Stem definition | Drug id | CAS RN |
---|---|---|
substances of the imipramine group | 1592 | 23047-25-8 |
Dose | Unit | Route |
---|---|---|
0.11 | g | O |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 1, 1977 | YEAR INTRODUCED |
None
Source | Code | Description |
---|---|---|
ATC | N06AA07 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Non-selective monoamine reuptake inhibitors |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D000929 | Antidepressive Agents, Tricyclic |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
CHEBI has role | CHEBI:35469 | antidepressant |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Depressive disorder | indication | 35489007 | DOID:2848 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.05 | Basic |
pKa2 | 5.01 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Ki | 8.27 | WOMBAT-PK | IUPHAR | |||
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 7.15 | WOMBAT-PK | IUPHAR | |||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 6.34 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 6.47 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 6.89 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.48 | WOMBAT-PK | |||||
D(2) dopamine receptor | GPCR | Ki | 5.70 | PDSP | |||||
Histamine H1 receptor | GPCR | Ki | 6.44 | WOMBAT-PK | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 7 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.70 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.17 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.34 | PDSP |
ID | Source |
---|---|
N0000167255 | NUI |
C0023961 | UMLSCUI |
7551 | IUPHAR_LIGAND_ID |
D01285 | KEGG_DRUG |
6465 | RXNORM |
321831005 | SNOMEDCT_US |
395772004 | SNOMEDCT_US |
N0000167255 | NDFRT |
004095 | NDDF |
CHEMBL87708 | ChEMBL_ID |
3947 | PUBCHEM_CID |
CHEMBL2106638 | ChEMBL_ID |
D008127 | MESH_DESCRIPTOR_UI |
OCA4JT7PAW | UNII |
2909 | INN_ID |
26786-32-3 | SECONDARY_CAS_RN |
CHEBI:47782 | CHEBI |
None