metixene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1780 4969-02-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methixene hydrochloride monohydrate
  • metixene
  • methixene
  • metixen
  • tremaril
  • tremonil
  • metixene hydrochloride
  • methixene hydrochloride
  • metixene HCl
  • methixene HCl
  • Molecular weight: 309.47
  • Formula: C20H23NS
  • CLOGP: 5.84
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -6.48
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N04AA03 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
ANTICHOLINERGIC AGENTS
Tertiary amines
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48407 antiparkinson agent
CHEBI has role CHEBI:48876 muscarinic antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Parkinsonism indication 32798002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.34 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST CHEMBL CHEMBL
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST CHEMBL CHEMBL
Cholinesterase Enzyme IC50 5.80 CHEMBL

External reference:

IDSource
D01871 KEGG_DRUG
C0066139 UMLSCUI
CHEBI:51024 CHEBI
CHEMBL1201342 ChEMBL_ID
CHEMBL1200426 ChEMBL_ID
DB00340 DRUGBANK_ID
C005111 MESH_SUPPLEMENTAL_RECORD_UI
4167 PUBCHEM_CID
7232 IUPHAR_LIGAND_ID
7081-40-5 SECONDARY_CAS_RN
258230 RXNORM
001765 NDDF
004712 NDDF
323245002 SNOMEDCT_US
387354009 SNOMEDCT_US
64558005 SNOMEDCT_US
1582 INN_ID
32VY6L26ZW UNII

Pharmaceutical products:

None