maxacalcitol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 1638 103909-75-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • 22-oxacalcitriol
  • maxacalcitol
  • oxarol
  • Molecular weight: 418.62
  • Formula: C26H42O4
  • CLOGP: 4.17
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 69.92
  • ALOGS: -4.45
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Shunt stenosis 452.73 51.29 53 421 487 63488061
Shunt occlusion 258.64 51.29 33 441 632 63487916
Cardiac failure 59.68 51.29 23 451 89119 63399429
Peripheral arterial occlusive disease 53.62 51.29 11 463 4190 63484358

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Shunt stenosis 468.82 53.36 65 756 717 34955393
Shunt occlusion 241.42 53.36 37 784 833 34955277
Peripheral arterial occlusive disease 105.51 53.36 25 796 5849 34950261

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Shunt stenosis 876.81 46.27 118 1417 1273 79741580
Shunt occlusion 477.00 46.27 70 1465 1434 79741419
Peripheral arterial occlusive disease 159.80 46.27 36 1499 8222 79734631
Angina unstable 84.62 46.27 25 1510 16502 79726351
Cardiac failure 72.60 46.27 42 1493 154800 79588053
Shunt infection 60.32 46.27 9 1526 203 79742650
Cerebral infarction 53.12 46.27 23 1512 45653 79697200
Shunt aneurysm 47.34 46.27 6 1529 37 79742816

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D016588 Anticarcinogenic Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pustular psoriasis indication 200973000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor EC50 9.07 CHEMBL
Vitamin D3 receptor Transcription factor AGONIST EC50 8.21 IUPHAR

External reference:

IDSource
D01098 KEGG_DRUG
C0043872 UMLSCUI
CHEBI:31801 CHEBI
MCZ PDB_CHEM_ID
CHEMBL333950 ChEMBL_ID
DB06272 DRUGBANK_ID
C051883 MESH_SUPPLEMENTAL_RECORD_UI
6398761 PUBCHEM_CID
2784 IUPHAR_LIGAND_ID
7438 INN_ID
N2UJM5NBF6 UNII

Pharmaceutical products:

None