levosulpiride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sulpiride derivatives and analogues 1577 23672-07-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levopraid
  • levosulpiride
  • (-)-Sulpiride
  • L-Sulpiride
  • lesuride
  • levobren
  • levopride
  • Molecular weight: 341.43
  • Formula: C15H23N3O4S
  • CLOGP: 1.15
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 101.73
  • ALOGS: -2.80
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebellar syndrome 101.17 48.72 18 422 3521 63485061
Galactorrhoea 85.44 48.72 16 424 4139 63484443
Serotonin syndrome 63.67 48.72 18 422 28664 63459918
Sopor 58.78 48.72 16 424 22148 63466434
Hyperprolactinaemia 55.26 48.72 11 429 3889 63484693
Hyperthermia 51.14 48.72 12 428 9144 63479438

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 95.25 42.11 27 699 32983 79710679
Cerebellar syndrome 88.26 42.11 18 708 5462 79738200
Galactorrhoea 83.06 42.11 16 710 3630 79740032
Drug interaction 54.30 42.11 38 688 415145 79328517
Serotonin syndrome 50.70 42.11 18 708 45009 79698653
Hyperprolactinaemia 50.23 42.11 11 715 4665 79738997
Disorganised speech 46.39 42.11 9 717 2108 79741554
Drug abuse 44.68 42.11 24 702 162667 79580995

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AL07 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Benzamides
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35476 neuroleptics
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:50919 antiemetico

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.47 acidic
pKa2 12.66 acidic
pKa3 8.85 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 7.29 CHEMBL
D(3) dopamine receptor GPCR Ki 7.06 CHEMBL
D(4) dopamine receptor GPCR Ki 5.68 CHEMBL
Myeloperoxidase Enzyme IC50 5.12 CHEMBL
D(2) dopamine receptor GPCR Ki 8.16 CHEMBL
D(1A) dopamine receptor GPCR Ki 4.30 CHEMBL
Dopamine receptor GPCR IC50 6.68 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 4.82 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 4.57 CHEMBL

External reference:

IDSource
D07312 KEGG_DRUG
C0210380 UMLSCUI
CHEBI:64119 CHEBI
CHEMBL267044 ChEMBL_ID
DB16021 DRUGBANK_ID
C078143 MESH_SUPPLEMENTAL_RECORD_UI
688272 PUBCHEM_CID
958 IUPHAR_LIGAND_ID
6593 INN_ID
JTG7R315LK UNII
018683 NDDF
1179629009 SNOMEDCT_US
702795007 SNOMEDCT_US

Pharmaceutical products:

None