levamfetamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1562	156-34-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

levamphetamine
levoamphetamine
R-Amphetamine
L-Amphetamine
levamfetamine
levamfetamine succinate

Molecular weight: 135.21
Formula: C9H13N
CLOGP: 1.74
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 26.02
ALOGS: -1.89
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D018759	Adrenergic Uptake Inhibitors
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D000697	Central Nervous System Stimulants
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018765	Dopamine Uptake Inhibitors
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014179	Neurotransmitter Uptake Inhibitors
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D013566	Sympathomimetics

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.89	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	4.33		CHEMBL
Trace amine-associated receptor 1	GPCR	Q96RJ0	TAAR1_HUMAN		EC50	6.60		CHEMBL
Trace amine-associated receptor 1	GPCR		TAAR1_MACMU		EC50	5.73		CHEMBL
Trace amine-associated receptor 1	GPCR		TAAR1_RAT		EC50	7.47		CHEMBL
Trace amine-associated receptor 1	GPCR		TAAR1_MOUSE		EC50	7.19		CHEMBL
Serotonin (5-HT) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT1A_RAT 5HT1B_RAT 5HT1D_RAT 5HT1F_RAT 5HT2B_RAT 5HT6R_RAT 5HT7R_RAT 5HT5A_RAT 5HT5B_RAT 5HT3A_RAT 5HT4R_RAT 5HT3B_RAT		Kd	5.16		CHEMBL

External reference:

ID	Source
D04704	KEGG_DRUG
CHEBI:42724	CHEBI
FRD	PDB_CHEM_ID
CHEMBL19393	ChEMBL_ID
CHEMBL2106371	ChEMBL_ID
5634-40-2	SECONDARY_CAS_RN
85242006	SNOMEDCT_US
C0301355	UMLSCUI
D000661	MESH_DESCRIPTOR_UI
1313	INN_ID
32893	PUBCHEM_CID
R87US8P740	UNII

Pharmaceutical products:

None