metharbital Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 1740 50-11-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metharbital
  • metabarbital
  • methabarbitone
  • metharbitone
  • methylbarbital
  • N-Methylbarbital
  • Molecular weight: 198.22
  • Formula: C9H14N2O3
  • CLOGP: 1.14
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 66.48
  • ALOGS: -1.01
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.20 g O

Approvals:

DateAgencyCompanyOrphan
None FDA ABBVIE

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AA30 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Barbiturates and derivatives

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Epilepsy indication 84757009 DOID:1826
Insomnia indication 193462001
Tonic-clonic epilepsy indication 352818000 DOID:7725

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.43 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4018729 VUID
N0000147034 NUI
C0025629 UMLSCUI
D01382 KEGG_DRUG
02OS7K758T UNII
2 INN_ID
4018729 VANDF
6825 RXNORM
30676006 SNOMEDCT_US
001419 NDDF
4099 PUBCHEM_CID
CHEBI:31827 CHEBI
CHEMBL450 ChEMBL_ID
DB00463 DRUGBANK_ID
C084822 MESH_SUPPLEMENTAL_RECORD_UI
7230 IUPHAR_LIGAND_ID

Pharmaceutical products:

None