minoxidil indications/contra

Stem definitionDrug idCAS RN
vasodilators 1814 38304-91-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • minoxidil
  • loniten
  • rogaine
A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)
  • Molecular weight: 209.25
  • Formula: C9H15N5O
  • CLOGP: 0.02
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 93.63
  • ALOGS: -1.02
  • ROTB: 1

Drug dosage:

DoseUnitRoute
20 mg O

Approvals:

DateAgencyCompanyOrphan
Oct. 18, 1979 FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pericardial effusion 193.96 38.95 42 553 6019 3379245
Dermatitis contact 115.21 38.95 22 573 1656 3383608
Hypotension 110.37 38.95 43 552 49471 3335793
Alopecia 98.42 38.95 31 564 18955 3366309
Tachycardia 84.20 38.95 29 566 23342 3361922
Hypertension 77.01 38.95 31 564 38435 3346829
Dizziness 76.95 38.95 38 557 76474 3308790
Drug ineffective 75.35 38.95 43 552 116047 3269217
Oedema peripheral 73.29 38.95 29 566 34332 3350932
Wrong patient received medication 72.26 38.95 11 584 208 3385056
Hypertrichosis 70.37 38.95 11 584 249 3385015
Palpitations 66.01 38.95 23 572 19060 3366204
Product use issue 54.19 38.95 19 576 15982 3369282
Fluid retention 49.18 38.95 15 580 8143 3377121
Hair growth abnormal 47.22 38.95 9 586 663 3384601
Pleural effusion 43.96 38.95 17 578 18762 3366502
Hair texture abnormal 43.01 38.95 8 587 516 3384748
Dyspnoea 40.79 38.95 28 567 102906 3282358
Pruritus 40.21 38.95 21 574 46812 3338452
Acute kidney injury 39.04 38.95 21 574 49662 3335602

Pharmacologic Action:

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SourceCodeDescription
ATC C02DC01 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
Pyrimidine derivatives
ATC D11AX01 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35674 antihypertensive agent
FDA PE N0000175379 Arteriolar Vasodilation
FDA EPC N0000175564 Arteriolar Vasodilator
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Alopecia indication 56317004 DOID:987
Pericarditis contraindication 3238004 DOID:1787
Myocardial infarction contraindication 22298006 DOID:5844
Orthostatic hypotension contraindication 28651003
Cardiac tamponade contraindication 35304003 DOID:115
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Cerebrovascular disease contraindication 62914000 DOID:6713
Kidney disease contraindication 90708001 DOID:2527
Angina pectoris contraindication 194828000
Cerebrovascular accident contraindication 230690007 DOID:6713
Pheochromocytoma contraindication 302835009
Pericardial effusion contraindication 373945007 DOID:118
Dermatosis of scalp contraindication 402694007 DOID:3136

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.35 Basic
pKa2 2.62 Basic

Orange Book patent data (new drug applications)

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Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
5% MEN'S ROGAINE JOHNSON AND JOHNSON N021812 Jan. 20, 2006 OTC AEROSOL, FOAM TOPICAL 6946120 April 20, 2019 TOPICAL AEROSOL HAIR REGROWTH TREATMENT
5% WOMEN'S ROGAINE JOHNSON AND JOHNSON N021812 Feb. 28, 2014 OTC AEROSOL, FOAM TOPICAL 6946120 April 20, 2019 TOPICAL AEROSOL HAIR REGROWTH TREATMENT

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 2, Kir6.2 Ion channel OPENER CHEMBL SCIENTIFIC LITERATURE
ATP-sensitive inward rectifier potassium channel 1 Ion channel IC50 6.97 WOMBAT-PK

External reference:

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IDSource
DB00350 DRUGBANK_ID
4254 IUPHAR_LIGAND_ID
4018077 VUID
N0000146416 NUI
C0026196 UMLSCUI
D00418 KEGG_DRUG
5965120SH1 UNII
2987 INN_ID
CHEMBL802 ChEMBL_ID
4201 PUBCHEM_CID
4018077 VANDF
7147 MMSL
6984 RXNORM
387272001 SNOMEDCT_US
49577002 SNOMEDCT_US
5119 MMSL
d00135 MMSL
N0000007452 NDFRT
N0000146416 NDFRT
000637 NDDF
CHEBI:6942 CHEBI
D008914 MESH_DESCRIPTOR_UI
MXD PDB_CHEM_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
good sense hair regrowth treatment HUMAN OTC DRUG LABEL 1 0113-0294 AEROSOL, FOAM 5 g TOPICAL ANDA 12 sections
Good Sense Hair Regrowth Treatment HUMAN OTC DRUG LABEL 1 0113-0798 SOLUTION 3 g TOPICAL ANDA 10 sections
Basic Care Hair Regrowth HUMAN OTC DRUG LABEL 1 0113-7798 SOLUTION 3 g TOPICAL ANDA 9 sections
Qilib Hair Regrowth Treatment for Men HUMAN OTC DRUG LABEL 1 0299-4805 SOLUTION 5 g TOPICAL NDA 9 sections
Qilib Hair Regrowth Treatment for Women HUMAN OTC DRUG LABEL 1 0299-4820 SOLUTION 2 g TOPICAL NDA 9 sections
minoxidil HUMAN OTC DRUG LABEL 1 0363-0294 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections
minoxidil HUMAN OTC DRUG LABEL 1 0363-0798 SOLUTION 3 g TOPICAL ANDA 10 sections
Solution HUMAN OTC DRUG LABEL 1 0363-2173 SOLUTION 0.02 g TOPICAL ANDA 13 sections
Hair Regrowth Treatment HUMAN OTC DRUG LABEL 1 0472-0066 SOLUTION 2 g TOPICAL ANDA 9 sections
Hair Regrowth Treatment For Men HUMAN OTC DRUG LABEL 1 0472-0094 SOLUTION 50 mg TOPICAL ANDA 10 sections
Minoxidil HUMAN PRESCRIPTION DRUG LABEL 1 0591-5642 TABLET 2.50 mg ORAL ANDA 14 sections
Minoxidil HUMAN PRESCRIPTION DRUG LABEL 1 0591-5643 TABLET 10 mg ORAL ANDA 14 sections
Minoxidil HUMAN PRESCRIPTION DRUG LABEL 1 0615-7593 TABLET 2.50 mg ORAL ANDA 12 sections
up and up hair regrowth treatment for women HUMAN OTC DRUG LABEL 1 11673-189 SOLUTION 2 g TOPICAL ANDA 10 sections
up and up hair regrowth treatment for men HUMAN OTC DRUG LABEL 1 11673-632 SOLUTION 5 g TOPICAL ANDA 9 sections
up and up hair regrowth treatment for men HUMAN OTC DRUG LABEL 1 11673-707 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections
Up and Up minoxidil HUMAN OTC DRUG LABEL 1 11673-856 SOLUTION 2 g TOPICAL ANDA 10 sections
Minoxidil HUMAN OTC DRUG LABEL 1 11822-0129 AEROSOL, FOAM 50 mg TOPICAL ANDA 16 sections
Minoxidil HUMAN OTC DRUG LABEL 1 11822-0202 SOLUTION 2 g TOPICAL ANDA 10 sections
renewal for men HUMAN OTC DRUG LABEL 1 11822-0294 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections
Daylogic For Men HUMAN OTC DRUG LABEL 1 11822-0606 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections
Hair Regrowth Treatment for Women HUMAN OTC DRUG LABEL 1 11822-0667 SOLUTION 2 g TOPICAL ANDA 10 sections
minoxidil HUMAN OTC DRUG LABEL 1 11822-0798 SOLUTION 3 g TOPICAL ANDA 9 sections
signature care hair regrowth treatment for women HUMAN OTC DRUG LABEL 1 21130-163 AEROSOL, FOAM 50 mg TOPICAL ANDA 16 sections
signature care hair regrowth treatment HUMAN OTC DRUG LABEL 1 21130-273 SOLUTION 3 g TOPICAL ANDA 9 sections
Signature Care Hair Regrowth Treatment for men HUMAN OTC DRUG LABEL 1 21130-750 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections
Loesch Hair Regrowth Formula HUMAN OTC DRUG LABEL 1 25280-006 SOLUTION 3 g TOPICAL ANDA 17 sections
Loesch Hair Regrowth Formula HUMAN OTC DRUG LABEL 1 25280-007 SOLUTION 2 g TOPICAL ANDA 17 sections
hair regrowth treatment HUMAN OTC DRUG LABEL 1 30142-202 SOLUTION 2 g TOPICAL ANDA 10 sections
hair regrowth treatment for men HUMAN OTC DRUG LABEL 1 30142-294 AEROSOL, FOAM 5 g TOPICAL ANDA 10 sections