methocarbamol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1747 532-03-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methocarbamol
  • glycerylguaiacolate carbamate
  • guaiacol glyceryl ether carbamate
  • guaiphenesin carbamate
  • guaiamar carbamate
A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
  • Molecular weight: 241.24
  • Formula: C11H15NO5
  • CLOGP: 0.15
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 91.01
  • ALOGS: -1.76
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g O
3 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 16, 1957 FDA AUXILIUM PHARMS LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 114.40 12.86 189 21350 145484 63321999
Necrosis ischaemic 64.85 12.86 20 21519 840 63466643
Contraindicated product administered 61.35 12.86 3 21536 217645 63249838
Pneumonia streptococcal 53.79 12.86 21 21518 1790 63465693
Treatment failure 49.60 12.86 5 21534 199038 63268445
Beta haemolytic streptococcal infection 48.12 12.86 20 21519 2005 63465478
Acquired haemophilia 45.52 12.86 16 21523 1015 63466468
Drug intolerance 45.51 12.86 24 21515 308637 63158846
Maternal exposure during pregnancy 44.65 12.86 10 21529 220052 63247431
Glossodynia 43.28 12.86 5 21534 178871 63288612
Gallbladder polyp 41.71 12.86 14 21525 773 63466710
Systemic lupus erythematosus 41.38 12.86 10 21529 208908 63258575
Spinal operation 39.23 12.86 28 21511 8243 63459240
Surgery 38.63 12.86 54 21485 35858 63431625
Diabetes mellitus inadequate control 35.44 12.86 34 21505 15092 63452391
Fall 34.86 12.86 240 21299 392094 63075389
Infusion related reaction 33.45 12.86 21 21518 245500 63221983
Muscle spasms 32.86 12.86 122 21417 156028 63311455
Multiple drug therapy 31.44 12.86 18 21521 3628 63463855
Depression 31.42 12.86 141 21398 196351 63271132
Intervertebral disc protrusion 30.64 12.86 39 21500 23670 63443813
Wound 30.08 12.86 9 21530 163254 63304229
Anxiety 29.62 12.86 149 21390 217392 63250091
Product dose omission issue 29.49 12.86 157 21382 234156 63233327
Joint swelling 28.39 12.86 42 21497 327624 63139859
Suspected suicide 26.13 12.86 20 21519 6548 63460935
Migraine 25.39 12.86 85 21454 103261 63364222
Drug hypersensitivity 24.63 12.86 185 21354 310502 63156981
Alopecia 24.02 12.86 49 21490 337487 63129996
Amnesia 23.84 12.86 56 21483 55529 63411954
Off label use 23.33 12.86 134 21405 674328 62793155
Lower respiratory tract infection 23.12 12.86 8 21531 132299 63335184
Back disorder 22.54 12.86 23 21516 10994 63456489
Exercise tolerance decreased 22.44 12.86 17 21522 5480 63462003
Pre-existing condition improved 22.15 12.86 20 21519 8224 63459259
Blood pressure inadequately controlled 21.67 12.86 16 21523 4962 63462521
Illness 21.67 12.86 50 21489 49009 63418474
Exposure during pregnancy 21.59 12.86 13 21526 155534 63311949
Respiratory arrest 21.19 12.86 39 21500 32606 63434877
Back pain 20.76 12.86 157 21382 263988 63203495
Therapeutic product effect decreased 20.69 12.86 21 21518 193166 63274317
Exposure via skin contact 20.65 12.86 7 21532 398 63467085
Bronchitis 20.21 12.86 90 21449 124845 63342638
Neutropenia 19.93 12.86 18 21521 174987 63292496
Multiple sclerosis 19.59 12.86 32 21507 24340 63443143
Loss of consciousness 19.04 12.86 85 21454 118036 63349447
Multiple sclerosis relapse 18.82 12.86 47 21492 48431 63419052
Analgesic drug level increased 18.57 12.86 11 21528 2361 63465122
Withdrawal syndrome 18.49 12.86 28 21511 19969 63447514
Hepatic enzyme increased 18.44 12.86 25 21514 202303 63265180
Feeling abnormal 18.35 12.86 99 21440 148293 63319190
Febrile neutropenia 17.74 12.86 9 21530 118440 63349043
Somnolence 17.44 12.86 112 21427 178573 63288910
Discomfort 17.02 12.86 19 21520 167355 63300128
Impaired quality of life 16.75 12.86 22 21517 13761 63453722
Therapy interrupted 16.50 12.86 35 21504 32420 63435063
Cardio-respiratory arrest 16.24 12.86 51 21488 59908 63407575
Thyroiditis chronic 16.14 12.86 3 21536 12 63467471
Attention deficit hyperactivity disorder 15.95 12.86 11 21528 3065 63464418
Road traffic accident 15.81 12.86 37 21502 36595 63430888
Toxicity to various agents 15.67 12.86 140 21399 247110 63220373
Therapy cessation 15.66 12.86 33 21506 30424 63437059
Kidney infection 15.43 12.86 28 21511 23148 63444335
Neck pain 15.27 12.86 55 21484 69263 63398220
Psoriasis 15.09 12.86 64 21475 86893 63380590
Suicidal ideation 15.02 12.86 51 21488 62370 63405113
Rheumatoid arthritis 14.00 12.86 42 21497 253777 63213706
Memory impairment 13.87 12.86 71 21468 104187 63363296
Oesophagitis 13.85 12.86 21 21518 14987 63452496
Pancytopenia 13.59 12.86 8 21531 96925 63370558
Intervertebral disc disorder 13.51 12.86 12 21527 4831 63462652
Obstruction 13.50 12.86 10 21529 3117 63464366
Rib fracture 13.43 12.86 26 21513 22571 63444912
Cardiac failure 13.01 12.86 7 21532 89135 63378348
Malignant neoplasm of spinal cord 12.99 12.86 3 21536 40 63467443

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory depression 125.57 14.58 68 8998 16177 34931688
Drug dependence 122.55 14.58 77 8989 24140 34923725
Product prescribing error 89.47 14.58 62 9004 22865 34925000
Child abuse 78.89 14.58 19 9047 408 34947457
Epidural lipomatosis 61.88 14.58 19 9047 1035 34946830
Juvenile idiopathic arthritis 50.93 14.58 19 9047 1878 34945987
Victim of child abuse 43.15 14.58 14 9052 913 34946952
Intentional product misuse 28.37 14.58 46 9020 45565 34902300
Phonophobia 27.82 14.58 7 9059 181 34947684
Depression 26.86 14.58 70 8996 97028 34850837
Obesity 26.69 14.58 24 9042 12854 34935011
Back disorder 21.38 14.58 16 9050 6635 34941230
Back pain 19.84 14.58 73 8993 121716 34826149
Spinal operation 19.11 14.58 11 9055 2933 34944932
Drug abuse 18.37 14.58 62 9004 99034 34848831
Serum procollagen type III N-terminal propeptide increased 18.28 14.58 4 9062 55 34947810
Anxiety 18.25 14.58 62 9004 99366 34848499
Memory impairment 17.19 14.58 36 9030 43282 34904583
Subgaleal haematoma 16.22 14.58 4 9062 95 34947770
General physical health deterioration 15.39 14.58 7 9059 128262 34819603
Intervertebral disc degeneration 15.39 14.58 13 9053 6404 34941461
Pancytopenia 15.38 14.58 3 9063 95154 34852711
Pain 14.67 14.58 97 8969 204578 34743287
Post-traumatic neck syndrome 14.60 14.58 4 9062 145 34947720

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 95.80 12.12 220 23524 245547 79475097
Respiratory depression 86.05 12.12 69 23675 27561 79693083
Drug dependence 83.08 12.12 80 23664 40689 79679955
Child abuse 76.18 12.12 19 23725 410 79720234
Necrosis ischaemic 62.75 12.12 20 23724 1070 79719574
Product prescribing error 57.78 12.12 69 23675 44744 79675900
Epidural lipomatosis 56.43 12.12 19 23725 1209 79719435
Beta haemolytic streptococcal infection 49.97 12.12 20 23724 2077 79718567
Pneumonia streptococcal 44.77 12.12 20 23724 2725 79717919
Spinal operation 41.21 12.12 27 23717 7890 79712754
Victim of child abuse 40.87 12.12 14 23730 939 79719705
Gallbladder polyp 40.35 12.12 14 23730 976 79719668
Fall 38.73 12.12 263 23481 487366 79233278
Acquired haemophilia 37.96 12.12 16 23728 1895 79718749
Depression 37.85 12.12 146 23598 216644 79504000
Anxiety 36.00 12.12 158 23586 248354 79472290
Drug intolerance 34.18 12.12 18 23726 264101 79456543
Back disorder 34.11 12.12 28 23716 11550 79709094
Surgery 32.06 12.12 44 23700 32722 79687922
Juvenile idiopathic arthritis 31.73 12.12 19 23725 4744 79715900
Respiratory arrest 31.12 12.12 59 23685 57491 79663153
Contraindicated product administered 30.75 12.12 5 23739 157533 79563111
Neutropenia 28.74 12.12 26 23718 287684 79432960
Intentional product misuse 28.36 12.12 77 23667 95088 79625556
Treatment failure 28.02 12.12 8 23736 170478 79550166
Back pain 25.26 12.12 166 23578 304014 79416630
Infusion related reaction 25.23 12.12 19 23725 230218 79490426
Pancytopenia 25.07 12.12 9 23735 165736 79554908
Intervertebral disc protrusion 25.06 12.12 33 23711 23588 79697056
Multiple drug therapy 23.93 12.12 15 23729 4063 79716581
Intervertebral disc degeneration 23.18 12.12 26 23718 15759 79704885
Drug abuser 23.06 12.12 17 23727 5996 79714648
Thrombocytopenia 23.06 12.12 27 23717 265232 79455412
Exposure via skin contact 22.98 12.12 7 23737 322 79720322
Muscle spasms 22.97 12.12 108 23636 174622 79546022
Diabetes mellitus inadequate control 22.86 12.12 32 23712 24232 79696412
Multiple sclerosis relapse 21.89 12.12 45 23699 46488 79674156
Feeling abnormal 21.37 12.12 99 23645 159100 79561544
Systemic lupus erythematosus 21.21 12.12 5 23739 121144 79599500
Contusion 21.07 12.12 94 23650 148682 79571962
Memory impairment 20.93 12.12 77 23667 111657 79608987
Cardiac failure 20.85 12.12 10 23734 154832 79565812
Glossodynia 20.80 12.12 3 23741 103334 79617310
Suspected suicide 20.13 12.12 20 23724 10556 79710088
Phonophobia 19.89 12.12 7 23737 509 79720135
Maternal exposure during pregnancy 19.67 12.12 8 23736 136530 79584114
Migraine 19.61 12.12 64 23680 87429 79633215
Loss of consciousness 19.36 12.12 100 23644 167843 79552801
Back injury 18.38 12.12 19 23725 10504 79710140
Serum procollagen type III N-terminal propeptide increased 18.23 12.12 4 23740 48 79720596
Pain in extremity 18.20 12.12 177 23567 364361 79356283
General physical health deterioration 18.09 12.12 34 23710 275204 79445440
Road traffic accident 17.97 12.12 40 23704 43624 79677020
Drug hypersensitivity 17.91 12.12 151 23593 298765 79421879
Amnesia 17.77 12.12 50 23694 63007 79657637
Pain 17.73 12.12 301 23443 703501 79017143
Product dose omission issue 17.54 12.12 130 23614 247407 79473237
Therapy cessation 17.28 12.12 36 23708 37526 79683118
Suicidal ideation 17.25 12.12 56 23688 76284 79644360
Cardio-respiratory arrest 17.24 12.12 71 23673 108439 79612205
Analgesic drug level increased 16.93 12.12 11 23733 3167 79717477
Emotional distress 16.88 12.12 37 23707 39932 79680712
Malignant neoplasm progression 16.53 12.12 10 23734 135980 79584664
Wound 16.42 12.12 7 23737 116172 79604472
Blood pressure inadequately controlled 16.26 12.12 14 23730 6163 79714481
Overdose 16.18 12.12 102 23642 184104 79536540
Oesophageal stenosis 16.00 12.12 12 23732 4342 79716302
Interstitial lung disease 15.58 12.12 7 23737 112593 79608051
Joint swelling 15.40 12.12 40 23704 288606 79432038
Obesity 15.39 12.12 33 23711 35092 79685552
Gastrointestinal disorder 14.83 12.12 9 23735 122196 79598448
Febrile neutropenia 14.77 12.12 29 23715 230970 79489674
Psoriasis 14.53 12.12 59 23685 89528 79631116
Bronchitis 14.51 12.12 77 23667 130567 79590077
Off label use 14.50 12.12 187 23557 907028 78813616
Subgaleal haematoma 14.33 12.12 4 23740 135 79720509
Attention deficit hyperactivity disorder 14.16 12.12 10 23734 3299 79717345
Spinal fusion surgery 14.05 12.12 12 23732 5226 79715418
Spinal osteoarthritis 14.02 12.12 21 23723 16906 79703738
Pyrexia 13.97 12.12 132 23612 678577 79042067
Lower respiratory tract infection 13.72 12.12 11 23733 129209 79591435
Neck pain 13.31 12.12 51 23693 75366 79645278
Intervertebral disc displacement 13.24 12.12 5 23739 444 79720200
Therapy interrupted 13.22 12.12 29 23715 31312 79689332
Head injury 12.94 12.12 32 23712 37337 79683307
Therapeutic product effect decreased 12.86 12.12 18 23726 163845 79556799
Intervertebral disc disorder 12.83 12.12 11 23733 4814 79715830
Insomnia 12.69 12.12 120 23624 245050 79475594
Fracture nonunion 12.62 12.12 7 23737 1515 79719129
Hepatic enzyme increased 12.49 12.12 22 23722 182588 79538056
Leukopenia 12.27 12.12 10 23734 116503 79604141
Vision blurred 12.16 12.12 63 23681 105835 79614809

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03BA03 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
ATC M03BA53 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
ATC M03BA73 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
MeSH PA D002491 Central Nervous System Agents
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:51371 muscle relaxants
FDA PE N0000175730 Centrally-mediated Muscle Relaxation
FDA EPC N0000175737 Muscle Relaxant

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Spasticity indication 221360009
Muscle Spasm with Pain indication
Tetanus Adjunct Treatment indication
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Gastrointestinal ulcer contraindication 40845000
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Acute nephropathy contraindication 58574008
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Anemia due to enzyme deficiency contraindication 111577008
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Breastfeeding (mother) contraindication 413712001
Acute erosive gastritis contraindication 444926003




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Acute inflammatory and traumatic conditions of the skeletal muscles Indication
Cats Reducing muscular spasms Indication
Dogs Acute inflammatory and traumatic conditions of the skeletal muscles Indication
Dogs Reducing muscular spasms Indication
Horses Acute inflammatory and traumatic conditions of the skeletal muscles Indication
Horses Reducing muscular spasms Indication

🐶 Veterinary products

ProductApplicantIngredients
Robaxin-V Injectable Kinetic Technologies LLC 1
Robaxin-V Tablets Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 1 Enzyme INHIBITOR Ki 7.60 IUPHAR CHEMBL

External reference:

IDSource
4017879 VUID
N0000146232 NUI
D00402 KEGG_DRUG
4017879 VANDF
C0025659 UMLSCUI
CHEBI:6832 CHEBI
CHEMBL1201117 ChEMBL_ID
DB00423 DRUGBANK_ID
D008721 MESH_DESCRIPTOR_UI
4107 PUBCHEM_CID
6829 IUPHAR_LIGAND_ID
776 INN_ID
125OD7737X UNII
6845 RXNORM
5075 MMSL
988 MMSL
d00965 MMSL
001669 NDDF
387486000 SNOMEDCT_US
83973001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0143-1290 TABLET 500 mg ORAL ANDA 21 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0143-1292 TABLET 750 mg ORAL ANDA 21 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0276-0510 TABLET, COATED 1000 mg ORAL ANDA 18 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0404-9909 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 11 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0404-9909 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 11 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 0404-9992 INJECTION, SOLUTION 1000 mg INTRAVENOUS ANDA 12 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0440-1740 TABLET 500 mg ORAL ANDA 23 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0517-1825 INJECTION 100 mg INTRAMUSCULAR ANDA 20 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 0615-8435 TABLET, FILM COATED 500 mg ORAL ANDA 20 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 0615-8435 TABLET, FILM COATED 500 mg ORAL ANDA 20 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 0615-8436 TABLET, FILM COATED 750 mg ORAL ANDA 20 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 0615-8436 TABLET, FILM COATED 750 mg ORAL ANDA 20 sections
ROBAXIN HUMAN PRESCRIPTION DRUG LABEL 1 0641-6103 INJECTION 100 mg INTRAMUSCULAR NDA 22 sections
ROBAXIN HUMAN PRESCRIPTION DRUG LABEL 1 0641-6217 INJECTION 100 mg INTRAMUSCULAR NDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7057 TABLET 500 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7057 TABLET 500 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7058 TABLET 750 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7058 TABLET 750 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10135-664 TABLET, FILM COATED 500 mg ORAL ANDA 19 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10135-665 TABLET, FILM COATED 750 mg ORAL ANDA 19 sections
Methocarbamol Tablets, USP, 500 mg HUMAN PRESCRIPTION DRUG LABEL 1 10135-722 TABLET, FILM COATED 500 mg ORAL ANDA 20 sections
Methocarbamol Tablets, USP, 500 mg HUMAN PRESCRIPTION DRUG LABEL 1 10135-722 TABLET, FILM COATED 500 mg ORAL ANDA 20 sections
Methocarbamol Tablets, USP, 750 mg HUMAN PRESCRIPTION DRUG LABEL 1 10135-723 TABLET, FILM COATED 750 mg ORAL ANDA 20 sections
Methocarbamol Tablets, USP, 750 mg HUMAN PRESCRIPTION DRUG LABEL 1 10135-723 TABLET, FILM COATED 750 mg ORAL ANDA 20 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10544-259 TABLET 750 mg ORAL ANDA 21 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10544-464 TABLET 750 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10544-622 TABLET 750 mg ORAL ANDA 19 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10544-773 TABLET 500 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10544-956 TABLET 750 mg ORAL ANDA 23 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 16590-147 TABLET 500 mg ORAL ANDA 21 sections