lorajmine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiarrhythmics, ajmaline derivatives 1604 47562-08-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lorajmine hydrochloride
  • lorajmine
  • lorajmine HCl
A monochloroacetyl derivative of ajmaline. It is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases.
  • Molecular weight: 402.92
  • Formula: C22H27ClN2O3
  • CLOGP: 2.21
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 53.01
  • ALOGS: -2.96
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01BA12 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class Ia
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.89 acidic
pKa2 7.15 Basic
pKa3 6.37 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D04774 KEGG_DRUG
40819-93-0 SECONDARY_CAS_RN
C0024001 UMLSCUI
CHEBI:135646 CHEBI
CHEMBL3989762 ChEMBL_ID
CHEMBL3989784 ChEMBL_ID
D064794 MESH_DESCRIPTOR_UI
DB13651 DRUGBANK_ID
76957773 PUBCHEM_CID
3889 INN_ID
F96VX65849 UNII

Pharmaceutical products:

None