lysine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1622	56-87-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: L-Lysine lysine L-(+)-Lysine lysine hydrochloride lysine HCl	An essential amino acid. It is often added to animal feed. Molecular weight: 146.19 Formula: C6H14N2O2 CLOGP: -3.42 LIPINSKI: 0 HAC: 4 HDO: 3 TPSA: 89.34 ALOGS: -0.14 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

L-Lysine
lysine
L-(+)-Lysine
lysine hydrochloride
lysine HCl

An essential amino acid. It is often added to animal feed.

Molecular weight: 146.19
Formula: C6H14N2O2
CLOGP: -3.42
LIPINSKI: 0
HAC: 4
HDO: 3
TPSA: 89.34
ALOGS: -0.14
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

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Date	Agency	Company
July 25, 2019	EMA	Advanced Accelerator Applications
June 23, 2021	PMDA	FUJIFILM TOYAMA CHEMICAL Co., Ltd.
None	FDA

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FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Foetal growth restriction	44.92	19.75	16	3046	7537	63478423
Infantile apnoea	32.69	19.75	8	3054	1025	63484935
Cerebral haemorrhage	28.47	19.75	18	3044	30711	63455249
Selective eating disorder	27.17	19.75	8	3054	2064	63483896
Sinusitis	21.67	19.75	39	3023	226614	63259346

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Vasoplegia syndrome	34.81	27.17	8	714	1848	34954361
Compartment syndrome	30.94	27.17	8	714	3010	34953199
Coma scale abnormal	28.69	27.17	8	714	4000	34952209

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Vasoplegia syndrome	25.38	19.90	8	2746	3622	79738012
Compartment syndrome	22.74	19.90	8	2746	5074	79736560

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	B05XB03	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTION ADDITIVES Amino acids
ATC	V03AF11	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Detoxifying agents for antineoplastic treatment
CHEBI has role	CHEBI:27027	trace elements
CHEBI has role	CHEBI:35623	anticonvulsants
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Renal radiation exposure from Lutetium (177Lu) oxodotreotide	indication	218190002
Partial Central Diabetes Insipidus	indication
Classical phenylketonuria	contraindication	7573000
Poisoning by digitalis glycoside	contraindication	12876009
Sarcoidosis	contraindication	31541009	DOID:11335
End stage renal disease	contraindication	46177005	DOID:784
Humoral hypercalcemia of malignancy	contraindication	47709007
Heart disease	contraindication	56265001	DOID:114
Hypercalcemia	contraindication	66931009	DOID:12678
Ventricular fibrillation	contraindication	71908006

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.99	acidic
pKa2	10.46	Basic
pKa3	9.86	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glutathione reductase, mitochondrial	Enzyme	P00390	GSHR_HUMAN		Ki	4.26		CHEMBL

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External reference:

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ID	Source
LYS	PDB_CHEM_ID
000931	NDDF
005151	NDDF
10705	MMSL
233693	MMSL
40036	MMSL
4018682	VUID
4018682	VANDF
4018689	VANDF
418834008	SNOMEDCT_US

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0180	INJECTION	464 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0180	INJECTION	464 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0184	INJECTION, EMULSION	464 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0184	INJECTION, EMULSION	464 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0188	INJECTION	464 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0188	INJECTION	464 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0194	INJECTION	464 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0194	INJECTION	464 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0198	INJECTION	348 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0198	INJECTION	348 mg	INTRAVENOUS	NDA	21 sections

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