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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
menatetrenone 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists
1685
863-61-6
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
menatetrenone
Menaquinone 4
Vitamin MK 4
vitamin k2
Molecular weight: 444.66
Formula: C31H40O2
CLOGP: 10.24
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 34.14
ALOGS: -5.96
ROTB: 11
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
0.23 %
Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
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Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Cerebral infarction
43.40
32.63
16
1056
23877
63464073
Hepatic function abnormal
43.19
32.63
18
1054
37124
63450826
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Cerebral haemorrhage
78.43
32.26
31
921
34906
34921073
Cerebral infarction
40.17
32.26
18
934
27437
34928542
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Cerebral haemorrhage
90.52
25.11
40
2182
57633
79684533
Cerebral infarction
79.21
25.11
34
2188
45642
79696524
Hepatic function abnormal
69.69
25.11
36
2186
73071
79669095
Platelet count decreased
45.62
25.11
40
2182
194624
79547542
Disseminated intravascular coagulation
41.02
25.11
20
2202
35822
79706344
Brain herniation
41.01
25.11
13
2209
7450
79734716
Pneumonia
38.54
25.11
67
2155
660179
79081987
Altered state of consciousness
34.44
25.11
19
2203
43803
79698363
Embolic stroke
32.37
25.11
11
2211
7815
79734351
Upper respiratory tract inflammation
30.57
25.11
9
2213
4026
79738140
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
M05BX08
MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
CHEBI has role
CHEBI:76971
Escherichia coli metabolites
CHEBI has role
CHEBI:22586
antioxidants
CHEBI has role
CHEBI:50646
antiosteoporotic
CHEBI has role
CHEBI:63726
neuroprotective agents
CHEBI has role
CHEBI:67079
anti-inflammatory agents
CHEBI has role
CHEBI:77746
Homo sapiens metabolite
MeSH PA
D003029
Coagulants
MeSH PA
D006401
Hematologic Agents
MeSH PA
D006490
Hemostatics
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hemorrhagic disease of the newborn due to vitamin K deficiency
indication
12546009
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Alpha-synuclein
Transporter
P37840
SYUA_HUMAN
IC50
4.82
CHEMBL
Cruzipain
Enzyme
CYSP_TRYCR
IC50
4.74
CHEMBL
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External reference:
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ID
Source
1L3
PDB_CHEM_ID
012756
NDDF
013766
NDDF
22606007
SNOMEDCT_US
2771
IUPHAR_LIGAND_ID
27Y876D139
UNII
29495
RXNORM
3292
INN_ID
337527
MMSL
35482
MMSL
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Pharmaceutical products:
None
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menatetrenone