aminoacridine indications/contra

Stem definitionDrug idCAS RN
acridine derivatives 160 90-45-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aminacrine hydrochloride
  • aminoacridine
  • 9-Acridinamine monohydrochloride
  • 9-Aminoacridine monohydrochloride
  • NSC-7571
  • aminacrine
  • 9-Aminoacridine
  • aminacrin
  • izoacridina
  • monacrin
  • aminacrine HCl
A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.
  • Molecular weight: 194.24
  • Formula: C13H10N2
  • CLOGP: 3.09
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 38.91
  • ALOGS: -3.41
  • ROTB: 0

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC D08AA02 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Acridine derivatives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D004396 Coloring Agents
MeSH PA D005456 Fluorescent Dyes
MeSH PA D007202 Indicators and Reagents
MeSH PA D049408 Luminescent Agents
MeSH PA D009153 Mutagens
MeSH PA D009676 Noxae

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Kidney disease contraindication 90708001 DOID:2527
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Disease of liver contraindication 235856003 DOID:409
Porphyria contraindication 418470004 DOID:13268

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.54 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Trypanothione reductase Enzyme Ki 4.42 CHEMBL

External reference:

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IDSource
CHEBI:51803 CHEBI
4018614 VUID
N0000179393 NUI
C0282047 UMLSCUI
D02905 KEGG_DRUG
78OY3Z0P7Z UNII
1476 INN_ID
CHEMBL43184 ChEMBL_ID
7019 PUBCHEM_CID
645 RXNORM
6602005 SNOMEDCT_US
4019604 VANDF
N0000006774 NDFRT
N0000147700 NDFRT
004875 NDDF
714291009 SNOMEDCT_US
CHEMBL1330022 ChEMBL_ID
134-50-9 SECONDARY_CAS_RN
DB11561 DRUGBANK_ID
D000585 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None