DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
lormetazepam 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
diazepam derivatives
1608
848-75-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
lormetazepam
methyllorazepam
N-Methyllorazepam
Molecular weight: 335.18
Formula: C16H12Cl2N2O2
CLOGP: 2.40
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 52.90
ALOGS: -4.31
ROTB: 1
Drug dosage:
Dose
Unit
Route
1
mg
O
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
75 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
t_half (Half-life)
4.90 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
4 mL/min/kg
Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)
2
Bocci G, Oprea TI, Benet LZ
Vd (Volume of distribution)
1.60 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.12 %
Lombardo F, Berellini G, Obach RS
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Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Coma
508.71
26.89
230
9412
64134
63415246
Drug abuse
485.55
26.89
231
9411
72287
63407093
Poisoning deliberate
334.12
26.89
106
9536
11112
63468268
Sopor
243.00
26.89
100
9542
22064
63457316
Drug dependence
220.27
26.89
96
9546
24387
63454993
Somnolence
208.29
26.89
190
9452
178495
63300885
Intentional overdose
185.39
26.89
124
9518
74028
63405352
Toxicity to various agents
171.78
26.89
199
9443
247051
63232329
Miosis
168.44
26.89
57
9585
7296
63472084
Drug interaction
156.71
26.89
183
9459
228948
63250432
Showing 1 to 10 of 67 entries
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7
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Coma
340.99
23.63
157
5181
45521
34906072
Drug abuse
261.09
23.63
171
5167
98925
34852668
Drug dependence
114.00
23.63
61
5277
24156
34927437
Intentional overdose
101.62
23.63
70
5268
43604
34907989
Miosis
87.53
23.63
38
5300
9497
34942096
Poisoning deliberate
77.72
23.63
33
5305
7811
34943782
Somnolence
75.96
23.63
89
5249
111027
34840566
Toxicity to various agents
75.35
23.63
120
5218
200242
34751351
Respiratory distress
55.62
23.63
45
5293
35620
34915973
Drug use disorder
52.99
23.63
21
5317
4170
34947423
Showing 1 to 10 of 34 entries
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1
2
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4
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Coma
806.66
20.07
383
14039
100266
79629700
Drug abuse
600.22
20.07
370
14052
162321
79567645
Poisoning deliberate
376.91
20.07
138
14284
18690
79711276
Sopor
270.85
20.07
128
14294
32882
79697084
Intentional overdose
252.31
20.07
184
14238
105776
79624190
Drug dependence
242.36
20.07
127
14295
40642
79689324
Miosis
241.09
20.07
95
14327
15694
79714272
Somnolence
238.83
20.07
253
14169
238728
79491238
Toxicity to various agents
203.00
20.07
310
14112
421230
79308736
Suicide attempt
181.57
20.07
137
14285
82795
79647171
Showing 1 to 10 of 106 entries
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N05CD06
NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Benzodiazepine derivatives
CHEBI has role
CHEBI:35717
hypnotics
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D002492
Central Nervous System Depressants
MeSH PA
D006993
Hypnotics and Sedatives
Showing 1 to 5 of 5 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
7.75
acidic
pKa2
0.26
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
004099
NDDF
13314
PUBCHEM_CID
28894
RXNORM
387570005
SNOMEDCT_US
4339
INN_ID
7553
IUPHAR_LIGAND_ID
96233008
SNOMEDCT_US
C0065185
UMLSCUI
C023842
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:52993
CHEBI
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Pharmaceutical products:
None
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lormetazepam