liothyronine indications/contra

Stem definitionDrug idCAS RN
1585 6893-02-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • liothyronine
  • liothyronine sodium
  • triiodothyronine
  • liothyronin
A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
  • Molecular weight: 650.98
  • Formula: C15H12I3NO4
  • CLOGP: 2.63
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 3
  • TPSA: 92.78
  • ALOGS: -4.52
  • ROTB: 5

Drug dosage:

DoseUnitRoute
60 mcg O
60 mcg P

Approvals:

DateAgencyCompanyOrphan
May 8, 1956 FDA KING PHARMS R AND D

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthyroidism 117.14 37.43 21 224 2813 3382801
Hypothyroidism 62.01 37.43 14 231 5875 3379739
Completed suicide 58.76 37.43 19 226 31095 3354519
Alopecia 54.47 37.43 16 229 18970 3366644
Fatigue 54.21 37.43 25 220 107215 3278399
Drug ineffective 52.31 37.43 25 220 116065 3269549
Product quality issue 49.07 37.43 16 229 26719 3358895
Rhinovirus infection 46.98 37.43 7 238 288 3385326
Palpitations 45.69 37.43 14 231 19069 3366545
Thyrotoxic periodic paralysis 42.23 37.43 5 240 32 3385582
Thyroid function test abnormal 41.24 37.43 7 238 663 3384951
Acute respiratory distress syndrome 40.85 37.43 10 235 5884 3379730
Atrial fibrillation 38.55 37.43 13 232 23928 3361686
Intentional product misuse 37.63 37.43 11 234 12690 3372924

Pharmacologic Action:

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SourceCodeDescription
ATC H03AA02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
THYROID PREPARATIONS
Thyroid hormones
ATC H03AA03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
THYROID PREPARATIONS
Thyroid hormones
FDA EPC N0000175946 l-Triiodothyronine
FDA Chemical/Ingredient N0000006165 Triiodothyronine

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Goiter indication 3716002 DOID:12176
Myxedema coma indication 21263006
Hypothyroidism indication 40930008 DOID:1459
Myxedema indication 43153006 DOID:11634
Congenital hypothyroidism indication 190268003
Simple goiter indication 267369002 DOID:13195
Malignant tumor of thyroid gland indication 363478007 DOID:1781
T3 Suppression for Thyroid Function Test indication
Mild Hypothyroidism indication
Diagnostic Test for Thyroid Dysfunction indication
Myocardial infarction contraindication 22298006 DOID:5844
Thyrotoxic crisis contraindication 29028009 DOID:12837
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Osteoporosis contraindication 64859006 DOID:11476
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Angina pectoris contraindication 194828000
Osteopenia contraindication 312894000
Primary adrenocortical insufficiency contraindication 373662000 DOID:13774
Disorder of coronary artery contraindication 414024009

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.08 acidic
pKa2 8.12 acidic
pKa3 8.77 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thyroid hormone receptor alpha Nuclear hormone receptor AGONIST Kd 10.24 CHEMBL CHEMBL
Thyroid hormone receptor beta Nuclear hormone receptor AGONIST Ki 10.10 CHEMBL CHEMBL
THAP domain-containing protein 1 Unclassified EC50 9 WOMBAT-PK
Proliferating cell nuclear antigen Unclassified IC50 5.44 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 4.64 CHEMBL
Adenosine receptor A1 GPCR Ki 6.62 DRUG MATRIX
Cytochrome P450 2C9 Enzyme EC50 6.30 WOMBAT-PK
GABA-A receptor; anion channel Ion channel EC50 5.15 CHEMBL
Thyroid hormone receptor beta Transcription factor IC50 8.74 CHEMBL

External reference:

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IDSource
DB00279 DRUGBANK_ID
4022167 VUID
N0000020173 NUI
C0041014 UMLSCUI
2634 IUPHAR_LIGAND_ID
D01011 KEGG_DRUG
06LU7C9H1V UNII
653 INN_ID
61275002 SNOMEDCT_US
4022167 VANDF
N0000006165 NDFRT
N0000020173 NDFRT
350358003 SNOMEDCT_US
d00658 MMSL
004882 NDDF
10814 RXNORM
CHEMBL1544 ChEMBL_ID
CHEMBL1201119 ChEMBL_ID
5920 PUBCHEM_CID
55-06-1 SECONDARY_CAS_RN
D014284 MESH_DESCRIPTOR_UI
CHEBI:18258 CHEBI
T3 PDB_CHEM_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
LIOTHYRONINE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0179-0018 TABLET 25 ug ORAL ANDA 11 sections
LIOTHYRONINE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0179-0019 TABLET 5 ug ORAL ANDA 11 sections
Liothyronine sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3611 TABLET 5 ug ORAL ANDA 12 sections
Liothyronine sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3612 TABLET 25 ug ORAL ANDA 12 sections
Liothyronine sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3613 TABLET 50 ug ORAL ANDA 12 sections
Thyrolar HUMAN PRESCRIPTION DRUG LABEL 1 0456-0040 TABLET 3.10 ug ORAL NDA 12 sections
Thyrolar HUMAN PRESCRIPTION DRUG LABEL 1 0456-0045 TABLET 6.25 ug ORAL NDA 12 sections
Thyrolar HUMAN PRESCRIPTION DRUG LABEL 1 0456-0050 TABLET 12.50 ug ORAL NDA 12 sections
Thyrolar HUMAN PRESCRIPTION DRUG LABEL 1 0456-0055 TABLET 25 ug ORAL NDA 12 sections
Thyrolar HUMAN PRESCRIPTION DRUG LABEL 1 0456-0060 TABLET 37.50 ug ORAL NDA 12 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0574-0220 TABLET 5 ug ORAL ANDA 13 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0574-0222 TABLET 25 ug ORAL ANDA 13 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0574-0223 TABLET 50 ug ORAL ANDA 13 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16590-303 TABLET 50 1 ORAL ANDA 13 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-964 TABLET 5 ug ORAL ANDA 12 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 39822-0151 INJECTION, SOLUTION 10 ug INTRAVENOUS ANDA 12 sections
Triostat HUMAN PRESCRIPTION DRUG LABEL 1 42023-120 INJECTION 10 ug INTRAVENOUS NDA 12 sections
NP Thyroid 15 HUMAN PRESCRIPTION DRUG LABEL 2 42192-327 TABLET 2.25 ug ORAL unapproved drug other 21 sections
NP Thyroid 120 HUMAN PRESCRIPTION DRUG LABEL 2 42192-328 TABLET 18 ug ORAL unapproved drug other 21 sections
NP Thyroid 30 HUMAN PRESCRIPTION DRUG LABEL 2 42192-329 TABLET 4.50 ug ORAL unapproved drug other 21 sections
NP Thyroid 60 HUMAN PRESCRIPTION DRUG LABEL 2 42192-330 TABLET 9 ug ORAL unapproved drug other 21 sections
NP Thyroid 90 HUMAN PRESCRIPTION DRUG LABEL 2 42192-331 TABLET 13.50 ug ORAL unapproved drug other 21 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 42794-018 TABLET 5 ug ORAL ANDA 12 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 42794-019 TABLET 25 ug ORAL ANDA 12 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 42794-020 TABLET 50 ug ORAL ANDA 12 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 43063-252 TABLET 50 ug ORAL ANDA 12 sections
Liothyronine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 43063-253 TABLET 25 ug ORAL ANDA 13 sections
Cytomel HUMAN PRESCRIPTION DRUG LABEL 1 50090-0413 TABLET 5 ug ORAL NDA 12 sections
LIOTHYRONINE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 51655-122 TABLET 50 ug ORAL ANDA 11 sections
NP THYROID 90 HUMAN PRESCRIPTION DRUG LABEL 2 51655-124 TABLET 13.50 ug ORAL unapproved drug other 19 sections