amitriptylinoxide indications/contra

Stem definitionDrug idCAS RN
181 4317-14-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amitriptylinoxide
  • amitriptyline N-oxide
  • amitriptyline oxide
  • Molecular weight: 293.41
  • Formula: C20H23NO
  • CLOGP: 4.32
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 23.06
  • ALOGS: -6.02
  • ROTB: 3

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.84 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase IC50 5 CHEMBL

External reference:

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IDSource
C0772039 UMLSCUI
D07449 KEGG_DRUG
CHEMBL627 ChEMBL_ID
20313 PUBCHEM_CID
CHEBI:135224 CHEBI
C006566 MESH_SUPPLEMENTAL_RECORD_UI
TYR2U59WMA UNII
3926 INN_ID
DB13114 DRUGBANK_ID

Pharmaceutical products:

None