menadione indications/contra

Stem definitionDrug idCAS RN
1683 58-27-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • menadione
  • menadion
  • menaphthon
  • menaphthone
  • menaquinone
  • 2-Methyl-1,4-naphthalenedione
  • Molecular weight: 172.18
  • Formula: C11H8O2
  • CLOGP: 2.45
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS: -2.53
  • ROTB: 0

Drug dosage:

DoseUnitRoute
10 mg O
2 mg P

Approvals:

DateAgencyCompanyOrphan
None FDA LILLY

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC B02BA02 BLOOD AND BLOOD FORMING ORGANS
ANTIHEMORRHAGICS
VITAMIN K AND OTHER HEMOSTATICS
Vitamin K
CHEBI has role CHEBI:50733 nutraceutical

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Amine oxidase [flavin-containing] A Enzyme Ki 4.59 CHEMBL
Glutathione reductase, mitochondrial Enzyme Ki 4.92 CHEMBL
Dual specificity phosphatase Cdc25C Enzyme IC50 4.73 CHEMBL
M-phase inducer phosphatase 2 Enzyme IC50 5.66 CHEMBL
Ubiquitin carboxyl-terminal hydrolase isozyme L3 Enzyme IC50 4.15 CHEMBL
Amine oxidase [flavin-containing] B Enzyme Ki 6.40 CHEMBL
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 6 CHEMBL
Trypanothione reductase Enzyme IC50 4.26 CHEMBL
Dual specificity protein phosphatase 6 Unclassified IC50 4.69 CHEMBL
Dual specificity protein phosphatase 1 Unclassified IC50 4.62 CHEMBL

External reference:

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IDSource
CHEBI:28869 CHEBI
DB00170 DRUGBANK_ID
4019127 VUID
N0000147378 NUI
C0025270 UMLSCUI
D02335 KEGG_DRUG
CHEMBL590 ChEMBL_ID
12V8PA4WCH UNII
1182-68-9 SECONDARY_CAS_RN
6728 RXNORM
69169004 SNOMEDCT_US
412244007 SNOMEDCT_US
4019127 VANDF
69576000 SNOMEDCT_US
NOCODE MMSL
N0000005058 NDFRT
N0000147378 NDFRT
001039 NDDF
4055 PUBCHEM_CID
VK3 PDB_CHEM_ID

Pharmaceutical products:

None