methyl aminolevulinate indications/contra

Stem definitionDrug idCAS RN
168 33320-16-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aminolevulinic acid methyl ester
  • 5-Amino-4-oxopentanoic acid methyl ester
  • methyl aminolevulinate
  • methyl aminolevulinate hydrochloride
  • methyl aminolevulinate HCl
  • Molecular weight: 145.16
  • Formula: C6H11NO3
  • CLOGP: -0.67
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 69.39
  • ALOGS: 0.18
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
July 27, 2004 FDA GALDERMA LABS LP

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC L01XD03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Sensitizers used in photodynamic/radiation therapy
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:47868 photosensitizing agent
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:50177 dermatologic drug
FDA EPC N0000175846 Porphyrin Precursor
FDA Chemical/Ingredient N0000171207 Porphyrinogens

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Non-Hyperkeratotic Actinic Keratoses indication
Photosensitivity contraindication 90128006

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.43 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
CHEBI:724125 CHEBI
4028718 VUID
N0000178414 NUI
C1134467 UMLSCUI
D04988 KEGG_DRUG
585NM85KYM UNII
79416-27-6 SECONDARY_CAS_RN
DB00992 DRUGBANK_ID
409397005 SNOMEDCT_US
408043009 SNOMEDCT_US
337068 RXNORM
25794 MMSL
4028718 VANDF
N0000178414 NDFRT
009997 NDDF
CHEMBL1096562 ChEMBL_ID
CHEMBL1201093 ChEMBL_ID
C114767 MESH_SUPPLEMENTAL_RECORD_UI
157922 PUBCHEM_CID

Pharmaceutical products:

None