minaprine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1812 | 25905-77-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Agr 1240 refers to di-HCl; short-acting type A MAO inhibitor (MAOI) of mild potency; structure
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AX07 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D011619 | Psychotropic Drugs |
| CHEBI has role | CHEBI:35469 | antidepressants |
| CHEBI has role | CHEBI:38323 | cholinergic drugs |
| CHEBI has role | CHEBI:48407 | antiparkinson agent |
| CHEBI has role | CHEBI:50949 | SSRI |
| CHEBI has role | CHEBI:51039 | dopamine reuptake inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.08 | Basic |
| pKa2 | 4.32 | Basic |
| pKa3 | 0.81 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | GPCR | Ki | 4.77 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 4.07 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | IC50 | 4.77 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 4.07 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D05039 | KEGG_DRUG |
| C0066561 | UMLSCUI |
| CHEBI:51038 | CHEBI |
| CHEMBL278819 | ChEMBL_ID |
| DB00805 | DRUGBANK_ID |
| C006149 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4199 | PUBCHEM_CID |
| 3503 | INN_ID |
| 25953-17-7 | SECONDARY_CAS_RN |
| 00U7GX0NLM | UNII |
| 236400 | RXNORM |
| 005843 | NDDF |
| 005844 | NDDF |
| CHEMBL1364551 | ChEMBL_ID |
| CHEMBL536932 | ChEMBL_ID |
Pharmaceutical products:
None