DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
moxonidine ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
alpha-2 adrenoreceptor agonists
1856
75438-57-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
moxonidine
normoxocin
moxonidin
Molecular weight: 241.68
Formula: C9H12ClN5O
CLOGP: 1.51
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 71.43
ALOGS: -3.33
ROTB: 2
Drug dosage:
Dose
Unit
Route
0.30
mg
O
ADMET properties:
Show
10
25
50
100
entries
Search:
Property
Value
Reference
BA (Bioavailability)
88 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
BDDCS (Biopharmaceutical Drug Disposition Classification System)
4
Bocci G, Oprea TI, Benet LZ
t_half (Half-life)
2.20 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
11 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
1.80 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.93 %
Lombardo F, Berellini G, Obach RS
S (Water solubility)
0.80 mg/mL
Bocci G, Oprea TI, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose)
0.12 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Showing 1 to 8 of 8 entries
Previous
1
Next
Approvals:
Show
10
25
50
100
entries
Search:
Date
Agency
Company
Orphan
Jan. 1, 1991
YEAR INTRODUCED
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Female)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
General physical health deterioration
124.36
25.07
102
3895
201300
63283725
Renal impairment
100.80
25.07
65
3932
88290
63396735
Product prescribing error
86.06
25.07
39
3958
26250
63458775
Hypertensive crisis
77.72
25.07
31
3966
15255
63469770
Acute kidney injury
74.41
25.07
87
3910
263328
63221697
Lactic acidosis
53.27
25.07
32
3965
38255
63446770
Electrocardiogram abnormal
51.51
25.07
20
3977
9159
63475866
Hyperkalaemia
43.14
25.07
32
3965
54171
63430854
Bradycardia
42.72
25.07
36
3961
73191
63411834
Electrolyte imbalance
39.33
25.07
21
3976
20055
63464970
Showing 1 to 10 of 26 entries
Previous
1
2
3
Next
FDA Adverse Event Reporting System (Male)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Acute kidney injury
64.54
24.41
117
3687
304871
34648256
Product prescribing error
62.74
24.41
36
3768
22891
34930236
Labelled drug-drug interaction medication error
59.19
24.41
30
3774
14909
34938218
Benign gastrointestinal neoplasm
54.55
24.41
10
3794
135
34952992
Hyperkaliuria
51.13
24.41
9
3795
95
34953032
Hypotension
38.05
24.41
78
3726
221571
34731556
Product monitoring error
37.24
24.41
15
3789
4366
34948761
Papillary renal cell carcinoma
36.95
24.41
8
3796
260
34952867
Peripheral artery stenosis
36.68
24.41
10
3794
862
34952265
Schizophrenia
36.06
24.41
18
3786
8648
34944479
Showing 1 to 10 of 22 entries
Previous
1
2
3
Next
FDA Adverse Event Reporting System (Geriatric)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Product prescribing error
146.17
20.11
75
7351
44738
79692224
Acute kidney injury
141.10
20.11
205
7221
519199
79217763
General physical health deterioration
110.75
20.11
132
7294
275106
79461856
Renal impairment
108.90
20.11
101
7325
157682
79579280
Hypertensive crisis
89.32
20.11
42
7384
20728
79716234
Labelled drug-drug interaction medication error
75.15
20.11
41
7385
27609
79709353
Hyperkalaemia
72.68
20.11
70
7356
114328
79622634
Bradycardia
62.75
20.11
70
7356
135487
79601475
Benign gastrointestinal neoplasm
55.82
20.11
10
7416
139
79736823
Hyperkaliuria
47.70
20.11
9
7417
169
79736793
Showing 1 to 10 of 44 entries
Previous
1
2
3
4
5
Next
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
Show
10
25
50
100
entries
Search:
Source
Code
Description
ATC
C02AC05
CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIADRENERGIC AGENTS, CENTRALLY ACTING
Imidazoline receptor agonists
ATC
C02LC05
CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION
Imidazoline receptor agonists in combination with diuretics
MeSH PA
D000959
Antihypertensive Agents
MeSH PA
D002317
Cardiovascular Agents
Showing 1 to 4 of 4 entries
Previous
1
Next
Drug Use
| Suggest Off label Use Form|
|View source of the data|
Show
10
25
50
100
entries
Search:
Disease
Relation
SNOMED_ID
DOID
Essential hypertension
indication
59621000
DOID:10825
Showing 1 to 1 of 1 entries
Previous
1
Next
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
Show
10
25
50
100
entries
Search:
Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
7.96
Basic
pKa2
2.26
Basic
Showing 1 to 2 of 2 entries
Previous
1
Next
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
Show
10
25
50
100
entries
Search:
Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Nischarin
Membrane receptor
Q9Y2I1
NISCH_HUMAN
AGONIST
Ki
8.38
CHEMBL
SCIENTIFIC LITERATURE
5-hydroxytryptamine receptor 1A
GPCR
P08908
5HT1A_HUMAN
Ki
6.40
DRUG MATRIX
Alpha-2C adrenergic receptor
GPCR
P18825
ADA2C_HUMAN
Ki
5.70
CHEMBL
Alpha-2A adrenergic receptor
GPCR
P08913
ADA2A_HUMAN
Ki
6.82
CHEMBL
5-hydroxytryptamine receptor 1A
GPCR
5HT1A_RAT
IC50
6.15
CHEMBL
Nischarin
Unclassified
NISCH_RAT
Ki
7.11
CHEMBL
Alpha-2B adrenergic receptor
GPCR
ADA2B_RAT
Ki
6
CHEMBL
Showing 1 to 7 of 7 entries
Previous
1
Next
External reference:
Show
10
25
50
100
entries
Search:
ID
Source
006139
NDDF
12574
IUPHAR_LIGAND_ID
30257
RXNORM
318706009
SNOMEDCT_US
395805008
SNOMEDCT_US
4810
PUBCHEM_CID
5207
INN_ID
C0066837
UMLSCUI
C043482
MESH_SUPPLEMENTAL_RECORD_UI
CC6X0L40GW
UNII
Showing 1 to 10 of 14 entries
Previous
1
2
Next
Pharmaceutical products:
None
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
moxonidine