methsuximide indications/contra

Stem definitionDrug idCAS RN
1758 77-41-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mesuximid
  • methsuximide
  • celontin
  • mesuximide
  • mesuximidum
  • methsuximid
  • racemic methsuximide
  • (+/-)-Mesuximide
anticonvulsant effective in petit mal & psychomotor epilepsy; has a number of unpleasant & toxic side effects; minor descriptor (75-86); on-line & INDEX MEDICUS search SUCCINIMIDES (75-86); RN given refers to parent cpd without isomeric designation
  • Molecular weight: 203.24
  • Formula: C12H13NO2
  • CLOGP: 1.46
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 37.38
  • ALOGS: -1.98
  • ROTB: 1

Drug dosage:

DoseUnitRoute
0.90 g O

Approvals:

DateAgencyCompanyOrphan
Feb. 8, 1957 FDA PARKE DAVIS

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC N03AD03 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Succinimide derivatives
FDA EPC N0000175753 Anti-epileptic Agent
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents

Drug Use (View source of the data)

scroll-->
DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006 DOID:1825
Epilepsy indication 84757009 DOID:1826
Suicidal thoughts contraindication 6471006
Depressive disorder contraindication 35489007 DOID:2848
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Aggressive behavior contraindication 61372001
Kidney disease contraindication 90708001 DOID:2527
Acute intermittent porphyria contraindication 234422006 DOID:3890
Disease of liver contraindication 235856003 DOID:409
Neutropenic disorder contraindication 303011007 DOID:1227
Epilepsy characterized by intractable complex partial seizures off-label use 442481002

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated T-type calcium channel Ion channel BLOCKER CHEMBL CHEMBL

External reference:

scroll-->
IDSource
4018637 VUID
N0000146950 NUI
C0109002 UMLSCUI
D00404 KEGG_DRUG
0G76K8X6C0 UNII
582 INN_ID
CHEMBL697 ChEMBL_ID
6476 PUBCHEM_CID
4018637 VANDF
N0000146950 NDFRT
N0000006594 NDFRT
001630 NDDF
d00292 MMSL
5084 MMSL
47858 RXNORM
386187007 SNOMEDCT_US
58325006 SNOMEDCT_US
CHEBI:6846 CHEBI
DB05246 DRUGBANK_ID
C100286 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

scroll-->
ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Celontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0525 CAPSULE 300 mg ORAL NDA 13 sections