mebendazole indications/contra

Stem definitionDrug idCAS RN
anthelminthics, tiabendazole derivatives 1641 31431-39-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mebendazole
  • vermox
A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
  • Molecular weight: 295.30
  • Formula: C16H13N3O3
  • CLOGP: 3.08
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 84.08
  • ALOGS: -3.87
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.20 g O

Approvals:

DateAgencyCompanyOrphan
June 28, 1974 FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 128.87 61.84 30 206 15521 3370102
Exposure during pregnancy 102.31 61.84 28 208 27535 3358088

Pharmacologic Action:

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SourceCodeDescription
ATC P02CA01 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTHELMINTICS
ANTINEMATODAL AGENTS
Benzimidazole derivatives
ATC P02CA51 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTHELMINTICS
ANTINEMATODAL AGENTS
Benzimidazole derivatives
FDA EPC N0000175481 Antihelminthic
MeSH PA D000871 Anthelmintics
CHEBI has role CHEBI:35444 antinematodal drug
MeSH PA D000890 Anti-Infective Agents
MeSH PA D050256 Antimitotic Agents
MeSH PA D000969 Antinematodal Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D050258 Mitosis Modulators
MeSH PA D050257 Tubulin Modulators

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Ascariasis indication 2435008 DOID:456
Trichuriasis indication 3752003 DOID:1252
Enterobiasis indication 266162007 DOID:7457
Necator Americanus Infection indication
Ancylostoma Duodenale Infection indication
Disease of liver contraindication 235856003 DOID:409
Infection by Gnathostoma off-label use 44086001 DOID:11379
Capillaria infection off-label use 52979002 DOID:12474
Echinococcus granulosus infection off-label use 75006000 DOID:1495
Echinococcus multilocularis off-label use 86648009
Infection by larvae of Trichinella spiralis off-label use 88264003 DOID:9784
Angiostrongyliasis due to Angiostrongylus costaricensis off-label use
Angiostrongyliasis due to Angiostrongylus cantonensis off-label use

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.61 acidic
pKa2 13.2 acidic
pKa3 2.93 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

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Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
500MG VERMOX JANSSEN PHARMS N208398 Oct. 19, 2016 DISCN TABLET, CHEWABLE ORAL Oct. 19, 2019 NEW STRENGTH

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosine-protein kinase ABL1 Kinase Ki 5.34 CHEMBL
Vascular endothelial growth factor receptor 2 Kinase IC50 5.44 CHEMBL
Tubulin Structural INHIBITOR CHEMBL CHEMBL
Tubulin Structural INHIBITOR CHEMBL CHEMBL
Calmodulin-domain protein kinase 1 Kinase IC50 6.17 CHEMBL

External reference:

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IDSource
4019270 VUID
N0000147469 NUI
C0025023 UMLSCUI
D00368 KEGG_DRUG
CHEMBL685 ChEMBL_ID
DB00643 DRUGBANK_ID
4030 PUBCHEM_CID
4019270 VANDF
1672 MMSL
6672 RXNORM
387311004 SNOMEDCT_US
56059005 SNOMEDCT_US
5026 MMSL
d00154 MMSL
N0000006419 NDFRT
N0000147469 NDFRT
002987 NDDF
81G6I5V05I UNII
2942 INN_ID
CHEBI:6704 CHEBI
D008463 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
VERMOX HUMAN PRESCRIPTION DRUG LABEL 1 50458-675 TABLET, CHEWABLE 500 mg ORAL NDA 17 sections
VERMOX HUMAN PRESCRIPTION DRUG LABEL 1 50580-070 TABLET, CHEWABLE 100 mg ORAL NDA 18 sections
EMVERM HUMAN PRESCRIPTION DRUG LABEL 1 52054-107 TABLET, CHEWABLE 100 mg ORAL ANDA 13 sections
MEBENDAZOLE HUMAN PRESCRIPTION DRUG LABEL 1 54868-3732 TABLET, CHEWABLE 100 mg ORAL ANDA 12 sections
Mebendazole HUMAN PRESCRIPTION DRUG LABEL 1 63629-1528 TABLET, CHEWABLE 100 mg ORAL ANDA 11 sections
EMVERM HUMAN PRESCRIPTION DRUG LABEL 1 64896-669 TABLET, CHEWABLE 100 mg ORAL ANDA 13 sections