meclofenamic acid Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory, anthranilic acid derivatives 1650 644-62-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • meclofenamic acid
  • meclophenamic acid
  • meclofenamate sodium
  • meclofenamate
A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
  • Molecular weight: 296.15
  • Formula: C14H11Cl2NO2
  • CLOGP: 6.26
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 2
  • TPSA: 49.33
  • ALOGS: -4.91
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
June 25, 1980 FDA

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intestinal diaphragm disease 33.07 0 3 3 118 4638868

Pharmacologic Action:

SourceCodeDescription
ATC M01AG04 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Fenamates
ATC M02AA18 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35493 antipyretic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Rheumatoid arthritis indication 69896004 DOID:7148
Dysmenorrhea indication 266599000
Menorrhagia indication 386692008
Osteoarthritis indication 396275006
Ankylosing spondylitis off-label use 9631008 DOID:7147
Vascular headache off-label use 128187005
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Gastrointestinal hemorrhage contraindication 74474003
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Peripheral edema contraindication 271809000
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.2 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 6.70 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 6.66 WOMBAT-PK CHEMBL
Arachidonate 5-lipoxygenase Enzyme INHIBITOR IC50 4.33 WOMBAT-PK CHEMBL
Fatty acid-binding protein, intestinal Cytosolic other Ki 5.05 CHEMBL
Aldo-keto reductase family 1 member C2 Enzyme IC50 5.06 CHEMBL
Aldo-keto reductase family 1 member C1 Enzyme IC50 5.50 CHEMBL
Androgen receptor Nuclear hormone receptor IC50 4.19 WOMBAT-PK
Transthyretin Secreted IC50 4.30 CHEMBL
Mitogen-activated protein kinase 1 Kinase IC50 5.50 DRUG MATRIX
Aldo-keto reductase family 1 member C3 Enzyme IC50 6.27 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.70 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 6.59 CHEMBL
Cyclooxygenase Enzyme IC50 7 CHEMBL
Arachidonate 5-lipoxygenase Enzyme IC50 4.62 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 7.30 CHEMBL

External reference:

IDSource
4019080 VUID
N0000147341 NUI
C0025042 UMLSCUI
D00169 KEGG_DRUG
48I5LU4ZWD UNII
2165 INN_ID
770315008 SNOMEDCT_US
4019080 VANDF
6678 RXNORM
96172003 SNOMEDCT_US
002387 NDDF
67254-91-5 SECONDARY_CAS_RN
CHEBI:6710 CHEBI
CHEMBL509 ChEMBL_ID
CHEMBL876 ChEMBL_ID
DB00939 DRUGBANK_ID
JMS PDB_CHEM_ID
4037 PUBCHEM_CID
D008469 MESH_DESCRIPTOR_UI
CHEMBL1562610 ChEMBL_ID
7219 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Meclofenamate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-2150 CAPSULE 50 mg ORAL ANDA 13 sections
Meclofenamate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3000 CAPSULE 100 mg ORAL ANDA 13 sections