menatetrenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists 1685 863-61-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • menatetrenone
  • Menaquinone 4
  • Vitamin MK 4
  • vitamin k2
  • Molecular weight: 444.66
  • Formula: C31H40O2
  • CLOGP: 10.24
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS: -5.96
  • ROTB: 11

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 0.23 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral infarction 43.40 32.63 16 1056 23877 63464073
Hepatic function abnormal 43.19 32.63 18 1054 37124 63450826

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral haemorrhage 78.43 32.26 31 921 34906 34921073
Cerebral infarction 40.17 32.26 18 934 27437 34928542

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral haemorrhage 90.52 25.11 40 2182 57633 79684533
Cerebral infarction 79.21 25.11 34 2188 45642 79696524
Hepatic function abnormal 69.69 25.11 36 2186 73071 79669095
Platelet count decreased 45.62 25.11 40 2182 194624 79547542
Disseminated intravascular coagulation 41.02 25.11 20 2202 35822 79706344
Brain herniation 41.01 25.11 13 2209 7450 79734716
Pneumonia 38.54 25.11 67 2155 660179 79081987
Altered state of consciousness 34.44 25.11 19 2203 43803 79698363
Embolic stroke 32.37 25.11 11 2211 7815 79734351
Upper respiratory tract inflammation 30.57 25.11 9 2213 4026 79738140
Pneumonia aspiration 29.38 25.11 20 2202 66947 79675219
Brain oedema 28.61 25.11 14 2208 25249 79716917
Thalamus haemorrhage 27.70 25.11 7 2215 1775 79740391
Pyrexia 25.13 25.11 57 2165 678652 79063514

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BX08 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
MeSH PA D003029 Coagulants
MeSH PA D006401 Hematologic Agents
MeSH PA D006490 Hemostatics
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:50646 antiosteoporotic
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:77746 Homo sapiens metabolite
MeSH PA D000933 Antifibrinolytic Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hemorrhagic disease of the newborn due to vitamin K deficiency indication 12546009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-synuclein Transporter IC50 4.82 CHEMBL
Cruzipain Enzyme IC50 4.74 CHEMBL

External reference:

IDSource
D00100 KEGG_DRUG
C0065936 UMLSCUI
CHEBI:16374 CHEBI
1L3 PDB_CHEM_ID
CHEMBL259223 ChEMBL_ID
DB12148 DRUGBANK_ID
C030814 MESH_SUPPLEMENTAL_RECORD_UI
2771 IUPHAR_LIGAND_ID
3292 INN_ID
27Y876D139 UNII
5282367 PUBCHEM_CID
DB14936 DRUGBANK_ID
29495 RXNORM
337527 MMSL
35482 MMSL
37263 MMSL
d09345 MMSL
012756 NDDF
013766 NDDF
22606007 SNOMEDCT_US
712684001 SNOMEDCT_US
D024482 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None