lucanthone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1616 479-50-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lucanthone
  • lucanthone hydrochloride
  • lucanthone HCl
One of the SCHISTOSOMICIDES, it has been replaced largely by HYCANTHONE and more recently PRAZIQUANTEL. (From Martindale The Extrapharmacopoeia, 30th ed., p46)
  • Molecular weight: 340.49
  • Formula: C20H24N2OS
  • CLOGP: 5.19
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 1
  • TPSA: 32.34
  • ALOGS: -5.03
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000980 Antiplatyhelmintic Agents
MeSH PA D012556 Schistosomicides
CHEBI has role CHEBI:25435 mutagens
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:38941 schistosomicide drugs
CHEBI has role CHEBI:47868 photosensitising agent
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:50276 topoisomerase I inhibitors
CHEBI has role CHEBI:50750 inhibitors of type II topoisomerase
CHEBI has role CHEBI:60809 adjuvants

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.72 Basic
pKa2 3.44 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA-(apurinic or apyrimidinic site) lyase Enzyme IC50 5.30 CHEMBL

External reference:

IDSource
D04791 KEGG_DRUG
C0024071 UMLSCUI
CHEBI:51052 CHEBI
CHEMBL279014 ChEMBL_ID
DB04967 DRUGBANK_ID
D008154 MESH_DESCRIPTOR_UI
10180 PUBCHEM_CID
337 INN_ID
548-57-2 SECONDARY_CAS_RN
FC6D57000M UNII
002982 NDDF
004876 NDDF
68310009 SNOMEDCT_US
CHEMBL2007389 ChEMBL_ID

Pharmaceutical products:

None