moracizine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diphenylmethyl piperazine derivatives 1842 31883-05-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • moricizine hydrochloride
  • moracizine
  • moricizine
  • ethmozine
  • moricizine HCl
An antiarrhythmia agent used primarily for ventricular rhythm disturbances.
  • Molecular weight: 427.52
  • Formula: C22H25N3O4S
  • CLOGP: 2.64
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 71.11
  • ALOGS: -4.10
  • ROTB: 6

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.75 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 35.09 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
June 19, 1990 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01BG01 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Other antiarrhythmics, class I and III
FDA EPC N0000175426 Antiarrhythmic
CHEBI has role CHEBI:38070 antiarrhythmic agent
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D061567 Voltage-Gated Sodium Channel Blockers

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ventricular arrhythmia indication 44103008




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.75 acidic
pKa2 6.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL

External reference:

IDSource
4019551 VUID
N0000179669 NUI
D02087 KEGG_DRUG
29560-58-5 SECONDARY_CAS_RN
4019551 VANDF
4019845 VANDF
C0079856 UMLSCUI
CHEBI:6997 CHEBI
CHEMBL1075 ChEMBL_ID
CHEMBL1200334 ChEMBL_ID
DB00680 DRUGBANK_ID
34633 PUBCHEM_CID
7244 IUPHAR_LIGAND_ID
151721 RXNORM
1620 MMSL
5135 MMSL
d00307 MMSL
003553 NDDF
004488 NDDF
108489008 SNOMEDCT_US
350598002 SNOMEDCT_US
373726009 SNOMEDCT_US
D016293 MESH_DESCRIPTOR_UI
2998 INN_ID
71OK3Z1ESP UNII

Pharmaceutical products:

None