medetomidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1655 86347-14-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • medetomidine hydrochloride
  • medetomidine
  • (+/-)-Medetomidine
  • dl-Medetomidine
  • medetomidine HCl
An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.
  • Molecular weight: 200.29
  • Formula: C13H16N2
  • CLOGP: 3.10
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 28.68
  • ALOGS: -3.06
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058647 Adrenergic alpha-2 Receptor Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sedation in Intubated Patients indication
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Hypertensive disorder contraindication 38341003 DOID:10763
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Cardiac Decompensation contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Sedation and analgesia Indication
Dogs To facilitate clinical examinations not requiring muscle relaxation Indication
Dogs To facilitate clinical procedures not requiring muscle relaxation Indication
Dogs Minor surgical procedures not requiring muscle relaxation Indication
Dogs Minor dental procedures not requiring intubation Indication

🐶 Veterinary products

ProductApplicantIngredients
Domitor Orion Corp. 1
Zenalpha Dechra, Ltd. 2
Placadine Modern Veterinary Therapeutics LLC 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.36 acidic
pKa2 6.76 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha-2 GPCR EC50 8.52 CHEMBL
Adrenergic receptor alpha-1 GPCR EC50 5.93 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 7.72 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 5.96 CHEMBL

External reference:

IDSource
D04883 KEGG_DRUG
86347-15-1 SECONDARY_CAS_RN
C0125656 UMLSCUI
CHEBI:48552 CHEBI
CHEMBL77921 ChEMBL_ID
DB11428 DRUGBANK_ID
CHEMBL537161 ChEMBL_ID
D020926 MESH_DESCRIPTOR_UI
68602 PUBCHEM_CID
5697 INN_ID
MR15E85MQM UNII
29428 RXNORM
018899 NDDF
018900 NDDF
782158001 SNOMEDCT_US
96228009 SNOMEDCT_US

Pharmaceutical products:

None