minoxidil Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
vasodilators 1814 38304-91-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • minoxidil
  • loniten
  • rogaine
A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)
  • Molecular weight: 209.25
  • Formula: C9H15N5O
  • CLOGP: 0.02
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 93.63
  • ALOGS: -1.02
  • ROTB: 1

Drug dosage:

DoseUnitRoute
20 mg O

Approvals:

DateAgencyCompanyOrphan
Oct. 18, 1979 FDA

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypertrichosis 417.38 37.99 55 764 329 4637844
Product formulation issue 321.49 37.99 45 774 442 4637731
Pericardial effusion 261.09 37.99 57 762 8041 4630132
Alopecia 156.41 37.99 49 770 28031 4610142
Dermatitis contact 137.63 37.99 27 792 2214 4635959
Hypotension 114.52 37.99 49 770 67351 4570822
Hypertension 103.21 37.99 42 777 50756 4587417
Dizziness 93.18 37.99 48 771 99823 4538350
Palpitations 92.26 37.99 32 787 24814 4613359
Oedema peripheral 89.62 37.99 36 783 41936 4596237
Tachycardia 85.20 37.99 32 787 31113 4607060
Drug ineffective 74.89 37.99 52 767 186009 4452164
Product use in unapproved indication 72.83 37.99 27 792 25246 4612927
Dyspnoea 63.25 37.99 42 777 138943 4499230
Hair growth abnormal 56.51 37.99 11 808 858 4637315
Fluid retention 55.31 37.99 18 801 11403 4626770
Drug hypersensitivity 52.56 37.99 29 790 68371 4569802
Arrhythmia 52.19 37.99 18 801 13614 4624559
Pruritus 48.27 37.99 28 791 72544 4565629
Hair texture abnormal 46.65 37.99 9 810 669 4637504
Acute kidney injury 46.37 37.99 27 792 70404 4567769
Skin burning sensation 43.25 37.99 11 808 2905 4635268
Oedema 43.04 37.99 17 802 18734 4619439
Product label on wrong product 42.53 37.99 6 813 61 4638112
Pleural effusion 42.00 37.99 18 801 24380 4613793
Application site reaction 41.79 37.99 8 811 570 4637603
Heart rate increased 39.74 37.99 16 803 18526 4619647
Hair colour changes 38.22 37.99 8 811 897 4637276

Pharmacologic Action:

SourceCodeDescription
ATC C02DC01 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
Pyrimidine derivatives
ATC D11AX01 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
FDA PE N0000175379 Arteriolar Vasodilation
FDA EPC N0000175564 Arteriolar Vasodilator
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35674 antihypertensive agent
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Alopecia indication 56317004 DOID:987
Pericarditis contraindication 3238004 DOID:1787
Myocardial infarction contraindication 22298006 DOID:5844
Orthostatic hypotension contraindication 28651003
Cardiac tamponade contraindication 35304003 DOID:115
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Cerebrovascular disease contraindication 62914000 DOID:6713
Kidney disease contraindication 90708001 DOID:557
Angina pectoris contraindication 194828000
Cerebrovascular accident contraindication 230690007
Pheochromocytoma contraindication 302835009
Pericardial effusion contraindication 373945007 DOID:118
Dermatosis of scalp contraindication 402694007 DOID:3136

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.35 Basic
pKa2 2.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 2, Kir6.2 Ion channel OPENER CHEMBL SCIENTIFIC LITERATURE
ATP-sensitive inward rectifier potassium channel 1 Ion channel IC50 6.97 WOMBAT-PK

External reference:

IDSource
4018077 VUID
N0000146416 NUI
C0026196 UMLSCUI
D00418 KEGG_DRUG
5965120SH1 UNII
2987 INN_ID
49577002 SNOMEDCT_US
4018077 VANDF
7147 MMSL
6984 RXNORM
387272001 SNOMEDCT_US
5119 MMSL
d00135 MMSL
000637 NDDF
4201 PUBCHEM_CID
CHEBI:6942 CHEBI
CHEMBL802 ChEMBL_ID
DB00350 DRUGBANK_ID
MXD PDB_CHEM_ID
D008914 MESH_DESCRIPTOR_UI
4254 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Good Sense Hair Regrowth Treatment HUMAN OTC DRUG LABEL 1 0113-0798 SOLUTION 3 g TOPICAL ANDA 10 sections
Good Sense Hair Regrowth Treatment HUMAN OTC DRUG LABEL 1 0113-1129 AEROSOL, FOAM 50 mg TOPICAL ANDA 16 sections
basic care hair regrowth treatment HUMAN OTC DRUG LABEL 1 0113-7129 AEROSOL, FOAM 50 mg TOPICAL ANDA 16 sections
basic care hair regrowth treatment HUMAN OTC DRUG LABEL 1 0113-7202 SOLUTION 2 g TOPICAL ANDA 10 sections
basic care hair regrowth treatment HUMAN OTC DRUG LABEL 1 0113-7294 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections
Basic Care Hair Regrowth HUMAN OTC DRUG LABEL 1 0113-7798 SOLUTION 3 g TOPICAL ANDA 9 sections
minoxidil HUMAN OTC DRUG LABEL 1 0363-0294 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections
minoxidil HUMAN OTC DRUG LABEL 1 0363-0798 SOLUTION 3 g TOPICAL ANDA 10 sections
hair regrowth treatment HUMAN OTC DRUG LABEL 1 0363-1129 AEROSOL, FOAM 50 mg TOPICAL ANDA 16 sections
Solution HUMAN OTC DRUG LABEL 1 0363-2173 SOLUTION 0.02 g TOPICAL ANDA 13 sections
hair regrowth treatment HUMAN OTC DRUG LABEL 1 0363-2294 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections
hair regrowth treatment HUMAN OTC DRUG LABEL 1 0363-2798 SOLUTION 3 g TOPICAL ANDA 9 sections
hair regrowth treatment HUMAN OTC DRUG LABEL 1 0363-7202 SOLUTION 2 g TOPICAL ANDA 10 sections
Minoxidil HUMAN OTC DRUG LABEL 1 0472-0066 SOLUTION 2 g TOPICAL ANDA 9 sections
Minoxidil HUMAN OTC DRUG LABEL 1 0472-0094 SOLUTION 50 mg TOPICAL ANDA 10 sections
minoxidil HUMAN OTC DRUG LABEL 1 0472-1660 AEROSOL, FOAM 5 g TOPICAL ANDA 9 sections
minoxidil HUMAN OTC DRUG LABEL 1 0472-1665 AEROSOL, FOAM 5 g TOPICAL ANDA 15 sections
Minoxidil HUMAN PRESCRIPTION DRUG LABEL 1 0591-5642 TABLET 2.50 mg ORAL ANDA 14 sections
Minoxidil HUMAN PRESCRIPTION DRUG LABEL 1 0591-5643 TABLET 10 mg ORAL ANDA 14 sections
Minoxidil HUMAN PRESCRIPTION DRUG LABEL 1 0615-7593 TABLET 2.50 mg ORAL ANDA 12 sections
just for men minoxidil HUMAN OTC DRUG LABEL 1 11509-0798 SOLUTION 3 g TOPICAL ANDA 9 sections
up and up hair regrowth treatment for women HUMAN OTC DRUG LABEL 1 11673-189 SOLUTION 2 g TOPICAL ANDA 10 sections
up and up hair regrowth treatment for women HUMAN OTC DRUG LABEL 1 11673-431 AEROSOL, FOAM 50 mg TOPICAL ANDA 16 sections
up and up hair regrowth treatment for men HUMAN OTC DRUG LABEL 1 11673-632 SOLUTION 5 g TOPICAL ANDA 10 sections
up and up hair regrowth treatment for men HUMAN OTC DRUG LABEL 1 11673-707 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections
Minoxidil HUMAN OTC DRUG LABEL 1 11822-0129 AEROSOL, FOAM 50 mg TOPICAL ANDA 16 sections
Minoxidil HUMAN OTC DRUG LABEL 1 11822-0202 SOLUTION 2 g TOPICAL ANDA 10 sections
Daylogic For Men HUMAN OTC DRUG LABEL 1 11822-0606 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections
minoxidil HUMAN OTC DRUG LABEL 1 11822-0798 SOLUTION 3 g TOPICAL ANDA 9 sections
signature care hair regrowth treatment for women HUMAN OTC DRUG LABEL 1 21130-163 AEROSOL, FOAM 50 mg TOPICAL ANDA 16 sections