maxacalcitol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
Vitamin D analogues/derivatives	1638	103909-75-7

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

22-oxacalcitriol
maxacalcitol
oxarol

Molecular weight: 418.62
Formula: C26H42O4
CLOGP: 4.17
LIPINSKI: 0
HAC: 4
HDO: 3
TPSA: 69.92
ALOGS: -4.45
ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Shunt stenosis	452.73	51.29	53	421	487	63488061
Shunt occlusion	258.64	51.29	33	441	632	63487916
Cardiac failure	59.68	51.29	23	451	89119	63399429
Peripheral arterial occlusive disease	53.62	51.29	11	463	4190	63484358

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Shunt stenosis	468.82	53.36	65	756	717	34955393
Shunt occlusion	241.42	53.36	37	784	833	34955277
Peripheral arterial occlusive disease	105.51	53.36	25	796	5849	34950261

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Shunt stenosis	876.81	46.27	118	1417	1273	79741580
Shunt occlusion	477.00	46.27	70	1465	1434	79741419
Peripheral arterial occlusive disease	159.80	46.27	36	1499	8222	79734631
Angina unstable	84.62	46.27	25	1510	16502	79726351
Cardiac failure	72.60	46.27	42	1493	154800	79588053
Shunt infection	60.32	46.27	9	1526	203	79742650
Cerebral infarction	53.12	46.27	23	1512	45653	79697200
Shunt aneurysm	47.34	46.27	6	1529	37	79742816

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D016588	Anticarcinogenic Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pustular psoriasis	indication	200973000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.7	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Vitamin D3 receptor	Nuclear hormone receptor	P11473	VDR_HUMAN		EC50	9.07		CHEMBL
Vitamin D3 receptor	Transcription factor		VDR_RAT	AGONIST	EC50	8.21		IUPHAR

External reference:

ID	Source
D01098	KEGG_DRUG
C0043872	UMLSCUI
CHEBI:31801	CHEBI
MCZ	PDB_CHEM_ID
CHEMBL333950	ChEMBL_ID
DB06272	DRUGBANK_ID
C051883	MESH_SUPPLEMENTAL_RECORD_UI
6398761	PUBCHEM_CID
2784	IUPHAR_LIGAND_ID
7438	INN_ID
N2UJM5NBF6	UNII

Pharmaceutical products:

None