aminohippuric acid indications/contra

Stem definitionDrug idCAS RN
165 61-78-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aminohippurate
  • aminohippuric acid
  • 4-Aminohippuric acid
  • p-Aminohippuric acid
  • aminohippurate sodium
The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.
  • Molecular weight: 194.19
  • Formula: C9H10N2O3
  • CLOGP: -0.25
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 92.42
  • ALOGS: -1.79
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1944 FDA MERCK

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC V04CH30 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for renal function and ureteral injuries
MeSH PA D007202 Indicators and Reagents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Decreased cardiac function contraindication 43650005
Decompensated cardiac failure contraindication 195111005

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.84 acidic
pKa2 12.82 acidic
pKa3 2.76 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 22 member 6 Transporter Ki 5.22 CHEMBL
Solute carrier family 22 member 6 Transporter Ki 5.03 CHEMBL

External reference:

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IDSource
CHEBI:104011 CHEBI
DB00345 DRUGBANK_ID
4810 IUPHAR_LIGAND_ID
N0000011185 NUI
C0030123 UMLSCUI
D06890 KEGG_DRUG
CHEMBL463 ChEMBL_ID
2148 PUBCHEM_CID
7832 RXNORM
N0000011185 NDFRT
004885 NDDF
CHEMBL1200365 ChEMBL_ID
D010130 MESH_DESCRIPTOR_UI
SUO3KVS1O9 UNII
94-16-6 SECONDARY_CAS_RN

Pharmaceutical products:

None