medetomidine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
1655 86347-14-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • medetomidine hydrochloride
  • medetomidine
  • (+/-)-Medetomidine
  • dl-Medetomidine
  • medetomidine HCl
An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.
  • Molecular weight: 200.29
  • Formula: C13H16N2
  • CLOGP: 3.11
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 28.68
  • ALOGS: -3.06
  • ROTB: 2

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058647 Adrenergic alpha-2 Receptor Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Sedation in Intubated Patients indication
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Hypertensive disorder contraindication 38341003 DOID:10763
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:2527
Disease of liver contraindication 235856003 DOID:409
Cardiac Decompensation contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.36 acidic
pKa2 6.76 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha-2 GPCR EC50 8.52 CHEMBL
Adrenergic receptor alpha-1 GPCR EC50 5.93 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 7.72 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 5.96 CHEMBL

External reference:

IDSource
C0065852 UMLSCUI
D04883 KEGG_DRUG
68602 PUBCHEM_CID
52016 RXNORM
N0000167067 NDFRT
96228009 SNOMEDCT_US
CHEMBL77921 ChEMBL_ID
CHEBI:48552 CHEBI
CHEMBL537161 ChEMBL_ID
BH210P244U UNII
86347-15-1 SECONDARY_CAS_RN
5697 INN_ID
D020926 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None