mivotilate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
hepatoprotectants, di(propan-2-yl- 2-(2H-1,3-dithiol-2-ylidene)propanedioate and analogues 1823 130112-42-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mivotilate
  • Molecular weight: 330.44
  • Formula: C12H14N2O3S3
  • CLOGP: 2.65
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 68.29
  • ALOGS: -3.36
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 48
kinase-selectivity-class ACVR2A,AURKB,AXL,BRAF,CAMK2D,CDK16,CDK4,CDK9,CLK4,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FGFR1,GRK2,GSK3B,HIPK2,IRAK1,JAK2,MAP2K6,MAP3K14,MAP3K2,MAP3K7,MAPK12,MAPK7,MARK4,PDK4,PIM3,PRKAA1,PRKDC,SIK2,STK33,SYK,TEK,TTK 36
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.29 acidic
pKa2 3.68 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C2825468 UMLSCUI
CHEBI:135409 CHEBI
CHEMBL3301677 ChEMBL_ID
148185 PUBCHEM_CID
7727 INN_ID
0789652QUL UNII
0789652QUL INXIGHT DRUGS

Pharmaceutical products:

None