amlexanox 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiallergics, tixanox group | 182 | 68302-57-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The mechanism of action by which amlexanox accelerates healing of aphthous ulcers is unknown. In vitro studies have demonstrated amlexanox to be a potent inhibitor of the formation and/or release of inflammatory mediators (histamine and leukotrienes) from mast cells, neutrophils and mononuclear cells.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| fu (Fraction unbound in plasma) | 0 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 17, 1996 | FDA | ULURU |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A01AD07 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Other agents for local oral treatment |
| ATC | R03DX01 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Other systemic drugs for obstructive airway diseases |
| MeSH PA | D018926 | Anti-Allergic Agents |
| FDA PE | N0000175628 | Decreased Histamine Release |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
| CHEBI has role | CHEBI:49201 | anti-ulcer drugs |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Aphthous ulcer of mouth | indication | 426965005 | DOID:9663 |
| Stomatitis | contraindication | 61170000 | DOID:9637 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.47 | acidic |
| pKa2 | 7.04 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Phosphodiesterase 4 | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| Transthyretin | Secreted | Kd | 4.70 | CHEMBL | |||||
| Inhibitor of nuclear factor kappa-B kinase subunit epsilon | Kinase | INHIBITOR | IC50 | 6 | IUPHAR | ||||
| Serine/threonine-protein kinase TBK1 | Kinase | INHIBITOR | IC50 | 6 | IUPHAR | ||||
| G-protein coupled receptor 35 | GPCR | EC50 | 5.40 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021055 | VUID |
| N0000148519 | NUI |
| D01828 | KEGG_DRUG |
| 320442 | RXNORM |
| C0103049 | UMLSCUI |
| CHEBI:31205 | CHEBI |
| CHEMBL1096 | ChEMBL_ID |
| DB01025 | DRUGBANK_ID |
| C045742 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2161 | PUBCHEM_CID |
| 7113 | IUPHAR_LIGAND_ID |
| 5950 | INN_ID |
| BRL1C2459K | UNII |
| 11374 | MMSL |
| 4179 | MMSL |
| 108897008 | SNOMEDCT_US |
| 413507000 | SNOMEDCT_US |
| ANW | PDB_CHEM_ID |
| 4021055 | VANDF |
| 006853 | NDDF |
Pharmaceutical products:
None