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medetomidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1655 | 86347-14-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK4,PIK3CB,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK,ULK1 | 44 | |||
| kinase-selectivity-class | AXL,BRAF,CSF1R,DDR1,EPHB4,ERBB2,GRK2,PDK4,PIK3CB,PIK3CD,SIK2 | 11 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000316 | Adrenergic alpha-Agonists |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D006993 | Hypnotics and Sedatives |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D058647 | Adrenergic alpha-2 Receptor Agonists |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Sedation in Intubated Patients | indication | ||
| Complete atrioventricular block | contraindication | 27885002 | |
| Hypovolemia | contraindication | 28560003 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Low blood pressure | contraindication | 45007003 | |
| Chronic heart failure | contraindication | 48447003 | |
| Bradycardia | contraindication | 48867003 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Cardiac Decompensation | contraindication |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Sedation and analgesia | Indication |
| Dogs | To facilitate clinical examinations not requiring muscle relaxation | Indication |
| Dogs | To facilitate clinical procedures not requiring muscle relaxation | Indication |
| Dogs | Minor surgical procedures not requiring muscle relaxation | Indication |
| Dogs | Minor dental procedures not requiring intubation | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Domitor | Orion Corp. | 1 |
| Zenalpha | Dechra, Ltd. | 2 |
| Placadine | Modern Veterinary Therapeutics LLC | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.36 | acidic |
| pKa2 | 6.76 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 | GPCR | EC50 | 8.52 | CHEMBL | |||||
| Adrenergic receptor alpha-1 | GPCR | EC50 | 5.93 | CHEMBL | |||||
| Adrenergic receptor alpha-2 | GPCR | Ki | 7.72 | CHEMBL | |||||
| Adrenergic receptor alpha-1 | GPCR | Ki | 5.96 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D04883 | KEGG_DRUG |
| 86347-15-1 | SECONDARY_CAS_RN |
| C0125656 | UMLSCUI |
| CHEBI:48552 | CHEBI |
| CHEMBL77921 | ChEMBL_ID |
| DB11428 | DRUGBANK_ID |
| CHEMBL537161 | ChEMBL_ID |
| D020926 | MESH_DESCRIPTOR_UI |
| 68602 | PUBCHEM_CID |
| 5697 | INN_ID |
| MR15E85MQM | UNII |
| 29428 | RXNORM |
| 018899 | NDDF |
| 018900 | NDDF |
| 782158001 | SNOMEDCT_US |
| 96228009 | SNOMEDCT_US |
Pharmaceutical products:
None