17.90 10.40 8 228961 106 79515313
Morganella infection 17.87 10.40 19 228950 1108 79514311
Hepatic vein stenosis 17.86 10.40 7 228962 65 79515354
Psychotic disorder 17.86 10.40 60 228909 41342 79474077
Skin hypertrophy 17.85 10.40 42 228927 4886 79510533
Antiviral drug level above therapeutic 17.77 10.40 7 228962 66 79515353
Coronary artery occlusion 17.73 10.40 11 228958 15304 79500115
Stomatococcal infection 17.71 10.40 11 228958 294 79515125
Fungating wound 17.71 10.40 6 228963 35 79515384
Movement disorder 17.65 10.40 32 228937 27227 79488192
Urine output decreased 17.63 10.40 100 228869 17922 79497497
Neuralgia 17.60 10.40 44 228925 33340 79482079
Pericarditis infective 17.60 10.40 10 228959 226 79515193
Disability 17.58 10.40 14 228955 17106 79498313
Pathergy reaction 17.56 10.40 6 228963 36 79515383
Dental caries 17.54 10.40 6 228963 11814 79503605
Enterocolitis viral 17.50 10.40 12 228957 381 79515038
Pyelonephritis fungal 17.48 10.40 10 228959 229 79515190
Eosinophilia 17.40 10.40 69 228900 45276 79470143
Retinal coloboma 17.39 10.40 5 228964 15 79515404
Iris coloboma 17.39 10.40 5 228964 15 79515404
Cutaneous leishmaniasis 17.39 10.40 11 228958 304 79515115
Cyst 17.38 10.40 9 228960 13831 79501588
Photosensitivity reaction 17.34 10.40 112 228857 21015 79494404
Perihepatic abscess 17.33 10.40 9 228960 169 79515250
Retinopathy haemorrhagic 17.32 10.40 7 228962 71 79515348
Aplastic anaemia 17.29 10.40 99 228870 17806 79497613
Hepatocellular injury 17.27 10.40 74 228895 47519 79467900
Upper-airway cough syndrome 17.24 10.40 6 228963 11687 79503732
Staphylococcal skin infection 17.23 10.40 22 228947 1562 79513857
Poikiloderma 17.23 10.40 12 228957 391 79515028
Spinal osteoarthritis 17.18 10.40 14 228955 16913 79498506
Upper respiratory tract infection 17.14 10.40 173 228796 90995 79424424
Tremor 17.12 10.40 365 228604 169718 79345701
Renal artery thrombosis 17.10 10.40 13 228956 486 79514933
Glycosylated haemoglobin increased 17.10 10.40 18 228951 19242 79496177
Prostatic abscess 17.09 10.40 12 228957 396 79515023
Chronic sinusitis 17.07 10.40 8 228961 13018 79502401
Hepatitis C virus test 17.06 10.40 7 228962 74 79515345
Cytokine release syndrome 17.06 10.40 50 228919 35948 79479471
Scleroderma renal crisis 17.03 10.40 14 228955 587 79514832
Viral cardiomyopathy 17.03 10.40 6 228963 40 79515379
Renal adenoma 17.03 10.40 6 228963 40 79515379
Nocturia 17.02 10.40 9 228960 13672 79501747
Malignant ascites 16.99 10.40 19 228950 1173 79514246
Staphylococcal scalded skin syndrome 16.96 10.40 12 228957 401 79515018
Isosporiasis 16.86 10.40 9 228960 179 79515240
Orchitis 16.80 10.40 20 228949 1321 79514098
Acute pulmonary histoplasmosis 16.77 10.40 10 228959 248 79515171
Epididymitis 16.72 10.40 24 228945 1906 79513513
Pneumococcal infection 16.71 10.40 17 228952 941 79514478
Biliary hamartoma 16.70 10.40 5 228964 18 79515401
Nephritis haemorrhagic 16.70 10.40 5 228964 18 79515401
Fascioliasis 16.66 10.40 4 228965 4 79515415
Insulin resistant diabetes 16.66 10.40 4 228965 4 79515415
Myocarditis mycotic 16.66 10.40 4 228965 4 79515415
Retinal vasculitis 16.66 10.40 20 228949 1333 79514086
Eating disorder 16.59 10.40 21 228948 20676 79494743
Orbital infection 16.58 10.40 7 228962 80 79515339
Arteriosclerosis coronary artery 16.56 10.40 16 228953 17800 79497619
Pseudomonal sepsis 16.56 10.40 47 228922 6127 79509292
Mechanical ventilation 16.52 10.40 29 228940 2735 79512684
Pulmonary congestion 16.51 10.40 33 228936 27067 79488352
Blood immunoglobulin M increased 16.50 10.40 20 228949 1346 79514073
Right ventricular diastolic collapse 16.50 10.40 7 228962 81 79515338
Meningomyelitis herpes 16.50 10.40 7 228962 81 79515338
Bradyphrenia 16.50 10.40 5 228964 10635 79504784
Splenic peliosis 16.49 10.40 5 228964 19 79515400
Progressive bulbar palsy 16.49 10.40 5 228964 19 79515400
Upper motor neurone lesion 16.49 10.40 10 228959 256 79515163
Neuropsychiatric lupus 16.47 10.40 9 228960 188 79515231
Squamous cell carcinoma of the oral cavity 16.45 10.40 13 228956 515 79514904
Ischaemic stroke 16.45 10.40 45 228924 33086 79482333
Wrong product administered 16.41 10.40 3 228966 9009 79506410
Rotavirus infection 16.41 10.40 15 228954 727 79514692
Pelvic pain 16.36 10.40 9 228960 13372 79502047
Irritable bowel syndrome 16.33 10.40 108 228861 62133 79453286
Hirsutism 16.32 10.40 20 228949 1362 79514057
Post herpetic neuralgia 16.32 10.40 28 228941 2593 79512826
Hypoplastic anaemia 16.29 10.40 5 228964 20 79515399
Disseminated varicella 16.19 10.40 4 228965 5 79515414
Skin hypopigmentation 16.18 10.40 17 228952 978 79514441
Salmonellosis 16.14 10.40 23 228946 1815 79513604
Parvovirus B19 test positive 16.12 10.40 8 228961 136 79515283
Pseudallescheria infection 16.10 10.40 5 228964 21 79515398
Metastases to muscle 16.05 10.40 11 228958 349 79515070
Surgical procedure repeated 16.03 10.40 15 228954 749 79514670
Herpes simplex viraemia 16.01 10.40 12 228957 439 79514980
Graft haemorrhage 15.99 10.40 7 228962 88 79515331
Accident 15.95 10.40 3 228966 8828 79506591
Bile duct necrosis 15.91 10.40 5 228964 22 79515397
Kaposi sarcoma inflammatory cytokine syndrome 15.91 10.40 5 228964 22 79515397
Bladder transitional cell carcinoma stage III 15.88 10.40 6 228963 50 79515369
Shock 15.82 10.40 193 228776 43355 79472064
Urinary tract candidiasis 15.82 10.40 15 228954 762 79514657
Ventricular extrasystoles 15.78 10.40 20 228949 19684 79495735
Renal infarct 15.78 10.40 28 228941 2663 79512756
Viral oesophagitis 15.78 10.40 4 228965 6 79515413
Thyroid tuberculosis 15.73 10.40 5 228964 23 79515396
Aortitis salmonella 15.73 10.40 5 228964 23 79515396
Acinetobacter bacteraemia 15.72 10.40 10 228959 279 79515140
Central nervous system immune reconstitution inflammatory response 15.67 10.40 6 228963 52 79515367
Hepatic failure 15.67 10.40 255 228714 60957 79454462
Apnoea 15.63 10.40 7 228962 11697 79503722
T-cell lymphoma 15.62 10.40 19 228950 1284 79514135
Tooth extraction 15.61 10.40 6 228963 10989 79504430
Neurosarcoidosis 15.56 10.40 11 228958 367 79515052
Restrictive allograft syndrome 15.56 10.40 5 228964 24 79515395
Neuromyelitis optica spectrum disorder 15.53 10.40 17 228952 1025 79514394
Limb injury 15.50 10.40 39 228930 29489 79485930
Infusion site erythema 15.50 10.40 4 228965 9456 79505963
Keratoacanthoma 15.49 10.40 17 228952 1028 79514391
Erythropoiesis abnormal 15.48 10.40 12 228957 462 79514957
Serratia bacteraemia 15.48 10.40 6 228963 54 79515365
Cachexia 15.46 10.40 68 228901 11015 79504404
Genital herpes simplex 15.43 10.40 11 228958 372 79515047
Lymphadenopathy mediastinal 15.42 10.40 37 228932 4359 79511060
Vestibular nystagmus 15.40 10.40 4 228965 7 79515412
Urinary bladder toxicity 15.39 10.40 5 228964 25 79515394
Endotoxic shock 15.39 10.40 5 228964 25 79515394
Neurofibrosarcoma 15.39 10.40 9 228960 215 79515204
Wound infection fungal 15.39 10.40 9 228960 215 79515204
Visual field defect 15.39 10.40 59 228910 8986 79506433
Plasmacytoma 15.38 10.40 37 228932 4366 79511053
Tracheitis 15.33 10.40 19 228950 1309 79514110
Natural killer-cell leukaemia 15.32 10.40 7 228962 98 79515321
Colon dysplasia 15.32 10.40 9 228960 217 79515202
Faecaloma 15.31 10.40 7 228962 11557 79503862
Viral diarrhoea 15.28 10.40 11 228958 378 79515041
Portal vein thrombosis 15.28 10.40 44 228925 5783 79509636
Breath sounds abnormal 15.28 10.40 14 228955 15970 79499449
Pancreatic fistula 15.25 10.40 7 228962 99 79515320
Intensive care unit acquired weakness 15.25 10.40 23 228946 1910 79513509
Japanese spotted fever 15.23 10.40 5 228964 26 79515393
Seizure 15.23 10.40 419 228550 188415 79327004
Chronic myeloid leukaemia recurrent 15.23 10.40 10 228959 295 79515124
Ankylosing spondylitis 15.23 10.40 8 228961 12197 79503222
Actinomycotic sepsis 15.19 10.40 7 228962 100 79515319
Transplantation associated food allergy 15.19 10.40 7 228962 100 79515319
Chest wall abscess 15.17 10.40 9 228960 221 79515198
Haemorrhagic cyst 15.17 10.40 10 228959 297 79515122
Meningitis listeria 15.17 10.40 17 228952 1052 79514367
Infertility 15.17 10.40 14 228955 687 79514732
Colorectal adenocarcinoma 15.15 10.40 11 228958 383 79515036
Humerus fracture 15.14 10.40 4 228965 9309 79506110
Pyramidal tract syndrome 15.05 10.40 13 228956 584 79514835
Parapox virus infection 15.05 10.40 4 228965 8 79515411
Erectile dysfunction 15.04 10.40 12 228957 14652 79500767
Spindle cell sarcoma 15.03 10.40 9 228960 225 79515194
Viral myositis 15.01 10.40 6 228963 59 79515360
Gastric disorder 14.98 10.40 56 228913 37377 79478042
Meningism 14.95 10.40 14 228955 700 79514719
Infective uveitis 14.92 10.40 5 228964 28 79515391
Acute hepatic failure 14.92 10.40 142 228827 29971 79485448
Haemorrhoids 14.89 10.40 39 228930 29089 79486330
Hyperfibrinogenaemia 14.89 10.40 7 228962 105 79515314
Intervertebral disc degeneration 14.88 10.40 14 228955 15771 79499648
Rheumatic fever 14.88 10.40 136 228833 28389 79487030
Bone infarction 14.85 10.40 12 228957 491 79514928
Endothelial dysfunction 14.85 10.40 9 228960 230 79515189
Clostridial infection 14.84 10.40 43 228926 5671 79509748
Sebaceous gland disorder 14.83 10.40 6 228963 61 79515358
Ophthalmic vein thrombosis 14.82 10.40 9 228960 231 79515188
Renal atrophy 14.80 10.40 22 228947 1803 79513616
Granuloma skin 14.80 10.40 4 228965 9170 79506249
Antisynthetase syndrome 14.77 10.40 8 228961 164 79515255
Therapeutic response decreased 14.77 10.40 272 228697 66581 79448838
Culture wound positive 14.76 10.40 11 228958 399 79515020
Gastrointestinal wall thickening 14.76 10.40 27 228942 2630 79512789
Acinetobacter sepsis 14.75 10.40 6 228963 62 79515357
Kidney anastomosis 14.74 10.40 4 228965 9 79515410
Anorectal infection bacterial 14.74 10.40 4 228965 9 79515410
Vascular pseudoaneurysm ruptured 14.73 10.40 8 228961 165 79515254
Metastases to lymph nodes 14.66 10.40 64 228905 10333 79505086
Myocarditis toxoplasmal 14.66 10.40 6 228963 63 79515356
Stenotrophomonas bacteraemia 14.66 10.40 6 228963 63 79515356
Dialysis 14.63 10.40 97 228872 18365 79497054
Lipids abnormal 14.61 10.40 13 228956 608 79514811
Gallbladder rupture 14.60 10.40 16 228953 966 79514453
Pyrexia 14.60 10.40 2191 226778 676518 78838901
Herpes simplex encephalitis 14.59 10.40 14 228955 722 79514697
Endotoxaemia 14.57 10.40 3 228966 0 79515419
Breast pain 14.53 10.40 3 228966 8262 79507157
Urticaria cholinergic 14.50 10.40 5 228964 31 79515388
Parathyroid hyperplasia 14.47 10.40 8 228961 171 79515248
Gastrointestinal fungal infection 14.46 10.40 12 228957 510 79514909
Cholestasis 14.45 10.40 220 228749 51889 79463530
Pleomorphism 14.44 10.40 4 228965 10 79515409
Renal arteritis 14.44 10.40 4 228965 10 79515409
Pityriasis rubra pilaris 14.43 10.40 7 228962 113 79515306
Tenosynovitis 14.42 10.40 14 228955 15540 79499879
Endoscopy upper gastrointestinal tract abnormal 14.42 10.40 6 228963 66 79515353
Oral discomfort 14.41 10.40 5 228964 9755 79505664
Increased tendency to bruise 14.38 10.40 6 228963 10458 79504961
Penile ulceration 14.32 10.40 11 228958 418 79515001
Limbic encephalitis 14.32 10.40 15 228954 860 79514559
Chromaturia 14.31 10.40 33 228936 25713 79489706
Anaemia 14.29 10.40 1092 227877 443923 79071496
Genital lesion 14.26 10.40 12 228957 520 79514899
Renal lymphocele 14.26 10.40 7 228962 116 79515303
Encephalitis Japanese B 14.26 10.40 6 228963 68 79515351
Optic discs blurred 14.26 10.40 6 228963 68 79515351
Blood calcium increased 14.23 10.40 6 228963 10394 79505025
Liver transplant 14.21 10.40 36 228933 4387 79511032
Sebaceous carcinoma 14.21 10.40 7 228962 117 79515302
Gonococcal infection 14.18 10.40 6 228963 69 79515350
Malabsorption 14.18 10.40 39 228930 4993 79510426
Bartonellosis 14.17 10.40 4 228965 11 79515408
Ventricular tachycardia 14.14 10.40 67 228902 41868 79473551
Hypoproteinaemia 14.13 10.40 34 228935 4012 79511407
Hepatic steatosis 14.11 10.40 58 228911 37680 79477739
Peripancreatic fluid collection 14.10 10.40 6 228963 70 79515349
Sudden death 14.07 10.40 27 228942 22484 79492935
Oropharyngeal candidiasis 14.00 10.40 21 228948 1736 79513683
Ultrasound kidney abnormal 13.98 10.40 5 228964 35 79515384
Pulmonary function test decreased 13.98 10.40 51 228918 7586 79507833
Sinusitis 13.97 10.40 441 228528 195060 79320359
Benign prostatic hyperplasia 13.92 10.40 8 228961 11604 79503815
Norovirus test positive 13.90 10.40 13 228956 649 79514770
Venous haemorrhage 13.88 10.40 10 228959 344 79515075
Non-cardiac chest pain 13.85 10.40 5 228964 9519 79505900
C-reactive protein increased 13.84 10.40 274 228695 128753 79386666
Skin abrasion 13.82 10.40 11 228958 13445 79501974
Complication associated with device 13.76 10.40 18 228951 17478 79497941
Metastases to abdominal wall 13.76 10.40 8 228961 189 79515230
Delirium 13.75 10.40 166 228803 84461 79430958
Plasma cells decreased 13.74 10.40 5 228964 37 79515382
Iliac artery disease 13.67 10.40 4 228965 13 79515406
Necrotising bronchiolitis 13.67 10.40 4 228965 13 79515406
Sickle cell anaemia with crisis 13.67 10.40 3 228966 7919 79507500
Capnocytophaga infection 13.64 10.40 7 228962 128 79515291
Retroperitoneal neoplasm 13.63 10.40 5 228964 38 79515381
T-lymphocyte count decreased 13.60 10.40 12 228957 555 79514864
Choking 13.59 10.40 9 228960 12092 79503327
Myositis 13.58 10.40 98 228871 19070 79496349
Purpura fulminans 13.57 10.40 8 228961 194 79515225
Nerve injury 13.54 10.40 5 228964 9387 79506032
Pancreatic pseudoaneurysm 13.53 10.40 6 228963 78 79515341
Haematuria 13.49 10.40 275 228694 68561 79446858
Splenic vein thrombosis 13.46 10.40 14 228955 796 79514623
Pneumococcal sepsis 13.43 10.40 20 228949 1642 79513777
Infusion site swelling 13.43 10.40 3 228966 7823 79507596
Thymoma 13.43 10.40 9 228960 275 79515144
Hypernatraemia 13.41 10.40 13 228956 14438 79500981
Arterial thrombosis 13.39 10.40 26 228943 2648 79512771
Arterial disorder 13.37 10.40 22 228947 1968 79513451
Nephrosclerosis 13.35 10.40 21 228948 1809 79513610
Lung consolidation 13.33 10.40 56 228913 8891 79506528
Femoral nerve palsy 13.32 10.40 6 228963 81 79515338
Proctalgia 13.32 10.40 6 228963 9995 79505424
Drug level above therapeutic 13.31 10.40 55 228914 8668 79506751
Fluorosis 13.26 10.40 7 228962 136 79515283
Laryngeal stenosis 13.26 10.40 16 228953 1072 79514347
Drug dependence 13.25 10.40 66 228903 40703 79474716
Metastases to salivary gland 13.23 10.40 4 228965 15 79515404
Rheumatoid factor positive 13.22 10.40 109 228860 59730 79455689
Meningitis candida 13.22 10.40 7 228962 137 79515282
Red blood cell schistocytes present 13.21 10.40 12 228957 577 79514842
Epiglottic erythema 13.20 10.40 5 228964 42 79515377
Hepatic infection bacterial 13.20 10.40 5 228964 42 79515377
Transient hypogammaglobulinaemia of infancy 13.20 10.40 5 228964 42 79515377
Osteomyelitis bacterial 13.19 10.40 11 228958 471 79514948
Blue toe syndrome 13.17 10.40 12 228957 579 79514840
Skin toxicity 13.15 10.40 53 228916 8261 79507158
Laryngitis 13.14 10.40 16 228953 16023 79499396
Cholecystitis chronic 13.11 10.40 6 228963 9900 79505519
Atrioventricular block first degree 13.10 10.40 10 228959 12481 79502938
Embryonal rhabdomyosarcoma 13.09 10.40 5 228964 43 79515376
Abortion spontaneous 13.09 10.40 136 228833 29371 79486048
Severe acute respiratory syndrome 13.08 10.40 7 228962 140 79515279
Renal artery perforation 13.03 10.40 4 228965 16 79515403
Viral mutation identified 13.03 10.40 32 228937 3826 79511593
Serratia sepsis 13.01 10.40 8 228961 210 79515209
Pharyngitis 12.99 10.40 28 228941 22347 79493072
Pneumonia staphylococcal 12.97 10.40 37 228932 4837 79510582
Cytomegalovirus mucocutaneous ulcer 12.94 10.40 6 228963 87 79515332
Blood pressure diastolic abnormal 12.94 10.40 97 228872 19105 79496314
Aortic valve disease mixed 12.91 10.40 7 228962 144 79515275
Hypertensive crisis 12.90 10.40 25 228944 20745 79494674
Renal cell carcinoma stage I 12.90 10.40 5 228964 45 79515374
Tuberous sclerosis complex 12.88 10.40 6 228963 88 79515331
Human chorionic gonadotropin decreased 12.84 10.40 4 228965 17 79515402
Generalised tonic-clonic seizure 12.80 10.40 187 228782 43723 79471696
Aortic pseudoaneurysm 12.80 10.40 5 228964 46 79515373
Anorectal varices 12.80 10.40 5 228964 46 79515373
Furuncle 12.76 10.40 3 228966 7551 79507868
Joint stiffness 12.76 10.40 67 228902 40763 79474656
Metastases to skin 12.75 10.40 20 228949 1719 79513700
Pericardial effusion 12.74 10.40 195 228774 46042 79469377
Forced vital capacity decreased 12.71 10.40 20 228949 1723 79513696
Conjunctivitis 12.71 10.40 35 228934 25680 79489739
Acute coronary syndrome 12.65 10.40 26 228943 21107 79494312
Frustration tolerance decreased 12.63 10.40 3 228966 7499 79507920
Psychomotor hyperactivity 12.58 10.40 18 228951 16831 79498588
Precursor T-lymphoblastic lymphoma/leukaemia 12.58 10.40 6 228963 93 79515326
Gastroduodenal ulcer 12.57 10.40 11 228958 503 79514916
Colitis erosive 12.57 10.40 7 228962 152 79515267
Opsoclonus myoclonus 12.55 10.40 8 228961 224 79515195
Abdominal abscess 12.55 10.40 47 228922 7080 79508339
Visual agnosia 12.50 10.40 3 228966 3 79515416
Lymphocele marsupialisation 12.50 10.40 3 228966 3 79515416
Systemic bartonellosis 12.50 10.40 3 228966 3 79515416
Bartonella test positive 12.50 10.40 3 228966 3 79515416
Sialocele 12.50 10.40 3 228966 3 79515416
Fascial infection 12.50 10.40 3 228966 3 79515416
Transfusion associated graft versus host disease 12.50 10.40 3 228966 3 79515416
Alcaligenes infection 12.50 10.40 3 228966 3 79515416
Iliac artery rupture 12.50 10.40 3 228966 3 79515416
Pancreatic abscess 12.47 10.40 6 228963 95 79515324
Antineutrophil cytoplasmic antibody positive 12.45 10.40 17 228952 1289 79514130
Transient acantholytic dermatosis 12.44 10.40 7 228962 155 79515264
Amyloidosis senile 12.43 10.40 5 228964 50 79515369
CSF culture positive 12.43 10.40 5 228964 50 79515369
Cytomegalovirus test 12.43 10.40 5 228964 50 79515369
Vanishing bile duct syndrome 12.42 10.40 20 228949 1758 79513661
Eructation 12.41 10.40 8 228961 10901 79504518
Infection 12.39 10.40 829 228140 240883 79274536
Tooth fracture 12.39 10.40 9 228960 11521 79503898
Giardiasis 12.38 10.40 9 228960 314 79515105
Erosive duodenitis 12.38 10.40 22 228947 2095 79513324
Flavobacterium infection 12.36 10.40 6 228963 97 79515322
Enterobacter bacteraemia 12.34 10.40 14 228955 878 79514541
Joint tuberculosis 12.33 10.40 7 228962 158 79515261
Alanine aminotransferase abnormal 12.32 10.40 5 228964 8862 79506557
Hepatocellular carcinoma 12.32 10.40 55 228914 8966 79506453
Viral uveitis 12.30 10.40 6 228963 98 79515321
Pyonephrosis 12.30 10.40 6 228963 98 79515321
Chloroma 12.24 10.40 13 228956 757 79514662
Bacterial colitis 12.19 10.40 6 228963 100 79515319
Systemic viral infection 12.19 10.40 6 228963 100 79515319
Post infection glomerulonephritis 12.19 10.40 6 228963 100 79515319
Hepatitis C antibody positive 12.18 10.40 8 228961 236 79515183
Streptococcal infection 12.18 10.40 54 228915 8776 79506643
Chronic inflammatory demyelinating polyradiculoneuropathy 12.17 10.40 16 228953 1169 79514250
Renal arteriosclerosis 12.16 10.40 9 228960 323 79515096
Tropical spastic paresis 12.15 10.40 4 228965 21 79515398
International normalised ratio decreased 12.15 10.40 4 228965 8066 79507353
Dyspnoea at rest 12.13 10.40 3 228966 7299 79508120
Intestinal obstruction 12.13 10.40 73 228896 42947 79472472
Muscle neoplasm 12.09 10.40 5 228964 54 79515365
Second primary malignancy 12.09 10.40 14 228955 14336 79501083
Pneumonia pneumococcal 12.09 10.40 32 228937 4005 79511414
Oesophageal injury 12.09 10.40 6 228963 102 79515317
Pulse absent 12.06 10.40 7 228962 10096 79505323
Soft tissue necrosis 12.05 10.40 14 228955 901 79514518
Peripheral vascular disorder 12.05 10.40 4 228965 8026 79507393
Acute respiratory failure 12.04 10.40 239 228730 59302 79456117
Urogenital infection bacterial 12.03 10.40 6 228963 103 79515316
Blood iron decreased 12.02 10.40 16 228953 15418 79500001
Inflammatory myofibroblastic tumour 12.02 10.40 7 228962 166 79515253
Typhoid fever 12.01 10.40 5 228964 55 79515364
Bacterial translocation 12.01 10.40 12 228957 650 79514769
Malignant melanoma 12.01 10.40 78 228891 14663 79500756
Glomerulonephritis minimal lesion 12.01 10.40 13 228956 774 79514645
Tonsillar exudate 12.00 10.40 4 228965 22 79515397
Adult T-cell lymphoma/leukaemia 11.97 10.40 9 228960 331 79515088
Subdural haematoma 11.95 10.40 48 228921 31386 79484033
Biopsy kidney 11.94 10.40 7 228962 168 79515251
Hyperthyroidism 11.92 10.40 29 228940 22180 79493239
Tension headache 11.91 10.40 3 228966 7208 79508211
Skin hyperpigmentation 11.90 10.40 47 228922 7256 79508163
Macular degeneration 11.90 10.40 9 228960 11287 79504132
Seborrhoeic keratosis 11.88 10.40 23 228946 2337 79513082
Bone disorder 11.88 10.40 23 228946 19090 79496329
Groin pain 11.87 10.40 12 228957 13068 79502351
Systemic bacterial infection 11.86 10.40 5 228964 57 79515362
Viral acanthoma 11.85 10.40 4 228965 23 79515396
Small cell lung cancer recurrent 11.85 10.40 4 228965 23 79515396
Pneumothorax 11.85 10.40 129 228840 28194 79487225
Fibrin D dimer increased 11.83 10.40 5 228964 8649 79506770
Neoplasm malignant 11.83 10.40 49 228920 31761 79483658
Device occlusion 11.81 10.40 10 228959 11856 79503563
Splenic necrosis 11.80 10.40 7 228962 172 79515247
CSF white blood cell count increased 11.78 10.40 6 228963 108 79515311
Vasculitis 11.76 10.40 117 228852 24985 79490434
Diverticulitis intestinal perforated 11.75 10.40 8 228961 251 79515168
Palmar-plantar erythrodysaesthesia syndrome 11.73 10.40 52 228917 33082 79482337
Campylobacter infection 11.73 10.40 20 228949 1843 79513576
Myocardial ischaemia 11.69 10.40 36 228933 25483 79489936
Intestinal ulcer 11.69 10.40 21 228948 2017 79513402
Tongue oedema 11.68 10.40 3 228966 7114 79508305
Peripheral artery aneurysm 11.64 10.40 10 228959 446 79514973
Disseminated paracoccidioidomycosis 11.64 10.40 3 228966 5 79515414
Solid organ transplant rejection 11.64 10.40 3 228966 5 79515414
Splenic infection fungal 11.63 10.40 6 228963 111 79515308
Stress cardiomyopathy 11.63 10.40 9 228960 11157 79504262
Spermatozoa progressive motility decreased 11.63 10.40 5 228964 60 79515359
Neurological symptom 11.58 10.40 53 228916 8730 79506689
Normochromic anaemia 11.58 10.40 10 228959 449 79514970
Embolic stroke 11.57 10.40 4 228965 7822 79507597
Pancreas transplant 11.55 10.40 5 228964 61 79515358
Red blood cell sedimentation rate abnormal 11.55 10.40 27 228942 20936 79494483
Gastrointestinal pain 11.52 10.40 7 228962 9848 79505571
Paradoxical drug reaction 11.52 10.40 46 228923 7139 79508280
Immunoglobulins decreased 11.52 10.40 18 228951 1542 79513877
Drug level changed 11.51 10.40 11 228958 564 79514855
Gastroenteritis 11.51 10.40 149 228820 33933 79481486
Periorbital infection 11.49 10.40 6 228963 114 79515305
Injury 11.48 10.40 155 228814 77341 79438078
Respiration abnormal 11.48 10.40 4 228965 7784 79507635
Malignant catatonia 11.47 10.40 10 228959 455 79514964
Bone tuberculosis 11.43 10.40 11 228958 569 79514850
Sexual dysfunction 11.42 10.40 4 228965 7759 79507660
Myasthenia gravis crisis 11.41 10.40 15 228954 1096 79514323
Aortic dissection 11.41 10.40 32 228937 4143 79511276
Cryoglobulinaemia 11.40 10.40 13 228956 820 79514599
Ear pain 11.39 10.40 52 228917 32817 79482602
Globulins decreased 11.36 10.40 10 228959 461 79514958
Dermatitis contact 11.35 10.40 9 228960 11024 79504395
Gastric ulcer 11.35 10.40 148 228821 33757 79481662
Enterocolitis 11.35 10.40 76 228893 14436 79500983
Cytomegalovirus gastrointestinal ulcer 11.34 10.40 5 228964 64 79515355
Hyperaesthesia 11.33 10.40 11 228958 12211 79503208
Immobile 11.33 10.40 3 228966 6970 79508449
Substance-induced psychotic disorder 11.33 10.40 28 228941 3361 79512058
Tuberculoma of central nervous system 11.32 10.40 11 228958 576 79514843
Kidney enlargement 11.30 10.40 16 228953 1255 79514164
Skin cancer metastatic 11.29 10.40 3 228966 6 79515413
Nonkeratinising carcinoma of nasopharynx 11.29 10.40 3 228966 6 79515413
Reflux nephropathy 11.29 10.40 3 228966 6 79515413
Plasma cell disorder 11.29 10.40 3 228966 6 79515413
Mesangioproliferative glomerulonephritis 11.26 10.40 6 228963 119 79515300
Wound sepsis 11.24 10.40 7 228962 188 79515231
Chest expansion decreased 11.24 10.40 7 228962 188 79515231
Pulmonary thrombosis 11.23 10.40 11 228958 12160 79503259
Gynaecomastia 11.23 10.40 4 228965 7677 79507742
Glomerular vascular disorder 11.21 10.40 7 228962 189 79515230
Paraspinal abscess 11.21 10.40 7 228962 189 79515230
Diffuse mesangial sclerosis 11.20 10.40 5 228964 66 79515353
Underdose 11.16 10.40 53 228916 33098 79482321
Perineal ulceration 11.14 10.40 5 228964 67 79515352
Dermatomyositis 11.14 10.40 29 228940 3594 79511825
Neutrophil count increased 11.11 10.40 45 228924 29351 79486068
Myelitis transverse 11.08 10.40 20 228949 1927 79513492
Mantle cell lymphoma stage IV 11.07 10.40 5 228964 68 79515351
Injection site discolouration 11.07 10.40 4 228965 7610 79507809
Gingivitis ulcerative 11.06 10.40 8 228961 277 79515142
Abdominal wound dehiscence 11.06 10.40 8 228961 277 79515142
Anhedonia 11.04 10.40 16 228953 14882 79500537
Metastatic malignant melanoma 11.03 10.40 25 228944 2838 79512581
Fat necrosis 11.03 10.40 13 228956 850 79514569
Respiratory tract infection viral 11.01 10.40 32 228937 4227 79511192
Chronic myelomonocytic leukaemia 10.99 10.40 13 228956 853 79514566
Giant cell myocarditis 10.98 10.40 3 228966 7 79515412
Bronchitis fungal 10.98 10.40 3 228966 7 79515412
Erysipelothrix infection 10.98 10.40 3 228966 7 79515412
Toxic leukoencephalopathy 10.97 10.40 15 228954 1139 79514280
Thyroid stimulating hormone deficiency 10.95 10.40 4 228965 30 79515389
Page kidney 10.94 10.40 5 228964 70 79515349
Vitamin D deficiency 10.92 10.40 15 228954 14264 79501155
Epileptic encephalopathy 10.91 10.40 10 228959 486 79514933
Blast crisis in myelogenous leukaemia 10.91 10.40 13 228956 860 79514559
Right ventricular failure 10.87 10.40 33 228936 23464 79491955
Spermatozoa progressive motility abnormal 10.84 10.40 4 228965 31 79515388
Urticaria aquagenic 10.84 10.40 4 228965 31 79515388
Lyme carditis 10.84 10.40 4 228965 31 79515388
Adenocarcinoma 10.83 10.40 30 228939 3856 79511563
Oesophagitis 10.80 10.40 112 228857 24177 79491242
Coeliac disease 10.78 10.40 10 228959 11341 79504078
Lung squamous cell carcinoma metastatic 10.75 10.40 5 228964 73 79515346
Eye infection 10.74 10.40 11 228958 11909 79503510
Cryptitis 10.74 10.40 8 228961 290 79515129
Quadriparesis 10.74 10.40 28 228941 3473 79511946
Desmoplastic melanoma 10.73 10.40 4 228965 32 79515387
Abdominal lymphadenopathy 10.71 10.40 16 228953 1318 79514101
Pharyngitis streptococcal 10.70 10.40 9 228960 10705 79504714
Renal aplasia 10.70 10.40 6 228963 132 79515287
St. Louis encephalitis 10.69 10.40 3 228966 8 79515411
Surgery 10.67 10.40 53 228916 32713 79482706
Palatal ulcer 10.62 10.40 6 228963 134 79515285
Brucellosis 10.62 10.40 6 228963 134 79515285
Encephalitis protozoal 10.62 10.40 4 228965 33 79515386
Hepatic infection 10.62 10.40 14 228955 1026 79514393
Enterocolitis haemorrhagic 10.59 10.40 21 228948 2173 79513246
Carotid artery stenosis 10.55 10.40 6 228963 8752 79506667
High-grade B-cell lymphoma 10.54 10.40 6 228963 136 79515283
Lacrimal haemorrhage 10.52 10.40 4 228965 34 79515385
Ocular hypertension 10.48 10.40 17 228952 1503 79513916
Vasculitis gastrointestinal 10.46 10.40 6 228963 138 79515281
Eventration repair 10.44 10.40 3 228966 9 79515410
Fibrodysplasia ossificans progressiva 10.44 10.40 3 228966 9 79515410
Vascular graft infection 10.44 10.40 3 228966 9 79515410
Coccidioides encephalitis 10.44 10.40 3 228966 9 79515410
Osteomyelitis acute 10.41 10.40 10 228959 516 79514903

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000904 Antibiotics, Antitubercular
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000995 Antitubercular Agents
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:53746 EC 1.1.1.205 inhibitor
CHEBI has role CHEBI:149553 anticoronaviral drug
FDA EPC N0000175613 Antimetabolite Immunosuppressant
CHEBI has role CHEBI:25442 mycotoxins
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:76964 Penicillium metabolites
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
The suppression of graft-versus-host disease in hematopoietic stem cell transplantation indication 234646005
Prevention of Cardiac Transplant Rejection indication
Prevention of Liver Transplant Rejection indication
Prevention of Kidney Transplant Rejection indication
Prevention of Lung Transplant Rejection off-label use
Herpes zoster contraindication 4740000 DOID:8536
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Cytomegalovirus infection contraindication 28944009
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Gastrointestinal ulcer contraindication 40845000
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Gastrointestinal hemorrhage contraindication 74474003
Herpes simplex contraindication 88594005 DOID:8566
Malignant lymphoma contraindication 118600007 DOID:0060058
Deficiency of hypoxanthine phosphoribosyltransferase contraindication 124275001
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Primary malignant neoplasm contraindication 372087000
Malignant neoplasm of skin contraindication 372130007 DOID:4159
Breastfeeding (mother) contraindication 413712001
Opportunistic Fungal Infection contraindication
BK Polyomavirus Reactivation Nephropathy contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.03 acidic
pKa2 6.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Inosine-5'-monophosphate dehydrogenase 1 Enzyme INHIBITOR Ki 7.48 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Inosine-5'-monophosphate dehydrogenase 2 Enzyme INHIBITOR Ki 8.16 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
4020921 VUID
N0000148406 NUI
D00752 KEGG_DRUG
116680-01-4 SECONDARY_CAS_RN
4020921 VANDF
4021128 VANDF
4021418 VANDF
C0209368 UMLSCUI
CHEBI:8764 CHEBI
CHEBI:168396 CHEBI
MOA PDB_CHEM_ID
CHEMBL1456 ChEMBL_ID
D009173 MESH_DESCRIPTOR_UI
DB00688 DRUGBANK_ID
5281078 PUBCHEM_CID
6831 IUPHAR_LIGAND_ID
9242ECW6R0 UNII
237112 RXNORM
164451 MMSL
18132 MMSL
210716 MMSL
5141 MMSL
7547 MMSL
d03839 MMSL
d05217 MMSL
005013 NDDF
005014 NDDF
007639 NDDF
386976000 SNOMEDCT_US
409330005 SNOMEDCT_US
409331009 SNOMEDCT_US
441632007 SNOMEDCT_US
C0026933 UMLSCUI
CHEMBL1200955 ChEMBL_ID
DB01024 DRUGBANK_ID
2950 INN_ID
24280-93-1 SECONDARY_CAS_RN
446541 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0259 CAPSULE 250 mg ORAL NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0259 CAPSULE 250 mg ORAL NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0259 CAPSULE 250 mg ORAL NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0260 TABLET, FILM COATED 500 mg ORAL NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0260 TABLET, FILM COATED 500 mg ORAL NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0260 TABLET, FILM COATED 500 mg ORAL NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0261 POWDER, FOR SUSPENSION 200 mg ORAL NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0261 POWDER, FOR SUSPENSION 200 mg ORAL NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0261 POWDER, FOR SUSPENSION 200 mg ORAL NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0298 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0298 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS NDA 36 sections
CellCept HUMAN PRESCRIPTION DRUG LABEL 1 0004-0298 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS NDA 36 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0054-0163 CAPSULE 250 mg ORAL ANDA 30 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0054-0163 CAPSULE 250 mg ORAL ANDA 30 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0054-0166 TABLET 500 mg ORAL ANDA 30 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0054-0166 TABLET 500 mg ORAL ANDA 30 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0093-7334 CAPSULE 250 mg ORAL ANDA 30 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0093-7334 CAPSULE 250 mg ORAL ANDA 30 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0093-7334 CAPSULE 250 mg ORAL ANDA 30 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-2250 CAPSULE 250 mg ORAL ANDA 31 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-2250 CAPSULE 250 mg ORAL ANDA 31 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-2250 CAPSULE 250 mg ORAL ANDA 31 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-2250 CAPSULE 250 mg ORAL ANDA 31 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-4472 TABLET, FILM COATED 500 mg ORAL ANDA 31 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-4472 TABLET, FILM COATED 500 mg ORAL ANDA 31 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-4472 TABLET, FILM COATED 500 mg ORAL ANDA 31 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0378-4472 TABLET, FILM COATED 500 mg ORAL ANDA 31 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0480-1175 POWDER, FOR SUSPENSION 200 mg ORAL ANDA 33 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0480-1175 POWDER, FOR SUSPENSION 200 mg ORAL ANDA 33 sections
Mycophenolate Mofetil HUMAN PRESCRIPTION DRUG LABEL 1 0480-3571 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections