mepivacaine indications/contra

Stem definitionDrug idCAS RN
local anaesthetics 1700 96-88-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mepivacaine
  • (+/-)-Mepivacaine
  • carbocain
  • carbocaine
  • DL-Mepivacaine
  • mepicaine
  • tevacaine
  • mepivacaine hydrochloride
  • mepivacaine HCl
A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
  • Molecular weight: 246.35
  • Formula: C15H22N2O
  • CLOGP: 2.10
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.34
  • ALOGS: -2.60
  • ROTB: 2

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 6, 1960 FDA EASTMAN KODAK

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Generalised tonic-clonic seizure 71.59 68.45 18 344 8024 3377473
Anaesthetic complication 70.61 68.45 12 350 773 3384724

Pharmacologic Action:

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SourceCodeDescription
ATC N01BB03 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Amides
ATC N01BB53 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Amides
FDA EPC N0000175682 Amide Local Anesthetic
FDA Chemical/Ingredient N0000007681 Amides
FDA PE N0000175976 Local Anesthesia
MeSH PA D000777 Anesthetics
MeSH PA D000779 Anesthetics, Local
CHEBI has role CHEBI:36333 local anaesthetic
CHEBI has role CHEBI:88188 drug allergen
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Local anesthesia, by infiltration indication 44596000
Local anesthesia indication 386761002
Administration of Regional Anesthesia indication
Administration of Local Anesthetic Nerve Block indication
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Kidney disease contraindication 90708001 DOID:2527
Myasthenia gravis contraindication 91637004 DOID:437
Disease of liver contraindication 235856003 DOID:409
Deficiency of cholinesterase contraindication 360607009

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.06 acidic
pKa2 7.81 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 9 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL
Sodium channel protein type 8 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL
Sodium channel protein type 3 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL
Sodium channel protein type 1 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL

External reference:

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IDSource
4019815 VUID
N0000147904 NUI
C0025384 UMLSCUI
7224 IUPHAR_LIGAND_ID
D00738 KEGG_DRUG
4VFX2L7EM5 UNII
1722-62-9 SECONDARY_CAS_RN
DB00961 DRUGBANK_ID
4062 PUBCHEM_CID
6759 RXNORM
59560006 SNOMEDCT_US
391673008 SNOMEDCT_US
d01398 MMSL
4019815 VANDF
N0000006401 NDFRT
N0000147904 NDFRT
004567 NDDF
988 INN_ID
CHEMBL1087 ChEMBL_ID
CHEBI:6759 CHEBI
CHEMBL1200440 ChEMBL_ID
D008619 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Scandonest 2% L HUMAN PRESCRIPTION DRUG LABEL 2 0362-1097 INJECTION, SOLUTION 20 mg SUBCUTANEOUS ANDA 2 sections
Scandonest 3% Plain HUMAN PRESCRIPTION DRUG LABEL 1 0362-1098 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Mepivacaine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-6730 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Mepivacaine Hydrochloride with Levonordefrin HUMAN PRESCRIPTION DRUG LABEL 2 0404-6740 INJECTION, SOLUTION 20 mg SUBCUTANEOUS ANDA 12 sections
Carbocaine HUMAN PRESCRIPTION DRUG LABEL 1 0409-1036 INJECTION, SOLUTION 10 mg EPIDURAL NDA 12 sections
Carbocaine HUMAN PRESCRIPTION DRUG LABEL 1 0409-1038 INJECTION, SOLUTION 10 mg INFILTRATION NDA 12 sections
Carbocaine HUMAN PRESCRIPTION DRUG LABEL 1 0409-1041 INJECTION, SOLUTION 15 mg EPIDURAL NDA 12 sections
Carbocaine HUMAN PRESCRIPTION DRUG LABEL 1 0409-1067 INJECTION, SOLUTION 20 mg EPIDURAL NDA 12 sections
Carbocaine HUMAN PRESCRIPTION DRUG LABEL 1 0409-2047 INJECTION, SOLUTION 20 mg INFILTRATION NDA 12 sections
Carbocaine HUMAN PRESCRIPTION DRUG LABEL 1 31382-753 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Carbocaine with Neo-Cobefrin HUMAN PRESCRIPTION DRUG LABEL 2 31382-931 INJECTION, SOLUTION 20 mg SUBCUTANEOUS ANDA 12 sections
IQ Dental Mepivacaine HUMAN PRESCRIPTION DRUG LABEL 1 42756-1080 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Mepivacaine HUMAN PRESCRIPTION DRUG LABEL 1 43128-005 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Pearson Mepivacaine HUMAN PRESCRIPTION DRUG LABEL 1 43305-1080 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Mepivacaine HUMAN PRESCRIPTION DRUG LABEL 1 50227-1080 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Mepivacaine HUMAN PRESCRIPTION DRUG LABEL 2 50227-1090 INJECTION, SOLUTION 20 mg SUBCUTANEOUS ANDA 12 sections
Mepivacaine HUMAN PRESCRIPTION DRUG LABEL 1 51004-0053 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Scandonest L HUMAN PRESCRIPTION DRUG LABEL 2 51004-1097 INJECTION, SOLUTION 20 mg SUBCUTANEOUS ANDA 2 sections
Scandonest Plain HUMAN PRESCRIPTION DRUG LABEL 1 51004-1098 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Isocaine HUMAN PRESCRIPTION DRUG LABEL 1 51004-2020 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Polocaine-MPF HUMAN PRESCRIPTION DRUG LABEL 1 63323-260 INJECTION, SOLUTION 10 mg EPIDURAL ANDA 12 sections
Polocaine HUMAN PRESCRIPTION DRUG LABEL 1 63323-283 INJECTION, SOLUTION 10 mg INFILTRATION ANDA 12 sections
Polocaine-MPF HUMAN PRESCRIPTION DRUG LABEL 1 63323-293 INJECTION, SOLUTION 15 mg EPIDURAL ANDA 12 sections
Polocaine-MPF HUMAN PRESCRIPTION DRUG LABEL 1 63323-294 INJECTION, SOLUTION 20 mg EPIDURAL ANDA 12 sections
Polocaine HUMAN PRESCRIPTION DRUG LABEL 1 63323-296 INJECTION, SOLUTION 20 mg INFILTRATION ANDA 12 sections
Polocaine HUMAN PRESCRIPTION DRUG LABEL 1 66312-441 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Mepivacaine HUMAN PRESCRIPTION DRUG LABEL 1 66467-9760 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
Mepivacaine Hydrochloride and Levonordefrin HUMAN PRESCRIPTION DRUG LABEL 2 66467-9790 INJECTION, SOLUTION 20 mg SUBCUTANEOUS ANDA 12 sections
Mepivacaine HUMAN PRESCRIPTION DRUG LABEL 1 66975-406 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections
MEPIVACAINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 67239-0201 INJECTION, SOLUTION 30 mg SUBCUTANEOUS ANDA 12 sections