mupirocin indications/contra

Stem definitionDrug idCAS RN
1857 12650-69-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mupirocin
  • mupricin
  • pseudomonic acid
  • turixin
  • mupirocin calcium
  • bactroban
  • BRL 4910A
A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.
  • Molecular weight: 500.63
  • Formula: C26H44O9
  • CLOGP: 1.54
  • LIPINSKI: 1
  • HAC: 9
  • HDO: 4
  • TPSA: 146.05
  • ALOGS: -4.28
  • ROTB: 17

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1987 FDA GLAXOSMITHKLINE

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nasal vestibulitis 144.27 93.70 15 196 26 3385622
Purpura senile 94.48 93.70 10 201 22 3385626
Cheilitis 94.00 93.70 15 196 1156 3384492

Pharmacologic Action:

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SourceCodeDescription
ATC D06AX09 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Other antibiotics for topical use
ATC R01AX06 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Other nasal preparations
FDA EPC N0000175515 RNA Synthetase Inhibitor Antibacterial
FDA MoA N0000175516 RNA Synthetase Inhibitors
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors
CHEBI has role CHEBI:36047 antibacterial drug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Impetigo indication 48277006 DOID:8504
Staph Aureus Traumatic Skin Lesion Infection indication
Traumatic Skin Lesion Streptococcus Pyogenes Infection indication
Methicillin-Resistant Staphylococcus Aureus Nasal Colonization indication
Skin irritation contraindication 367466007
Folliculitis off-label use 13600006 DOID:4409
Atopic dermatitis off-label use 24079001 DOID:3310
Eczema off-label use 43116000 DOID:2723
Epidermolysis bullosa off-label use 61003004 DOID:2730
Ecthyma off-label use 85791004 DOID:11907
Furunculosis off-label use 112650006
Minor Bacterial Skin Infections off-label use

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.76 acidic
pKa2 12.42 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Isoleucine--tRNA ligase, cytoplasmic Enzyme IC50 9.10 CHEMBL
Isoleucine--tRNA ligase Enzyme INHIBITOR DRUGBANK CHEMBL
Isoleucine--tRNA ligase Enzyme INHIBITOR CHEMBL CHEMBL
Isoleucine--tRNA ligase Enzyme WOMBAT-PK

External reference:

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IDSource
DB00410 DRUGBANK_ID
4019345 VUID
N0000147519 NUI
C0085259 UMLSCUI
D01076 KEGG_DRUG
CHEMBL719 ChEMBL_ID
4019345 VANDF
N0000147519 NDFRT
N0000007274 NDFRT
002802 NDDF
42372 RXNORM
387397004 SNOMEDCT_US
71453003 SNOMEDCT_US
47751 MMSL
5138 MMSL
446596 PUBCHEM_CID
D0GX863OA5 UNII
5276 INN_ID
CHEMBL2068726 ChEMBL_ID
115074-43-6 SECONDARY_CAS_RN
D016712 MESH_DESCRIPTOR_UI
CHEBI:7025 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
BACTROBAN HUMAN PRESCRIPTION DRUG LABEL 1 0029-1526 OINTMENT 20 mg TOPICAL NDA 16 sections
BACTROBAN HUMAN PRESCRIPTION DRUG LABEL 1 0029-1527 CREAM 20 mg TOPICAL NDA 16 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 0093-1010 OINTMENT 20 mg TOPICAL ANDA 16 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 0168-0352 OINTMENT 20 mg TOPICAL ANDA 16 sections
BACTROBAN HUMAN PRESCRIPTION DRUG LABEL 1 16590-028 CREAM 20 mg TOPICAL NDA 12 sections
MUPIROCIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-158 OINTMENT 20 mg TOPICAL ANDA 11 sections
mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 17856-0112 OINTMENT 20 mg TOPICAL ANDA 12 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 21695-188 OINTMENT 20 mg TOPICAL ANDA 12 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 42254-137 OINTMENT 20 mg TOPICAL ANDA 11 sections
mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 42254-229 OINTMENT 20 mg TOPICAL ANDA 12 sections
CENTANY HUMAN PRESCRIPTION DRUG LABEL 1 43538-300 OINTMENT 20 mg TOPICAL NDA 16 sections
Centany HUMAN PRESCRIPTION DRUG LABEL 1 43538-310 OINTMENT 20 mg TOPICAL NDA 16 sections
mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 45802-112 OINTMENT 20 mg TOPICAL ANDA 17 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 45865-722 OINTMENT 20 mg TOPICAL ANDA 12 sections
BACTROBAN HUMAN PRESCRIPTION DRUG LABEL 1 49999-521 CREAM 21.50 mg TOPICAL NDA 12 sections
mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 49999-644 OINTMENT 20 mg TOPICAL ANDA 11 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 50090-0898 OINTMENT 20 mg TOPICAL ANDA 16 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 50090-1929 OINTMENT 20 mg TOPICAL ANDA 16 sections
mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 50268-572 OINTMENT 20 mg TOPICAL ANDA 12 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 50436-0025 OINTMENT 20 mg TOPICAL ANDA 16 sections
mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 50436-0112 OINTMENT 20 mg TOPICAL ANDA 12 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 50436-0180 OINTMENT 20 mg TOPICAL ANDA 16 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 50436-1010 OINTMENT 20 mg TOPICAL ANDA 16 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 51672-1312 OINTMENT 20 mg TOPICAL ANDA 17 sections
mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 52959-743 OINTMENT 20 mg TOPICAL ANDA 12 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 53002-9850 OINTMENT 20 mg TOPICAL ANDA 16 sections
Pre and Post Sx Pouch HUMAN PRESCRIPTION DRUG LABEL 3 53225-5000 KIT 20 mg TOPICAL ANDA 12 sections
BACTROBAN HUMAN PRESCRIPTION DRUG LABEL 1 54868-4325 OINTMENT 20 mg TOPICAL NDA 12 sections
Bactroban HUMAN PRESCRIPTION DRUG LABEL 1 54868-4642 CREAM 20 mg TOPICAL NDA 13 sections
Mupirocin HUMAN PRESCRIPTION DRUG LABEL 1 54868-4958 OINTMENT 20 mg TOPICAL ANDA 12 sections