malotilate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
hepatoprotectants, di(propan-2-yl- 2-(2H-1,3-dithiol-2-ylidene)propanedioate and analogues 1627 59937-28-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • kantec
  • malotilate
  • Molecular weight: 288.38
  • Formula: C12H16O4S2
  • CLOGP: 3.52
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 52.60
  • ALOGS: -3.80
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 57
kinase-selectivity-class AURKB,AXL,BRAF,CAMK2B,CAMK2D,CDK16,CDK4,CDK9,CLK4,DDR1,DYRK1B,DYRK3,EIF2AK3,EPHB4,ERBB2,FGFR1,GRK2,GSK3A,GSK3B,HIPK2,IKBKB,IRAK1,IRAK3,JAK2,MAP2K6,MAP3K14,MAP3K2,MAP3K7,MAPK1,MAPK12,MAPK7,MAPK8,MARK4,PIK3CB,PIM3,PRKAA1,PRKDC,SIK2,STK10,STK33,SYK,TEK,TGFBR1,TTK,UHMK1,ZAP70 46
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01770 KEGG_DRUG
C0058158 UMLSCUI
CHEBI:31798 CHEBI
CHEMBL1697754 ChEMBL_ID
4006 PUBCHEM_CID
4944 INN_ID
RV59PND975 UNII
RV59PND975 INXIGHT DRUGS

Pharmaceutical products:

None