mepitiostane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1699 21362-69-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • S-10364
  • thioderon
  • mepitiostane
orally active anti-estrogenic steroid; RN refers to (2alpha,3alpha,5alpha,17beta)-isomer; structure
  • Molecular weight: 404.65
  • Formula: C25H40O2S
  • CLOGP: 6.29
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 18.46
  • ALOGS: -6.96
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK,TGFBR1 21
kinase-selectivity-class EIF2AK3,GRK2 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004965 Estrogen Antagonists
MeSH PA D006727 Hormone Antagonists
MeSH PA D006728 Hormones
MeSH PA D045930 Anabolic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01602 KEGG_DRUG
C0065964 UMLSCUI
CHEBI:31818 CHEBI
CHEMBL2104860 ChEMBL_ID
C006242 MESH_SUPPLEMENTAL_RECORD_UI
9909202 PUBCHEM_CID
3915 INN_ID
O00404969K UNII

Pharmaceutical products:

None